Designing of special clothing based on experimental researches of material properties

The article presents the results of experimental researches on determination of thermal and physical characteristics of thermal insulating materials using the principle of spatial three-dimensional presentation of the study object with distributed parameters. The proposed method of research and obtained experimental results provide an opportunity to determine thermal and physical properties of materials with high accuracy, which creates the conditions for improvement of the quality of special clothes designing

Holographic Recording Media based on Electron Donor Oligomers

For optical holographic recording by photothermoplastic technique reversible holographic media based on oligomers with hole type of conductivity are used. New carbazole containing radial tetrasubstituted silanes and germanes are described in the present work

A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening.

The unparalleled global effort to combat the continuing severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic over the last year has resulted in promising prophylactic measures. However, a need still exists for cheap, effective therapeutics, and targeting multiple points in the viral life cycle could help tackle the current, as well as future, coronaviruses. Here, we leverage our recently developed, ultra-large-scale in silico screening platform, VirtualFlow, to search for inhibitors that target SARS-CoV-2. In this unprecedented structure-based virtual campaign, we screened roughly 1 billion molecules against each of 40 different target sites on 17 different potential viral and host targets. In addition to targeting the active sites of viral enzymes, we also targeted critical auxiliary sites such as functionally important protein-protein interactions

Эффективность и безопасность джозамицина при лечении нетяжелой внебольничной пневмонии в рутинной клинической практике: результаты проспективной многоцентровой наблюдательной программы

Aim. A goal of this noninterventional prospective multicenter observational program was to evaluate efficacy and safety of josamycin in patients with nonsevere communityacquired pneumonia (CAP) in routine clinical practice.Methods. Patients (n = 104) with radiological signs of pneumonia were treated with josamycin (Wilprafen® Solutab®, dispersible tablets 1 000 mg). Complete resolution of CAP was achieved in 95.6 % of patients, a clinically significant improvement was seen in 3.3 % of patients and a lack of effect was seen in 1 (1.1 %) patient. Radiological followup did not reveal worsening in any patients.The results of this study have demonstrated that josamycin was highly effective (> 95 %) and had a good safety profile in outpatients with nonsevere CAP.С целью изучения эффективности и безопасности препарата джозамицин при лечении пациентов с нетяжелой внебольничной пневмонией (ВП) в рутинной клинической практике реализована неинтервенционная проспективная многоцентровая наблюдательная программа. Пациентам (n = 104) с рентгенологически подтвержденным диагнозом ВП в качестве антибактериального препарата назначался джозамицин (Вильпрафен® Солютаб®, таблетки диспергируемые 1 000 мг). По данным оценки клинической эффективности терапии у 95,6 % пациентов отмечалось полное выздоровление, у 3,3 % – клинически значимое улучшение, отсутствие эффекта от проводимой терапии – лишь в 1 (1,1 %) случае. При контрольном рентгенологическом обследовании отрицательной динамики не выявлено ни у одного пациента. По результатам наблюдательной программы при лечении пациентов с нетяжелой ВП в амбулаторных условиях показаны высокая эффективность (> 95 %) и хороший профиль безопасности препарата

Management of patients with neurological complications of diabetes mellitus

The article presents a clinical case of an elderly patient who had consulted a neurologist due to rapidly developed various complications of diabetes in the form of damage to the peripheral and central nervous systems. The debut of diabetic amyotrophy two years ago in our patient was mistakenly considered as a manifestation of osteochondrosis of the lumbosacral spine. The recommended drug therapy did not reduce symptoms and caused gastrointestinal disorders, which led to the independent withdrawal of all drugs. Polypharmacy reduced the patient’s adherence to therapy and reduced the frequency of regular visits to the doctor.The article deals with the pathogenesis of the main neurological complications of diabetes (diabetic neuropathy and cognitive disorders) in elderly people with arterial hypertension. The possibility of their therapeutic correction to reduce the number of medications taken by patients is discussed. Tactics of polymorbid patients taking into account concomitant chronic diseases should include normalization of glucose levels, correction of vascular risk factors, non-pharmacological methods of treatment - lifestyle changes, diet therapy, regular moderate physical activity. The use of alpha-lipoic (thioctic) acid (Berlithion) as a lipophilic antioxidant will help to slow down the development of complications