Factors Influencing the Unethical Behavioral Intention of College Business Students: Theory of Planned Behavior

The growth of inappropriate accounting transactions, corporate scandals, and fraudulent financial reporting has created an environment of mistrust of corporations and the people who manage them. There is a need to understand the underlying factors associated with these trends, and to apply that knowledge to the education of the future generation of managers--students in pursuit of a business degree. Academic cheating has been found to correlate with fraudulent financial activity (Chen & Teng, 2006; Rod & Richardson, 1994). Understanding the attitudes and intentions of college students, when faced with a difficult decision, is vital (Peppas & Diskin, 2001). From an accessible population of approximately 805 community college business students enrolled in core business classes, 485 students participated in this exploratory (comparative) and explanatory (correlational) study. Multiple regression analyses tested hypothesized relationships between student characteristics, personality dimensions, attitude, subjective norm, perceived behavioral control, and intention to fraudulently report financial information using the Ten-Item Personality Inventory (TIPI) developed by Gosling, Rentfrow, and Swan (2003), and a scenario based on the constructs related to the theory of planned behavior (TPB) developed by Ajzen and Fishbein (1980). Results of psychometric analyses indicated estimates of TIP1 reliability were lower among this sample compared to previous samples, while TPB estimates were consistent with previous studies. Results of factor analyses found that although the attitude and intent items formed one, rather than two, factors, the factor structure of the subjective norm and perceived behavioral control constructs were supported. The TIP1 analyses produced four, rather than five dimensions. Female students were more conscientious, while male students were more open to experiences. Results of hypotheses testing indicated two of the five personality dimensions, conscientiousness and agreeableness, followed the hypothesized order of importance in explaining the intention to fraudulently report financial information. TPB constructs, attitude and subjective norm, were positive explanatory variables of intent. A more extensive personality inventory instrument may offer a better understanding of the relationship between personality dimension and intention. The use of a national sample may provide insight into trends occurring in the college classroom, and improve the generalizability of future results

Rainfall threshold definition using an entropy decision approach and radar data

Flash flood events are floods characterised by a very rapid response of basins to storms, often resulting in loss of life and property damage. Due to the specific space-time scale of this type of flood, the lead time available for triggering civil protection measures is typically short. Rainfall threshold values specify the amount of precipitation for a given duration that generates a critical discharge in a given river cross section. If the threshold values are exceeded, it can produce a critical situation in river sites exposed to alluvial risk. It is therefore possible to directly compare the observed or forecasted precipitation with critical reference values, without running online real-time forecasting systems. The focus of this study is the Mignone River basin, located in Central Italy. The critical rainfall threshold values are evaluated by minimising a utility function based on the informative entropy concept and by using a simulation approach based on radar data. The study concludes with a system performance analysis, in terms of correctly issued warnings, false alarms and missed alarms

An entropy approach for evaluating the maximum information content achievable by an urban rainfall network

Hydrological models are the basis of operational flood-forecasting systems. The accuracy of these models is strongly dependent on the quality and quantity of the input information represented by rainfall height. Finer space-time rainfall resolution results in more accurate hazard forecasting. In this framework, an optimum raingauge network is essential in predicting flood events. This paper develops an entropy-based approach to evaluate the maximum information content achievable by a rainfall network for different sampling time intervals. The procedure is based on the determination of the coefficients of transferred and nontransferred information and on the relative isoinformation contours. The nontransferred information value achieved by the whole network is strictly dependent on the sampling time intervals considered. An empirical curve is defined, to assess the objective of the research: the nontransferred information value is plotted versus the associated sampling time on a semi-log scale. The curve has a linear trend. In this paper, the methodology is applied to the high-density raingauge network of the urban area of Rome

Disentangling the Structure-Activity Relationships of Naphthalene Diimides as Anticancer G-Quadruplex-Targeting Drugs

In the context of developing efficient anticancer therapies aimed at eradicating any sort of tumors, G-quadruplexes represent excellent targets. Small molecules able to interact with G-quadruplexes can interfere with cell pathways specific of tumors and common to all cancers. Naphthalene diimides (NDIs) are among the most promising, putative anticancer G-quadruplextargeting drugs, due to their ability to simultaneously target multiple G-quadruplexes and their strong, selective in vitro and in vivo anticancer activity. Here, all the available biophysical, biological, and structural data concerning NDIs targeting Gquadruplexes were systematically analyzed. Structure−activity correlations were obtained by analyzing biophysical data of their interactions with G-quadruplex targets and control duplex structures, in parallel to biological data concerning the antiproliferative activity of NDIs on cancer and normal cells. In addition, NDI binding modes to G-quadruplexes were discussed in consideration of the structures and properties of NDIs by in-depth analysis of the available structural models of G-quadruplex/NDI complexes

Anti-VEGF DNA-based aptamers in cancer therapeutics and diagnostics

The vascular endothelial growth factor (VEGF) family and its receptors play fundamental roles not only in physiological but also in pathological angiogenesis, characteristic of cancer progression. Aiming at finding putative treatments for several malignancies, various small molecules, antibodies, or protein-based drugs have been evaluated in vitro and in vivo as VEGF inhibitors, providing efficient agents approved for clinical use. Due to the high clinical importance of VEGF, also a great number of anti-VEGF nucleic acid-based aptamers-that is, oligonucleotides able to bind with high affinity and specificity a selected biological target-have been developed as promising agents in anticancer strategies. Notable research efforts have been made in optimization processes of the identified aptamers, searching for increased target affinity and/or bioactivity by exploring structural analogues of the lead compounds. This review is focused on recent studies devoted to the development of DNA-based aptamers designed to target VEGF. Their therapeutic potential as well as their significance in the construction of highly selective biosensors is here discussed

intermittent or continuous panitumumab pan plus folfiri for first line treatment of patients pts with ras braf wild type wt metastatic colorectal cancer mcrc a randomized phase ii trial improve

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Cross-sectional study to develop and describe psychometric characteristics of a patient-reported instrument (PROFFIT) for measuring financial toxicity of cancer within a public healthcare system

Objectives To measure and explain financial toxicity (FT) of cancer in Italy, where a public healthcare system exists and patients with cancer are not expected (or only marginally) to pay out-of-pocket for healthcare. Setting Ten clinical oncological centres, distributed across Italian macroregions (North, Centre, South and Islands), including hospitals, university hospitals and national research institutes. Participants From 8 October 2019 to 11 December 2019, 184 patients, aged 18 or more, who were receiving or had received within the previous 3 months active anticancer treatment were enrolled, 108 (59%) females and 76 (41%) males. Intervention A 30-item prefinal questionnaire, previously developed within the qualitative tasks of the project, was administered, either electronically (n=115) or by paper sheet (n=69). Primary and secondary outcome measures According to the protocol and the International Society for Pharmacoeconomics and Outcomes Research methodology, the final questionnaire was developed by mean of explanatory factor analysis and tested for reliability, internal consistency (Cronbach's α test and item-total correlation) and stability of measurements over time (test-retest reliability by intraclass correlation coefficient and weighted Cohen's kappa coefficient). Results After exploratory factor analysis, a score measuring FT (FT score) was identified, made by seven items dealing with outcomes of FT. The Cronbach's alpha coefficient for the FT score was 0.87 and the item-total correlation coefficients ranged from 0.53 to 0.74. Further, nine single items representing possible determinants of FT were also retained in the final instrument. Test-retest analysis revealed a good internal validity of the FT score and of the 16 items retained in the final questionnaire. Conclusions The Patient-Reported Outcome for Fighting FInancial Toxicity (PROFFIT) instrument consists of 16 items and is the first reported instrument to assess FT of cancer developed in a country with a fully public healthcare system. Trial registration number NCT03473379

High-dose recombinant interleukin-2/verapamil combination in advanced cancer.

No abstract availabl