Recent finding and new technologies in nephrolithiasis: a review of the recent literature

This review summarizes recent literature on advances regarding renal and ureteral calculi, with particular focus in areas of recent advances in the overall field of urolithiasis. Clinical management in everyday practice requires a complete understanding of the issues regarding metabolic evaluation and subgrouping of stone-forming patients, diagnostic procedures, effective treatment regime in acute stone colic, medical expulsive therapy, and active stone removal. In this review we focus on new perspectives in managing nephrolitihiasis and discuss recentadvances, including medical expulsive therapy, new technologies, and refinements of classical therapy such as shock wave lithotripsy, give a fundamental modification of nephrolithiasis management. Overall, this field appears to be the most promising, capable of new developments in ureterorenoscopy and percutaneous approaches. Further improvements are expected from robotic-assisted procedures, such as flexible robotics in ureterorenoscopy

Anxiety disorders predict fasting to control weight:A longitudinal large cohort study of adolescents

To determine whether anxiety disorders are prospectively associated with fasting for weight-loss/to avoid weight-gain, a behaviour that precedes and is typical of anorexia nervosa (AN), during adolescence

Post-Mortem Immunohistochemical Evidence of β2-Adrenergic Receptor Expression in the Adrenal Gland

The evidence from post-mortem biochemical studies conducted on cortisol and catecholamines suggest that analysis of the adrenal gland could provide useful information about its role in human pathophysiology and the stress response. Authors designed an immunohistochemical study on the expression of the adrenal β2-adrenergic receptor (β2-AR), a receptor with high-affinity for catecholamines, with the aim to show which zones it is expressed in and how its expression differs in relation to the cause of death. The immunohistochemical study was performed on adrenal glands obtained from 48 forensic autopsies of subjects that died as a result of different pathogenic mechanisms using a mouse monoclonal β2-AR antibody. The results show that immunoreactivity for β2-AR was observed in all adrenal zones. Furthermore, immunoreactivity for β2-AR has shown variation in the localization and intensity of different patterns in relation to the original cause of death. To the best of our knowledge, this is the first study that demonstrates β2-AR expression in the human cortex and provides suggestions on the possible involvement of β2-AR in human cortex hormonal stimulation. In conclusion, the authors provide a possible explanation for the observed differences in expression in relation to the cause of death

[ARFID - Avoidant and restrictive food intake disorder : clinical characteristics]

Le trouble de restriction ou évitement de l’ingestion des aliments (ARFID, Avoidant and Restrictive Food Intake Disorder) est un «nouveau» diagnostic introduit dans le manuel diagnostique et statistique des troubles mentaux, 5e édition (DSM-5) en 2013. L’ARFID est un trouble hétérogène qui semble être commun dans les milieux cliniques ; il est associé à d’importants taux de comorbidités physiques et psychologiques et impacte la santé physique et le fonctionnement psychosocial. Nous présentons un aperçu de la littérature disponible sur l’ARFID et décrivons la compréhension actuelle de ses corrélats. Nous décrivons également deux cas cliniques qui illustrent l’ARFID dans la pratique clinique. Avoidant and restrictive food intake disorder (ARFID) is a « new » diagnosis introduced in the Diagnostic and statistical manual of mental disorders, fifth edition (DSM-5) in 2013. ARFID is a heterogeneous disorder that seems to be common in clinical settings and is associated with high levels of physical and psychological comorbidity and impact on physical health and psychosocial functioning. We present an overview of the available literature on ARFID and describe the current understanding of its correlates. We also describe two cases that exemplify ARFID in clinical practice

Exceptional response to immunotherapy in association with radiotherapy in patient with breast metastasis from urothelial carcinoma: A case report

Most common sites of metastasis of urothelial carcinoma (UC) are lungs, liver, lymph nodes and bone. Pembrolizumab, a humanized monoclonal antibody directed against programmed cell death protein-1 (PD-1), represents an effective second-line therapy for advanced UC. Radiotherapy has been shown to induce a mechanism of immunogenic cell death (ICD) resulting in immune memory and advantageous systemic effects. We present the first case of breast metastasis (BM) from a UC described in literature who had an exceptional response to second-line therapy with pembrolizumab in association with radiotherapy, showing the efficacy of combining immunotherapy and radiotherapy even in patients with atypical metastatic sites

Forensic tools for the diagnosis of electrocution death: Case study and literature review

Diagnosis of death by electrocution may be difficult when electric marking is not visible or unclear. Accordingly, the body of a man who appeared to have died from accidental electrocution was carefully forensically analysed. Macroscopic and microscopic analysis of the current mark was carried out using a variable-pressure scanning electron microscope equipped with energy dispersive X-ray microanalyser to highlight skin metallisation, indicating the presence of iron and zinc. The histological findings of electrocution myocardial damage were supported by the results of biochemical analysis which demonstrated the creatine kinase-MB and cardiac troponin I elevation. The effects of electric current flow were also highlighted by perforations of endothelial surface of a pulmonary artery using scanning electron microscope, and all the results were analysed by the main tools suggested in the literature

Isolation of Yersinia enterocolitica biotype 1 A

A survey has been carried out for the presence of Yersinia enterocolitioca in raw meat products. One hundred and twenty raw beef, chicken and ham samples were assayed for the presence of Yersinia enterocolitica by the 4 degrees °C enrichment method after 2 weeks of incubation using phosphate buffered saline. Yersinia enterocolitica biotype 1 A non agglutinable (NAG) was isolated from a sample of beef and identified by Api 20 E System and additional biochemical tests, Lipase, ?-D-Glucosidase and Pyrazinamidase. The Author related about pathogenicity of Yersinia enterocolitica biotype 1 A that may cause symptoms similar to that caused by virulent biotypes. The presence of Yersinia enterocolitica in raw meat products represents a health risk for consumers therefore was suggested to yersiniosis control and further surveillance studies on epidemiology of such emerging pathogens

Shock wave lithotripsy for a renal stone in a tetraplegic patient as a trigger for life-threatening posterior reversible encephalopathy syndrome

Shock wave lithotripsy (SWL) is considered a non-invasive treatment for urinary stones and usually advocated for frail patients with spinal cord injury (SCI). We report a life-threatening complication, called posterior reversible encephalopathy syndrome (PRES), in a tetraplegic person who underwent SWL for a small renal stone. Based on our experience, we recommend performing SWL with caution in SCI patients and in tertiary referral hospitals that can promptly manage similar severe complications

An examination of autism spectrum traits in adolescents with anorexia nervosa and their parents

There may be a link between anorexia nervosa and autism spectrum disorders. The aims of this study were to examine whether adolescents with anorexia nervosa have autism spectrum and/or obsessive-compulsive traits, how many would meet diagnostic criteria for autism spectrum disorder, and whether these traits are shared by parents