324 research outputs found
Adsorptive Voltammetry of 4-chlordehydromethyltestosterone
The article presents the results of the study of the electrochemical behavior of the anabolic steroid 4-chlordehydromethyltestosterone. The studies detected operating conditions for the voltammetric determination of anabolic glassy carbon electrode. The influence of such factors as pH, supporting electrolyte, the electrolysis and adsorption component on the analytical signal of the analyte was studied. The algorithm of sample preparation is presented and conditions for the quantitative determination of the active ingredient of the drug βTurinabolβ by voltammetry is proposed. The evaluation of the proposed method accuracy was conducted
Asymptomatic Lone Atrial Fibrillation in Pregnant Women
We examined 43 pregnant women with paroxysms of asymptomatic lone atrial fibrillation. It was revealed that the increasing of the gestational age leads to increase of number of single, paired and group supraventricular extrasystoles; single and paired ventricular extrasystoles; number and duration of paroxysms of atrial fibrillation. However, the number of extrasystoles and paroxysms of arrhythmia decreased to baseline values after delivery. Thus, it was proved that pregnancy contributes to the increase of paroxysms of lone atrial fibrillation due to the increased influence of modulating components on the triggering extrasystoles. The importance of the method of 24-hour ECG monitoring in the detection of arrhythmia in pregnant women is emphasized.
Keywords: lone atrial fibrillation, extrasystole, pregnancy
Nephelometric Method for Determination of Growth Parameters of Chlorella Culture
Nephelometric method for the determination of growth parameters of chlorella culture using a photoelectric colorimeter was described. Use of photoelectric colorimeter for cell counting in suspension requires periodic calibration of meter readings using chlorella standard culture (with a certain cell concentration). Chlorella vulgaris IPPAS Π‘-66, IPPAS Π‘-111 and IPPAS Π‘-2019 strains served as object of research. Density of initial in vitro suspensions (after inoculation) was 0.9 mln cells/ml. Cultivation was carried out during 12 days on a Hoagland medium with a pH of 7 (temperature of 35βC, illumination of 10 klx). Sample selection for analysis and measurement was carried out daily, three times per day. Based on the obtained data, readings of photoelectric colorimeter KFK-3.01 were calibrated via direct count of chlorella cells quantity in Goryaevβs chamber. Use of calibration curve made it possible to reduce significantly time and error in determination of cell number in suspension cultures. The proposed technique allows counting chlorella cells in the growth and development dynamics with sufficient accuracy, high sensitivity, reproducibility and speed. It can be used for comparative determination of the growth parameters of strains in vitro, standardization of suspension cultures, semi-quantitative determination of chlorella biomass in order to predict the yield of desired product
Neurotrophins in the pathogenesis of pulmonary hypertension and right ventricular dysfunction
Pulmonary hypertension (PH) is a pathophysiological and hemodynamic condition that complicates the course of various diseases and negatively affects morbidity and mortality. The search for the new pathophysiological mechanisms for PH development and progression, the markers for predicting the PH course, and the possible targets for therapy remains relevant. This review is devoted to the role of neurotrophin (NT) system in PH pathogenesis, the possible use of NT and their receptors as a laboratory marker of its severity, and also as a potential target for influencing the pulmonary artery remodeling in PH. In addition, the participation of NTs in neoangiogenesis and restoration of nervous and muscle tissues was described
The Impact of Generator Market Power on the Electricity Hedge Market
The incentive of an electricity generating firm with market power to influence the market price depends strongly on the volume the firm has pre-sold in the forward, or hedge, markets. However, the choice of hedge level may be a strategic decision in itself. In the normal case where participants in the hedge market cannot observe the hedge position of dominant generators, we show that the optimal choice of hedging for a dominant generator facing a linear demand curve is an all-or-nothing decision and there is no equilibrium level of hedging in pure strategies. This outcome may explain an observed lack of hedge market liquidity in wholesale electricity markets where individual generators have substantial market power. We perform the analysis for the monopoly and oligopoly cases and extend it for realistic cost functions and various degrees of competitiveness in the market. These results contribute to the extensive body of research on the price formation and strategic behavior in electricity forward and spot markets, as well as providing implications for transparency initiatives in market design
Influence of Infrastructure on Population Distribution and Socio-Economic Development of Russian Regions
ΠΡΡΠΎΠΊΠΈΠΉ ΡΡΠΎΠ²Π΅Π½Ρ Π΄ΠΈΠ²Π΅ΡΠ³Π΅Π½ΡΠΈΠΈ Π² Π΄Π΅ΠΌΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΈ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎ-ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΠΈ ΡΠ²Π»ΡΠ΅ΡΡΡ Π·Π½Π°ΡΠΈΠΌΡΠΌ Π±Π°ΡΡΠ΅ΡΠΎΠΌ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΡ ΡΡΡΠΎΠΉΡΠΈΠ²ΠΎΠ³ΠΎ ΡΠΎΡΡΠ° ΡΠΎΡΡΠΈΠΉΡΠΊΠΎΠΉ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΠΊΠΈ. ΠΠ°Π½Π½Π°Ρ ΡΡΠ°ΡΡΡ ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π° Π°Π½Π°Π»ΠΈΠ·Ρ Π²Π»ΠΈΡΠ½ΠΈΡ ΡΡΠΎΠ²Π½Ρ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ Π½Π° ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ°Π·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΈ ΡΠ΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π ΠΎΡΡΠΈΠΈ. ΠΡΠ½ΠΎΠ²Π½ΠΎΠΉ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°ΡΠ΅Π»ΡΡΠΊΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ ΡΠ²Π»ΡΠ»ΠΎΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΏΡΠ°ΠΊΡΠΈΡΠ΅ΡΠΊΠΈΡ
Π²ΠΎΠΏΡΠΎΡΠΎΠ², ΡΠ²ΡΠ·Π°Π½Π½ΡΡ
Ρ Π²ΡΡΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠ΅ΠΉ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ ΠΊΠ°ΠΊ ΡΠ°ΠΊΡΠΎΡΠ° ΡΠ°ΡΡΠ΅Π»Π΅Π½ΠΈΡ ΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΡΠ»Π΅Π½Π½ΠΎΡΡΠΈ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΡΠ΅Π³ΠΈΠΎΠ½ΠΎΠ² ΡΡΡΠ°Π½Ρ Ρ ΡΡΠ΅ΡΠΎΠΌ ΠΈΡ
ΠΌΠΈΠ³ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΏΡΠΈΠ²Π»Π΅ΠΊΠ°ΡΠ΅Π»ΡΠ½ΠΎΡΡΠΈ. ΠΠ°Π·ΠΎΠ²ΡΠΌ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠΎΠΈΡΠΊ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΡΡΠΎΠ²Π½Π΅ΠΌ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ΅Π³ΠΈΠΎΠ½Π° ΠΈ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌΠΈ ΡΠ°Π·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠΌΠΈΡΡ Π΅Π³ΠΎ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡΡ ΠΈ ΠΌΠΈΠ³ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΌ ΠΏΡΠΈΡΠΎΡΡΠΎΠΌ. ΠΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΡΠΊΠ°Π·Π°Π½Π½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ ΡΠ°Π·ΠΌΠ΅ΡΠ΅Π½ΠΈΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΡΠ°ΡΡΡΠΈΡΡΠ²Π°Π»Π°ΡΡ Ρ ΠΈΠ½Π΄Π΅ΠΊΡΠ°ΠΌΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠΉ, ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ, ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ, ΠΊΠΎΠΌΠΌΡΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΈ ΡΠ΅Π»Π΅ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ. ΠΠ»Ρ ΡΡΠΈΡ
ΠΆΠ΅ ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠ² ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ Π±ΡΠ»Π° ΡΠ°ΡΡΡΠΈΡΠ°Π½Π° ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ Ρ Π²Π°Π»ΠΎΠ²ΡΠΌ ΡΠ΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠΌ. Π ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠ΅ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΠΎΠ½Π½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠΊΠ°Π·Π°Π», ΡΡΠΎ ΡΡΡΠ΅ΡΡΠ²ΡΠ΅Ρ ΡΠ»Π°Π±Π°Ρ ΠΏΡΡΠΌΠ°Ρ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΡΠ΅Π³ΠΈΠΎΠ½Π°, Π²Π΅Π»ΠΈΡΠΈΠ½ΠΎΠΉ Π΅Π³ΠΎ ΠΌΠΈΠ³ΡΠ°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΠΏΡΠΈΡΠΎΡΡΠ° ΠΈ Π²ΡΠ΅ΠΌΠΈ ΠΈΠ½Π΄Π΅ΠΊΡΠ°ΠΌΠΈ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ, ΠΊΡΠΎΠΌΠ΅ ΡΠΎΡΠΈΠ°Π»ΡΠ½ΠΎΠ³ΠΎ. ΠΠ°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΡΠΈΠ»ΡΠ½Π°Ρ ΠΏΡΡΠΌΠ°Ρ Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΡ Π½Π°Π±Π»ΡΠ΄Π°Π΅ΡΡΡ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΡΠ΅Π³ΠΈΠΎΠ½ΠΎΠ² ΠΈ ΠΈΠ½Π΄Π΅ΠΊΡΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ. Π₯ΠΎΡΠΎΡΠ°Ρ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½Π°Ρ Π΄ΠΎΡΡΡΠΏΠ½ΠΎΡΡΡ ΠΎΠ±Π»Π΅Π³ΡΠ°Π΅Ρ Π΄ΠΎΡΡΡΠΏ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ ΠΊ Π΄ΡΡΠ³ΠΈΠΌ Π²ΠΈΠ΄Π°ΠΌ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ, ΠΏΠΎΠ²ΡΡΠ°Ρ ΡΡΠΎΠ²Π΅Π½Ρ ΡΠ²ΡΠ·Π°Π½Π½ΠΎΡΡΠΈ ΡΠ΅ΡΡΠΈΡΠΎΡΠΈΠΉ ΠΈ ΠΈΡ
Π΄Π΅ΠΌΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π». ΠΠ½Π°ΡΠΈΠΌΠΎΡΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ ΠΏΡΠΎΡΠ²Π»ΡΠ΅ΡΡΡ Π² ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡ
ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ΅Π³ΠΈΠΎΠ½ΠΎΠ² Π½Π΅ ΠΌΠ΅Π½Π΅Π΅ ΡΡΠΊΠΎ, ΡΠ΅ΠΌ Π² ΡΠΎΡΠΈΠ°Π»ΡΠ½ΡΡ
. ΠΡΠΎ ΠΏΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ ΠΊΠΎΡΡΠ΅Π»ΡΡΠΈΡ ΠΌΠ΅ΠΆΠ΄Ρ Π²Π°Π»ΠΎΠ²ΡΠΌ ΡΠ΅Π³ΠΈΠΎΠ½Π°Π»ΡΠ½ΡΠΌ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠΌ ΠΈ ΡΡΠΎΠ²Π½Π΅ΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠ°Π½ΡΠΏΠΎΡΡΠ½ΠΎΠΉ, ΡΠ΅Π»Π΅ΠΊΠΎΠΌΠΌΡΠ½ΠΈΠΊΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΈ ΡΠ½Π΅ΡΠ³Π΅ΡΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΡΡΠ°ΡΠΈΡΡΠΈΡΠ΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠ΄ΠΈΠ» Π½Π°Π»ΠΈΡΠΈΠ΅ Π²Π·Π°ΠΈΠΌΠΎΡΠ²ΡΠ·ΠΈ ΠΌΠ΅ΠΆΠ΄Ρ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΠΌΠΈ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΠΈ ΡΠ°ΡΡΠ΅Π»Π΅Π½ΠΈΠ΅ΠΌ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡ, Ρ
ΠΎΡΡ ΠΈ Π½Π΅ ΡΠ°ΠΊ ΡΠ²Π½ΠΎ, ΡΡΠΎ Π΄ΠΎΠΊΠ°Π·ΡΠ²Π°Π΅Ρ Π½Π°Π»ΠΈΡΠΈΠ΅ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ° ΡΠ°ΠΊΡΠΎΡΠΎΠ², ΡΡΠ΅Π΄ΠΈ ΠΊΠΎΡΠΎΡΡΡ
ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΠ½ΡΠΉ Π½Π΅ ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΠ²ΠΈΡΠ½ΡΠΌ. Π’Π΅ΠΌ Π½Π΅ ΠΌΠ΅Π½Π΅Π΅, ΠΈΠΌΠ΅Π½Π½ΠΎ ΡΠ½ΡΡΠΈΠ΅ ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΠ½ΡΡ
ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΠΉ ΠΈ ΠΏΠΎΠ²ΡΡΠ΅Π½ΠΈΠ΅ ΠΊΠ°ΡΠ΅ΡΡΠ²Π° ΠΈ Π΄ΠΎΡΡΡΠΏΠ½ΠΎΡΡΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
Π²ΠΈΠ΄ΠΎΠ² ΠΈΠ½ΡΡΠ°ΡΡΡΡΠΊΡΡΡΡ Π±ΡΠ΄Π΅Ρ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΠΏΡΠ΅ΠΎΠ΄ΠΎΠ»Π΅Π½ΠΈΡ ΠΊΠ°ΠΊ Π΄Π΅ΠΌΠΎΠ³ΡΠ°ΡΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ, ΡΠ°ΠΊ ΠΈ ΡΠΊΠΎΠ½ΠΎΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠΆΠ°ΡΠΈΡ ΠΏΡΠΎΡΡΡΠ°Π½ΡΡΠ²Π° Π ΠΎΡΡΠΈΠΈ.High divergence of demographic and socio-economic development significantly hinders the sustainable growth of the Russian economy. This article analyses the influence of infrastructure on population distribution and development of Russian regions. The study focuses on theoretical and practical issues related to identifying the features of infrastructure development as a factor of settlement and formation of population, considering the migration attractiveness of Russian regions. The research aimed to reveal a correlation between the regional infrastructure development and population distribution characterised by its density and net migration. To this end, we calculated the correlation between these indicators of population distribution and development indices of transport, energy, social, communal and telecommunications infrastructure. Additionally, the correlation between gross regional product and the same infrastructure development indices was estimated. The correlation analysis revealed the presence of a weak positive relationship between the regional population density, net migration, and all infrastructure development indices, except for social one. The strongest positive relationship is observed between the regional population density and the transport infrastructure development index. Good transport accessibility gives people easier access to other types of infrastructure and consequently increases the spatial connectivity and demographic potential of certain areas. Infrastructure development greatly influences not only social indicators of regional development but also economic ones, as shown by the correlation between gross regional product and development indices of transport, telecommunications and energy infrastructure. Thus, according to the conducted statistical analysis, the existing but weak relationship between infrastructure development indices and population distribution confirms the presence of a set of factors, where infrastructure is not the main one. Nevertheless, the removal of infrastructure constraints and an increase in the infrastructure quality and availability will help overcome both the demographic and economic contraction of Russia
ΠΠΠΠΠ’Π ΠΠ₯ΠΠΠΠ§ΠΠ‘ΠΠΠ Π‘ΠΠΠ‘ΠΠ Π«, ΠΠΠΠΠ€ΠΠ¦ΠΠ ΠΠΠΠΠΠ«Π ΠΠΠΠΠ’ΠΠ Π Π‘ΠΠΠ―ΠΠ ΠΠ ΠΠΠΠΠΠΠΠΠΠ― ΠΠΠ― ΠΠΠ ΠΠΠΠΠΠΠΠ― ΠΠΠΠ Π Π Π’Π£Π’Π Π ΠΠΠΠΠ‘ΠΠ₯ Π§ΠΠΠΠΠΠΠ
Current article presents the results of using a solid carbon-containing electrochemical sensor modified with arenediazonium salts (ME-ADT-COOH) for the joint determination of copper and mercury in human hair. The sensitivity of the determination of copper and mercury ions using a graphite electrode modified with gold and arenediazonium salts with a substituent carboxy group is higher compared to the other carbon-containing modified electrodes. The influence of the concentration of arenediazonium tosylates with various substituents on the obtained analytical signal was studied. The conditions for the manufacturing the new carbon-containing modified electrochemical sensor have been developed. The effective surface area of the modified electrode was calculated, which was estimated using a cyclic voltammogram against the background of 0.1 M KCl with the addition of potassium hexacyanoferrate (Π‘=5*10-4mol/l) salts and calculated using the Randles-Ε evΔΓk equation for the reversible electrode process. A linear range of determined concentrations in the voltametric determination of microelements on the arendiazonium-modified gold-graphite electrode was established - from 0.1 to 12 Β΅g/g. The error of the determination did not exceed 25 %. The correctness of the results of the determination of copper and mercury in real objects by the βintroduced-foundβ method, which correlates well with the known values, has been verified.Keywords: voltammetry, modifier, arenediazonium tosylates, gold-graphite electrode, copper, mercury, hairDOI: http://dx.doi.org/10.15826/analitika.2022.26.2.004G.B. Slepchenko, M.S. Ostapenko, Yu.A. Akeneev, E.S. MoiseevaNational Research Tomsk Polytechnic University,Lenina Avenue, 30, Tomsk, 634050, Russian FederationΠΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΠ²Π΅ΡΠ΄ΠΎΠ³ΠΎ ΡΠ³Π»Π΅ΡΠΎΠ΄ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅Π³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π½ΡΠΎΡΠ°, ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠΎΠ»ΡΠΌΠΈ Π°ΡΠ΅Π½Π΄ΠΈΠ°Π·ΠΎΠ½ΠΈΡ (ΠΠ-ADT-Π‘ΠΠΠ), Π΄Π»Ρ ΡΠΎΠ²ΠΌΠ΅ΡΡΠ½ΠΎΠ³ΠΎ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΌΠ΅Π΄ΠΈ ΠΈ ΡΡΡΡΠΈ Π² Π²ΠΎΠ»ΠΎΡΠ°Ρ
ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°. Π§ΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΈΠΎΠ½ΠΎΠ² ΠΌΠ΅Π΄ΠΈ ΠΈ ΡΡΡΡΠΈ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Π³ΡΠ°ΡΠΈΡΠΎΠ²ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΠ΄Π°, ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π·ΠΎΠ»ΠΎΡΠΎΠΌ ΠΈ Π°ΡΠ΅Π½Π΄ΠΈΠ°Π·ΠΎΠ½ΠΈΠ΅Π²ΡΠΌΠΈ ΡΠΎΠ»ΡΠΌΠΈ Ρ Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»Π΅ΠΌ ΠΊΠ°ΡΠ±ΠΎΠΊΡΠΈ-Π³ΡΡΠΏΠΏΠΎΠΉ, Π²ΡΡΠ΅ ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Ρ Π΄ΡΡΠ³ΠΈΠΌΠΈ ΡΠ³Π»Π΅ΡΠΎΠ΄ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠΈΠΌΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠ΄Π°ΠΌΠΈ. ΠΠ·ΡΡΠ΅Π½ΠΎ Π²Π»ΠΈΡΠ½ΠΈΠ΅ ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΈ ΡΠΎΠ·ΠΈΠ»Π°ΡΠΎΠ² Π°ΡΠ΅Π½Π΄ΠΈΠ°Π·ΠΎΠ½ΠΈΡ Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠΌΠΈ Π·Π°ΠΌΠ΅ΡΡΠΈΡΠ΅Π»ΡΠΌΠΈ Π½Π° ΠΏΠΎΠ»ΡΡΠ°Π΅ΠΌΡΠΉ Π°Π½Π°Π»ΠΈΡΠΈΡΠ΅ΡΠΊΠΈΠΉ ΡΠΈΠ³Π½Π°Π». Π Π°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΡΡΠ»ΠΎΠ²ΠΈΡ ΠΈΠ·Π³ΠΎΡΠΎΠ²Π»Π΅Π½ΠΈΡ Π½ΠΎΠ²ΠΎΠ³ΠΎ ΡΠ³Π»Π΅ΡΠΎΠ΄ΡΠΎΠ΄Π΅ΡΠΆΠ°ΡΠ΅Π³ΠΎ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΡ
ΠΈΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΡΠ΅Π½ΡΠΎΡΠ°. ΠΡΠΎΠΈΠ·Π²Π΅Π΄Π΅Π½ ΡΠ°ΡΡΠ΅Ρ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΠΏΠ»ΠΎΡΠ°Π΄ΠΈ ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΠ΄Π°, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»Π°ΡΡ Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΡΠΈΠΊΠ»ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π²ΠΎΠ»ΡΡΠ°ΠΌΠΏΠ΅ΡΠΎΠ³ΡΠ°ΠΌΠΌΡ Π½Π° ΡΠΎΠ½Π΅ 0.1 M KCl Ρ Π΄ΠΎΠ±Π°Π²ΠΊΠΎΠΉ ΡΠΎΠ»Π΅ΠΉ Π³Π΅ΠΊΡΠ°ΡΠΈΠ°Π½ΠΎΡΠ΅ΡΡΠ°ΡΠ° ΠΊΠ°Π»ΠΈΡ (Π‘ = 5Β·10-4 ΠΌΠΎΠ»Ρ/Π») ΠΈ ΡΠ°ΡΡΡΠΈΡΡΠ²Π°Π»Π°ΡΡ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ Π ΡΠ½Π΄Π»ΡΠ°-Π¨Π΅Π²ΡΠΈΠΊΠ° Π΄Π»Ρ ΠΎΠ±ΡΠ°ΡΠΈΠΌΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ Π»ΠΈΠ½Π΅ΠΉΠ½ΡΠΉ Π΄ΠΈΠ°ΠΏΠ°Π·ΠΎΠ½ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅ΠΌΡΡ
ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΈΠΉ ΠΏΡΠΈ Π²ΠΎΠ»ΡΡΠ°ΠΌΠΏΠ΅ΡΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΎΠΌ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠΈ ΠΌΠΈΠΊΡΠΎΡΠ»Π΅ΠΌΠ΅Π½ΡΠΎΠ² Π½Π° ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΌ Π°ΡΠ΅Π½Π΄ΠΈΠ°Π·ΠΎΠ½ΠΈΠ΅ΠΌ Π·ΠΎΠ»ΠΎΡΠΎ-Π³ΡΠ°ΡΠΈΡΠΎΠ²ΠΎΠΌ ΡΠ»Π΅ΠΊΡΡΠΎΠ΄Π΅ β ΠΎΡ 0.1 Π΄ΠΎΒ 12 ΠΌΠΊΠ³/Π³. ΠΠΎΠ³ΡΠ΅ΡΠ½ΠΎΡΡΡ ΠΈΡ
ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠ°Π»Π° 25 %. ΠΡΠΎΠ²Π΅ΡΠ΅Π½Π° ΠΊΠΎΡΡΠ΅ΠΊΡΠ½ΠΎΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠ² ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΠΌΠ΅Π΄ΠΈ ΠΈ ΡΡΡΡΠΈ Π² ΡΠ΅Π°Π»ΡΠ½ΡΡ
ΠΎΠ±ΡΠ΅ΠΊΡΠ°Ρ
ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ Β«Π²Π²Π΅Π΄Π΅Π½ΠΎ-Π½Π°ΠΉΠ΄Π΅Π½ΠΎΒ», Ρ
ΠΎΡΠΎΡΠΎ ΠΊΠΎΡΡΠ΅Π»ΠΈΡΡΡΡΠ΅Π³ΠΎ Ρ ΠΈΠ·Π²Π΅ΡΡΠ½ΡΠΌΠΈ Π·Π½Π°ΡΠ΅Π½ΠΈΡΠΌΠΈ.ΠΠ»ΡΡΠ΅Π²ΡΠ΅ ΡΠ»ΠΎΠ²Π°: Π²ΠΎΠ»ΡΡΠ°ΠΌΠΏΠ΅ΡΠΎΠΌΠ΅ΡΡΠΈΡ, ΠΌΠΎΠ΄ΠΈΡΠΈΠΊΠ°ΡΠΎΡ, Π°ΡΠ΅Π½Π΄ΠΈΠ°Π·ΠΎΠ½ΠΈΠΉ ΡΠΎΠ·ΠΈΠ»Π°Ρ, ΠΎΡΠ³Π°Π½ΠΎ-ΠΌΠΎΠ΄ΠΈΡΠΈΡΠΈΡΠΎΠ²Π°Π½Π½ΡΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ΄, ΠΌΠ΅Π΄Ρ, ΡΡΡΡΡ, Π²ΠΎΠ»ΠΎΡΡDOI: http://dx.doi.org/10.15826/analitika.2022.26.2.00
Dynamics of endothelial function indexes in patients with post-Covid syndrome using a combination drug of ethylmethylhydroxyperidine succinate/vitamin B6
Aim: to evaluate endothelial function in patients after COVID-19 before and after treatment with combination drug of ethylmethylhydroxyperidine succinate (EMHPS)/vitamin B
THE SIGNIFICANCE OF OSTEOPONTINE AND MATRIX METALLOPROTEASE-9 IN THORACAL AORTA ANEURYSM DEVELOPMENT
Aim. To evaluate the significance of osteopontine and MMP-9 in the development of thoracal aorta aneurysm in patients with tricuspid (TAV) and bicuspid (BAV) aorta valve. Material and methods. Totally 94 patients included with the dilation of thoracal aorta for more than 40 mm, and 50 patients without aorta pathology, that were the comparison group. All patients underwent echocardiographic study by Vivid 7 (GE, USA) device by standard protocol. The osteopontine concentration and MMP-9 were measured in blood serum with manual plate immune-enzyme assay. Results. The concentration of MMP-9 in blood serum of the patients with aorta pathology and TAV did not differ significantly with the value in comparison group. Otherwise, in IHD the concentration of MMP-9 was significantly higher than in patients without aorta pathology (164,9Β±76,6 ng/ml and 106,8Β±82,7 ng/ml, respectively, p<0,01) and closely correlated with the Valsalva sinuses diameters (r=0,302, Ρ=0,007). Comparative analysis of the osteopontine serum concentration did not show differences in the subgroups studied.Conclusion. The positive correlation revealed of the aorta diameter and concentration of MMP-9 in blood serum of the patients with BAV confirms not only the differences in the pathogenesis of thoracal aorta aneurysm in TAV and BAV, but makes it possible to think on the usage of MMP-9 as biomarker of thoracal aorta dilatation
Effectiveness of immunosuppressive therapy for lymphocytic myocarditis according: data from actual clinical practice
Aim. To compare the effectiveness of standard heart failure therapy with and without combined immunosuppressive therapy in patients with documented lymphocytic myocarditis (LM) based on data from actual clinical practice.Material and methods. This observational study included 70 patients with documented LM, 40% (n=28) of whom received immunosuppressive therapy. All patients underwent standard echocardiographic and laboratory investigations, endomyocardial biopsy with histological, immunohistochemical and molecular genetic analysis. Contrast-enhanced cardiac magnetic resonance imaging was performed in 74% of patients. All patients received standard therapy for heart failure at baseline.Results. The groups did not differ in demographic and echocardiographic characteristics. The appointment of immunosuppressive therapy was accompanied by an increase in ejection fraction by 12,2% compared to 6,4% (p=0,02). There were no significant differences in combined endpoints (survival and the need for heart transplantation) depending on therapy regimen (log-rank p=0,97).Conclusion. The prognosis of patients with chronic LM depends on the process activity, the severity of impaired hemodynamics and ventricular arrhythmias, as well as on the presence of persistent viral infection. Compliance with patient selection algorithm before prescribing immunosuppressive therapy is associated with the improvement in myocardial global contractility
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