The main problems of building the system of statistical indicators in the field of cryonics

Cryonics as rather inconsistent, but constantly developing sphere of activity of modern society cannot be adequately estimated by means of separate private indicators or even their enlarged groups. This requires the development of a system of indicators that includes not only the traditional parameters of material and technical base and human capacity, but also the scale, intensity, results and consequences of cryonic activities. The key problems of the system of indicators of critical activity statistics, its features and possible approaches to its construction have been considered in the article

Dissipative soliton resonance in a full polarization-maintaining fiber ring laser at different values of dispersion

We investigated the dissipative solitons resonance in an ytterbium-doped fiber ring laser in which all the elements are polarization maintaining (PM). A semiconductor saturable absorber mirror was used as a mode-locker. The cavity included a normal dispersion single-mode fiber (SMF) and an anomalous dispersion photonic crystal fiber. The change of the length of the PM SMF allows the variation of the net-normal dispersion of the cavity in the range from 0.022 ps2 to 0.262 ps2. As the absolute value of the net-normal dispersion increases from 0.022 ps2 to 0.21 ps2, a square-shaped single pulse transformed to a single right-angle trapezoid-shaped pulse, and, at the dispersion of 0.262 ps2, to multiple right-angle trapezoid-shaped pulses, per round-trip

Combination of hypomorphic mutations of the Drosophila homologues of aryl hydrocarbon receptor and nucleosome assembly protein family genes disrupts morphogenesis, memory and detoxification

Aryl hydrocarbon receptor is essential for biological responses to endogenous and exogenous toxins in mammals. Its Drosophila homolog spineless plays an important role in fly morphogenesis. We have previously shown that during morphogenesis spineless genetically interacts with CG5017 gene, which encodes a nucleosome assembly factor and may affect cognitive function of the fly. We now demonstrate synergistic interactions of spineless and CG5017 in pathways controlling oxidative stress response and long-term memory formation in Drosophila melanogaster. Oxidative stress was induced by low doses of X-ray irradiation of flies carrying hypomorphic mutation of spineless, mutation of CG5017, and their combination. To determine the sensitivity of these mutants to pharmacological modifiers of the irradiation effect, we irradiated flies growing on standard medium supplemented by radiosensitizer furazidin and radioprotector serotonin. The effects of irradiation were investigated by analyzing leg and antenna morphological structures and by using real-time PCR to measure mRNA expression levels for spineless, Cyp6g1 and Gst-theta genes. We also examined long-term memory in these mutants using conditioned courtship suppression paradigm. Our results show that the interaction of spineless and CG5017 is important for regulation of morphogenesis, long-term memory formation, and detoxification during oxidative stress. Since spineless and CG5017 are evolutionary conserved, these results must be considered when evaluating the risk of combining similar mutations in other organisms, including humans

DEVELOPMENT OF A GROUP OF MOBILE ROBOTS FOR CONDUCTING COMPREHENSIVE RESEARCH OF DANGEROUS WAVE CHARACTERISTICS IN COASTAL ZONES

New methods and approaches for carrying out comprehensive measurements of hazardous waves (tsunami, storm surges) and background wave climate with telemetrically related group of ground, surface and underwater based robots are discussed. The design and equipment list of the ground robot are considered. It includes three various types of movers, an add-on for the installation of devices on the mobile platform and the hardware part. Ground robot was tested in 2016 on the coast of Sakhalin Island, cape Svobodny. Based on test results there were made conclusions on the possibility of increasing mobility of the ground robot and expanding its use. Specially designed underwater robot collects data using a video inspection system and a hydrostatic wave recorder with a string sensor. It has the ability to adjust the position of the center of gravity to increase stability when driving on steep slopes of the seabed. The surface robot was designed for conducting detailed bathymetry measurements of investigated water areas by means of a multi-beam echo sounder. Underwater and surface-based robots were tested in July 2017 on Sakhalin Island. Both robotic systems were merged into the united local network. The results of their operation were obtained to verify the data from measuring systems of the ground robot. In 2018, it is planned to conduct a series of tests involving the three robots and merging them into a local network to manage and process data in real-time

Нормативное регулирование обязательной иммунопрофилактики гриппа в системе управления заболеваемостью медицинских работников.

In article the interconnected provisions of the federal legislation and regulations of federal executive authorities regulating a question of obligatory immunization of health workers against flu in aspect of legal consequences of refusal of her are considered. The analysis of the existing regulations and materials of jurisprudence concerning carrying out obligatory vaccination of health workers against flu is carried out. By results of the analysis it is shown that today a problematic issue is absence of the accurate standardly consolidated criteria of reference of these or those categories of medical personnel to group of the subjects of obligatory immunization performing works with sick infectious diseases and, respectively, against flu. It doesn’t allow the management of the medical organizations to differentiate specifically mentioned professions and positions owing to what the requirement about obligatory carrying out preventive inoculations against flu of those health workers whose obligatory vaccination isn’t provided actually is compulsion to vaccination. Therefore, the subsequent discharge from work in case of refusal it работни from carrying out an inoculation strikes at his rights (as in this case, for example, time of discharge isn’t subject to payment and inclusion in the length of service granting the right for the annual paid vacation) and is illegal.It is offered to accept as such criterion the labor function fixed by the statutory act of authorized federal executive authority for concrete positions of employees of the medical organizations providing performance of work with sick infectious diseases. The recommendations to heads of the medical organizations concerning the publication of local acts on the organization of vaccinal prevention of flu and adoption of administrative decisions after written refusals of vaccination are provided.В статье рассматриваются взаимосвязанные положения федерального законодательства и нормативных правовых актов федеральных органов исполнительной власти, регулирующие вопрос обязательной иммунизации медицинских работников против гриппа в аспекте правовых последствий отказа от неё. Проведён анализ действующих нормативных правовых актов и материалов судебной практики по вопросу проведения обязательной вакцинации медицинских работников против гриппа. По результатам анализа показано, что на сегодняшний день проблемным вопросом является отсутствие чётких нормативно закреплённых критериев отнесения тех или иных категорий медицинского персонала к группе выполняющих работы с больными инфекционными заболеваниями и, соответственно, подлежащих обязательной иммунизации против гриппа. Это не позволяет руководству медицинских организаций конкретно разграничить упомянутые профессии и должности, вследствие чего требование об обязательном проведении профилактических прививок против гриппа тех медицинских работников, обязательная вакцинация которых не предусмотрена, фактически является принуждением к вакцинации. Следовательно, последующее отстранение от работы в случае отказа такого работника от проведения прививки ущемляет его права (поскольку в данном случае, например, время отстранения не подлежит оплате и включению в стаж работы, дающий право на ежегодный оплачиваемый отпуск) и является незаконным.Предлагается принять в качестве такого критерия закреплённую нормативным актом уполномоченного федерального органа исполнительной власти трудовую функцию для конкретных должностей работников медицинских организаций, предусматривающую выполнение работ с больными инфекционными заболеваниями. Приводятся рекомендации руководителям медицинских организаций, касающиеся издания локальных актов по организации вакцинопрофилактики гриппа и принятия управленческих решений после письменных отказов от вакцинации

Digital receivers for low-frequency radio telescopes UTR-2, URAN, GURT

This paper describes digital radio astronomical receivers used for decameter and meter wavelength observations. This paper describes digital radio astronomical receivers used for decameter and meter wavelength observations. Since 1998, digital receivers performing on-the-fly dynamic spectrum calculations or waveform data recording without data loss have been used at the UTR-2 radio telescope, the URAN VLBI system, and the GURT new generation radio telescope. Here we detail these receivers developed for operation in the strong interference environment that prevails in the decameter wavelength range. Data collected with these receivers allowed us to discover numerous radio astronomical objects and phenomena at low frequencies, a summary of which is also presented.Comment: 24 pages, 15 figure

Antrax in Primorsky Territory (1919–2020). Communication 2. Episootiological- Epidemiological Situation and Zoning of Administrative Territories

The aim of the study was to analyze the epizootiological and epidemiological situation in the Primorsky Territory (1919–2020) and to zone the administrative districts in regard to anthrax. Materials and methods. Accounting and reporting documents, information and archival materials were collected and analyzed, statistical reference books and literature sources were used. A comprehensive epizootiological and epidemiological survey of 12 supposed places of anthrax burials and cattle burial grounds was carried out, and their biological hazard assessed. Results and discussion. Within the framework of updating the Cadastre of stationary potentially hazardous as regards anthrax areas in the Russian Federation (2005), the number of infected farm animals and human cases was specified: according to official data, over the period of 1930–1979, the disease in 173 animals and 34 people with five deaths was registered in 82 stationary unfavorable for anthrax areas of 22 municipalities of the region. Together with the veterinary service of the region, an audit of 12 supposed places of anthrax burials in seven districts of the region was conducted. Based on the results of a comprehensive epizootiological and epidemiological survey, high biological hazard was established for 2 and potential one – for 1 anthrax burials. The culture of Bacillus anthracis isolated on the territory of Primorsky Territory belongs to one of the canonical SNP clusters – A.Br.008/009 of the global genetic line A (subgroup A1). Five criteria for assessing the epizootiological and epidemiological disadvantage for anthrax and the ranking of indicators of the administrative territories in the region have been determined. Zoning of the administrative territories of the region according to risk of anthrax has been carried out. Prophylactic anti-epizootic and anti-epidemic measures have been put forward

Analysis of the frequency of radiological signs of destructive changes in the hard tissues of the disto-aproximal surfaces of the second permanent molars in the presence of the third molars

Ризик розвитку карієсу залежить від наявності карієсогенних чинників. Дистальноапроксимальні поверхні коронок зубів характеризуються як ділянки з низькою карієсрезистентністю. Незважаючи на різноманіття засобів та предметів гігієнічного догляду за порожниною рота, проблема карієсу в цій зоні залишається актуальною. При цьому положення зубу у зубному ряду може спричиняти суттєвий вплив на можливість реалізації навіть досконалих мануальних навичок очищення даної ділянки та сприяти формуванню патологічних змін твердих тканин