Gender equalities: what lies ahead. Work, Employment and Society, 35 (4) . pp. 615-620. ISSN 0950-0170

It is hard to over-estimate the importance of the social sciences in informing us of deepening inequalities at work and how they are likely to play out as the economic crisis generated by the Covid-19 pandemic unfolds. Understanding the long-term impact of the pandemic requires us to think across the intersection of work and society. This is challenging work as part of taking an intersectional position means accepting that transmission thrives on inequality where occupation and occupational risk are often mapped onto class, race, ethnicity, sex and geography (Middleton et al., 2020). [...

Migrants with insecure legal status and access to work: the role of ethnic solidarity networks

This article explores the complexities of ethnic solidarity and ethnic capital in enabling participation on labour markets for migrants with insecure legal status in the UK. By drawing together research insights and data from a questionnaire survey of 178 Iraqi-Kurdish migrants with insecure legal status, four focus groups and ten expert interviews, this paper examines how ‘unauthorised’ migrants get access to the segmented labour market at a time of increased in-border controls in the UK. It argues that conflict-generated diasporas such as the Kurds display a distinct solidarity with their community members with insecure legal status and provide access to the labour markets against the tangible threat of in-border migration enforcement. We term this form of solidarity as stretched solidarity which emerges during risky, difficult and destitute times and it is a reluctant act of empathy and socio-political position. This paper identifies the social phenomenon of stretched solidarity and sets out a model for understanding its embeddedness within conflict-generated diasporic networks

Migrants at work: perspectives, perceptions and new connections. Work, Employment and Society, 34 (5) . pp. 745-748. ISSN 0950-0170

Migration – and the experiences of migrants – continue to occupy an important and controversial place in the scholarly and political debates on contemporary labour markets and societies. As new scenarios emerge at local, national and global levels, new insights and perspectives become necessary. The articles in this themed issue reflect the interest Work, Employment and Society has had in the topic of labour migrations and migrants at work for well over a decade and which led, for example, to the themed issue Migration at Work: Spaces, Borders and Boundaries in 32(5), 2018. Migration has of course been a prominent issue across the social sciences, and in recent years particularly in relation to the ‘refugee crisis’ of 2015 and to intra-European migration ahead of and in light of Brexit. The experiences of migrants from Eastern and Central Europe in the workplace, their overqualification and devaluing of their cultural capital, and their positioning within segmented labour markets have produced a number of articles in past issues (e.g. Ciupijus, 2011; Samaluk, 2016; Sirkeci et al., 2018) to which those in the current issue (Leschke and Weiss; Rydzik and Anitha) make an important addition. [...

Analisis Perbandingan Kinerja Keuangan Sebelum Dan Sesudah Merger (Studi Kasus Pada PT. Xl Axiata Tbk)

The background in this study is to make the merger as one of the techniques for a company to survive in today's tight competition and also so that a company can strengthen its capital structure. The purpose of this study is to analyze whether there are differences in corporate financial performance before and after the merger based on financial ratios. Benefits in this study is as a source of corporate information on the financial performance of the company, so that later investors will be more appropriate in making investments.Company's financial performance is measured by using the financial statements consisting of income statement and balance sheet in the period 2012 to 2015, with data source namely secondary data obtained from Indonesia stock exchange in the period 2 years before the merger of 2012-2013 and 2 years after the merger 2014-2015. Comparison of financial ratio analysis is done by using several ratios, namely Profitability Ratio, Activity Ratio, Liquidity Ratio and Solvency Ratio. And also use data analysis techniques that is financial ratios.The results of the calculation of 8 financial ratios used, there are 6 financial ratios that decreased after the merger activities are Net Profit Margin, Gross Profit Margin, TurnOver Total Assets, Fixed Assets TurnOver, Debt Ratio and Debt To Equity Ratio. And 2 financial ratios of Current Ratio and Cash Ratio increased after conducting merger activity. It can be concluded that this company experienced a lot of decline in financial performance when conducting merger activity. As one of the suggestions, the company should review the cooperation or penggabunngan this business because based on the analysis of financial ratios, when companies merger financial performance decreased while the company is still standing alone or single financial performance is very good

Multiple Testing Methods For ChIP-Chip High Density Oligonucleotide Array Data

Cawley et al. (2004) have recently mapped the locations of binding sites for three transcription factors along human chromosomes 21 and 22 using ChIP-Chip experiments. ChIP-Chip experiments are a new approach to the genome-wide identification of transcription factor binding sites and consist of chromatin (Ch) immunoprecipitation (IP) of transcription factor-bound genomic DNA followed by high density oligonucleotide hybridization (Chip) of the IP-enriched DNA. We investigate the ChIP-Chip data structure and propose methods for inferring the location of transcription factor binding sites from these data. The proposed methods involve testing for each probe whether it is part of a bound sequence or not using a scan statistic that takes into account the spatial structure of the data. Different multiple testing procedures are considered for controlling the family-wise error rate and false discovery rate. A nested-Bonferroni adjustment, that is more powerful than the traditional Bonferroni adjustment when the test statistics are dependent, is discussed. Simulation studies show that taking into account the spatial structure of the data substantially improves the sensitivity of the multiple testing procedures. Application of the proposed methods to ChIP-Chip data for transcription factor p53 identified many potential target binding regions along human chromosomes 21 and 22. Among these identified regions, 18% fall within a 3kb vicinity of the 5\u27UTR of a known gene or CpG island, 31% fall between the codon start site and the codon end site of a known gene but not inside an exon. More than half of these potential target sequences contain the p53 consensus binding site or very close matches to it. Moreover, these target segments include the 13 experimentally verified p53 binding regions of Cawley et al. (2004), as well as 49 additional regions that show higher hybridization signal than these 13 experimentally verified regions

Pancytopenýa and Sepsýs due to Meropenem: A Case Report

Meropenem is one of the most commonly used antibacterial agents with relatively few side effects. Serious adverse reactions reported with meropenem are rare with an incidence of 1 %. Recently we came across two rare adverse effects of meropenem in one patient with acute renal failure. There was pancytopenia and sepsis, respectively. To the best of ourknowledge, a only few cases have been reported in the literature that document an association between meropenem administration and pancytopenia, and about half of these cases were sepsis. With the use of meropenem becoming more widespread, these two rare but fatal complications of meropenem should be borne in mind.Keywords: Meropenem, Pancytopenia, Sepsis, Fatal complication

Role of the impact parameter in exoplanet transmission spectroscopy

Transmission spectroscopy is a promising tool for the atmospheric characterization of transiting exoplanets. Because the planetary signal is faint, discrepancies have been reported regarding individual targets. We investigate the dependence of the estimated transmission spectrum on deviations of the orbital parameters of the star-planet system that are due to the limb-darkening effects of the host star. We describe how the uncertainty on the orbital parameters translates into an uncertainty on the planetary spectral slope. We created synthetic transit light curves in seven different wavelength bands, from the near-ultraviolet to the near-infrared, and fit them with transit models parameterized by fixed deviating values of the impact parameter $b$. Our simulations show a wavelength-dependent offset that is more pronounced at the blue wavelengths where the limb-darkening effect is stronger. This offset introduces a slope in the planetary transmission spectrum that becomes steeper with increasing $b$ values. Variations of $b$ by positive or negative values within its uncertainty interval introduce positive or negative slopes, thus the formation of an error envelope. The amplitude from blue optical to near-infrared wavelength for a typical uncertainty on $b$ corresponds to one atmospheric pressure scale height and more. This impact parameter degeneracy is confirmed for different host types; K stars present prominently steeper slopes, while M stars indicate features at the blue wavelengths. We demonstrate that transmission spectra can be hard to interpret, basically because of the limitations in defining a precise impact parameter value for a transiting exoplanet. This consequently limits a characterization of its atmosphere

Loss-Based Estimation with Cross-Validation: Applications to Microarray Data Analysis and Motif Finding

Current statistical inference problems in genomic data analysis involve parameter estimation for high-dimensional multivariate distributions, with typically unknown and intricate correlation patterns among variables. Addressing these inference questions satisfactorily requires: (i) an intensive and thorough search of the parameter space to generate good candidate estimators, (ii) an approach for selecting an optimal estimator among these candidates, and (iii) a method for reliably assessing the performance of the resulting estimator. We propose a unified loss-based methodology for estimator construction, selection, and performance assessment with cross-validation. In this approach, the parameter of interest is defined as the risk minimizer for a suitable loss function and candidate estimators are generated using this (or possibly another) loss function. Cross-validation is applied to select an optimal estimator among the candidates and to assess the overall performance of the resulting estimator. This general estimation framework encompasses a number of problems which have traditionally been treated separately in the statistical literature, including multivariate outcome prediction and density estimation based on either uncensored or censored data. This article provides an overview of the methodology and describes its application to two problems in genomic data analysis: the prediction of biological and clinical outcomes (possibly censored) using microarray gene expression measures and the identification of regulatory motifs (i.e., transcription factor binding sites) in DNA sequences

A simple concept for covering pressure sores : wound edge-based propeller perforator flap

We present a new surgical modification to allow propeller perforator flaps to cover pressure sores at various locations. We used a propeller perforator flap concept based on the detection of newly formed perforator vessels located 1 cm from the wound margin and stimulated by the chronic inflammation process. Between January 2009 and January 2017, 33 wound edge-based propeller perforator flaps were used to cover pressure sores at various locations in 28 patients. In four cases more than one flap was used on the same patient. The patients comprised 18 males and 10 females with a mean age of 4125 (range, 16-70) years. All patients underwent follow-up for 0-12 months. The mean follow-up duration was 503 months. Venous congestion was observed in three flaps that were rotated by 180 degrees (91%). However, there was a significant difference between flaps rotated by 90 degrees and 180 degrees according to the complication rate (P = 0034). Out of 33 flaps, 29 flaps healed uneventfully. Patients were able to sit and lie on their flaps three weeks after surgery. In our study, we were able to obtain satisfying final results using these novel flaps