Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study

Recent findings highlight that there are prenatal risks for affective disorders that are mediated by glucocorticoid mechanisms, and may be specific to females. There is also evidence of sex differences in prenatal programming mechanisms and developmental psychopathology, whereby effects are in opposite directions in males and females. As birth weight is a risk for affective disorders, we sought to investigate whether maternal prenatal cortisol may have sex-specific effects on fetal growth. Participants were 241 mothers selected from the Wirral Child Health and Development Study (WCHADS) cohort (n=1233) using a psychosocial risk stratifier, so that responses could be weighted back to the general population. Mothers provided saliva samples, which were assayed for cortisol, at home over 2 days at 32 weeks gestation (on waking, 30-min post-waking and during the evening). Measures of infant birth weight (corrected for gestational age) were taken from hospital records. General population estimates of associations between variables were obtained using inverse probability weights. Maternal log of the area under the curve cortisol predicted infant birth weight in a sex-dependent manner (interaction term P=0.029). There was a positive and statistically significant association between prenatal cortisol in males, and a negative association in females that was not statistically significant. A sex interaction in the same direction was evident when using the waking (P=0.015), and 30-min post-waking (P=0.013) cortisol, but not the evening measure. There was no interaction between prenatal cortisol and sex to predict gestational age. Our findings add to an emerging literature that suggests that there may be sex-specific mechanisms that underpin fetal programming

Soil moisture modelling of a SMOS pixel: interest of using the PERSIANN database over the Valencia Anchor Station

In the framework of Soil Moisture and Ocean Salinity (SMOS) Calibration/Validation (Cal/Val) activities, this study addresses the use of the PERSIANN-CCS<sup>1</sup>database in hydrological applications to accurately simulate a whole SMOS pixel by representing the spatial and temporal heterogeneity of the soil moisture fields over a wide area (50×50 km<sup>2</sup>). The study focuses on the Valencia Anchor Station (VAS) experimental site, in Spain, which is one of the main SMOS Cal/Val sites in Europe. <br><br> A faithful representation of the soil moisture distribution at SMOS pixel scale (50×50 km<sup>2</sup>) requires an accurate estimation of the amount and temporal/spatial distribution of precipitation. To quantify the gain of using the comprehensive PERSIANN database instead of sparsely distributed rain gauge measurements, comparisons between in situ observations and satellite rainfall data are done both at point and areal scale. An overestimation of the satellite rainfall amounts is observed in most of the cases (about 66%) but the precipitation occurrences are in general retrieved (about 67%). <br><br> To simulate the high variability in space and time of surface soil moisture, a Soil Vegetation Atmosphere Transfer (SVAT) model – ISBA (Interactions between Soil Biosphere Atmosphere) is used. The interest of using satellite rainfall estimates as well as the influence that the precipitation events can induce on the modelling of the water content in the soil is depicted by a comparison between different soil moisture data. Point-like and spatialized simulated data using rain gauge observations or PERSIANN – CCS database as well as ground measurements are used. It is shown that a good adequacy is reached in most part of the year, the precipitation differences having less impact upon the simulated soil moisture. The behaviour of simulated surface soil moisture at SMOS scale is verified by the use of remote sensing data from the Advanced Microwave Scanning Radiometer on Earth observing System (AMSR-E). We show that the PERSIANN database provides useful information at temporal and spatial scales in the context of soil moisture retrieval. <br><br> <br><br> <sup>1</sup>Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks-Cloud Classification System – <a href="http://chrs.web.uci.edu/persiann"target="_blank">http://chrs.web.uci.edu/persiann</a&gt

Disentangling quality and safety indicator data: a longitudinal, comparative study of hand hygiene compliance and accreditation outcomes in 96 Australian hospitals.

The study aims are twofold. First, to investigate the suitability of hand hygiene as an indicator of accreditation outcomes and, second, to test the hypothesis that hospitals with better accreditation outcomes achieve higher hand hygiene compliance rates

Built to last? the sustainability of health system improvements, interventions and change strategies: A study protocol for a systematic review

© 2017 Article author(s) (or their employer(s) unless otherwise stated in the text of the article). All rights reserved. No commercial use is permitted unless otherwise expressly granted. Introduction The sustainability of healthcare interventions and change programmes is of increasing importance to researchers and healthcare stakeholders interested in creating sustainable health systems to cope with mounting stressors. The aim of this protocol is to extend earlier work and describe a systematic review to identify, synthesise and draw meaning from studies published within the last 5 years that measure the sustainability of interventions, improvement efforts and change strategies in the health system. Methods and analysis The protocol outlines a method by which to execute a rigorous systematic review. The design includes applying primary and secondary data collection techniques, consisting of a comprehensive database search complemented by contact with experts, and searching secondary databases and reference lists, using snowballing techniques. The review and analysis process will occur via an abstract review followed by a full-text screening process. The inclusion criteria include English-language, peer-reviewed, primary, empirical research articles published after 2011 in scholarly journals, for which the full text is available. No restrictions on location will be applied. The review that results from this protocol will synthesise and compare characteristics of the included studies. Ultimately, it is intended that this will help make it easier to identify and design sustainable interventions, improvement efforts and change strategies. Ethics and dissemination As no primary data were collected, ethical approval was not required. Results will be disseminated in conference presentations, peer-reviewed publications and among policymaker bodies interested in creating sustainable health systems

The development, design, testing, refinement, simulation and application of an evaluation framework for communities of practice and social-professional networks

Background. Communities of practice and social-professional networks are generally considered to enhance workplace experience and enable organizational success. However, despite the remarkable growth in interest in the role of collaborating structures in a range of industries, there is a paucity of empirical research to support this view. Nor is there a convincing model for their systematic evaluation, despite the significant potential benefits in answering the core question: how well do groups of professionals work together and how could they be organised to work together more effectively? This research project will produce a rigorous evaluation methodology and deliver supporting tools for the benefit of researchers, policymakers, practitioners and consumers within the health system and other sectors. Given the prevalence and importance of communities of practice and social networks, and the extent of investments in them, this project represents a scientific innovation of national and international significance. Methods and design. Working in four conceptual phases the project will employ a combination of qualitative and quantitative methods to develop, design, field-test, refine and finalise an evaluation framework. Once available the framework will be used to evaluate simulated, and then later existing, health care communities of practice and social-professional networks to assess their effectiveness in achieving desired outcomes. Peak stakeholder groups have agreed to involve a wide range of members and participant organisations, and will facilitate access to various policy, managerial and clinical networks. Discussion. Given its scope and size, the project represents a valuable opportunity to achieve breakthroughs at two levels; firstly, by introducing novel and innovative aims and methods into the social research process and, secondly, through the resulting evaluation framework and tools. We anticipate valuable outcomes in the improved understanding of organisational performance and delivery of care. The project's wider appeal lies in transferring this understanding to other health jurisdictions and to other industries and sectors, both nationally and internationally. This means not merely publishing the results, but contextually interpreting them, and translating them to advance the knowledge base and enable widespread institutional and organisational application

Turning Points in the Evolution of Isolated Neutron Stars' Magnetic Fields

During the life of isolated neutron stars (NSs) their magnetic field passes through a variety of evolutionary phases. Depending on its strength and structure and on the physical state of the NS (e.g. cooling, rotation), the field looks qualitatively and quantitatively different after each of these phases. Three of them, the phase of MHD instabilities immediately after NS's birth, the phase of fallback which may take place hours to months after NS's birth, and the phase when strong temperature gradients may drive thermoelectric instabilities, are concentrated in a period lasting from the end of the proto--NS phase until 100, perhaps 1000 years, when the NS has become almost isothermal. The further evolution of the magnetic field proceeds in general inconspicuous since the star is in isolation. However, as soon as the product of Larmor frequency and electron relaxation time, the so-called magnetization parameter, locally and/or temporally considerably exceeds unity, phases, also unstable ones, of dramatic changes of the field structure and magnitude can appear. An overview is given about that field evolution phases, the outcome of which makes a qualitative decision regarding the further evolution of the magnetic field and its host NS.Comment: References updated, typos correcte

How do online patient support communities affect the experience of inflammatory bowel disease?: an online survey

Objective: To explore how participation in an online support community may impact upon the experience of inflammatory bowel disease (IBD). Design: An online survey. Setting: Study participants recruited through 35 IBD online communities. Participants: A total of 249 males and females aged 16–69 years, living with either Crohn’s disease (65.9%) or ulcerative colitis (26.1%) or awaiting formal diagnosis (8%). Results: Patients reported being members for an average of two years, with the majority accessing the community on a daily (46.9%) or weekly (40%) basis. Spending on average four hours per week online, approximately two-thirds of members posted between one and five messages per week. Members joined to find others in a similar situation and to obtain and share information and emotional support. Through participation members accessed a wealth of knowledge about all aspects of living with IBD and this was helpful in terms of accepting their illness and learning to manage it. The community also helped members see their illness more positively as well as contributing to an improvement in subjective wellbeing. However, some negatives aspects were noted. Conclusions: Online support communities may provide a useful shared space through which IBD patients may seek and provide both informational and emotional support. Many of these benefits may not be available through traditional healthcare. Whilst online support communities may be beneficial for those who choose to participate in them, they are not without limitations. Health professionals should be aware of the potential benefits and limitations of online communities

Magnetic fileds of coalescing neutron stars and the luminosity function of short gamma-ray burst

Coalescing neutron star binaries are believed to be the most reliable sources for ground-based detectors of gravitational waves and likely progenitors of short gamma-ray bursts. In the process of coalescence, magnetic fields of neutron stars can induce interesting observational manifestations and affect the form of gravitational wave signal. In this papaer we use the population synthesis method to model the expected distribution of neutron star magnetic fields during the coalescence under different assumptions on the initial parameters of neutron stars and their magnetic field evolution. We discuss possible elecotrmagnetic phenomena preceding the coalescence of magnetized neutron star binaries and the effect of magnetic field on the gravitational wave signal. We find that a log-normal (Gaussian in logarithms) distribution of the initial magnetic fields of neutron stars, which agrees with observed properties of radio pulsars, produces the distribution of the magnetic field energy during the coalescence that adequately describes the observed luminosity function of short gamma-ray bursts under different assumptions on the field evolution and initial parameters of neutron stars. This agreement lends further support to the model of coalescing neutron star binaries as progenitors of gamma-ray bursts.Comment: v.2, LATEX, 25 pages, inc. 7 ps figures, Astron. Lett., in press. Typos corrected, reference adde