A novel hybrid algorithm for morphological analysis: artificial Neural-Net-XMOR

In this study, we present a novel algorithm that combines a rule-based approach and an artificial neural network-based approach in morphological analysis. The usage of hybrid models including both techniques is evaluated for performance improvements. The proposed hybrid algorithm is based on the idea of the dynamic generation of an artificial neural network according to two-level phonological rules. In this study, the combination of linguistic parsing, a neural network-based error correction model, and statistical filtering is utilized to increase the coverage of pure morphological analysis. We experimented hybrid algorithm applying rule-based and long short-term memory-based (LSTM-based) techniques, and the results show that we improved the morphological analysis performance for optical character recognizer (OCR) and social media data. Thus, for the new hybrid algorithm with LSTM, the accuracy reached 99.91% for the OCR dataset and 99.82% for social media data. © TÜBİTAK

Electrochemical determination of aripiprazole based on aluminium oxide nanoparticles modified carbon paste electrode

The electrochemical oxidation of aripiprazole was explored at a carbon paste electrode modified with aluminium oxide nanoparticles by cyclic voltammetry and square-wave anodic adsorptive stripping voltammetry. Experimental parameters such as carbon paste composition, scan rate, buffer pH, accumulation time, and accumulation potential were optimized in order to obtain high analytical performance. The incorporation of aluminium oxide nanoparticles into the carbon paste matrix enhanced the effective surface area of the carbon paste electrode and improved the sensitivity. On the aluminium oxide nanoparticles modified carbon paste electrode, aripiprazole exhibited an irreversible anodic peak at +1.17 V in pH 1.8 BR buffer solution. Under optimum conditions, the peak current exhibited a linear dependence with aripiprazole concentration between 0.03 and 8.0 µM with a detection limit of 0.006 ?M. The analytical applicability of the voltammetric method was evaluated by quantification of ARP in human serum samples and pharmaceutical formulations. © TÜBİTAKNKUBAP.01, YGLA.16.018This study was supported by Tekirdağ Namık Kemal University Scientific Research Projects Coodination Unit (project no: NKUBAP.01.YGLA.16.018)

Sedoanalgesia Administration with Propofol and Ketamine for Minor Urologic Interventions

Aim: In this study we aimed to administer sedoanalgesia with propofol and ketamine combination in patients undergoing planned minor urologic interventions with limited anesthesia. By combining these two medications, lower doses may be used, and we aimed to provide sufficient sedation, analgesia and amnesia without disrupting hemodynamic and respiratory stability and to increase patient and surgeon satisfaction. Material-Method: The study included 53 patients with planned minor urologic interventions aged from 19 to 85 years and physical situation ASA I-III. After six hours starvation, patients were taken to the surgery. Patients were monitored for electrocardiography (ECG), oxygen saturation (SPO2 ) and non-invasive blood pressure. For use if necessary a nasal O2 cannula was inserted. A vein in the back of the left hand was opened and 5 ml/min isotonic sodium chloride infusion was begun. Patient heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP), mean arterial pressure (MAP) and oxygen saturation (SpO2 ) values were measured and a 5 point sedation scale (Table 1) was used to measure sedation scores. Basal values were recorded (0 min). Later patients were randomly divided into two groups with Group I administered intraurethral lidocaine gel for local anesthesia by the surgeon, while Group II were administered intravenous 0.015 mg/kg midazolam, 0.5 mg/kg 1% ketamine and 0.5 mg/kg 1% propofol by the authors for sedoanalgesia. At five minute intervals the HR, SAP, DAP, MAP, SpO2 values and sedation scores were measured and recorded. Results: Statistical evaluation found a statistically significant increase in SAP, DAP and MAP values measured at the 5th minute in Group I patients compared to preoperative values. In Group I patients, when the heart rate measured in the 1st and 5th minutes are compared with preoperative values there was a statistically significant increase identified. In Group II patients, there was a statistically significant fall in SpO2 values in the 1st and 5th minutes compared with preoperative values. When patient and surgeon satisfaction are compared with Group I, Group II was found to be statistically significantly higher. Though the blood pressure and heart rate increases in Group I patients were statistically significant, they were not at levels that required clinical intervention and/or treatment. Similarly the SpO2 decrease observed in Group II patients did not fall below 90% in any patient in spite of being statistically significant and rose again without clinical intervention and/or treatment. Conclusion: In this study we showed that sedoanalgesia administration with propofol and ketamine may be an alternative method for patients undergoing minor urology interventions that does not disrupt hemodynamic and respiratory stability, does not delay patient discharge, has low side effect incidence and has high patient and surgeon satisfaction

Turkey: Coronary and structural heart interventions from 2010 to 2015

Growing populations and ageing demographics lead to an increased burden of ischaemic heart disease and related cardiovascular interventions, resulting in pressure on healthcare sys-Tems. Although the healthcare system in Turkey has undergone comprehensive remodelling over the last decade, there are many challenges to overcome, including better reimbursement for car-diovascular interventions, standardisation of interventional cardiology services and research-related activities. In this manuscript, we present an overview of coronary and structural heart interventions in Turkey, as well as providing information on current reimbursement policies and the healthcare system. © Europa Digital and Publishing 2017. All Rights Reserved

Improving the sensitivity of future GW observatories in the 1-10 Hz band: Newtonian and seismic noise

The next generation gravitational wave interferometric detectors will likely be underground detectors to extend the GW detection frequency band to frequencies below the Newtonian noise limit. Newtonian noise originates from the continuous motion of the Earth’s crust driven by human activity, tidal stresses and seismic motion, and from mass density fluctuations in the atmosphere. It is calculated that on Earth’s surface, on a typical day, it will exceed the expected GW signals at frequencies below 10 Hz. The noise will decrease underground by an unknown amount. It is important to investigate and to quantify this expected reduction and its effect on the sensitivity of future detectors, to plan for further improvement strategies. We report about some of these aspects. Analytical models can be used in the simplest scenarios to get a better qualitative and semi-quantitative understanding. As more complete modeling can be done numerically, we will discuss also some results obtained with a finite-element-based modeling tool. The method is verified by comparing its results with the results of analytic calculations for surface detectors. A key point about noise models is their initial parameters and conditions, which require detailed information about seismic motion in a real scenario. We will describe an effort to characterize the seismic activity at the Homestake mine which is currently in progress. This activity is specifically aimed to provide informations and to explore the site as a possible candidate for an underground observatory. Although the only compelling reason to put the interferometer underground is to reduce the Newtonian noise, we expect that the more stable underground environment will have a more general positive impact on the sensitivity.We will end this report with some considerations about seismic and suspension noise

Optical identification and follow-up observations of SRGA J213151.5+491400 -- a new magnetic cataclysmic variable discovered with SRG Observatory

We report results of optical identification and multi-wavelength study of a new polar-type magnetic cataclysmic variable (MCV), SRGA J213151.5+491400, discovered by Spectrum Roentgen-Gamma ($SRG$) observatory in the course of the all-sky survey. We present optical data from telescopes in Turkey (RTT-150 and T100 at the T\"UBITAK National Observatory), and in Russia (6-m and 1-m at SAO RAS), together with the X-ray data obtained with $ART-XC$ and $eROSITA$ telescopes aboard $SRG$ and the $NICER$ observatory. We detect SRGA J213151.5+491400 in a high state in 2020 (17.9 mag) that decreases about 3 mag into a low state (21 mag) in 2021. We find only one significant period using optical photometric time series analysis which reveals the white dwarf spin/orbital period to be 0.059710(1) days (85.982 min). The long slit spectroscopy in the high state yields a power law continuum increasing towards the blue with a prominent He II line along with the Balmer line emissions with no cyclotron humps; consistent with MCV nature. Doppler Tomography confirms the polar nature revealing ballistic stream accretion along with magnetic stream during the high state. These characteristics show that the new source is a polar-type MCV. $SRG$ $ART-XC$ detections yield an X-ray flux of (4.0-7.0)$\times$10$^{-12}$ erg cm$^2$ s$^{-1}$ in the high state. $eROSITA$ detects a dominating hot plasma component (kT$_{\rm{max}}$ $>$ 21 keV in the high state) declining to (4.0-6.0)$\times$10$^{-13}$ erg cm$^2$ s$^{-1}$ in 2021 (low state). The $NICER$ data obtained in the low state reveal a two-pole accretor showing a soft X-ray component at (6-7)$\sigma$ significance with a blackbody temperature of 15-18 eV. A soft X-ray component has never been detected for a polar in the low state before.Comment: 16 pages, 4 Tables and 15 Figures. Accepted for publication in A&A as it stand

Health and illness beliefs in adults with tuberculosis infection during the COVID-19 pandemic in the UK

BACKGROUND: COVID-19 disrupted the TB prevention programme in the UK, especially for TB infection (TBI) care. We explore whether experience of the COVID-19 pandemic impacted on patients' perceptions of TBI and its treatment. METHODS: Semi-structured interviews were conducted as part of the Research to Improve Detection and Treatment of TBI (RID-TB) programme, exploring perceptual and practical barriers to TBI treatment. Nineteen people diagnosed with TBI were interviewed between August 2020 and April 2021. Recordings were transcribed and analysed using a constant comparative approach, allowing for a dynamic and iterative exploration of themes. Themes are organised using the Perceptions and Practicalities Approach. FINDINGS: Some participants perceived TBI as a risk factor for increased susceptibility to COVID-19, while some thought that treatment for TBI might protect against COVID-19 or mitigate its effects. Adaptations to TB services (e.g., remote follow-up) and integrated practices during the COVID-19 restrictions (e.g., medication being posted) addressed some practical barriers to TBI treatment. However, we identified beliefs about TBI and COVID-19 that are likely to act as barriers to engagement with TBI treatment, including: interpreting service delays as an indication of TBI not being serious enough for treatment and concerns about contracting COVID-19 in TB clinics. INTERPRETATION: COVID-19 and TBI service delays influence people's perceptions and practical barriers to TBI treatment adherence. Failure to address these beliefs may lead to people's concerns about their treatment not being fully addressed. Utilised service adaptations like remote consultations to address practical barriers may be relevant beyond COVID-19