Clinical Dengue Data Analysis and Prediction using Multiple Classifiers: An Ensemble Techniques

The dengue infection is caused by the mosquito Aedes aegypti According to WHO 50 to 100 million dengue infections will occur every year Data-miming techniques will extract information from the raw data Dengue symptoms are fever severe headache body pain vomiting diarrhea cough pain in abdomen etc The research work is carried out on real data and the patient data is collected from the Department of General Medicine PESIMSR Kuppam Andrapradesh Dataset consists of 18 attributes and one target value Research work has been done on binary classification to classify dengue positive DF and dengue negative NDF cases using different ML techniques The proposed work demonstrates that ensemble techniques bagging boosting and stacking gives better results than other models The Extreme Gradient Boost XGB Random Forest by majority voting and stacking with different meta classifiers are the ensemble techniques used for the binary classification The dataset is divided into 80 training and 20 testing dataset Performance parameters used for the analysis are accuracy precision recall and f1 score and compared the proposed model with other ML models The experimental results shows that the accuracy of extended boost random forest and stacking is 98 99 99 for training dataset and 97 94 98 testing dataset respectively The extended metrics ROC Precision -Recall curve and AUC better analysi

Unitarizable Representations of the Deformed Para-Bose Superalgebra Uq[osp(1/2)] at Roots of 1

The unitarizable irreps of the deformed para-Bose superalgebra $pB_q$, which is isomorphic to $U_q[osp(1/2)]$, are classified at $q$ being root of 1. New finite-dimensional irreps of $U_q[osp(1/2)]$ are found. Explicit expressions for the matrix elements are written down.Comment: 19 pages, PlainTe

The quantum superalgebra Uq[osp(1/2n)]U_q[osp(1/2n)]: deformed para-Bose operators and root of unity representations

We recall the relation between the Lie superalgebra $osp(1/2n)$ and para-Bose operators. The quantum superalgebra $U_q[osp(1/2n)]$, defined as usual in terms of its Chevalley generators, is shown to be isomorphic to an associative algebra generated by so-called pre-oscillator operators satisfying a number of relations. From these relations, and the analogue with the non-deformed case, one can interpret these pre-oscillator operators as deformed para-Bose operators. Some consequences for $U_q[osp(1/2n)]$ (Cartan-Weyl basis, Poincar\'e-Birkhoff-Witt basis) and its Hopf subalgebra $U_q[gl(n)]$ are pointed out. Finally, using a realization in terms of ``$q$-commuting'' $q$-bosons, we construct an irreducible finite-dimensional unitary Fock representation of $U_q[osp(1/2n)]$ and its decomposition in terms of $U_q[gl(n)]$ representations when $q$ is a root of unity.Comment: 15 pages, LaTeX (latex twice), no figure

Neural processing of criticism and positive comments from relatives in individuals with schizotypal personality traits

Objectives. High negative expressed emotion by family members towards schizophrenia patients increases the risk of subsequent relapse. The study aimed to determine whether individuals with high schizotypy (HS) and low schizotypy (LS) would differ in activation of brain areas involved in cognitive control when listening to relative criticism

Decitabine impact on the endocytosis regulator RhoA, the folate carriers RFC1 and FOLR1, and the glucose transporter GLUT4 in human tumors.

BackgroundIn 31 solid tumor patients treated with the demethylating agent decitabine, we performed tumor biopsies before and after the first cycle of decitabine and used immunohistochemistry (IHC) to assess whether decitabine increased expression of various membrane transporters. Resistance to chemotherapy may arise due to promoter methylation/downregulation of expression of transporters required for drug uptake, and decitabine can reverse resistance in vitro. The endocytosis regulator RhoA, the folate carriers FOLR1 and RFC1, and the glucose transporter GLUT4 were assessed.ResultsPre-decitabine RhoA was higher in patients who had received their last therapy >3 months previously than in patients with more recent prior therapy (P = 0.02), and varied inversely with global DNA methylation as assessed by LINE1 methylation (r = -0.58, P = 0.006). Tumor RhoA scores increased with decitabine (P = 0.03), and RFC1 also increased in patients with pre-decitabine scores ≤150 (P = 0.004). Change in LINE1 methylation with decitabine did not correlate significantly with change in IHC scores for any transporter assessed. We also assessed methylation of the RFC1 gene (alias SLC19A1). SLC19A1 methylation correlated with tumor LINE1 methylation (r = 0.45, P = 0.02). There was a small (statistically insignificant) decrease in SLC19A1 methylation with decitabine, and there was a trend towards change in SLC19A1 methylation with decitabine correlating with change in LINE1 methylation (r = 0.47, P <0.15). While SLC19A1 methylation did not correlate with RFC1 scores, there was a trend towards an inverse correlation between change in SLC19A1 methylation and change in RFC1 expression (r = -0.45, P = 0.19).ConclusionsIn conclusion, after decitabine administration, there was increased expression of some (but not other) transporters that may play a role in chemotherapy uptake. Larger patient numbers will be needed to define the extent to which this increased expression is associated with changes in DNA methylation

Operational experience with the GEM detector assembly lines for the CMS forward muon upgrade

The CMS Collaboration has been developing large-area triple-gas electron multiplier (GEM) detectors to be installed in the muon Endcap regions of the CMS experiment in 2019 to maintain forward muon trigger and tracking performance at the High-Luminosity upgrade of the Large Hadron Collider (LHC); 10 preproduction detectors were built at CERN to commission the first assembly line and the quality controls (QCs). These were installed in the CMS detector in early 2017 and participated in the 2017 LHC run. The collaboration has prepared several additional assembly and QC lines for distributed mass production of 160 GEM detectors at various sites worldwide. In 2017, these additional production sites have optimized construction techniques and QC procedures and validated them against common specifications by constructing additional preproduction detectors. Using the specific experience from one production site as an example, we discuss how the QCs make use of independent hardware and trained personnel to ensure fast and reliable production. Preliminary results on the construction status of CMS GEM detectors are presented with details of the assembly sites involvement

Morpheus Reveals Distant Disk Galaxy Morphologies with JWST: The First AI/ML Analysis of JWST Images

The dramatic first images with JWST demonstrated its power to provide unprecedented spatial detail for galaxies in the high-redshift universe. Here, we leverage the resolution and depth of the JWST Cosmic Evolution Early Release Science Survey data in the Extended Groth Strip to perform pixel-level morphological classifications of galaxies in JWST F150W imaging using the Morpheus deep-learning framework for astronomical image analysis. By cross-referencing with existing photometric redshift catalogs from the Hubble Space Telescope (HST) CANDELS survey, we show that JWST images indicate the emergence of disk morphologies before z ∼ 2 and with candidates appearing as early as z ∼ 5. By modeling the light profile of each object and accounting for the JWST point-spread function, we find the high-redshift disk candidates have exponential surface brightness profiles with an average Sérsic index 〈n〉 = 1.04 and >90% displaying “disky” profiles (n < 2). Comparing with prior Morpheus classifications in CANDELS we find that a plurality of JWST disk galaxy candidates were previously classified as compact based on the shallower HST imagery, indicating that the improved optical quality and depth of the JWST helps to reveal disk morphologies that were hiding in the noise. We discuss the implications of these early disk candidates on theories for cosmological disk galaxy formation