1,671 research outputs found
New hypersonic facility capability at NASA Lewis Research Center
Four facility activities are underway at NASA Lewis Research Center to develop new hypersonic propulsion test capability. Two of these efforts consist of upgrades to existing operational facilities. The other two activities will reactivate facilities that have been in a standby condition for over 15 years. These four activities are discussed and the new test facilities NASA Lewis will have in place to support evolving high speed research programs are described
Time decay of the remanent magnetization in the spin glass model at T=0
Using the zero-temperature Metropolis dynamics, the time decay of the
remanent magnetization in the Edward-Anderson spin glass model with a
uniform random distribution of ferromagnetic and antiferromagnetic interactions
has been investigated. Starting from the saturation, the magnetization per spin
reveals a slow decrease with time, which can be approximated by a power
law:, . Moreover, its
relaxation does not lead it into one of the ground states, and therefore the
system is trapped in metastable isoenergetic microstates remaining magnetized.
Such behaviour is discussed in terms of a random walk the system performs on
its available configuration space.Comment: 9 pages, 3 figure
Newborn Screening for Homocystinuria Revealed a High Frequency of MAT I/III Deficiency in Iberian Peninsula
Acessível em: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375120/Homocystinuria due to cystathionine β-synthase deficiency or "classical homocystinuria" is a rare autosomal recessive condition resulting in altered sulfur metabolism with elevated methionine and homocysteine in plasma and homocystine in urine. This condition is characterized by a high clinical heterogeneity, which contributes to late clinical diagnosis, usually only made after irreversible damage has occurred. Treatment is effective if started before clinical symptoms. The analysis of methionine levels by tandem mass spectrometry (MS/MS) allows the newborn screening for homocystinuria, but false-positive results can be frequently obtained and lead to the unwanted identification of methionine adenosyl transferase (MAT I/III) deficiency. This latter condition is biochemically characterized by isolated persistent hypermethioninemia, accompanied in some individuals with slightly elevated levels of homocysteine in plasma. A dominant form of MAT I/III deficiency, associated with mutation p.R264H, seems to be very frequent in the Iberian Peninsula and usually has a clinically benign course. Both these metabolic disorders are screened in Galicia and Portugal since the introduction of the MS/MS technology, in 2000 and 2004, respectively, resulting in the identification of three patients with classical homocystinuria and 44 patients with MAT I/III deficiency. All but one heterozygous parent of MAT I/III patients, identified with the p.R264H mutation, are healthy adults around the age of 30/40. The implementation of a second-tier test for homocysteine in dried blood spots would considerably reduce the number of MAT I/III-deficient patients identified and improve the specificity and positive predictive value for classical homocystinuria screening
Hypermethioninaemia due to methionine adenosyltransferase I/III (MAT I/III) deficiency: diagnosis in an expanded neonatal screening programme
The Expanded Newborn Screening Program (MS/MS) in the region of Galicia (NW Spain) was initiated in 2000 and includes the measurement of methionine levels in dried blood spots. Between June 2000 and June 2007, 140 818 newborns were analysed, and six cases of persistent hypermethioninaemia were detected: one homocystinuria due to cystathionine β-synthase (CβS) deficiency, and five methionine adenosyltransferase I/III (MAT I/III) deficiencies. The five cases of MAT I/III deficiency represent an incidence of 1/28 163 newborns. In these five patients, methionine levels in dried blood spots ranged from 50 to 147 μmol/L. At confirmation of the persistence of the hypermethioninaemia in a subsequent plasma sample, plasma methionine concentrations were moderately elevated in 4 of the 5 patients (mean 256 μmol/L), while total homocysteine (tHcy) was normal; the remaining patient showed plasma methionine of 573 μmol/L and tHcy of 22.8 μmol/L. All five patients were heterozygous for the same dominant mutation, R264H in the MAT1A gene. With a diet not exceeding recommended protein requirements for their age, all patients maintained methionine levels below 300 μmol/L. Currently, with a mean of 2.5 years since diagnosis, the patients are asymptomatic and show developmental quotients within the normal range. Our results show a rather high frequency of hypermethioninaemia due to MAT I/III deficiency in the Galician neonatal population, indicating a need for further studies to evaluate the impact of persistent isolated hypermethioninaemia in neonatal screening programmes
Slow dynamics and aging in spin-glasses
Contribution presented by Eric Vincent in the Conference `Complex Behaviour
of Glassy Systems', Sitges, Barcelona, Spain, June, 1996. It contains a review
of the experimental results on Slow dynamics and aging in spin-glasses. It also
presents their comparison with recent theoretical developments in the
description of the out of equilibrium dynamics of disordered systems; namely,
the trap model and the mean-field theory.Comment: 35 pages, 12 figures, macro lmamult.sty (included
Stretched exponential relaxation in the mode-coupling theory for the Kardar-Parisi-Zhang equation
We study the mode-coupling theory for the Kardar-Parisi-Zhang equation in the
strong-coupling regime, focusing on the long time properties. By a saddle point
analysis of the mode-coupling equations, we derive exact results for the
correlation function in the long time limit - a limit which is hard to study
using simulations. The correlation function at wavevector k in dimension d is
found to behave asymptotically at time t as C(k,t)\simeq 1/k^{d+4-2z}
(Btk^z)^{\gamma/z} e^{-(Btk^z)^{1/z}}, with \gamma=(d-1)/2, A a determined
constant and B a scale factor.Comment: RevTex, 4 pages, 1 figur
The eSMA: description and first results
The eSMA ("extended SMA") combines the SMA, JCMT and CSO into a single
facility, providing enhanced sensitivity and spatial resolution owing to the
increased collecting area at the longest baselines. Until ALMA early science
observing (2011), the eSMA will be the facility capable of the highest angular
resolution observations at 345 GHz. The gain in sensitivity and resolution will
bring new insights in a variety of fields, such as protoplanetary/transition
disks, high-mass star formation, solar system bodies, nearby and high-z
galaxies. Therefore the eSMA is an important facility to prepare the grounds
for ALMA and train scientists in the techniques.
Over the last two years, and especially since November 2006, there has been
substantial progress toward making the eSMA into a working interferometer. In
particular, (i) new 345-GHz receivers, that match the capabilities of the SMA
system, were installed at the JCMT and CSO; (ii) numerous tests have been
performed for receiver, correlator and baseline calibrations in order to
determine and take into account the effects arising from the differences
between the three types of antennas; (iii) first fringes at 345 GHz were
obtained on August 30 2007, and the array has entered the science-verification
stage.
We report on the characteristics of the eSMA and its measured performance at
230 GHz and that expected at 345 GHz. We also present the results of the
commissioning and some initial science-verification observations, including the
first absorption measurement of the C/CO ratio in a galaxy at z=0.89, located
along the line of sight to the lensed quasar PKS1830-211, and on the imaging of
the vibrationally excited HCN line towards IRC+10216.Comment: 12 pages, 7 figures, paper number 7012-12, to appear in Proceedings
of SPIE vol. 7012: "Ground-based and Airborne Telescopes II", SPIE conference
on Astronomical Instrumentation, Marseille, 23-28 June 200
Product Differentiation Costs and Global Competition
The growing competitive intensity on the markets determines the emergence of
competition costs that are expressed at a corporate level and have implicit
repercussions for the supply system. This type of costs makes it possible to identify
a close link between competition costs and supply differentiation costs.
Classification by competitive intensity presupposes that the analysis performed
identifies the classification of company costs as the discriminating element, in
terms of the competitive pressure of the context in which the firm operates.
The emergence of competition costs is linked to an attempt to squeeze them as an
aspect of vertical, or more specifically, horizontal cooperation strategies.Product Differentiation; Differentiation Costs; Over-Supply; Global Competition; Marketing; Market-Driven Management; Global Corporations; Global Markets DOI:http://dx.doi.org/10.4468/2005.1.06garbelli
1.3 mm Wavelength VLBI of Sagittarius A*: Detection of Time-Variable Emission on Event Horizon Scales
Sagittarius A*, the ~4 x 10^6 solar mass black hole candidate at the Galactic
Center, can be studied on Schwarzschild radius scales with (sub)millimeter
wavelength Very Long Baseline Interferometry (VLBI). We report on 1.3 mm
wavelength observations of Sgr A* using a VLBI array consisting of the JCMT on
Mauna Kea, the ARO/SMT on Mt. Graham in Arizona, and two telescopes of the
CARMA array at Cedar Flat in California. Both Sgr A* and the quasar calibrator
1924-292 were observed over three consecutive nights, and both sources were
clearly detected on all baselines. For the first time, we are able to extract
1.3 mm VLBI interferometer phase information on Sgr A* through measurement of
closure phase on the triangle of baselines. On the third night of observing,
the correlated flux density of Sgr A* on all VLBI baselines increased relative
to the first two nights, providing strong evidence for time-variable change on
scales of a few Schwarzschild radii. These results suggest that future VLBI
observations with greater sensitivity and additional baselines will play a
valuable role in determining the structure of emission near the event horizon
of Sgr A*.Comment: 8 pages, submitted to ApJ
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