Reconstructed Overhanging Battlements. Executive Techniques and their Vulnerability in the Stronghold of Arquata del Tronto (Italy)

The stronghold of Arquata del Tronto was heavily damaged by earthquakes in 2016 and it drew the attention of the experts in reinforcing historic buildings. They regarded it as a case study, a predicting model of the failure in employing specific construction elements in fortified architecture, whose geometric and material data were only approximately considered. The overhanging battlement is the most seriously damaged part of the building and has raised particular attention and interest. As often happens in other castles and fortresses, it dates back to the late 19th and even more to the 20th century. A first close examination of the building’s repairs shows how the new additions, whose maintenance is difficult, ended in failure. The additions were inspired by ancient details, but nonetheless they are unreasonable from the point of view of structure and durability: they – and even more the irrational repairs of the last decades – are the principal cause of failure. Material decay – closely linked to circumstances and places – has also played a decisive role. An extensive and rigorous historical research is necessary to find the sources and to evaluate their nature and limits, as well as to relate all information to the building, thus operating in close correlation with the building archaeology, by now a so widespread and consolidated research field. Jointly, the written documents and the building itself in its historical stratification allow a better analysis of the structural behaviour , an essential step to achieve an effective restoration planning

Measurement of melatonin in body fluids: Standards, protocols and procedures

Abstract: The circadian rhythm of melatonin in saliva or plasma, or of the melatonin metabolite 6‐ sulphatoxymelatonin in urine, is a defining feature of suprachiasmatic nucleus function, the endogenous oscillatory pacemaker. These measurements are useful to evaluate problems related to the onset or offset of sleep and for assessing phase delays or advances of rhythms in entrained individuals. Additionally, they have become an important tool for psychiatric diagnosis, its use being recommended for phase typing in patients suffering from sleep and mood disorders. Thus, the development of sensitive and selective methods for the precise detection of melatonin in tissues and fluids of animals emerges as necessary. Due to its low concentration and the co‐existence of many other endogenous compounds in blood, the determination of melatonin has been an analytical challenge. This review discusses current methodologies employed for detection and quantification of melatonin in biological fluids and tissues

Additional chromosomal abnormalities in Philadelphia-positive clone : adverse prognostic influence on frontline imatinib therapy: a GIMEMA Working Party on CML analysis

Additional chromosomal abnormalities (ACAs) in Philadelphia-positive cells have been reported in 3c 5% of patients with newly diagnosed chronic myeloid leukemia (CML) in chronic phase (CP). Few studies addressing the prognostic significance of baseline ACAs in patients treated with imatinib have been published previously. The European LeukemiaNet recommendations suggest that the presence of ACAs at diagnosis is a "warning" for patients in early CP, but there is not much information about their outcome after therapy with tyrosine kinase inhibitors. To investigate the role of ACAs in early CP CML patients treated with imatinib mesylate, we performed an analysis in a large series of 559 patients enrolled in 3 prospective trials of the Gruppo Italiano Malattie Ematologiche dell'Adulto Working Party on CML: 378 patients were evaluable and ACAs occurred in 21 patients (5.6%). The overall cytogenetic and molecular response rates were significantly lower and the time to response was significantly longer in patients with ACAs. The long-term outcome of patients with ACAs was inferior, but the differences were not significant. The prognostic significance of each specific cytogenetic abnormality was not assessable. Therefore, we confirm that ACAs constitute an adverse prognostic factor in CML patients treated with imatinib as frontline therapy

From territory to buildings: Arquata del Tronto in a diachronic perspective

The mountain area between Umbria and the Marche, which was frequently hit by devastating earthquakes, is today a borderline case among the 'inner' or 'fragile areas': reconsidering the long-term relationships between social life and the construction of the towns, the land use, the communication routes, gives a sense and a measure to the rehabilitation and preservation of two buildings, the Rocca and the convent of San Francesco, which are the symbols of Arquata, but also highlights the roots of a deeper and more remote crisis. The studies on the Marche, after World War II, early proved the usefulness of seeing in a historical perspective topics which are today fundamental, as the environment and the sustainability, and are an essential premise of this attempt

Le pavimentazioni in seminato nell’edilizia storica cremonese

XVIII convegno internazionale Scienza e beni culturali, Bressanon

Forage Plant Ecophysiology under Different Stress Conditions

Forage production often occurs in fragile environments with low fertility and various limitations [...