21 research outputs found
Impacts of changes in groundwater recharge on the isotopic composition and geochemistry of seasonally ice-covered lakes: insights for sustainable management
Lakes are under increasing pressure due to widespread anthropogenic impacts
related to rapid development and population growth. Accordingly, many lakes
are currently undergoing a systematic decline in water quality. Recent
studies have highlighted that global warming and the subsequent changes in
water use may further exacerbate eutrophication in lakes. Lake evolution
depends strongly on hydrologic balance, and therefore on groundwater
connectivity. Groundwater also influences the sensitivity of lacustrine
ecosystems to climate and environmental changes, and governs their
resilience. Improved characterization of groundwater exchange with lakes is
needed today for lake preservation, lake restoration, and sustainable
management of lake water quality into the future. In this context, the aim of
the present paper is to determine if the future evolution of the climate, the
population, and the recharge could modify the geochemistry of lakes (mainly
isotopic signature and quality via phosphorous load) and if the isotopic
monitoring of lakes could be an efficient tool to highlight the variability
of the water budget and quality.
Small groundwater-connected lakes were chosen to simulate changes in water
balance and water quality expected under future climate change scenarios,
namely representative concentration pathways (RCPs) 4.5 and 8.5. Contemporary
baseline conditions, including isotope mass balance and geochemical
characteristics, were determined through an intensive field-based research
program prior to the simulations. Results highlight that future lake
geochemistry and isotopic composition trends will depend on four main
parameters: location (and therefore climate conditions), lake catchment size
(which impacts the intensity of the flux change), lake volume (which impacts
the range of variation), and lake G index (i.e., the percentage of
groundwater that makes up total lake inflows), the latter being the dominant
control on water balance conditions, as revealed by the sensitivity of lake
isotopic composition. Based on these model simulations, stable isotopes
appear to be especially useful for detecting changes in recharge to lakes
with a G index of between 50 and 80âŻ%, but response is non-linear.
Simulated monthly trends reveal that evolution of annual lake isotopic
composition can be dampened by opposing monthly recharge fluctuations. It is
also shown that changes in water quality in groundwater-connected lakes
depend significantly on lake location and on the intensity of recharge
change
Impacts of changes in groundwater recharge on the isotopic composition and geochemistry of seasonally ice-covered lakes: insights for sustainable management
Lakes are under increasing pressure due to widespread anthropogenic impacts
related to rapid development and population growth. Accordingly, many lakes
are currently undergoing a systematic decline in water quality. Recent
studies have highlighted that global warming and the subsequent changes in
water use may further exacerbate eutrophication in lakes. Lake evolution
depends strongly on hydrologic balance, and therefore on groundwater
connectivity. Groundwater also influences the sensitivity of lacustrine
ecosystems to climate and environmental changes, and governs their
resilience. Improved characterization of groundwater exchange with lakes is
needed today for lake preservation, lake restoration, and sustainable
management of lake water quality into the future. In this context, the aim of
the present paper is to determine if the future evolution of the climate, the
population, and the recharge could modify the geochemistry of lakes (mainly
isotopic signature and quality via phosphorous load) and if the isotopic
monitoring of lakes could be an efficient tool to highlight the variability
of the water budget and quality.
Small groundwater-connected lakes were chosen to simulate changes in water
balance and water quality expected under future climate change scenarios,
namely representative concentration pathways (RCPs) 4.5 and 8.5. Contemporary
baseline conditions, including isotope mass balance and geochemical
characteristics, were determined through an intensive field-based research
program prior to the simulations. Results highlight that future lake
geochemistry and isotopic composition trends will depend on four main
parameters: location (and therefore climate conditions), lake catchment size
(which impacts the intensity of the flux change), lake volume (which impacts
the range of variation), and lake G index (i.e., the percentage of
groundwater that makes up total lake inflows), the latter being the dominant
control on water balance conditions, as revealed by the sensitivity of lake
isotopic composition. Based on these model simulations, stable isotopes
appear to be especially useful for detecting changes in recharge to lakes
with a G index of between 50 and 80âŻ%, but response is non-linear.
Simulated monthly trends reveal that evolution of annual lake isotopic
composition can be dampened by opposing monthly recharge fluctuations. It is
also shown that changes in water quality in groundwater-connected lakes
depend significantly on lake location and on the intensity of recharge
change
BMP Signaling Modulates Hepcidin Expression in Zebrafish Embryos Independent of Hemojuvelin
Hemojuvelin (Hjv), a member of the repulsive-guidance molecule (RGM) family, upregulates transcription of the iron regulatory hormone hepcidin by activating the bone morphogenetic protein (BMP) signaling pathway in mammalian cells. Mammalian models have identified furin, neogenin, and matriptase-2 as modifiers of Hjv's function. Using the zebrafish model, we evaluated the effects of hjv and its interacting proteins on hepcidin expression during embryonic development. We found that hjv is strongly expressed in the notochord and somites of the zebrafish embryo and that morpholino knockdown of hjv impaired the development of these structures. Knockdown of hjv or other hjv-related genes, including zebrafish orthologs of furin or neogenin, however, failed to decrease hepcidin expression relative to liver size. In contrast, overexpression of bmp2b or knockdown of matriptase-2 enhanced the intensity and extent of hepcidin expression in zebrafish embryos, but this occurred in an hjv-independent manner. Furthermore, we demonstrated that zebrafish hjv can activate the human hepcidin promoter and enhance BMP responsive gene expression in vitro, but is expressed at low levels in the zebrafish embryonic liver. Taken together, these data support an alternative mechanism for hepcidin regulation during zebrafish embryonic development, which is independent of hjv
Comparison of 222Rn - ÎŽ13C investigations to calibrate groundwater discharge in rivers.
International audienc
Interactions between groundwater and seasonally ice-covered lakes: using water stable isotopes and radon-222 multi-layer mass balance models
International audienc
Comparison of 222Rn - ÎŽ13C investigations to calibrate groundwater discharge in rivers.
International audienc
The C. elegans engrailed homolog ceh-16 regulates the self-renewal expansion division of stem cell-like seam cells
Incidence of diabetes in HIV-infected patients treated with first-line integrase strand transfer inhibitors: a French multicentre retrospective study
International audienceAbstract Background Integrase strand transfer inhibitors (INSTIs) are increasingly used in patients living with HIV due to their safety, effectiveness and high genetic barrier. However, an association with weight gain has recently been suggested and several cases of diabetes mellitus have been reported with raltegravir and dolutegravir. The long-time metabolic impact of these recent molecules remains unclear. Objectives To assess if an INSTI as a third agent is statistically associated with new-onset diabetes mellitus compared with an NNRTI or a PI. Patients and methods Patients undergoing first-line combined ART (cART) without diabetes at baseline were retrospectively included from the DatâAIDS French cohort study (ClinicalTrials.gov NCT02898987). Incident diabetes mellitus was defined as a notification of new diabetes in the medical history, a glycated haemoglobin (HbA1c) level superior to 7.5% or the start of a diabetes therapy following the initiation of ART. Results From 2009 to 2017, 19â462 patients were included, among which 265 cases of diabetes mellitus occurred. Multivariate and survival analyses did not highlight an increase in new-onset diabetes in patients undergoing cART with an INSTI as a third agent compared with an NNRTI or a PI. BMI >30âkg/m2, age >37âyears old (in survival analysis), black race or Hispanic ethnicity, arterial hypertension and AIDS were associated with a higher proportion of incident diabetes. Conclusions INSTIs were not statistically associated with new-onset diabetes. However, clinicians should remain aware of this possible metabolic comorbidity, particularly in patients with a high BMI and older patients