Energy efficiency parametric design tool in the framework of holistic ship design optimization

Recent International Maritime Organization (IMO) decisions with respect to measures to reduce the emissions from maritime greenhouse gases (GHGs) suggest that the collaboration of all major stakeholders of shipbuilding and ship operations is required to address this complex techno-economical and highly political problem efficiently. This calls eventually for the development of proper design, operational knowledge, and assessment tools for the energy-efficient design and operation of ships, as suggested by the Second IMO GHG Study (2009). This type of coordination of the efforts of many maritime stakeholders, with often conflicting professional interests but ultimately commonly aiming at optimal ship design and operation solutions, has been addressed within a methodology developed in the EU-funded Logistics-Based (LOGBASED) Design Project (2004–2007). Based on the knowledge base developed within this project, a new parametric design software tool (PDT) has been developed by the National Technical University of Athens, Ship Design Laboratory (NTUA-SDL), for implementing an energy efficiency design and management procedure. The PDT is an integral part of an earlier developed holistic ship design optimization approach by NTUA-SDL that addresses the multi-objective ship design optimization problem. It provides Pareto-optimum solutions and a complete mapping of the design space in a comprehensive way for the final assessment and decision by all the involved stakeholders. The application of the tool to the design of a large oil tanker and alternatively to container ships is elaborated in the presented paper

Acousto-optic interaction enhancement in dual photonic-phononic cavities

Light control through elastic waves is a well established and mature technology. The underlying mechanism is the scattering of light due to the dynamic modulation of the refractive index and the material interfaces caused by an elastic wave, the so-called acousto-optic interaction. This interaction can be enhanced in appropriately designed structures that simultaneously localize light and elastic waves in the same region of space and operate as dual optical-elastic cavities, often called phoxonic or optomechanical cavities. Typical examples of phoxonic cavities are multilayer films with a dielectric sandwiched between two Bragg mirrors or, in general, defects in macroscopically periodic structures that exhibit dual band gaps for light and elastic waves. In the present work we consider dielectric particles as phoxonic cavities and study the influence of elastic eigenmode vibrations on the optical Mie resonances. An important issue is the excitation of elastic waves in such submicron particles and, in this respect, we analyze the excitation of high-frequency vibrations following thermal expansion induced by the absorption of a femtosecond laser pulse. For spherical particles, homogeneous thermalization leads to excitation of the particle breathing modes. We report a thorough study of the acousto-optic interaction, correct to all orders in the acousto-optic coupling parameter, by means of rigorous full electrodynamic and elastodynamic calculations, in both time and frequency domains. Our results show that, under double elastic-optical resonance conditions, strong acousto-optic interaction takes place and results in large dynamical shifts of the high-Q optical Mie resonances, manifested through multiphonon exchange mechanisms

GEOTHERMIC STATUS OF THERMOPYLAE - ANTHILI AREA IN FTHIOTIDA PREFECTURE

The purpose of this study was the discovery, identification and evaluation of directly exploitable geothermal fields, in the Thermopylae - Anthili area (100km2 ). After the evaluation and the processing of any preexisting data, followed the surface works, such as further geological mapping, tectonic and stratigraphic correlations and analyses, geothermal impressions, observations at 30 recorded points (springs, drillings, wells) regarding water sampling, chemical analyses, temperature, pH and conductivity measurements, special sampling for Br and isotopes analyses. The in depth works that took place concern geophysical prospecting, loggings, small and large diameter drillings. All the data were digitized and processed in a GIS environment. After correlating all the data collected for the region, a geological - geothermal model was constructed. According to this model, water percolates through permeable formations, joints and faults, gets mixed with the existing salt water, warms up and then ascends to the surface through faults and concentrates on proper reservoirs. Specifically, the region of Damasta where two areas of hot water reservoirs have been identified is of particular geothermal interest. The first, located in Triassic– Jurassic limestones (more than 600m deep), presents the greatest interest in terms of temperature and capacity, while the second (found on the surface and up to 350m deep) is located in Quaternary sediments and the upper formations of the underlying Late Cretaceous limestone

Do temperature, relative humidity and interspecific competition alter the population size and the damage potential of stored-product insect pests? A hierarchical multilevel modeling approach

The premises of stored agricultural products and food consists of a complex ecosystem in which several pests can seriously affect the quality and quantity of the products. In this study we utilize a 4-level hierarchical linear multilevel model in order to assess the effect of temperature, relative humidity (RH) and interspecific competition on the population size and damage potential of the larger grain borer, Prostephanus truncatus (Horn) (Coleoptera: Bostrychidae) and the lesser grain borer, Rhyzopertha dominica (F.) (Coleoptera: Bostrychidae). As RH was increased, we observed higher percentage of live insects, while increased levels of temperature significantly decreased the percentage of live insects. The combination of R. dominica and P. truncatus lead to reduction of the percentages of live insects in comparison to single species treatments. However, P. truncatus is more damaging than R. dominica in maize, based on the proportion of damaged kernels which were infested by each insect species. We expect our results to have bearing in the management of these species

Immunomodulatory interventions in myocardial infarction and heart failure: a systematic review of clinical trials and meta-analysis of IL-1 inhibition

Following a myocardial infarction (MI), the immune system helps to repair ischaemic damage and restore tissue integrity, but excessive inflammation has been implicated in adverse cardiac remodelling and development towards heart failure (HF). Pre-clinical studies suggest that timely resolution of inflammation may help prevent HF development and progression. Therapeutic attempts to prevent excessive post-MI inflammation in patients have included pharmacological interventions ranging from broad immunosuppression to immunomodulatory approaches targeting specific cell types or factors with the aim to maintain beneficial aspects of the early post-MI immune response. These include the blockade of early initiators of inflammation including reactive oxygen species and complement, inhibition of mast cell degranulation and leucocyte infiltration, blockade of inflammatory cytokines, and inhibition of adaptive B and T-lymphocytes. Herein, we provide a systematic review on post-MI immunomodulation trials and a meta-analysis of studies targeting the inflammatory cytokine Interleukin-1. Despite an enormous effort into a significant number of clinical trials on a variety of targets, a striking heterogeneity in study population, timing and type of treatment, and highly variable endpoints limits the possibility for meaningful meta-analyses. To conclude, we highlight critical considerations for future studies including (i) the therapeutic window of opportunity, (ii) immunological effects of routine post-MI medication, (iii) stratification of the highly diverse post-MI patient population, (iv) the potential benefits of combining immunomodulatory with regenerative therapies, and at last (v) the potential side effects of immunotherapies

Prognostic value of preoperative dynamic contrast-enhanced MRI perfusion parameters for high-grade glioma patients

INTRODUCTION: The prognostic value of the dynamic contrast-enhanced (DCE) MRI perfusion and its histogram analysis-derived metrics is not well established for high-grade glioma (HGG) patients. The aim of this prospective study was to investigate DCE perfusion transfer coefficient (Ktrans), vascular plasma volume fraction (vp), extracellular volume fraction (ve), reverse transfer constant (kep), and initial area under gadolinium concentration time curve (IAUGC) as predictors of progression-free (PFS) and overall survival (OS) in HGG patients. METHODS: Sixty-nine patients with suspected anaplastic astrocytoma or glioblastoma underwent preoperative DCE-MRI scans. DCE perfusion whole tumor region histogram parameters, clinical details, and PFS and OS data were obtained. Univariate, multivariate, and Kaplan–Meier survival analyses were conducted. Receiver operating characteristic (ROC) curve analysis was employed to identify perfusion parameters with the best differentiation performance. RESULTS: On univariate analysis, ve and skewness of vp had significant negative impacts, while kep had significant positive impact on OS (P < 0.05). ve was also a negative predictor of PFS (P < 0.05). Patients with lower ve and IAUGC had longer median PFS and OS on Kaplan–Meier analysis (P < 0.05). Ktrans and ve could also differentiate grade III from IV gliomas (area under the curve 0.819 and 0.791, respectively). CONCLUSIONS: High ve is a consistent predictor of worse PFS and OS in HGG glioma patients. vp skewness and kep are also predictive for OS. Ktrans and ve demonstrated the best diagnostic performance for differentiating grade III from IV gliomas

Acousto-optic interaction enhancement in dual photonic-phononic cavities

Light control through elastic waves is a well established and mature technology. The underlying mechanism is the scattering of light due to the dynamic modulation of the refractive index and the material interfaces caused by an elastic wave, the so-called acousto-optic interaction. This interaction can be enhanced in appropriately designed structures that simultaneously localize light and elastic waves in the same region of space and operate as dual optical-elastic cavities, often called phoxonic or optomechanical cavities. Typical examples of phoxonic cavities are multilayer films with a dielectric sandwiched between two Bragg mirrors or, in general, defects in macroscopically periodic structures that exhibit dual band gaps for light and elastic waves. In the present work we consider dielectric particles as phoxonic cavities and study the influence of elastic eigenmode vibrations on the optical Mie resonances. An important issue is the excitation of elastic waves in such submicron particles and, in this respect, we analyze the excitation of high-frequency vibrations following thermal expansion induced by the absorption of a femtosecond laser pulse. For spherical particles, homogeneous thermalization leads to excitation of the particle breathing modes. We report a thorough study of the acousto-optic interaction, correct to all orders in the acousto-optic coupling parameter, by means of rigorous full electrodynamic and elastodynamic calculations, in both time and frequency domains. Our results show that, under double elastic-optical resonance conditions, strong acousto-optic interaction takes place and results in large dynamical shifts of the high-Q optical Mie resonances, manifested through multiphonon exchange mechanisms

Slip distributions on active normal faults measured from LiDAR and field mapping of geomorphic offsets: an example from L\u2019Aquila, Italy, and implications for modelling seismic moment release

Surface slip distributions for an active normal fault in central Italy have been measured using terrestrial laser scanning (TLS), in order to assess the impact of changes in fault orientation and kinematics when modelling subsurface slip distributions that control seismic moment release. The southeastern segment of the surface trace of the Campo Felice active normal fault near the city of L\u2019Aquila was mapped and surveyed using techniques from structural geology and using TLS to define the vertical and horizontal offsets of geomorphic slopes since the last glacial maximum (15 \ub13 ka). The fault geometry and kinematics measured from 43 sites and throw/heave measurements from geomorphic offsets seen on 250 scarp profiles were analysed using a modification of the Kostrov equations to calculate the magnitudes and directions of horizontal principal strain-rates. The map trace of the studied fault is linear, except where a prominent bend has formed to link across a former left-stepping relay-zone. The dip of the fault and slip direction is constant across the bend. Throw-rates since 15 \ub13 ka decrease linearly from the fault centre to the tip, except in the location of the prominent bend where higher throw rates are recorded. Vertical coseismic offsets for two palaeoearthquake ruptures seen as fresh strips of rock at the base of the bedrock scarp also increase within the prominent bend. The principal strain-rate, calculated by combining strike, dip, slip-direction and post 15 \ub13 ka throw, decreases linearly from the fault centre towards the tip; the strain-rate does not increase across the prominent fault bend. The above shows that changes in fault strike, whilst having no effect on the principal horizontal strain-rate, can produce local maxima in throw-rates during single earthquakes that persist over the timescale of multiple earthquakes (15 \ub13 ka). Detailed geomorphological and structural investigation of active faults is therefore a critical input in order to properly define fault activity for the purpose of accurate seismic hazard assessment. We discuss the implications of modelling subsurface slip distributions for earthquake ruptures through inversion of GPS, InSAR and strong motion data using planar fault approximations, referring to recent examples on the nearby Paganica fault that ruptured in the Mw 6.3 2009 L\u2019Aquila Earthquak