Evolución de las infecciones de transmisión sexual en la ciudad de Valencia. Periodo 2004-2009

Las infecciones de transmisión sexual (ITS) han aumentado en los últimos años en toda la Unión Europea. La puesta en marcha de sistemas de notificación y registro de las enfermedades de declaración obligatoria (AVE) y sistemas de notificación automatizada de resultados de microbiología(RedMiVa) han permitido una mejora de la exhaustividad en la detección de casos y por tanto una mejor identificación y prevención de la transmisión de estas enfermedades.Un diseño clásico de vigilancia de salud pública para los registros de Sífilis del periodo 2005-2009 y de Infección gonocócica del periodo 2004-2009, nos permite analizar las características de los sujetos, su evolución temporal y hábitos sexuales en la ciudad de Valencia. Durante el periodo fueron notificados 321 casos de Sífilis y 596 de Infección Gonocócica. La evolución temporal de la incidencia pasó de 2,13 (2005) a 15,60 (2009) para la Sífilis; y de 2,13 (2004) a 26,36 (2009) para la Infección gonocócica. La introducción de la notificación microbiológica incrementó la detección de nuevos casos de ITS.La desproporción por género muestra una evolución creciente de la Razón de masculinidad. La Sífilis presenta cifras superiores entre los inmigrantes tanto en varones como en mujeres, mientras que para la Infección Gonocócica destaca una incidencia superior en mujeres autóctonas que entre las inmigrantes. El factor sexual de riesgomás frecuente para ambas enfermedades fue la existencia de parejas múltiples. El 42,68% de los pacientes con Sífilis y el 36,91% de los pacientes con Infección Gonocócica indicaron esta conducta.La tendencia creciente observada, con independencia de lo anterior, es concordante con informes de similar origen en nuestro país. No obstante, nuestras cifras de Incidencia Anual son sustancialmente mayores que las registradas en el conjunto de la nación.Esta evolución sugiere la necesidad de incrementar las  estrategias activas de prevención y uso de preservativos. De igual modo la detección temprana y el tratamiento correcto de las ITS requieren, en nuestra opinión, unamayor difusión de la información epidemiológica sobre ITS a los profesionales clínicos

The deuteron: structure and form factors

A brief review of the history of the discovery of the deuteron in provided. The current status of both experiment and theory for the elastic electron scattering is then presented.Comment: 80 pages, 33 figures, submited to Advances in Nuclear Physic

Effectiveness of influenza vaccination programme in preventing hospital admissions, Valencia, 2014/15 early results

Preliminary results for the 2014/15 season indicate low to null effect of vaccination against influenza A(H3N2)-related disease. As of week 5 2015, there have been 1,136 hospital admissions, 210 were due to influenza and 98% of subtype A strains were H3. Adjusted influenza vaccine effectiveness was 33% (range: 6–53%) overall and 40% (range: 13% to 59%) in those 65 years and older. Vaccination reduced by 44% (28–68%) the probability of admission with influenza.The study was funded by a contract between FISABIO and Sanofi-Pasteur

Differential Cross Section of DP-Elastic Scattering at Intermediate Energies

The deuteron-proton elastic scattering is studied in the multiple scattering expansion formalism. The contributions of the one-nucleon-exchange, single- and double scattering are taken into account. The Love and Franey parameterization of the nucleon-nucleon $t$-matrix is used, that gives an opportunity to include the off-energy-shell effects into calculations. Differential cross sections are considered at four energies, $T_d=390, 500, 880, 1200$ MeV. The obtained results are compared with the experimental data

Genetic diversity in cultivated carioca common beans based on molecular marker analysis

A wide array of molecular markers has been used to investigate the genetic diversity among common bean species. However, the best combination of markers for studying such diversity among common bean cultivars has yet to be determined. Few reports have examined the genetic diversity of the carioca bean, commercially one of the most important common beans in Brazil. In this study, we examined the usefulness of two molecular marker systems (simple sequence repeats – SSRs and amplified fragment length polymorphisms – AFLPs) for assessing the genetic diversity of carioca beans. The amount of information provided by Roger’s modified genetic distance was used to analyze SSR data and Jaccards similarity coefficient was used for AFLP data. Seventy SSRs were polymorphic and 20 AFLP primer combinations produced 635 polymorphic bands. Molecular analysis showed that carioca genotypes were quite diverse. AFLPs revealed greater genetic differentiation and variation within the carioca genotypes (Gst = 98% and Fst = 0.83, respectively) than SSRs and provided better resolution for clustering the carioca genotypes. SSRs and AFLPs were both suitable for assessing the genetic diversity of Brazilian carioca genotypes since the number of markers used in each system provided a low coefficient of variation. However, fingerprint profiles were generated faster with AFLPs, making them a better choice for assessing genetic diversity in the carioca germplasm

Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42\ub74% vs 44\ub72%; absolute difference \u20131\ub769 [\u20139\ub758 to 6\ub711] p=0\ub767; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5\u20138] vs 6 [5\u20138] cm H2O; p=0\ub70011). ICU mortality was higher in MICs than in HICs (30\ub75% vs 19\ub79%; p=0\ub70004; adjusted effect 16\ub741% [95% CI 9\ub752\u201323\ub752]; p<0\ub70001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0\ub780 [95% CI 0\ub775\u20130\ub786]; p<0\ub70001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status. Funding: No funding