К ВОПРОСУ ОБ АЛГОРИТМЕ ЛУЧЕВОЙ ДИАГНОСТИКИ ПЕРЕЛОМОВ СРЕДНЕЙ ЗОНЫ ЛИЦА, СОПРОВОЖДАЮЩИХСЯ ПОВРЕЖДЕНИЕМ ВЕРХНЕЧЕЛЮСТНОЙ ПАЗУХИ

The X-ray and spiral computed tomography pictures of patients with zygomatico-orbito-maxillary coplex fractures accompanied by damage of the maxillary sinus walls were analyzed. Residual displacement and emergence of hemosinus after close reduction and after open reduction with internal fixation were compaired. Radiography could be used as a screening for detection of indication for surgery. Computed tomography should be a regular method of postoperative diagnostic to evaluate sinus pneumatisation and anomalies of ostio-meatal unit.Изучены данные лучевой диагностики у пациентов с переломом скуло-орбитально-верхнечелюстного комплекса, сопровождающимся повреждением верхнечелюстной пазухи. Проведен анализ качества сопоставления костных отломков, а также частоты возникновения гемосинуса после закрытых и открытых методов хирургического лечения переломов по данным рентгенографии и компьютерной томографии. Сделан вывод о возможности использования рентгенографии в качестве скрининга для выявления показаний к хирургическому лечению и необходимости выполнения компьютерной томографии в послеоперационный период для оценки пневматизации верхнечелюстной пазухи и состояния остио-меатального комплекса

К ВОПРОСУ ОБ АЛГОРИТМЕ ЛУЧЕВОЙ ДИАГНОСТИКИ ПЕРЕЛОМОВ СРЕДНЕЙ ЗОНЫ ЛИЦА, СОПРОВОЖДАЮЩИХСЯ ПОВРЕЖДЕНИЕМ ВЕРХНЕЧЕЛЮСТНОЙ ПАЗУХИ

The X-ray and spiral computed tomography pictures of patients with zygomatico-orbito-maxillary coplex fractures accompanied by damage of the maxillary sinus walls were analyzed. Residual displacement and emergence of hemosinus after close reduction and after open reduction with internal fixation were compaired. Radiography could be used as a screening for detection of indication for surgery. Computed tomography should be a regular method of postoperative diagnostic to evaluate sinus pneumatisation and anomalies of ostio-meatal unit.Изучены данные лучевой диагностики у пациентов с переломом скуло-орбитально-верхнечелюстного комплекса, сопровождающимся повреждением верхнечелюстной пазухи. Проведен анализ качества сопоставления костных отломков, а также частоты возникновения гемосинуса после закрытых и открытых методов хирургического лечения переломов по данным рентгенографии и компьютерной томографии. Сделан вывод о возможности использования рентгенографии в качестве скрининга для выявления показаний к хирургическому лечению и необходимости выполнения компьютерной томографии в послеоперационный период для оценки пневматизации верхнечелюстной пазухи и состояния остио-меатального комплекса

Near 10 years and longer periods modulate circadians: intersecting anti aging and chronoastrobiological research

Biological cycles with relatively long and some unusual periods in the range of the half-week, the half-year, years, or decades are being discovered. Their prior neglect constituted a confounder in aging and much other research, which then \u201cflew blind\u201d concerning the uncertainties associated with these cycles when they are not assessed. The resolution of more about 10-year and other cycles, some reported herein, replaces the admission of complete unpredictability, implied by using the label \u201csecularity.\u201d Heretofore unaccounted-for variability becomes predictable insofar as it proves to be rhythmic and is mapped systematically to serve as a battery of useful reference values. About 10-year cycles in urinary 17-ketosteroid excretion and in heart rate and its variability, among others, are aligned with cycles of similar length in mortality from myocardial infarction. Associations accumulate between cycles of natural physical time structures, chronomes such as the 10.5-year (circadecennian) Schwabe and the 21-year (circavigintunennian) Hale cycles of solar activity, and chronomes in biota. There are about 50-year (circasemicentennian) cycles in mortality from stroke in Minnesota and in the Czech Republic and also in human morphology at birth, the latter result reducing the likelihood that these cycles are purely human made. Associations among large populations warrant long-term systematic coordinated sampling of natural physical and biological variables of interest for the design of countermeasures against already documented elevated risks of stroke, myocardial infarction, and other catastrophic diseases, notably in elderly adults. New findings will be introduced against the background of the documented value of mapping rhythms in medicine and gerontology. In both these fields, rhythms promise the seeming paradox of better care for less

Chronobiological analysis of blood pressure in a patient with atrial fibrillation at the development of heart failure and its therapeutic and surgical treatment

Dynamics of blood pressure (BP) and heart rate (HR) was traced by automatic monitoring every 30 min uninterruptedly along several months in a patient suffering from combined atrial fibrillation and heart failure during the development of disease and its therapeutic and surgical treatment (pacemaker implanting and atrioventricular ablation). Analyses of spectral components as well as signal's shape revealed instabilities in circadian and semicircadian parameters. A new approach for signal's form description without using cosine approximation is suggested. The meaning that referring a patient as dipper, night peaker, or nondipper might be useful at choosing tactics of his treatment is impugned, because all these "types" can transform themselves in the same person in few days. Optimization timing of treatment provides better results if not the "types" of daily profile would be taken to account but the real form of the BP-signal and timing its first and second derivatives. © 2013 Sergey Chibisov et al

Mitochondrial and Cytosolic One-Carbon Metabolism Is a Targetable Metabolic Vulnerability in Cisplatin-Resistant Ovarian Cancer

One-carbon (C1) metabolism is compartmentalized between the cytosol and mitochondria with the mitochondrial C1 pathway as the major source of glycine and C1 units for cellular biosynthesis. Expression of mitochondrial C1 genes including SLC25A32, serine hydroxymethyl transferase (SHMT) 2, 5,10-methylene tetrahydrofolate dehydrogenase 2, and 5,10-methylene tetrahydrofolate dehydrogenase 1-like was significantly elevated in primary epithelial ovarian cancer (EOC) specimens compared with normal ovaries. 5-Substituted pyrrolo[3,2-d]pyrimidine antifolates (AGF347, AGF359, AGF362) inhibited proliferation of cisplatin-sensitive (A2780, CaOV3, IGROV1) and cisplatin-resistant (A2780-E80, SKOV3) EOC cells. In SKOV3 and A2780-E80 cells, colony formation was inhibited. AGF347 induced apoptosis in SKOV3 cells. In IGROV1 cells, AGF347 was transported by folate receptor (FR) α. AGF347 was also transported into IGROV1 and SKOV3 cells by the proton-coupled folate transporter (SLC46A1) and the reduced folate carrier (SLC19A1). AGF347 accumulated to high levels in the cytosol and mitochondria of SKOV3 cells. By targeted metabolomics with [2,3,3-2H]L-serine, AGF347, AGF359, and AGF362 inhibited SHMT2 in the mitochondria. In the cytosol, SHMT1 and de novo purine biosynthesis (i.e., glycinamide ribonucleotide formyltransferase, 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) were targeted; AGF359 also inhibited thymidylate synthase. Antifolate treatments of SKOV3 cells depleted cellular glycine, mitochondrial NADH and glutathione, and showed synergistic in vitro inhibition toward SKOV3 and A2780-E80 cells when combined with cisplatin. In vivo studies with subcutaneous SKOV3 EOC xenografts in SCID mice confirmed significant antitumor efficacy of AGF347. Collectively, our studies demonstrate a unique metabolic vulnerability in EOC involving mitochondrial and cytosolic C1 metabolism, which offers a promising new platform for therapy

(276–279) Proposals to provide for registration of new names and nomenclatural acts

The Melbourne Congress of 2011 authorized a Special Committee on Registration of Algal and Plant Names (including fossils), which was established the following year (Wilson in Taxon 61: 878–879. 2012). Its explicit mandate was “to consider what would be involved in registering algal and plant names (including fossils), using a procedure analogous to that for fungal names agreed upon in Melbourne and included in the Code as Art. 42”, but expectations at the Nomenclature Section in Melbourne went farther than that. There was the hope that registration systems for at least some of the main groups would soon be set up, to be used and tested on a voluntary basis and, if found to be generally accepted, would persuade the subsequent Congress in Shenzhen, in 2017, to declare registration of new names an additional requirement for valid publication. The Melbourne Congress also approved mandatory registration of nomenclatural novelties in fungi, starting on 1 Jan 2013. The new Art. 42 of the Code (McNeill & al. in Regnum Veg. 154. 2012) requires authors to register any fungal nomenclatural novelty, prior to publication, with a recognized repository, whereupon they are provided with a unique identifier for each name, to be included in the protologue along with other Code-mandated information. Years before registration became mandatory, mycologists had been encouraged, often prompted by journal editors, to register their nomenclatural novelties prior to publication. Most complied. Consequently, when mandatory registration was proposed, it had strong support from the mycological community. There are currently three recognized repositories for fungal names. They vary somewhat in how they operate, but they share records of their registered novelties as soon as publication has been effected. One consequence of implementing mandatory registration is that locating new fungal names and combinations and associated protologue information is much simpler now than it was before. This makes it easier to incorporate the information into taxonomic studies and to update taxonomic treatments, inventories, and indices. A corollary is that, no matter what publication outlet an author chooses, the name cannot fail to be noticed. The positive experience in mycology makes extension of the registration concept to plants and algae a compelling idea. That experience shows that the best way to make mandatory registration of nomenclatural novelties palatable to botanists and phycologists is the establishment of trial registration at repositories with a history of involvement in and commitment to the indexing of names. Trial registration enables users to acquaint themselves with registration procedures, make suggestions on how they might be improved, and appreciate, by personal experience, the benefits of registration. Unfortunately, the task of establishing such repositories proved to be more complex and time-consuming than had been foreseen. Substantial progress has been made in the establishment of such centres (Barkworth & al., in this issue, pp. 670–672) but the Committee is not in a position to make firm proposals to regulate registration procedures, even less to make registration mandatory from a concrete future date. Nevertheless, the Committee sees it as imperative that the Shenzhen Congress be offered the opportunity to move forward with registration without having to wait six more years. In this spirit, we offer the proposals below. Proposal (276) would declare registration an ongoing concern of the botanical, mycological, and phycological community and provide the basic structure for making it possible. Proposal (277) and Prop. (278) would, in addition, define a flexible framework within which a system of voluntary registration could be developed for various categories of organisms. Proposal (279) would provide for future mandatory registration in a way that does not depend on the six-year intervals between International Botanical Congresses. Presentation of each proposal is followed by a summary of the support received from members of the Committee.Fil: Barkworth, Mary E.. State University of Utah; Estados UnidosFil: Watson, Mark. Royal Botanic Gardens; Reino UnidoFil: Barrie, Fred R.. Missouri Botanical Garden; Estados Unidos. Field Museum Of Natural History; Estados UnidosFil: Belyaeva, Irina V.. Royal Botanic Gardens; Reino UnidoFil: Chung, Richard C. K.. Forest Research Institute ; MalasiaFil: Dasková, Jirina. Národní Muzeum; República ChecaFil: Davidse, Gerrit. Missouri Botanical Garden; Estados UnidosFil: Dönmez, Ali A.. Hacettepe Üniversitesi; TurquíaFil: Doweld, Alexander B.. National Institute Of Carpology; RusiaFil: Dressler, Stefan. Senckenberg Forschungsinstitut Und Naturmuseum; AlemaniaFil: Flann, Christina. Naturalis Biodiversity Center; Países BajosFil: Gandhi, Kanchi. Harvard University; Estados UnidosFil: Geltman, Dmitry. Russian Academy of Science; RusiaFil: Glen, Hugh F.. Forest Hills; SudáfricaFil: Greuter, Werner. Freie Universität Berlin; AlemaniaFil: Head, Martin J.. Brock University; CanadáFil: Jahn, Regine. Freie Universität Berlin; AlemaniaFil: Janarthanam, Malapati K.. Goa University; IndiaFil: Katinas, Liliana. Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. División de Plantas Vasculares; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; ArgentinaFil: Kirk, Paul M.. Royal Botanic Gardens; Reino UnidoFil: Klazenga, Niels. Royal Botanic Gardens Victoria; AustraliaFil: Kusber, Wolf-Henning. Freie Universität Berlin; AlemaniaFil: Kvacek, Jirí. Národní Muzeum; República ChecaFil: Malécot, Valéry. Universite D'angers; FranciaFil: Mann, David G.. Royal Botanic Gardens; Reino UnidoFil: Marhold, Karol. Charles University; República ChecaFil: Nagamasu, Hidetoshi. Kyoto University; JapónFil: Nicolson, Nicky. Royal Botanic Gardens; Reino UnidoFil: Paton, Alan. Royal Botanic Gardens; Reino UnidoFil: Patterson, David J.. The University Of Sydney; AustraliaFil: Price, Michelle J.. Conservatoire et Jardin botaniques de la Ville de Genève; SuizaFil: van Reine, Willem F Prud' Homme. Naturalis Biodiversity Center; Países BajosFil: Schneider, Craig W.. Trinity College Hartford; Estados UnidosFil: Sennikov, Alexander. Russian Academy Of Sciences; RusiaFil: Smith, Gideon F.. Nelson Mandela Metropolitan University; Sudáfrica. Universidad de Coimbra; PortugalFil: Stevens, Peter F.. Missouri Botanical Garden; Estados Unidos. University of Missouri; Estados UnidosFil: Yang, Zhu-Liang. Kunming Institute Of Botany Chinese Academy Of Sciences; ChinaFil: Zhang, Xian-Chun. Chinese Academy of Sciences; República de ChinaFil: Zuccarello, Giuseppe C.. Victoria University Of Wellington; Nueva Zeland