Foraminifera of shallow and very shallow facies from the upper Eocene-lower Oligocene Kazandere Member, Soğucak Formation, Thrace Basin, northwest Turkey

The middle-late Eocene to early Oligocene sediments, mainly limestone of the Soğucak Formation with its shallow water marine foraminiferal species occur most widespread in the territory of the Thrace basin. So far, the very shallow water Priabonian sediments with here described foraminiferal species have not been reported from Tharece basin. The here established Kazandere memeber of the Soğurcak Formation located between Kıyıköy andKömürköy,(NW of Kırklarel) was studied with respect to the sedimentologic as (microscopic and macroscopic), environmental and descriptive paleontology of the bentic foraminifers. Furthermore, the Eocene-Oligocene boundary in the new member defined first by the here described very shallow-water Priabonian and known shallow-water early Oligocene foraminiferal species

Foraminifera of shallow and very shallow facies from the upper Eocene–lower Oligocene Kazandere Member, Soğucak Formation, Thrace Basin, northwest Turkey

The middle−upper Eocene to lower Oligocene Kazandere Limestone Member of the Soğucak Formation is widely represented in the Thrace Basin and rich in shallow-water marine foraminifera. Very shallow-water Priabonian facies described here include Borelis vonderschimitti, Borelis laxispira sp. nov., Chapmanina gassinensis, Chapmanina elongate sp. nov., Pfendericonusglobulus sp. nov., Orbitolites minimus,Coscinospira sp. Last occurrences of the aforementioned Priabonian species and first appearances of the shallow-water marine Rupelian species Nummulites fichteli, Nummulites vascus and Operculina complanata define the Eocene−Oligocene boundary in the new Kazandere Member at the northeast Thrace Basin

Examining mindfulness and moral disengagement in doping: Perspective of Turkish wrestlers

Introduction: Studies related to attitudes toward the use of prohibited substances in Turkish athletes are scarce. The World Anti-Doping Agency (WADA) has implemented anti-doping educational policies emphasizing doping-related education in studies conducted among Turkish wrestlers. However, it is still unclear the extent to which the wrestlers comply and adhere to these anti-doping policies. No research has previously examined the effect of anti-doping education on athletes' mindfulness and moral disengagement in doping (MDD). Therefore, the present study has a two-fold objective: first, to examine whether doping-related education (DRE) and the status of being a national athlete (NA) have an effect on athlete mindfulness and MDD. Second, to analyze the relationship between each sub-dimensions of athlete mindfulness: awareness (ASD), judgment (JSD), and refocus (RSD) with MDD. Methods: A total of 409 male wrestlers participated in this study. MANOVA analysis showed that NA and DRE alone have no effect on MDD but have a general effect on mindfulness. Results: The highest effect was on the ASD of being an NA ((Formula presented.) = 0.173). When the interaction effect of NA*DRE was examined, significant difference in MDD (F = 8.218, p = 0.004), ASD (F = 8.476, p = 0.004), JSD (F = 5.844, p = 0.016), and RSD (F = 11.476, p = 0.001) were found. MDD has a weak negative relationship with ASD (r = ?0.126) and RSD (r = ?0.041) and a weak positive relationship with the JSD sub-dimension (r = 0.140). Those results suggest that being a NA and having received anti-doping education affect moral disengagement in doping and athletes' mindfulness. Discussion: As a conclusion, it is recommended to increase awareness and anti-doping education among national-standard Turkish wrestlers to prevent them from engaging in doping behaviors. Copyright © 2023 Ayyıldız, Kayabeşler, Gülü, Yagin, Aldhahi, García-Grimau and Al-Mhanna.Princess Nourah Bint Abdulrahman University, PNU: PNURSP2023R 286This research was funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number (PNURSP2023R 286), Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

Congenital Diarrhea and Cholestatic Liver Disease: Phenotypic Spectrum Associated with MYO5B Mutations.

Myosin Vb (MYO5B) is a motor protein that facilitates protein trafficking and recycling in polarized cells by RAB11- and RAB8-dependent mechanisms. Biallelic MYO5B mutations are identified in the majority of patients with microvillus inclusion disease (MVID). MVID is an intractable diarrhea of infantile onset with characteristic histopathologic findings that requires life-long parenteral nutrition or intestinal transplantation. A large number of such patients eventually develop cholestatic liver disease. Bi-allelic MYO5B mutations are also identified in a subset of patients with predominant early-onset cholestatic liver disease. We present here the compilation of 114 patients with disease-causing MYO5B genotypes, including 44 novel patients as well as 35 novel MYO5B mutations, and an analysis of MYO5B mutations with regard to functional consequences. Our data support the concept that (1) a complete lack of MYO5B protein or early MYO5B truncation causes predominant intestinal disease (MYO5B-MVID), (2) the expression of full-length mutant MYO5B proteins with residual function causes predominant cholestatic liver disease (MYO5B-PFIC), and (3) the expression of mutant MYO5B proteins without residual function causes both intestinal and hepatic disease (MYO5B-MIXED). Genotype-phenotype data are deposited in the existing open MYO5B database in order to improve disease diagnosis, prognosis, and genetic counseling

The effect of serotonin on penicillin-induced epileptiform activity

Objective: This study was aimed at examining the epileptiform activity of the 5-HT2 serotonin receptor agonist and antagonist, and 5-hydroxytryptophan (5-HTP) in penicillin-induced epilepsy in albino Wistar rats. Methods: For this purpose, 90 albino male Wistar rats were used in this study. Epileptiform activity was induced by an injection of penicillin, an agonist of GABAA receptor, (500 IU, i.c.) into the somatomotor cortex. Thirty minutes after the injection of penicillin, 2,5-dimethoxy-4-iodoamphetamine (DOI, an agonist of 5-HT2 receptor) (0.5, 1, 2 and 4 mg/kg, i.p.), methysergide, an antagonist of 5-HT2 receptor, (1, 10, 20, 50 and 100 mu M, i.c.v.) and 5-HTP, precursor of 5-HT, (25, 50, 75 and 100 mg/kg, i.p.) were administered, respectively. Results: DOI, at the doses of 1 and 2 mg/kg, significantly decreased penicillin-induced epileptiform activity (p 0.05). Conclusion: The electrophysiological data from the present study suggest that serotonin 5-HT2 receptors have an important role in controlling penicillin-induced epileptiform activity in the rat

Türkiye’de altın spot ve vadeli piyasaların etkileşimi

This study explores the impact of gold derivatives market on the market efficiency of the Turkish financial markets over 2011-2018 period. The study uses price series of USD/Ons spot and futures contracts traded in Borsa Istanbul and US Commodity Exchange as reference indicators and employs the Vector Error Correction Model. The study results reveal that there is a significant unilateral relationship between the gold spot and derivatives markets, the spot market prices leading the derivative market both in the long and short run. The findings also show that there is a persistent influence of volatility in the gold market.Bu çalışma, Borsa İstanbul ve ABD Ticaret Borsası'nda işlem gören USD/Ons vadeli işlem sözleşmelerini referans gösterge alarak altın spot ve türev piyasasının Türk sermaye piyasalarına katkısını 2011-2018 yılları arasındaki dönem için araştırmaktadır. Bu kapsamda çalışmada, Hata Düzeltme Modeli kullanılarak altın vadeli işlem piyasasının devreye alınmasının piyasa verimliliğini ne yönde etkilediği ele alınmaktadır. Elde edilen sonuçlar, Borsa İstanbul’da işlem gören altın spot fiyatları ile vadeli işlem fiyatları arasında hem uzun hem de kısa vadede tek taraflı ve anlamlı bir ilişki olduğunu, spot piyasanın vadeli işlemler piyasasına önderlik ettiğini ortaya koymaktadır. Ayrıca bulgular, altın piyasasında volatilitenin kalıcı bir etkisi olduğunu da göstermektedir