Using temporary water to resupply fresh water (on example Kanaka SCC)

In boarding houses, located at the mouth of the Kanaka beam (SCC), the problem of provision with fresh drinking water worsened. So far, the provision with drinking water was carried out with water wells from the aquifer at a depth of up to 15 m from the earth surface

MONO- AND MIXED-HERPESVIRUS INFECTIONS: ASSOCIATION WITH CLINICAL SYNDROMES OF IMMUNODEFICIENCY

In recent years, the number of hard diagnosed, polysymptomatic and polysyndrome conditions and diseases caused by mono- and mixed-herpes infections has sharply increased in the practice of physicians of all specialties. The clinical aspects of the close attention of physicians, virologists and epidemiologists to this viral family are due not only to the onset of atypical forms of these infections, but also to the emergence of the relative new concept of “active chronic atypical infection” caused by herpesviruses and in particular the Epstein-Barr virus. We observed 198 people of both sexes aged between 23 and 60 years, suffering from mono- and mixed herpetic infections (EBV, CMV, HSV 1/2, and HSV type 6). 36% of these, suffered from mono-herpesvirus infections, mixed-herpesvirus infections were diagnosed in 63.7% of cases. A study of functioning characteristics of antiviral protection system as well as defects and disorders in the system of interferons was carried out in patients suffering from various mono-, mixed herpes virus infections and bacterial co-infections. The main clinical syndromes associated with these herpetic infections, as well as prevailing nosological forms of concomitant diseases were revealed. The revealed clinical syndromes and functioning characteristics of an antiviral protection will allow developing of a conceptual, individualized, etio- and immunopathogenetic therapy

Construction of a Value-Based Model of Image of the Russian and American Police in the Newspaper Discourse

В статье рассматривается вопрос о моделировании ценностной модели образа правоохранительных органов в русскоязычном и англоязычном газетном дискурсе.The article highlights the issue of the construction of a value-based model of the image of law enforcement agencies in Russian and English newspaper discourse

EARLY DIAGNOSTICS OF AUTOINFLAMMATORY DISORDERS ASSOCIATED WITH POST-VIRAL CHRONIC FATIGUE SYNDROME AND COGNITIVE IMPAIRMENTS IN CHRONIC MIXED HERPES VIRAL INFECTIONS

The steady increase in the number of autoimmune diseases and immune-mediated autoinflammatory processes causes an increased interest of doctors of all specialties in this topic and makes the issue of early detection of autoimmune disorders / autoimmune syndrome (AS) extremely urgent. These disorders often develop against the backdrop of an atypical stream of chronic active viral infections caused by persistent viruses, in particular those of the Herpesviridae family, and remain undiagnosed due to polysymptomatic disease, and various “clinical masks” of the disorders caused by them. The semi-quantitative method developed by us for screening assessment of the content of autoantibodies in the blood serum of patients suffering from ACAI caused by herpes viruses using the ELISA method (Immunodot) is a highly specific screening method that can allow for an objective assessment of the dynamics of the autoimmune process, as well as control the effectiveness of the ongoing complex antiviral and immunomodulatory therapy. The detection of autoantibodies of various specificity in the blood serum of patients suffering from an atypical chronic active infection caused by herpes viruses (ACAI) is an early diagnostic marker, necessary, first of all, to identify autoimmune pathology of the nervous system, which is associated with a long course of the active mixed herpes-viral process

Peculiarities of post-viral chronic fatigue syndrome associated with mild cognitive decline in patients with atypical chronic active herpesvirus infections

According to modern ideas, changes in the functioning of the immune system affect the immune processes in the nervous system, contributing to the development of neuro-immuno-inflammation and thereby indirectly affect the rate of progression of neurodegenerative processes. The aim of our study was to investigate the prevalence of post-viral chronic fatigue syndrome and cognitive impairment (aMCI) among patients with atypical, chronic active herpesvirus infections (ACA-HVI).Under our supervision were 126 patients of both sexes aged 18 to 60 years with ACA-HVI.It was established that mono-EBV infection affects 27.7%; mixed EBV infection is observed in 72.3% of patients. When assessing cognitive functioning using CGI, MMSE scales, the incidence of aMCI was found to be 68.3%: with mixed HVI — 87.4%, with mono HVI — 38.8%. During the study, significant limitations were identified in the use of standard scales due to the impossibility of conducting a comprehensive assessment of clinical status parameters and cognitive dysfunctions, as well as correlation of these parameters and assessment of dynamics of the immunocorrection. To achieve this goal the Scale of assessment of the criterion clinical symptoms of patients with ACA-HVI with CFS was used. It was shown that in mixed-HVI, the severity of symptoms exceeded the severity of symptoms of patients with mono-HVI and was 52.7 (43.1-62.2) and 38.0 (31.9-42.8) points, respectively (p > 0.05). Thus, it was found that patients suffering from mixed HVI have more pronounced, severe manifestations of CFS and aMCI, which are 1.5 times higher than similar manifestations in patients with mono-HVI, significantly reducing the quality of life of these patients, worsening their social adaptation.Prolonged persistence of herpes viruses in immune-compromised people creates conditions for constant antigenic stimulation and immune imbalance with the onset of secondary immunodeficiency or clinical manifestation of existing primary disorders in the immune system, which creates the prerequisites for the development of neuro-immuno-inflammatory changes in nervous system, followed by the formation of clinical manifestations of ME/CFS with different cognitive impairments that may be classified as aMCI

High energy hadrons in EAS at mountain altitude

An extensive simulation has been carried out to estimate the physical interpretation of dynamical factors such as , in terms of high energy interaction features, concentrated in the present analysis on the average transverse momentum. It appears that the large enhancement observed for versus primary energy, suggesting in earliest analysis a significant rise of with energy, is only the result of the limited resolution of the detectors and remains in agreement with a wide range of models used in simulations.Comment: 13 pages, 6 PostScript figures, LaTeX Subm. to JPhys

Development of the procedure of testing with the application of the expert evaluation method in psychophysiology

This article provides a detailed description of the stages of development of an information system of personalized psychophysiological testing using expert evaluation. The process of the information system design is presented, the developed functional models, database and algorithm of testing by students-experts are demonstrate

INVESTIGATION OF THE SUBJECT-SPATIAL ENVIRONMENT OF THE SCHOOL BY THE METHOD OF SEMANTIC DIFFERENTIAL

Introduction. Physical and psychological parameters of the school space have a significant impact on the motivation of a learning process and its results. Specificity of the school environment, its atmosphere and surroundings determine the meaning and nature of learning, a vector and activity of development and self-development of participants in the educational process, and determine their actions in it. This circumstance makes it necessary to develop reliable diagnostic tools that enable to study the environment of educational organizations, its impact on quality of activity and successful communications of school students and teachers. The aims of this article are the following: to reveal the possibilities of the comprehensive diagnostics of the school environment and its different spatial zones; to identify and compare the perception of school space by different participants of educational relations. Methodology and research methods. The main method of the research is Ch. Osgood’s Semantic Differential (SD) modified in the context of the features of the general stages of education. Data processing was carried out using the mid-group analysis, cross-group relations, and cluster and regression analysis using the method of step selection. Student’s t-test, Cronbach’s Alpha and Pearson’s Correlation were applied to test reliability and validity of the method of semantic differential and the received results.Results and scientific novelty. The level of suitability of a classical measurement technique by Ch. Osgood for the task solution is found out. Dichotomic pairs of characteristics of the subject-spatial environment of the school are singled out; the authors’ version of semantic differential is designed having applied those pairs. The hierarchical organization of the parameters of the subject-spatial environment of the school is proved; the level of comfort acts as the parameter integrating all its characteristics, which, however, is unequally regarded by students and teachers (total number of respondents sample was N = 661). Significant differences in the estimates of the subject-spatial environment in the groups of students and teachers (from p < 0.05 to p < 0.000) are established and described. Regression formulas for each group of participants of educational process are proposed; which can be followed to estimate optimum values of comfortable learning and professional-pedagogical activity as well as to adjust subject space of a certain school. Practical significance. The developed and approved diagnostic tool makes it possible to attract external and internal experts; to obtain the quantitative data that expand the field of application of mathematical statistics; and also can become a basis of the organization of longitudinal and comparative studies of the subject space of school. Regular monitoring can be considered as a predictor of psychological well-being conditions of an educational institution since the timely and exact estimates provide adoption of operational and effective measures for improvement of the environment of the educational organization in order to strengthen the efficiency of its performance and get better results of educational activity.Введение. Физические и психологические параметры образовательного пространства оказывают существенное влияние на мотивацию процесса познания и его результаты. Специфика школьной среды, ее атмосфера и антураж во многом определяют смысл и характер обучения, вектор и активность развития и саморазвития его субъектов, детерминируют их поведение. Данное обстоятельство обусловливает необходимость создания надежного инструментария для изучения среды образовательных организаций и ее воздействия на качество деятельности и успешность коммуникаций школьников и педагогов. Цели статьи состоят в раскрытии возможностей комплексной диагностики предметной школьной среды в целом и ее частных зон; в выявлении и сравнении оценок школьного пространства, которые даются разными участниками образовательных отношений. Методы и методики. Основным методом изложенного в публикации исследования является «Семантический дифференциал» Ч. Осгуда, модифицированный с учетом особенностей общей ступени образования. Данные опросов учащихся и педагогов обрабатывались посредством методов среднегруппового анализа, межгрупповых связей, кластерного и регрессионного анализа с привлечением методики шагового отбора переменных. Для проверки надежности и валидности метода семантического дифференциала и полученных результатов применялись Т-критерий Стьюдента, коэффициент альфа Кронбаха и коэффициент корреляции Пирсона. Результаты исследования и научная новизна. В ходе пилотного этапа исследования выяснена степень пригодности классического варианта метода Ч. Осгуда для решения поставленных задач. Выделены дихотомические пары характеристик школьной предметно-пространственной среды, из которых сконструирована авторская версия семантического дифференциала. Обоснована иерархическая система параметров предметного пространства школы, где параметром, интегрирующим все его характеристики, выступает «комфортность», которая, однако, неодинаково расценивается обучающимися и педагогами (общая численность выборки респондентов составила N = 661). Установлена и описана значимость различий (от p < 0,05 до p < 0,000) в их понимании реального и идеального предметного образовательного пространства. Предложены регрессионные формулы для каждой группы субъектов образовательного процесса, следуя которым можно определить оптимальные значения комфортного обучения и профессионально-педагогической деятельности и скорректировать предметное пространство конкретной школы. Практическая значимость. Разработанный и апробированный диагностический инструмент, позволяющий привлекать внешних и внутренних экспертов и получать количественные данные, расширяющие поле применения математической статистики, может стать основой организации лонгитюдных и сопоставительных исследований предметного пространства школы. Регулярное проведение подобного мониторинга может рассматриваться как предиктор психологического благополучия образовательного учреждения, так как своевременный и точный прогноз обеспечивает принятие оперативных и действенных мер по улучшению среды образовательной организации с целью усиления эффективности ее функционирования и повышения результатов образовательной деятельности

The effect on nitrogen oxide emission from agricultural soils

The study investigates the effect of biochar on nitrous oxide emission in Endoargic Anthrosols in the southern territory of the Russian Far East. Biochar (bio-charcoal) was applied in the amounts of 1 kg/m2 and 3 kg/m2 in combination with organic and mineral fertilizers to drained and drain-free fields during the vegetation season, and the five-gas analyzer G2508 (Picarro) was used. Cumulative flows of N2O were estimated. The analysis revealed that biochar reduces the emissions and the cumulative flow of nitrous oxide. The higher the dose of biochar, the lower the emission and cumulative flows of nitrous oxide, regardless of a drainage system. Biochar (1 kg/m2) reduced the cumulative N2O flow from the soil by 52.2% throughout the experiment conducted, while a dose of 3 kg/m2 allowed for 97.8% reduction. The study found that organic and mineral fertilizers can be effectively used in combination with biochar, as N2O emission from the soil with mineral fertilizers is significantly higher than from the soil with organic fertilizers. Biochar (1 kg/m2) combined with organic fertilizers reduces N2O emission by 53.7%, while a dose of 3 kg/m2 can reduce emissions by 88.9%. Biochar (1 kg/m2) combined with mineral fertilizers reduced the flow of N2O by 17.5%, while a 3 kg/m2 dose of biochar used with mineral fertilizers reduced the emission by 85.3%

ОПРЕДЕЛЕНИЕ АСКОРБИНОВОЙ КИСЛОТЫ В КРОВИ МЕТОДОМ ВЭЖХ

Sample preparation and HPLC conditions for the quantitative determination of ascorbic acid in objects with a complex matrix (blood) were studied. Influences of ascorbic acid degradation in the presence of different stabilizers and a sample matrix on the determination accuracy and sample stability were investigated. It was shown the possibility of ascorbic acid determination in blood samples, provided the mandatory acid denaturation in presence of the complexing and reducing agents. Data on stability of ascorbic acid in aqueous solutions and blood samples are provided.Key words: Ascorbic acid, HPLC, blood samples(Russian)DOI: http://dx.doi.org/10.15826/analitika.2013.17.3.008V.V. Khasanov, K.A. Dychko, T.T. Kuriaeva, E.V. Nesterova Tomsk State University,Tomsk, Russian FederationИзучены условия подготовки проб и ВЭЖХ разделения при количественном определении аскорбиновой кислоты в объекте со сложной матрицей (кровь). Исследованы процессы деградации аскорбиновой кислоты, влияние стабилизаторов и матрицы пробы на точность определений. Показана возможность определения аскорбиновой кислоты в крови при условии кислотной денатурации с обязательной стабилизацией комплексообразователем и восстановителем. Приведены данные по стабильности аскорбиновой кислоты в водных растворах и образцах из крови.Ключевые слова: аскорбиновая кислота, ВЭЖХ, определение в кровиDOI: http://dx.doi.org/10.15826/analitika.2013.17.3.008 Литература1. Филимонов В.Н., Сирицо С.И. Параметры гидрофобности для прогнозирования удерживания водорастворимых витаминов неполярным сорбентом в условиях обращенно-фазовой ВЭЖХ // Изв. вузов. Серия: Химия и химическая технология. 2009. Т. 52. № 6. С. 33-35.2. Measurement of vitamin C in blood components by high-performance liquid chromatography. Implication in assessing vitamin C status / S. Omaye et [al.] // Annals of the New York Academy of Sciences. 1987. V. 498. P. 389-401.3. Rapid and Reliable HPLC Method for the Determination of Vitamin C in Pharmaceutical Samples / S. Mitić et [al.] // Tropical Journal of Pharmaceutical Research. 2011. V. 10. P. 105-111. 4. Fontannaz P., Kilinç T., Heudi O. HPLC-UV determination of total vitamin C in a wide range of fortified food products // Food Chemistry. 2006. V. 94, № 4. P. 626–631.5. Improved HPLC Assay for Measuring Serum Vitamin C with 1-Methyluric Acid Used as an Electrochemically Active Internal Standard / L. McCoy et [al.] // Clinical Chemistry. 2005. V. 51. P. 1062-1064. 6. Руденко А.О., Карцова Л.А. Определение водорастворимых витаминов группы В и витамина С в комбикормах, премиксах и биологически-активных добавках методом обращенно-фазовой ВЭЖХ // Ж. аналит. химии. 2010. Т. 65, № 1. С. 73-78.7. Determination of Vitamin C (Ascorbic Acid) Using High Performance Liquid Chromatography Coupled with Electrochemical Detection / Z. Gazdik et [al.] // Sensors. 2008. № 8. P. 7097-7112.8. Determination of Vitamin C in Small Volumes of Blood by HPLC/EC / D. Watson et [al.] // Iranian Journal of Pharmaceutical Sciences. 2004. V. 1. P. 7-10. 9. Determination of plasma vitamin C concentration in fattening cattle / L. Haiying et [al.] // Animal Science J. 2003. V. 74, № 1. P. 7-10. 10. ВЭЖХ-анализ водорастворимых витаминов в составе поливитаминного сиропа «Олиговит» / В.М. Староверов и [др.] // Химико-фармацевтический журнал. 2004. Т. 38, № 3. С. 54-56.11. Определение водорастворимых витаминов в пищевых продуктах методом ВЭЖХ с масс-селективным детектированием / А.А. Бендрышев и [др.] // Заводская лаборатория. Диагностика материалов. 2010. Т. 76, № 8. С. 15-20.12. Филимонов В.Н., Сирицо С.И., Макрушин Н.А Особенности хроматографического разделения водорастворимых витаминов в изократической ОФ ВЭЖХ // Сорбционные и хроматографические процессы. 2006. Т. 6, № 2. С. 191-197. 13. Миронова И.И., Романова Л.А., Долгов В.В. Общеклинические исследования: моча, кал, ликвор, эякулят. Тверь: ООО "Издательство "Триада", 2005. 216 с.