55. How often should we obtain complete blood counts (CBC's) from patients receiving radical radiation therapy?

Data on factors influencing decline in peripheral blood counts during radiation treatment are sparse and no guidelines exist on the appropriate frequency of obtaining CBC's from the patients.Patients and methodsA series of charts from 460 consecutive patients receiving radiotherapy in 1995 and 1996 was reviewed. In the final database, the data from patients receiving definitive radiotherapy with information on baseline CBC's and at least two results during treatment were included (183 patients, 810 results). Critical nadir values of haemoglobin (HGB), white blood cells (WBC) and platelets (PLT) requiring further tests and interventions were defined as follows: HG

UVSat: a concept of an ultraviolet/optical photometric satellite

Time-series photometry from space in the ultraviolet can be presently done with only a few platforms, none of which is able to provide wide-field long-term high-cadence photometry. We present a concept of UVSat, a twin space telescope which will be capable to perform this kind of photometry, filling an observational niche. The satellite will host two telescopes, one for observations in the ultraviolet, the other for observations in the optical band. We also briefly show what science can be done with UVSat.Comment: 6 pages, 2 figures, accepted for publication in the Proceedings of the PAS (Proc. of the 2nd BRITE Science conference, Innsbruck

A Herschel Study of D/H in Water in the Jupiter-Family Comet 45P/Honda-Mrkos-Pajdušáková and Prospects for D/H Measurements with CCAT

We present Herschel observations of water isotopologues in the atmosphere of the Jupiter-family comet 45P/Honda–Mrkos–Pajdušáková. No HDO emission is detected, with a 3σ upper limit of 2.0 × 10^(−4) for the D/H ratio. This value is consistent with the earlier Herschel measurement in the Jupiter-family comet 103P/Hartley 2. The canonical value of 3 × 10^(−4) measured pre-Herschel in a sample of Oort-cloud comets can be excluded at a 4.5σ level. The observations presented here further confirm that a diversity of D/H ratios exists in the comet population and emphasize the need for additional measurements with future ground-based facilities, such as CCAT, in the post-Herschel era

Water, hydrogen cyanide, carbon monoxide, and dust production from distant comet 29P/Schwassmann-Wachmann 1

peer reviewedContext. 29P/Schwassmann-Wachmann 1 is a distant Centaur/comet, showing persistent CO-driven activity and frequent outbursts. Aims: We aim to better characterize its gas and dust activity from multiwavelength observations performed during outbursting and quiescent states. Methods: We used the HIFI, PACS and SPIRE instruments of the Herschel space observatory on several dates in 2010, 2011, and 2013 to observe the H2O 557 GHz and NH3 573 GHz lines and to image the dust coma in the far-infrared. Observations with the IRAM 30 m telescope were undertaken in 2007, 2010, 2011, and 2021 to monitor the CO production rate through the 230 GHz line, and to search for HCN at 89 GHz. The 70 and 160 µm PACS images were used to measure the thermal flux from the nucleus and the dust coma. Modeling was performed to constrain the size of the sublimating icy grains and to derive the dust production rate. Results: HCN is detected for the first time in comet 29P (at 5σ in the line area). H2O is detected as well, but not NH3. H2O and HCN line shapes differ strongly from the CO line shape, indicating that these two species are released from icy grains. CO production rates are in the range (2.9-5.6) × 10E28 s−1 (1400-2600 kg s−1). A correlation between the CO production rate and coma brightness is observed, as is a correlation between CO and H2O production. The correlation obtained between the excess of CO production and excess of dust brightness with respect to the quiescent state is similar to that established for the continuous activity of comet Hale-Bopp. The measured Q(H2O)/Q(CO) and Q(HCN)/Q(CO) production rate ratios are 10.0 ± 1.5 % and 0.12 ± 0.03 %, respectively, averaging the April-May 2010 measurements (Q(H2O) = (4.1 ± 0.6) × 10E27 s−1, Q(HCN) = (4.8 ± 1.1) × 10E25 s−1). We derive three independent and similar values of the effective radius of the nucleus, ~31 ± 3 km, suggesting an approximately spherical shape. The inferred dust mass-loss rates during quiescent phases are in the range 30-120 kg s−1, indicating a dust-to-gas mass ratio <0.1 during quiescent activity. We conclude that strong local heterogeneities exist on the surface of 29P, with quenched dust activity from most of the surface, but not in outbursting regions. Conclusions: The volatile composition of the atmosphere of 29P strongly differs from that of comets observed within 3 au from the Sun. The observed correlation between CO, H2O and dust activity may provide important constraints for the outburst-triggering mechanism

An upper limit for the water outgassing rate of the main-belt comet 176P/LINEAR observed with Herschel/HIFI

176P/LINEAR is a member of the new cometary class known as main-belt comets (MBCs). It displayed cometary activity shortly during its 2005 perihelion passage that may be driven by the sublimation of sub-surface ices. We have therefore searched for emission of the H2O 110-101 ground state rotational line at 557 GHz toward 176P/LINEAR with the Heterodyne Instrument for the Far Infrared (HIFI) on board the Herschel Space Observatory on UT 8.78 August 2011, about 40 days after its most recent perihelion passage, when the object was at a heliocentric distance of 2.58 AU. No H2O line emission was detected in our observations, from which we derive sensitive 3-sigma upper limits for the water production rate and column density of < 4e25 molec/s and of < 3e10 cm^{-2}, respectively. From the peak brightness measured during the object's active period in 2005, this upper limit is lower than predicted by the relation between production rates and visual magnitudes observed for a sample of comets by Jorda et al. (2008) at this heliocentric distance. Thus, 176P/LINEAR was likely less active at the time of our observation than during its previous perihelion passage. The retrieved upper limit is lower than most values derived for the H2O production rate from the spectroscopic search for CN emission in MBCs.Comment: 5 pages, 2 figures. Minor changes to match published versio

First results on Martian carbon monoxide from Herschel/HIFI observations

We report on the initial analysis of Herschel/HIFI carbon monoxide (CO) observations of the Martian atmosphere performed between 11 and 16 April 2010. We selected the (7-6) rotational transitions of the isotopes ^{13}CO at 771 GHz and C^{18}O at 768 GHz in order to retrieve the mean vertical profile of temperature and the mean volume mixing ratio of carbon monoxide. The derived temperature profile agrees within less than 5 K with general circulation model (GCM) predictions up to an altitude of 45 km, however, show about 12-15 K lower values at 60 km. The CO mixing ratio was determined as 980 \pm 150 ppm, in agreement with the 900 ppm derived from Herschel/SPIRE observations in November 2009.Comment: Accepted for publication in Astronomy and Astrophysics (special issue on HIFI first results); minor changes to match published versio