Observation of Magnetic Edge State and Dangling Bond State on Nanographene in Activated Carbon Fibers

The electronic structure of nanographene in pristine and fluorinated activated carbon fibers (ACFs) have been investigated with near-edge x-ray absorption fine structure (NEXAFS) and compared with magnetic properties we reported on previously. In pristine ACFs in which magnetic properties are governed by non-bonding edge states of the \pi-electron, a pre-peak assigned to the edge state was observed below the conduction electron {\pi}* peak close to the Fermi level in NEXAFS. Via the fluorination of the ACFs, an extra peak, which was assigned to the \sigma-dangling bond state, was observed between the pre-peak of the edge state and the {\pi}* peak in the NEXAFS profile. The intensities of the extra peak correlate closely with the spin concentration created upon fluorination. The combination of the NEXAFS and magnetic measurement results confirms the coexistence of the magnetic edge states of \pi-electrons and dangling bond states of \sigma-electrons on fluorinated nanographene sheets.Comment: 4 figures, to appear in Phys. Rev.

Logical Step-Indexed Logical Relations

Appel and McAllester's "step-indexed" logical relations have proven to be a simple and effective technique for reasoning about programs in languages with semantically interesting types, such as general recursive types and general reference types. However, proofs using step-indexed models typically involve tedious, error-prone, and proof-obscuring step-index arithmetic, so it is important to develop clean, high-level, equational proof principles that avoid mention of step indices. In this paper, we show how to reason about binary step-indexed logical relations in an abstract and elegant way. Specifically, we define a logic LSLR, which is inspired by Plotkin and Abadi's logic for parametricity, but also supports recursively defined relations by means of the modal "later" operator from Appel, Melli\`es, Richards, and Vouillon's "very modal model" paper. We encode in LSLR a logical relation for reasoning relationally about programs in call-by-value System F extended with general recursive types. Using this logical relation, we derive a set of useful rules with which we can prove contextual equivalence and approximation results without counting steps

A Complete Normal-Form Bisimilarity for State

International audienceWe present a sound and complete bisimilarity for an untyped $λ-calculus$ with higher-order local references. Our relation compares values by applying them to a fresh variable, like normal-form bisimilarity, and it uses environments to account for the evolving store. We achieve completeness by a careful treatment of evaluation contexts comprising open stuck terms. This work improves over Støvring and Lassen's incomplete environment-based normal-form bisimilarity for the $λρ-calculus$, and confirms, in relatively elementary terms, Jaber and Tabareau's result , that the state construct is discriminative enough to be characterized with a bisimilarity without any quantification over testing arguments

Towards a Type System for Security APIs

Abstract. Security API analysis typically only considers a subset of an API’s functions, with results bounded by the number of function calls. Furthermore, attacks involving partial leakage of sensitive information are usually not covered. Type-based static analysis has the potential to alleviate these shortcomings. To that end, we present a type system for secure information flow based upon the one of Volpano, Smith and Irvine [1], extended with types for cryptographic keys and ciphertext similar to those in Sumii and Pierce [2]. In contrast to some other type systems, the encryption and decryption of keys does not require special treatment. We show that a well-typed sequence of commands is non-interferent, based upon a definition of indistinguishability where, in certain circumstances, the adversary can distinguish between ciphertexts that correspond to encrypted public data.

A Compiled Implementation of Strong Reduction

International audienceMotivated by applications to proof assistants based on dependent types, we develop and prove correct a strong reducer and β-equivalence checker for the λ-calculus with products, sums, and guarded fixpoints. Our approach is based on compilation to the bytecode of an abstract machine performing weak reductions on non-closed terms, derived with minimal modifications from the ZAM machine used in the Objective Caml bytecode interpreter, and complemented by a recursive "read back" procedure. An implementation in the Coq proof assistant demonstrates important speed-ups compared with the original interpreter-based implementation of strong reduction in Coq

Phosphodiesterase-III Inhibitor Prevents Hemorrhagic Transformation Induced by Focal Cerebral Ischemia in Mice Treated with tPA

The purpose of the present study was to investigate whether cilostazol, a phosphodiesterase-III inhibitor and antiplatelet drug, would prevent tPA-associated hemorrhagic transformation. Mice subjected to 6-h middle cerebral artery occlusion were treated with delayed tPA alone at 6 h, with combined tPA plus cilostazol at 6 h, or with vehicle at 6 h. We used multiple imaging (electron microscopy, spectroscopy), histological and neurobehavioral measures to assess the effects of the treatment at 18 h and 7 days after the reperfusion. To further investigate the mechanism of cilostazol to beneficial effect, we also performed an in vitro study with tPA and a phosphodiesterase-III inhibitor in human brain microvascular endothelial cells, pericytes, and astrocytes. Combination therapy with tPA plus cilostazol prevented development of hemorrhagic transformation, reduced brain edema, prevented endothelial injury via reduction MMP-9 activity, and prevented the blood-brain barrier opening by inhibiting decreased claudin-5 expression. These changes significantly reduced the morbidity and mortality at 18 h and 7 days after the reperfusion. Also, the administration of both drugs prevented injury to brain human endothelial cells and human brain pericytes. The present study indicates that a phosphodiesterase-III inhibitor prevents the hemorrhagic transformation induced by focal cerebral ischemia in mice treated with tPA

Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice

The growth and spread of tumour cells depends on adequate vasculature. We have previously reported that the expression of interleukin-8 (IL-8) directly correlates with the vascularity of human gastric carcinomas. To provide evidence for a causal role of IL-8 in angiogenesis and tumorigenicity of human gastric cancer, we used the lipofectin method to stably transfect the human TMK-1 gastric carcinoma cells (low endogenous IL-8) with an IL-8 expression vector or control vector. Transfection with IL-8 did not affect the proliferation of cultured cells, yet the culture supernatants of the transfected (but not control) cells stimulated proliferation of human umbilical vein endothelial cells. The IL-8-transfected and control cells were injected into the gastric wall of nude mice. IL-8-transfected cells produced rapidly growing, highly vascular neoplasms as compared to control cells. These results provide direct evidence for the role of IL-8 in the angiogenesis and tumorigenicity of human gastric carcinomas. © 1999 Cancer Research Campaig