Investigation on the removal of the cavitation erosion risk in a control orifice inside a prototype diesel injector

A CFD investigation is in progress to study the cavitation characteristics and potential erosion risks of a control orifice in a prototype injector. An early design of the orifice resulted in cavitation erosion after endurance testing. A design modification eliminated the erosion and subsequent prototypes were free from damage. Initial results for the two designs using different simulation methods are discussed, along with the effects of different rates of evaporating and condensing mass transfer. Preliminary findings on possible erosion risk indicators comparing the eroding with the non-eroding design are presented

Canonical General Relativity on a Null Surface with Coordinate and Gauge Fixing

We use the canonical formalism developed together with David Robinson to st= udy the Einstein equations on a null surface. Coordinate and gauge conditions = are introduced to fix the triad and the coordinates on the null surface. Toget= her with the previously found constraints, these form a sufficient number of second class constraints so that the phase space is reduced to one pair of canonically conjugate variables: \Ac_2\and\Sc^2. The formalism is related to both the Bondi-Sachs and the Newman-Penrose methods of studying the gravitational field at null infinity. Asymptotic solutions in the vicinity of null infinity which exclude logarithmic behavior require the connection to fall off like $1/r^3$ after the Minkowski limit. This, of course, gives the previous results of Bondi-Sachs and Newman-Penrose. Introducing terms which fall off more slowly leads to logarithmic behavior which leaves null infinity intact, allows for meaningful gravitational radiation, but the peeling theorem does not extend to $\Psi_1$ in the terminology of Newman-Penrose. The conclusions are in agreement with those of Chrusciel, MacCallum, and Singleton. This work was begun as a preliminary study of a reduced phase space for quantization of general relativity.Comment: magnification set; pagination improved; 20 pages, plain te

Investigation of cavitation and air entrainment during pilot injection in real-size multi-hole diesel nozzles

This paper investigates the complex multiphase flow developing inside the micro-orifices of diesel injector nozzles during pilot injection. High speed micro-visualisations of a transparent serial production nozzle tip replica are used to record the multiphase flow inside the flow orifices as well as nearnozzle spray development. The physical processes taking place are explained with the aid of a three-phase (liquid, vapour and air) homogeneous mixture model utilized in the context of Large Eddy Simulations. Phase-change due to cavitation is considered with a model based on the Rayleigh-Plesset equation, while compressibility of all the phases is accounted for. Numerical simulations shed light on the interaction between the vortex flow and cavitation formation that take place simultaneously with air entrainment from the surrounding environment into the injector’s sac volume during the injection and the dwell time between successive injections. The experimentally observed flow phenomena are well captured by the simulation model. In particular the compression of pre-existing air bubbles inside the injector’s sac volume during the injector opening, cavitation vapor condensation and air suction after the needle closure are well reproduced

Verbs, times and objects

The aim of the paper is to demonstrate the fruitfulness of the influential verb typology developed by Zeno Vendler for recent debates in the philosophy of perception. Section one explains the verb typology and explains how Vendler applies it to different perceptual notions. Section two identifies various questions that arise from observations in Vendler’s paper that suggest that there is a match between the temporal properties of perceptual verb objects and the complex verb phrases of which they are a part. Subsequent discussion focuses on just one of these questions. Section three identifies and rejects a simple proposal about how to answer this question. Section four develops a ‘limited matching’ account. In the visual perception of events and processes there seems to be a match between the temporal duration, order and location of the events and processes which are the objects of perception and the subject’s perceiving them. But this matching is absent in cases of the perception of primary substances; objects which manifestly endure over time. Section five identifies and responds to some criticisms of this matching account. The conclusion notes some consequences of the discussion for contemporary debates about the temporal characteristics of perception

ARTS mediates apoptosis and regeneration of the intestinal stem cell niche

Stem cells (SCs) play a pivotal role in fueling homeostasis and regeneration. While much focus has been given to self-renewal and differentiation pathways regulating SC fate, little is known regarding the specific mechanisms utilized for their elimination. Here, we report that the pro-apoptotic protein ARTS (a Septin4 isoform) is highly expressed in cells comprising the intestinal SC niche and that its deletion protects Lgr5(+) and Paneth cells from undergoing apoptotic cell death. As a result, the Sept4/ARTS(-/-) crypt displays augmented proliferation and, in culture, generates massive cystic-like organoids due to enhanced Wnt/β-catenin signaling. Importantly, Sept4/ARTS(-/-) mice exhibit resistance against intestinal damage in a manner dependent upon Lgr5(+) SCs. Finally, we show that ARTS interacts with XIAP in intestinal crypt cells and that deletion of XIAP can abrogate Sept4/ARTS(-/-)-dependent phenotypes. Our results indicate that intestinal SCs utilize specific apoptotic proteins for their elimination, representing a unique target for regenerative medicine

Group art therapy as an adjunctive treatment for people with schizophrenia: a randomised controlled trial (MATISSE).

OBJECTIVE: To examine the clinical effectiveness and cost-effectiveness of referral to group art therapy plus standard care, compared with referral to an activity group plus standard care and standard care alone, among people with schizophrenia. DESIGN: A three-arm, parallel group, single-blind, pragmatic, randomised controlled trial. Participants were randomised via an independent and remote telephone randomisation service using permuted blocks, stratified by study centre. SETTING: Study participants were recruited from secondary care mental health and social services in four UK centres. PARTICIPANTS: Potential participants were aged 18 years or over, had a clinical diagnosis of schizophrenia, confirmed by an examination of case notes, and provided written informed consent. We excluded those who were unable to speak sufficient English to complete the baseline assessment, those with severe cognitive impairment and those already receiving arts therapy. INTERVENTIONS: Group art therapy was delivered by registered art therapists according to nationally agreed standards. Groups had up to eight members, lasted for 90 minutes and ran for 12 months. Members were given access to a range of art materials and encouraged to use these to express themselves freely. Activity groups were designed to control for the non-specific effects of group art therapy. Group facilitators offered various activities and encouraged participants to collectively select those they wanted to pursue. Standard care involved follow-up from secondary care mental health services and the option of referral to other services, except arts therapies, as required. MAIN OUTCOME MEASURES: Our co-primary outcomes were global functioning (measured using the Global Assessment of Functioning Scale - GAF) and mental health symptoms (measured using the Positive and Negative Syndrome Scale - PANSS) at 24 months. The main secondary outcomes were level of group attendance, social functioning, well-being, health-related quality of life, service utilisation and other costs measured 12 and 24 months after randomisation. RESULTS: Four hundred and seventeen people were recruited, of whom 355 (85%) were followed up at 2 years. Eighty-six (61%) of those randomised to art therapy and 73 (52%) of those randomised to activity groups attended at least one group. No differences in primary outcomes were found between the three study arms. The adjusted mean difference between art therapy and standard care at 24 months was -0.9 [95% confidence interval (CI) -3.8 to 2.1] on the GAF Scale and 0.7 (95% CI -3.1 to 4.6) on the PANSS Scale. Differences in secondary outcomes were not found, except that those referred to an activity group had fewer positive symptoms of schizophrenia at 24 months than those randomised to art therapy. Secondary analysis indicated that attendance at art therapy groups was not associated with improvements in global functioning or mental health. Although the total cost of the art therapy group was lower than the cost of the two comparison groups, referral to group art therapy did not appear to provide a cost-effective use of resources. CONCLUSIONS: Referring people with established schizophrenia to group art therapy as delivered in this randomised trial does not appear to improve global functioning or mental health of patients or provide a more cost-effective use of resources than standard care alone. TRIAL REGISTRATION: Current Controlled Trials ISRCTN 46150447. FUNDING: This project was funded by the NIHR Health Technology Assessment programme and will be published in full in Health Technology Assessment; Vol. 16, No. 8. See the HTA programme website for further project information

Liver x receptor alpha drives chemoresistance in response to side-chain hydroxycholesterols in triple negative breast cancer

Triple negative breast cancer (TNBC) is challenging to treat successfully because targeted therapies do not exist. Instead, systemic therapy is typically restricted to cytotoxic chemotherapy, which fails more often in patients with elevated circulating cholesterol. Liver x receptors are ligand-dependent transcription factors that are homeostatic regulators of cholesterol, and are linked to regulation of broad-affinity xenobiotic transporter activity in non-tumor tissues. We show that LXR ligands confer chemotherapy resistance in TNBC cell lines and xenografts, and that LXRalpha is necessary and sufficient to mediate this resistance. Furthermore, in TNBC patients who had cancer recurrences, LXRalpha and ligands were independent markers of poor prognosis and correlated with P-glycoprotein expression. However, in patients who survived their disease, LXRalpha signaling and P-glycoprotein were decoupled. These data reveal a novel chemotherapy resistance mechanism in this poor prognosis subtype of breast cancer. We conclude that systemic chemotherapy failure in some TNBC patients is caused by co-opting the LXRalpha:P-glycoprotein axis, a pathway highly targetable by therapies that are already used for prevention and treatment of other diseases

Data envelopment analysis in financial services: a citations network analysis of banks, insurance companies and money market funds

Development and application of the data envelopment analysis (DEA) method, have been the subject of numerous reviews. In this paper, we consider the papers that apply DEA methods specifically to financial services, or which use financial services data to experiment with a newly introduced DEA model. We examine 620 papers published in journals indexed in the Web of Science database, from 1985 to April 2016. We analyse the sample applying citations network analysis. This paper investigates the DEA method and its applications in financial services. We analyse the diffusion of DEA in three sub-samples: (1) banking groups, (2) money market funds, and (3) insurance groups by identifying the main paths, that is, the main flows of the ideas underlying each area of research. This allows us to highlight the main approaches, models and efficiency types used in each research areas. No unique methodological preference emerges within these areas. Innovations in the DEA methodologies (network models, slacks based models, directional distance models and Nash bargaining game) clearly dominate recent research. For each subsample, we describe the geographical distribution of these studies, and provide some basic statistics related to the most active journals and scholars