Electrical resistivity of nickel, iron and iron-silicon alloy melts at high pressure with implications for the thermal conductivity of the Earth’s core

The Earth’s liquid outer core (OC) is composed of Fe alloyed with up to 10% Ni and a small fraction of light elements. However, the effect of light elements such as Si on the transport properties of liquid Fe-alloy in Earth’s OC is not clear. Thermal conductivity (κ) and related electrical resistivity (ρ) are the least constrained parameters in OC. Therefore, the characterization of transport properties of Ni, Fe and Fe-Si at high pressure has important geophysical implications for the Earth’s core. The ρ of solid and liquid Ni, Fe and Fe 4%Si was measured at pressure and temperature up to 12 GPa and 2100 K, respectively. All experiments were conducted in a large volume multi-anvil press and the measurements were carried out using the new adaptation of the 4-wire method. A standard COnsortium on Materials Properties Research in Earth Sciences (COMPRES) octahedron cell was used as the pressure medium, while the internal components were redesigned to permit the preservation of the liquid sample geometry, to contain the melt and minimize the effect of diffusive contamination. In the solid state, the ρ of solid Fe and Ni exhibits the familiar pressure-dependent decrease after the Curie temperature (Tc). The anomalous ρ of Fe-4.5wt%Si above Tc is strongly modulated by temperature and pressure, and it is attributed to the phase transitions and structural ordering in the alloy. The ρ of liquid Ni remains constant at the onset of melting at all pressures. While ρ of liquid Fe decreases up to 5 GPa, it remains invariant along the melting boundary after the δ-γ-liquid triple point. The ρ of liquid Fe-4.5wt%Si remains constant along the melting boundary and matches 120 μΩcm for pure liquid Fe within the experimental uncertainties. The results are interpreted in the context of pressure dependent icosahedral short range ordering (ISRO) in liquid 3d metals and alloys. Based on this, it is postulated that ρ of Fe-alloys along the melting boundary remains invariant up to Earth’s inner core boundary. The κ at the core-mantle boundary and inner core boundary were calculated using the Weidemann-Franz law

Study protocol: Delayed intervention randomised controlled trial within the Medical Research Council (MRC) Framework to assess the effectiveness of a new palliative care service

Background: Palliative care has been proposed to help meet the needs of patients who suffer progressive non-cancer conditions but there have been few evaluations of service development initiatives. We report here a novel protocol for the evaluation of a new palliative care service in this context. Methods/Design: Using the MRC Framework for the Evaluation of Complex Interventions we modelled a new palliative care and neurology service for patients severely affected by Multiple Sclerosis (MS). We conducted qualitative interviews with patients, families and staff, plus a literature review to model and pilot the service. Then we designed a delayed intervention randomised controlled trial to test its effectiveness as part of phase II of the MRC framework. Inclusion criteria for the trial were patients identified by referring clinicians as having unresolved symptoms or psychological concerns. Referrers were advised to use a score of greater than 8 on the Expanded Disability Scale was a benchmark. Consenting patients newly referred to the new service were randomised to either receive the palliative care service immediately (fast-track) or after a 12-week wait (standard best practice). Face to face interviews were conducted at baseline (before intervention), and at 4–6, 10–12 (before intervention for the standard-practice group), 16– 18 and 22–24 weeks with patients and their carers using standard questionnaires to assess symptoms, palliative care outcomes, function, service use and open comments. Ethics committee approval was granted separately for the qualitative phase and then for the trial. Discussion: We publish the protocol trial here, to allow methods to be reviewed in advance of publication of the results. The MRC Framework for the Evaluation of Complex Interventions was helpful in both the design of the service, methods for evaluation in convincing staff and the ethics committee to accept the trial. The research will provide valuable information on the effects of palliative care among non-cancer patients and a method to evaluate palliative care in this context

Emigration of doctors, military and alternative service service Some proposals based on a survey of medical students

In the face of a critical shortage of skilled medical personnel, especially in the rural areas of South Africa, and high rates of emigration of doctors, a survey was conducted in 1989 of white male medical stl!dents at the University of the Witwatersrand to assess their intentions to emigrate, their reasons for emigrating and their attitudes to alternative civilian service. Ninety-five per cent of respondents still had military service obligations; 39% said they were considering emigrating. Military service was ranked as the first or second most important reason by 59% of those intending to emigrate and 47% said they would remain in South Africa if alternative service were available. The majority of those willing to do alternative service were also willing to do this in rural areas. The introduction of the option of alternative service would reduce emigration, increase the provision of medical care in rural areas, and acknowledge the right of individuals to serve the country in a non-militar: capacity

Simultaneous IUE, EXOSAT and optical observations of the unusual AM Her type variable H058+608

Simultaneous observations of the AM Her type variable H0538+608 made with IUE, EXOSAT, and a 1.3 m ground based telescope, and subsequent optical spectrophotometry at high and low resolution are discussed. The X-ray and optical data show clear evidence of a 3.30 + or - 0.03 hr period. Three SWP spectra were taken outside of eclipse and during overlapping phase intervals. The UV spectra contain strong emission lines characteristic of this class of objects and a flat continuum which appears to be deficient, given the brightness of source at optical and X-ray wavelengths. There is evidence for intensity variations in emission lines, particularly C IV. The X-ray light curves for H0538+608 reveal behavior which may be related to irregularities in its accretion flow

Stabilizing unstable periodic orbits in the Lorenz equations using time-delayed feedback control

For many years it was believed that an unstable periodic orbit with an odd number of real Floquet multipliers greater than unity cannot be stabilized by the time-delayed feedback control mechanism of Pyragus. A recent paper by Fiedler et al uses the normal form of a subcritical Hopf bifurcation to give a counterexample to this theorem. Using the Lorenz equations as an example, we demonstrate that the stabilization mechanism identified by Fiedler et al for the Hopf normal form can also apply to unstable periodic orbits created by subcritical Hopf bifurcations in higher-dimensional dynamical systems. Our analysis focuses on a particular codimension-two bifurcation that captures the stabilization mechanism in the Hopf normal form example, and we show that the same codimension-two bifurcation is present in the Lorenz equations with appropriately chosen Pyragus-type time-delayed feedback. This example suggests a possible strategy for choosing the feedback gain matrix in Pyragus control of unstable periodic orbits that arise from a subcritical Hopf bifurcation of a stable equilibrium. In particular, our choice of feedback gain matrix is informed by the Fiedler et al example, and it works over a broad range of parameters, despite the fact that a center-manifold reduction of the higher-dimensional problem does not lead to their model problem.Comment: 21 pages, 8 figures, to appear in PR

On shock waves and the role of hyperthermal chemistry in the early diffusion of overdense meteor trains

Studies of meteor trails have until now been limited to relatively simple models, with the trail often being treated as a conducting cylinder, and the head (if considered at all) treated as a ball of ionized gas. In this article, we bring the experience gleaned from other fields to the domain of meteor studies, and adapt this prior knowledge to give a much clearer view of the microscale physics and chemistry involved in meteor-trail formation, with particular emphasis on the first 100 or so milliseconds of the trail formation. We discuss and examine the combined physicochemical effects of meteor-generated and ablationally amplified cylindrical shock waves that appear in the ambient atmosphere immediately surrounding the meteor train, as well as the associated hyperthermal chemistry on the boundaries of the high temperature post-adiabatically expanding meteor train. We demonstrate that the cylindrical shock waves produced by overdense meteors are sufficiently strong to dissociate molecules in the ambient atmosphere when it is heated to temperatures in the vicinity of 6000 K, which substantially alters the considerations of the chemical processes in and around the meteor train. We demonstrate that some ambient O-2, along with O-2 that comes from the shock dissociation of O-3, survives the passage of the cylindrical shock wave, and these constituents react thermally with meteor metal ions, thereby subsequently removing electrons from the overdense meteor train boundary through fast, temperature-independent, dissociative recombination governed by the second Damkohler number. Possible implications for trail diffusion and lifetimes are discussed.Peer reviewe

Application of magnetically induced hyperthermia on the model protozoan Crithidia fasciculata as a potential therapy against parasitic infections

Magnetic hyperthermia is currently an EU-approved clinical therapy against tumor cells that uses magnetic nanoparticles under a time varying magnetic field (TVMF). The same basic principle seems promising against trypanosomatids causing Chagas disease and sleeping sickness, since therapeutic drugs available display severe side effects and drug-resistant strains. However, no applications of this strategy against protozoan-induced diseases have been reported so far. In the present study, Crithidia fasciculata, a widely used model for therapeutic strategies against pathogenic trypanosomatids, was targeted with Fe_{3}O_{4} magnetic nanoparticles (MNPs) in order to remotely provoke cell death using TVMFs. The MNPs with average sizes of d approx. 30 nm were synthesized using a precipitation of FeSO_{4}4 in basic medium. The MNPs were added to Crithidia fasciculata choanomastigotes in exponential phase and incubated overnight. The amount of uploaded MNPs per cell was determined by magnetic measurements. Cell viability using the MTT colorimetric assay and flow cytometry showed that the MNPs were incorporated by the cells with no noticeable cell-toxicity effects. When a TVMF (f = 249 kHz, H = 13 kA/m) was applied to MNP-bearing cells, massive cell death was induced via a non-apoptotic mechanism. No effects were observed by applying a TVMF on control (without loaded MNPs) cells. No macroscopic rise in temperature was observed in the extracellular medium during the experiments. Scanning Electron Microscopy showed morphological changes after TVMF experiments. These data indicate (as a proof of principle) that intracellular hyperthermia is a suitable technology to induce the specific death of protozoan parasites bearing MNPs. These findings expand the possibilities for new therapeutic strategies that combat parasitic infections.Comment: 9 pages, four supplementary video file

JAK2V617F promotes replication fork stalling with disease-restricted impairment of the intra-S checkpoint response

Cancers result from the accumulation of genetic lesions, but the cellular consequences of driver mutations remain unclear, especially during the earliest stages of malignancy. The V617F mutation in the JAK2 non-receptor tyrosine kinase (JAK2V617F) is present as an early somatic event in most patients with myeloproliferative neoplasms (MPNs), and the study of these chronic myeloid malignancies provides an experimentally tractable approach to understanding early tumorigenesis. Introduction of exogenous JAK2V617F impairs replication fork progression and is associated with activation of the intra-S checkpoint, with both effects mediated by phosphatidylinositide 3-kinase (PI3K) signaling. Analysis of clonally derived JAK2V617F-positive erythroblasts from MPN patients also demonstrated impaired replication fork progression accompanied by increased levels of replication protein A (RPA)-containing foci. However, the associated intra-S checkpoint response was impaired in erythroblasts from polycythemia vera (PV) patients, but not in those from essential thrombocythemia (ET) patients. Moreover, inhibition of p53 in PV erythroblasts resulted in more gamma-H2Ax (γ-H2Ax)–marked double-stranded breaks compared with in like-treated ET erythroblasts, suggesting the defective intra-S checkpoint function seen in PV increases DNA damage in the context of attenuated p53 signaling. These results demonstrate oncogene-induced impairment of replication fork progression in primary cells from MPN patients, reveal unexpected disease-restricted differences in activation of the intra-S checkpoint, and have potential implications for the clonal evolution of malignancies