A new access control unit for GANIL and SPIRAL 2

International audienceFor the GANIL safety revaluation and the new project of accelerator SPIRAL 2, it was decided to replace theexisting access control system for radiological controlled areas. These areas are all cyclotron rooms and experimental areas. The existing system is centralized around VME cards. Updating is becoming very problematic. The new UGA (access control unit) will becomposed of a pair of PLC to ensure the safety of each room. It will be supplemented by a system UGB (radiological control unit) that will assure the radiological monitoring of the area concerned

Unraveling the involvement of ABA in the water deficit-induced modulation of nitrogen metabolism in Medicago truncatula seedlings

Effects of water deficit and/or abscisic acid (ABA) were investigated on early seedling growth of Medicago truncatula, and on glutamate metabolism under dark conditions. Water deficit (simulated by polyethylene glycol, PEG), ABA and their combination resulted in a reduction in growth rate of the embryo axis, and also in a synergistic increase of free amino acid (AA) content. However, the inhibition of water uptake retention induced by water deficit seemed to occur in an ABA-independent manner. Expression of several genes involved in glutamate metabolism was induced during water deficit, whereas ABA, in combination or not with PEG, repressed them. The only exception came from a gene encoding 1-pyrroline-5-carboxylate synthetase (P5CS) which appeared to be induced in an ABA-dependent manner under water deficit. Our results demonstrate clearly the involvement of an ABA-dependent and an ABA-independent regulatory system, governing growth and glutamate metabolism under water deficit

High resolution spectroscopy of Pluto's atmosphere: detection of the 2.3 μ\mum CH4_4 bands and evidence for carbon monoxide

The goal is to determine the composition of Pluto's atmosphere and to constrain the nature of surface-atmosphere interactions. We perform high--resolution spectroscopic observations in the 2.33--2.36 $\mu$m range, using CRIRES at the VLT. We obtain (i) the first detection of gaseous methane in this spectral range, through lines of the $\nu_3$ + $\nu_4$ and $\nu_1$ + $\nu_4$ bands (ii) strong evidence (6-$\sigma$ confidence) for gaseous CO in Pluto. For an isothermal atmosphere at 90 K, the CH$_4$ and CO column densities are 0.75 and 0.07 cm-am, within factors of 2 and 3, respectively. Using a physically--based thermal structure model of Pluto's atmosphere also satisfying constraints from stellar occultations, we infer CH$_4$ and CO mixing ratios q$_{CH_4}$= 0.6$^{+0.6}_{-0.3}$% (consistent with results from the 1.66 $\mu$m range) and q$_{CO}$ = 0.5$^{+1}_{-0.25}$$\times10^{-3}$. The CO atmospheric abundance is consistent with its surface abundance. As for Triton, it is probably controlled by a thin, CO-rich, detailed balancing layer resulting from seasonal transport and/or atmospheric escape.Comment: Astronomy and Astrophysics Letters, in pres

Exponential Gain in Quantum Computing of Quantum Chaos and Localization

We present a quantum algorithm which simulates the quantum kicked rotator model exponentially faster than classical algorithms. This shows that important physical problems of quantum chaos, localization and Anderson transition can be modelled efficiently on a quantum computer. We also show that a similar algorithm simulates efficiently classical chaos in certain area-preserving maps.Comment: final published versio

Aspects of HF radio propagation

The propagation characteristics of radio signals are important parameters to consider when designing and operating radio systems. From the point of view Working Group 2 of the COST 296 Action, interest lies with effects associated with propagation via the ionosphere of signals within the HF band. Several aspects are covered in this paper: a) The directions of arrival and times of flight of signals received over a path oriented along the trough have been examined and several types of propagation effects identified. Of particular note, combining the HF observations with satellite measurements has identified the presence of irregularities within the floor of the trough that result in propagation displaced from the great circle direction. An understanding of the propagation effects that result in deviations of the signal path from the great circle direction are of particular relevance to the operation of HF radiolocation systems. b) Inclusion of the results from the above mentioned measurements into a propagation model of the northerly ionosphere (i.e. those regions of the ionosphere located poleward of, and including, the mid-latitude trough)and the use of this model to predict the coverage expected from transmitters where the signals impinge on the northerly ionosphere. c) Development of inversion techniques enabling backscatter ionograms obtained by an HF radar to be used to estimate the ionospheric electron density profile. This development facilitates the operation of over the horizon HF radars by enhancing the frequency management aspects of the systems. d) Various propagation prediction techniques have been tested against measurements made over the trough path mentioned above, and also over a long-range path between Cyprus and the UK. e) The effect of changes in the levels of ionospheric disturbances on the operational availability at various data throughput rates has been examined for the trough path mentioned earlier. The topics covered in this paper are necessarily brief, and the reader is referred to full papers referenced herein on individual aspects

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide.

We describe a novel self-assembling supramolecular nanotube system formed by a heterocyclic cationic molecule which was originally designed for its potential as an antiparasitic and DNA sequence recognition agent. Our structural characterisation work indicates that the nanotubes form via a hierarchical assembly mechanism that can be triggered and tuned by well-defined concentrations of simple alkali halide salts in water. The nanotubes assembled in NaCl have inner and outer diameters of ca. 22 nm and 26 nm respectively, with lengths that reach into several microns. Our results suggest the tubes consist of DB921 molecules stacked along the direction of the nanotube long axis. The tubes are stabilised by face-to-face π-π stacking and ionic interactions between the charged amidinium groups of the ligand and the negative halide ions. The assembly process of the nanotubes was followed using small-angle X-ray and neutron scattering, transmission electron microscopy and ultraviolet/visible spectroscopy. Our data demonstrate that assembly occurs through the formation of intermediate ribbon-like structures that in turn form helices that tighten and compact to form the final stable filament. This assembly process was tested using different alkali-metal salts, showing a strong preference for chloride or bromide anions and with little dependency on the type of cation. Our data further demonstrates the existence of a critical anion concentration above which the rate of self-assembly is greatly enhanced

A randomised, double-blind, controlled trial comparing two intra-articular hyaluronic acid preparations differing by their molecular weight in symptomatic knee osteoarthritis

Objectives: To compare the effects of an intermediate molecular weight (MW) intra-articular hyaluronic acid (HA) with a low MW product on knee osteoarthritis (OA) symptoms. Methods: Patients with symptomatic knee OA were enrolled inarandomised, controlled, double-blind, parallel-group, non-inferiority trial with the possibility to shift to superiority. Patients were randomised to GO-ON(MW 800–1500 kD, 25 mg/2.5 ml) or Hyalgan(MW 500–730 kD, 20 mg/2 ml) injected at 3-weekly intervals. The primary outcome was 6-month change in the WOMAC pain subscale (0–100 mm). Sample size was calculated on a non-inferiority margin of 9 mm, lower than the minimum perceptible clinical improvement. Secondary endpoints included OARSI-OMERACT responder rates Results: The intention-to-treat (ITT) and per-protocol (PP) populations consisted of 217 and 209 patients and 171 and 172 patients in the GO-ON and Hyalgan groups, respectively. ITT WOMAC pain of 47.5±1.0(SE) and 48.8±1.0 mm decreased by 22.9±1.4 mm with GO-ON and 18.4±1.5 mm with Hyalgan after 6 months. The primary analysis was conducted in the PP population followed by the ITT population.Mean (95% CI) differences in WOMAC pain change were 5.2 (0.9 to 9.6)mm and 4.5 (0.5 to 8.5)mm, respectively,favouring GO-ON, satisfying the claim for non-inferiority (lower limit>−9 mm) and for statistical superiority (95% CI all>0, p=0.021). Ahigher proportion of OARSI/OMERACT responders was observed with GO-ONthan with Hyalgan (73.3% vs58.4%, p=0.001). Both preparations were well tolerated. Conclusions: Treatment with 3-weekly injections of intermediate MW HA may be superior to low MW HA on knee OA symptoms over 6 months, with similar safety