Conocimiento y poder: Ciencia en la corte y utilidad política en la obra de Roger Bacon.

In his major works for the pope, as well as several other works from his maturity, Bacon focused on the utility of natural knowledge, both in terms of human know-how and what that know-how could produce. He looked to the courtly sciences (such as medicine, astral science, optics, and material science), which privilege application and knowledge gained through the sensorium, as sources of natural knowledge and as exemplars for the potential of natural knowledge. This essay argues that Roger Bacon’s work ought to be understood within the context of the court. Bacon’s emphasis on devices in the pursuit of knowledge and utility demonstrates the extent to which the courtly sciences (such as engineering, navigation, alchemy, and divination) were valued alongside traditional natural philosophical frameworks, and need to be understood in that context. Both the courtly sciences and Bacon’s theory of scientia experimentalis focus on materials, sensory knowledge, and knowledge of particulars in pursuit of applied ends. Bacon drew inspiration from the courtly sciences in theorizing how natural knowledge could serve ruling power. By examining Bacon’s major works on scientia experimentalis and analyzing his reliance on examples from the history of Alexander the Great, this essay demonstrates the interrelation of political power and erudite knowledge, and how they intersected through the cultivation and application of experimentum and technology. Finally, Bacon’s interest in the utility of knowledge suggests that courtly settings in this period are significant locations for the development and applications of natural knowledge.En sus principales trabajos para el Papa, así como en ciertas obras de madurez, Bacon se centró en la utilidad del conocimiento natural, tanto en términos de saber práctico humano como de lo que ese saber podía producir. Miró a las ciencias practicadas en la corte (como la medicina, la ciencia astral, la óptica y la ciencia de la materia), que privilegian la aplicación y el conocimiento obtenido a través de los sentidos, como fuentes de conocimiento natural y como ejemplos del potencial del conocimiento de la naturaleza. Este ensayo sostiene que la obra de Roger Bacon debe entenderse en el contexto de la corte. El énfasis de Bacon en los dispositivos para la búsqueda del conocimiento y la utilidad demuestra hasta qué punto las ciencias desarrolladas en la corte (la ingeniería, la navegación, la alquimia y la adivinación) se valoraban junto a distintos ámbitos filosóficos tradicionales sobre la naturaleza, y es en este contexto en el que deben ser entendidos. Tanto las ciencias desarrolladas en la corte como la teoría de Bacon sobre la scientia experimentalis se centran en los materiales, el conocimiento sensorial y el conocimiento que persigue fines aplicados de hechos concretos. Bacon se inspiró en las ciencias desarrolladas en la corte para teorizar cómo el conocimiento natural podía servir al poder gobernante. Examinando las principales obras de Bacon sobre la scientia experimentalis y analizando cómo recurre a ejemplos de la historia de Alejandro Magno, este ensayo demuestra la interrelación entre el poder político y el conocimiento erudito, y cómo se entrecruzan practicando y aplicando el experimentum y la tecnología. Por último, el interés de Bacon por la utilidad del conocimiento sugiere que los escenarios cortesanos de este periodo

Whimbrel Tracked with Satellite Transmitter on Migratory Flight Across North America

Two disjunct breeding populations of Whimbrel Numenius phaeopus have been described in the western hemisphere (American Ornithologists’ Union 1983). The western population breeds in portions of Alaska and across the Yukon and Northwest Territories of Canada while the eastern population breeds west and south of Hudson Bay (Skeel & Mallory 1996). Most of what we believe we know about the migratory pathways of these populations has been pieced together from circumstantial evidence gleaned from decades of field observations (Skeel & Mallory 1996, Taverner 1942). The populations have been thought to have separate migratory routes with little mixing where the western and eastern populations were confined to the Pacific and Atlantic Coasts, respectively. Here we present evidence of a transcontinental migration route that brings portions of the two Whimbrel populations into contact during spring migration..

Computational evidence for an early, amplified systemic inflammation program in polytrauma patients with severe extremity injuries

Extremity and soft tissue injuries contribute significantly to inflammation and adverse in-hospital outcomes for trauma survivors; accordingly, we examined the complex association between clinical outcomes inflammatory responses in this setting using in silico tools. Two stringently propensity-matched, moderately/severely injured (Injury Severity Score > 16) patient sub-cohorts of ~30 patients each were derived retrospectively from a cohort of 472 blunt trauma survivors and segregated based on their degree of extremity injury severity (above or below 3 on the Abbreviated Injury Scale). Serial blood samples were analyzed for 31 plasma inflammatory mediators. In addition to standard statistical analyses, Dynamic Network Analysis (DyNA) and Principal Component Analysis (PCA) were used to model systemic inflammation following trauma. Patients in the severe extremity injury sub-cohort experienced longer intensive care unit length of stay (LOS), total LOS, and days on a mechanical ventilator, with higher Marshall Multiple Organ Dysfunction (MOD) Scores over the first 7 days post-injury as compared to the mild/moderate extremity injury sub-cohort. The higher severity cohort had statistically significant elevated lactate, base deficit, and creatine phosphokinase on first blood draw, along with significant changes in multiple circulating inflammatory mediators. DyNA pointed to a sustained role for type 17 immunity in both sub-cohorts, along with IFN-γ in the severe extremity injury group. DyNA network complexity increased over 7 days post-injury in the severe injury group, while generally decreasing over this same time period in the mild/moderate injury group. PCA suggested a more robust activation of multiple pathways in the severe extremity injury group as compared to the mild/moderate injury group. These studies thus point to the possibility of self-sustaining inflammation following severe extremity injury vs. resolving inflammation following less severe extremity injury

Constraints on the Mode and Extent of Sedimentary Rock Alteration in Hyper-Arid and Hypo-Thermal Environments

Geologic evidence suggests that the surface of Mars has been dominated by cold, dry, and relatively stable environmental conditions over the past ~3.5 Ga. These conditions differ from those pre-sumed to be present prior to ~3.5 Ga, when observa-tions indicate that the martian surface was at least in-termittently able to support the prolonged flow of liq-uid water. Despite the more than 75% of martian his-tory dominated by cold, dry, and stable conditions, few investigations have studied weathering and alteration processes that may influence the martian surface dur-ing this time. Please see attachment

Co-administration of ethanol and nicotine: the enduring alterations in the rewarding properties of nicotine and glutamate activity within the mesocorticolimbic system of female alcohol-preferring (P) rats

RATIONALE: The co-abuse of ethanol (EtOH) and nicotine (NIC) increases the likelihood that an individual will relapse to drug use while attempting to maintain abstinence. There is limited research examining the consequences of long-term EtOH and NIC co-abuse. OBJECTIVES: The current experiments determined the enduring effects of chronic EtOH, NIC, or EtOH + NIC intake on the reinforcing properties of NIC and glutamate (GLU) activity within the mesocorticolimbic (MCL) system. METHODS: Alcohol-preferring (P) rats self-administered EtOH, Sacc + NIC, or EtOH + NIC combined for 10 weeks. The reinforcing properties of 0.1-3.0 μM NIC within the nucleus accumbens shell (AcbSh) were assessed following a 2-3-week drug-free period using intracranial self-administration (ICSA) procedures. The effects of EtOH, Sacc, Sacc + NIC, or EtOH + NIC intake on extracellular levels and clearance of glutamate (GLU) in the medial prefrontal cortex (mPFC) were also determined. RESULTS: Binge intake of EtOH (96-100 mg%) and NIC (21-27 mg/mL) were attained. All groups of P rats self-infused 3.0 μM NIC directly into the AcbSh, whereas only animals in the EtOH + NIC co-abuse group self-infused the 0.3 and 1.0 μM NIC concentrations. Additionally, self-administration of EtOH + NIC, but not EtOH, Sacc or Sacc + NIC, resulted in enduring increases in basal extracellular GLU levels in the mPFC. CONCLUSIONS: Overall, the co-abuse of EtOH + NIC produced enduring neuronal alterations within the MCL which enhanced the rewarding properties of NIC in the AcbSh and elevated extracellular GLU levels within the mPFC

Ethanol and nicotine interaction within the posterior ventral tegmental area in male and female alcohol-preferring rats: evidence of synergy and differential gene activation in the nucleus accumbens shell

RATIONALE: Ethanol and nicotine are frequently co-abused. The biological basis for the high co-morbidity rate is not known. Alcohol-preferring (P) rats will self-administer EtOH or nicotine directly into the posterior ventral tegmental area (pVTA). OBJECTIVE: The current experiments examined whether sub-threshold concentrations of EtOH and nicotine would support the development of self-administration behaviors if the drugs were combined. METHODS: Rats were implanted with a guide cannula aimed at the pVTA. Rats were randomly assigned to groups that self-administered sub-threshold concentrations of EtOH (50 mg%) or nicotine (1 μM) or combinations of ethanol (25 or 50 mg%) and nicotine (0.5 or 1.0 μM). Alterations in gene expression downstream projections areas (nucleus accumbens shell, AcbSh) were assessed following a single, acute exposure to EtOH (50 mg%), nicotine (1 μM), or ethanol and nicotine (50 mg% + 1 μM) directly into the pVTA. RESULTS: The results indicated that P rats would co-administer EtOH and nicotine directly into the pVTA at concentrations that did not support individual self-administration. EtOH and nicotine directly administered into the pVTA resulted in alterations in gene expression in the AcbSh (50.8-fold increase in brain-derived neurotrophic factor (BDNF), 2.4-fold decrease in glial cell line-derived neurotrophic factor (GDNF), 10.3-fold increase in vesicular glutamate transporter 1 (Vglut1)) that were not observed following microinjections of equivalent concentrations/doses of ethanol or nicotine. CONCLUSION: The data indicate that ethanol and nicotine act synergistically to produce reinforcement and alter gene expression within the mesolimbic dopamine system. The high rate of co-morbidity of alcoholism and nicotine dependence could be the result of the interactions of EtOH and nicotine within the mesolimbic dopamine system