Consumer reactions to self-expressive brand display

Brand names and other brand elements are often displayed on one’s body or clothes for the purpose of personal value expression. Despite the frequency of such brand displays in the marketplace, we know little about how consumers respond to seeing brands in this fashion. A recent view of consumer brand identification—the concept of brand engagement in self-concept (BESC)—provides a unique perspective from which to explore how consumers react when see-ing brands displayed by others. Across three experiments, we demonstrate a consistent pattern of findings indicating that consumers’ reactions to others ostentatiously displaying brands as means of value expression are strongest for those with high BESC levels and with a high value focus during brand exposure. The research highlights important variations in consumers’ responses to self-expressive brand stimuli associated with others; implications for branding practice and re-search are provided.Brand engagement; self-concept; advertising; brand management

Transgenesis and Genomics in Molecular Breeding of Forage Plants

Forage plant breeding has been largely based on phenotypic selection following sexual recombination of natural genetic variation found between and within ecotypes. Advances in plant genetic manipulation over the last 15 years have provided convincing evidence that these powerful technologies can complement and enhance plant breeding programs. Significant progress in the establishment of the methodologies required for the molecular breeding of forage plants has been made. Examples of current products and approaches for the application of these methodologies to forage grass and legume improvement are outlined. Large-scale genomic analysis of many organisms is under way with human, arabidopsis and rice genome sequences almost completed. Forage plant breeding is just now entering the genome era. The plethora of new technologies and tools now available for high-throughput gene discovery and genome-wide gene expression analysis have opened up opportunities for innovative applications in the identification, functional characterisation and use of genes of value in forage production systems and beyond. Examples of these opportunities, such as ‘molecular phenotyping’, ‘symbio-genomics’ and ‘xeno-genomics’ are introduced

Isolation and Characterisation of Genes Encoding Malate Synthesis and Transport Determinants in the Aluminum-Tolerant Australian Weeping-Grass (\u3cem\u3eMicrolaena Stipoides\u3c/em\u3e)

Acid soils cover some 40% of the Earth’s arable land where they represent a major limitation to plant production. Plant growth on acid soils is primarily limited due to aluminium (Al) solubilized by acidity into toxic Al3+ cations which will inhibit root growth resulting in poor uptake of water and nutrients. Many important pasture species lack sufficient Al tolerance within their germplasm to allow effective breeding for this character

Gene Discovery and Molecular Dissection of Lignin Biosynthesis in Perennial Ryegrass (Lolium Perenne)

Lignification of plant cell walls has been identified as a major factor limiting forage digestibility. It limits the amount of digestible energy available to livestock, resulting in an incomplete utilisation of cellulose and hemicellulose by ruminant animals. Modification of the lignin profile of ryegrasses (Lolium spp.) and fescues (Festuca spp.) is undertaken through modulating the expression of genes encoding enzymes involved in the biosynthesis of monolignols

Orally active antischistosomal early leads identified from the open access malaria box.

BACKGROUND: Worldwide hundreds of millions of schistosomiasis patients rely on treatment with a single drug, praziquantel. Therapeutic limitations and the threat of praziquantel resistance underline the need to discover and develop next generation drugs. METHODOLOGY: We studied the antischistosomal properties of the Medicines for Malaria Venture (MMV) malaria box containing 200 diverse drug-like and 200 probe-like compounds with confirmed in vitro activity against Plasmodium falciparum. Compounds were tested against schistosomula and adult Schistosoma mansoni in vitro. Based on in vitro performance, available pharmacokinetic profiles and toxicity data, selected compounds were investigated in vivo. PRINCIPAL FINDINGS: Promising antischistosomal activity (IC50: 1.4-9.5 µM) was observed for 34 compounds against schistosomula. Three compounds presented IC50 values between 0.8 and 1.3 µM against adult S. mansoni. Two promising early leads were identified, namely a N,N'-diarylurea and a 2,3-dianilinoquinoxaline. Treatment of S. mansoni infected mice with a single oral 400 mg/kg dose of these drugs resulted in significant worm burden reductions of 52.5% and 40.8%, respectively. CONCLUSIONS/SIGNIFICANCE: The two candidates identified by investigating the MMV malaria box are characterized by good pharmacokinetic profiles, low cytotoxic potential and easy chemistry and therefore offer an excellent starting point for antischistosomal drug discovery and development

The World's Highest-Grade Cobalt Mineralization at Bou Azzer Associated With Gondwana Supercontinent Breakup, Serpentinite and Kellwasser Hydrocarbon Source Rocks

Cobalt arsenide deposits associated with Neoproterozoic serpentinite in Morocco represent the highest-grade cobalt resource worldwide. Yet, genetic models for their origin remain controversial. We report here mineralogical and geochemical evidence for arsenide-calcite mineralization at Bou Azzer to constrain the temporal framework and identify the geodynamic trigger for mineralization mechanisms. To this end, radiometric ages for ore minerals are paramount for understanding the origin of the Bou Azzer cobalt arsenide deposit. New safflorite (CoAs2) rhenium-osmium (Re-Os) ages are Late Devonian in age: 380.4 ± 2.9 and 373.4 ± 1.2 to 368.1 ± 5.0 million years ago (Ma) for coarse-grained and fine-grained safflorite, respectively. These dates overlap with the timing of break-up of the supercontinent Gondwana, and the building of an arch-and-basin geometry from northern Africa to Arabia. Our findings temporally and spatially contextualize previous knowledge of fluid chemistry and mineralization mechanisms involving a two-fluid mixing. Arsenide mineralization resulted from mixing of a methane-dominated fluid with highly saline basinal brines that leached Os (187Os/188Osinitial = 0.120 ± 0.001), and by corollary cobalt, from Neoproterozoic serpentinite. Carbon and sulfur stable isotope data of ore-stage calcite and arsenides, respectively, show that hydrocarbons acted as the main reductant for mineralization. We speculate that the seawater-derived brines sank into the sedimentary basins adjacent to a carbonate platform with the Bou Azzer serpentinite in its basement in the Late Devonian. In the context of an enhanced geothermal gradient, such brines would have been involved in warm hydrothermal alteration of hydrocarbon source rocks of the local expression of the Kellwasser event in the geological record of present-day Morocco. This warm hydrothermal alteration of hydrocarbon source rocks may have taken place for coarse-grained safflorite mineralization (380.4 ± 2.9 Ma) shortly after ca. 382–381 Ma Lower Kellwasser horizons were deposited, or, for fine-grained safflorite mineralization (373.4 ± 1.2 to 368.1 ± 5.0 Ma) while the Upper Kellwasser horizons of present-day Morocco were being deposited

Application of Molecular Technologies in Forage Plant Breeding

Key points A range of molecular breeding technologies have been developed for forage plant species including both transgenic and non-transgenic methodologies. The application of these technologies has the potential to greatly increase the range of genetic variation that is available for incorporation into breeding programs and subsequent delivery to producers in the form of improved germplasm. Further developments in detailing the phenotypic effect of genes and alleles both through research in target species and through inference from results from model species will further refine the delivery of new forage cultivars

Genetic Variation in the Perennial Ryegrass Fungal Endophyte \u3cem\u3eNeotyphodium Lolii\u3c/em\u3e

The common fungal endophytes (Neotyphodium species) of temperate pasture grasses are associated with improved tolerance to water and nutrient stress and resistance to insect pests, but are also the causal agents of animal toxicoses. Considerable variation exists among grass-endophyte associations for these beneficial and detrimental agronomic traits. The extent to which this variation may be attributed to the endophyte genotype, the host genotype or environmental interactions is currently unknown. The development of molecular genetic markers for endophytes based on simple sequence repeat (SSR) loci and the demonstration of the specific detection of endophytes in planta with these markers (van Zijll de Jong et al., 2005) allows efficient assessment of endophyte diversity in grass populations

Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor

We have analyzed several cases of Beckwith-Wiedemann syndrome (BWS) with Wilms' tumor in a familial setting, which give insight into the complex controls of imprinting and gene expression in the chromosome 11p15 region. We describe a 2.2-kbp microdeletion in the H19/insulin-like growth factor 2 (IGF2)-imprinting center eliminating three target sites of the chromatin insulator protein CTCF that we believe here is necessary, but not sufficient, to cause BWS and Wilms' tumor. Maternal inheritance of the deletion is associated with IGF2 loss of imprinting and up-regulation of IGF2 mRNA. However, in at least one affected family member a second genetic lesion (a duplication of maternal 11p15) was identified and accompanied by a further increase in IGF2 rnRNA levels 35-fold higher than control values. Our results suggest that the combined effects of the H19//GF2-imprinting center microdeletion and 11p15 chromosome duplication were necessary for manifestation of BWS

When Does the Past Repeat Itself? The Interplay of Behavior Prediction and Personal Norms

Does asking people about their future behavior increase or decrease the likelihood that they will repeat their past behavior? In two laboratory and two field experiments, we find that behavior prediction strengthens behavior repetition, making people more likely to do what they normally do, when personal norms regarding engaging in a behavior are weak or not easily accessible. However, when personal norms are strong or made accessible at the time of the prediction request, behavior prediction weakens behavior repetition and increases the likelihood that people do what they think they should do-even if it's not what they normally would do. These findings provide new tools for influencing behavior repetition, reconcile some seemingly contradictory past findings, and contribute to the debate regarding the relative importance of habits and intentions in guiding behavior. T he repetition of unhealthy behaviors (such as overeating) and the lack of repetition of healthy behaviors (such as exercising) are leading contributors to preventable deaths in developed countrie