Green Book (2018) and BlacKKKlansman (2018): An Analysis of White and Black Perspectives in Contemporary Films Using Critical Race Theory

This research analyzes two films, Green Book (2018) and BlacKKKlansman (2018), to uncover the connections between diverse racial representation off-screen, and the presentation of non-white perspectives on-screen. This study uses CRT to frame the effects of diverse source materials and production teams on the films\u27 narratives

Endomorphisms and Translations of Semigroups

This thesis is a study of some of the properties of mappings or semigroups into semigroups. In Section 1, definitions and basic concepts are given, with brief mention of some well known properties of semigroups and of mappings. Section 2 is devoted to a few theroems which are useful in the process of finding the semigroup of all endomorphisms of a given semigroup. When theorems on endomorphisms are valid in the more general situation in which a semigroup is mapped homomorphically on another semigroup, we state and prove the theorems in the more general setting. Section 3 consists of some theroems and a short discussion of right and of left translations of semigroups. The rest of the paper is devoted to listing, in section 4, 1) the semigroups of all endomorphisms of semigroups of orders two, three and four, and 2) the semigroups of all right translations of and all left translations on semigroups of orders two, three and four

The Infra‐Red Absorption Spectrum of Mono‐Deutero‐Ethane under High Resolution

The infra‐red spectrum of C2H5D has been investigated under high resolution. As expected, the bands corresponding to degenerate vibrations of C2H6 are split into two components with oscillations in the symmetry plane and normal to the symmetry plane respectively. Analogues of several of the inactive C2H6 frequencies have also been observed, including a pair at 1122 cm−1 and 1159 cm−1 corresponding to a Raman line of ordinary ethane which has been predicted at about 1170 cm−1 but has not as yet been found.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69718/2/JCPSA6-17-2-182-1.pd

Eis Inhibitors

Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided

Stand-Level Green Biomass Equations for Sawtimber-Sized Loblolly Pine in Arkansas

Loblolly pine (Pinus taeda L.) is commercially the most important timber species in southern Arkansas and the southern United States. Results of stand-level timber inventories have traditionally been reported in terms of volume, yet loblolly pine sawtimber is bought and sold based on biomass. A straight forward stand-level conversion from volume per hectare to biomass per hectare does not exist for Arkansas, thus complicating the valuation of standing loblolly pine sawtimber. Two equations were developed to predict stand-level, outside-bark, green biomass per unit area for loblolly pine stands in southern Arkansas. The merchantable sawlog equation presented herein explained approximately 95% of the variation present and had an average error of 4.2 percent when applied to validation data. The equation for total merchantable biomass explained about 99% of the variation and had an average error of 1.5 percent when applied to validation data. Use of these equations should simplify the valuation of standing timber in loblolly pine sawtimber stands in southern Arkansas

Sense and Sequels: Analyzing Pride and Prejudice Inspired Fiction

Literary sequels, retellings, and adaptations of Jane Austen's six original novels have proliferated in the past 15 years, entering a wide array of genres and historical periods. While these novels have been studied in some detail, an empirical study of Jane Austen sequels and literary adaptations has yet to be performed. This study uses content analysis in order to determine and examine a number of key qualities that elucidate character, plot and language in ten Pride and Prejudice sequels, retellings and adaptations in order to determine how closely these sequels and adaptations align themselves with Austen's original. In doing so, it was discovered that, generally, adaptations tend to align themselves more closely with Austen's original in terms of plot and character description, while sequels and adaptations are less likely to depend on the original for character and plot inspiration

Intrinsic disorder and amphitropism in the mitochondrial fission mechanoenzyme Drp1

The Dynamin superfamily is a class of large GTPases that perform essential membrane remodeling events via self-assembly stimulated GTP hydrolysis in a manner that is not well understood. Malfunction in these enzymes is the basis of a number of diseases. Dynamin superfamily enzymes hydrolyze GTP via a G domain, self-assemble via a stalk domain, and may couple assembly and hydrolysis via a “bundle signaling element” domain. An additional “variable domain” (VD) is present in many superfamily members and may enable specific targeting to sites of action, but the nature of VD function is unclear in most dynamins. While VDs are not conserved in amino acid sequence, they may have similarities in function, namely allosteric regulation and membrane interaction. We identify two modes of membrane interaction in the dynamin superfamily: (1) tethering to the membrane via a transmembrane helix or a lipophilic anchor and (2) untethered, reversible interaction with membranes (amphitropism). We propose a subclassification of the dynamin superfamily into these two categories. We employ the mitochondrial dynamin, Drp1 as a model of the amphitropic dynamins because of its relative simplicity and relevance to human health. Specifically, we seek to identify the role of the Drp1 VD, or B domain, anticipating that it will also inform understanding of VDs in other amphitropic dynamins. We find that removal of the B domain from Drp1 results in enhanced assembly and GTP hydrolysis, suggesting that the B domain has an auto-inhibitory role. We find that the B domain is intrinsically disordered (ID) and surprisingly, undergoes phase separation or coacervation under conditions that induce other IDPs to fold. Finally, we show that the B domain binds lipid membranes with a specificity for cardiolipin, and that this interaction is enhanced under conditions that favor the coacervated state. Based on these findings we suggest the possibility that the B domain acts as an entropic bristle in order to inhibit Drp1 assembly, and that this auto-inhibition is relieved upon interaction of the B domain with a lipid membrane, perhaps involving the process of coacervation. We suspect that this model may also be applicable to other amphitropic dynamins

Positive effects of methylphenidate on hyperactivity are moderated by monoaminergic gene variants in children with autism spectrum disorders.

Methylphenidate (MPH) reduces hyperactive-impulsive symptoms common in children with autism spectrum disorders (ASDs), however, response and tolerability varies widely. We hypothesized monoaminergic gene variants may moderate MPH effects in ASD, as in typically developing children with attention-deficit/hyperactivity disorder. Genotype data were available for 64 children with ASD and hyperactivity who were exposed to MPH during a 1-week safety/tolerability lead-in phase and 58 who went on to be randomized to placebo and three doses of MPH during a 4-week blinded, crossover study. Outcome measures included the Clinical Global Impression-Improvement (CGI-I) scale and the Aberrant Behavior Checklist (ABC-hyperactivity index). A total of 14 subjects discontinued the study because of MPH side effects. Subjects were genotyped for variants in DRD1-DRD5, ADRA2A, SLC6A3, SLC6A4, MAOA and MAOB, and COMT. Forty-nine percent of the sample met positive responder criteria. In this modest but relatively homogeneous sample, significant differences by DRD1 (P=0.006), ADRA2A (P<0.02), COMT (P<0.04), DRD3 (P<0.05), DRD4 (P<0.05), SLC6A3 (P<0.05) and SLC6A4 (P<0.05) genotypes were found for responders versus non-responders. Variants in DRD2 (P<0.001) and DRD3 (P<0.04) were associated with tolerability in the 14 subjects who discontinued the trial. For this first MPH pharmacogenetic study in children with ASD, multiple monoaminergic gene variants may help explain individual differences in MPH's efficacy and tolerability