48 research outputs found
Field Evidence on Individual Behavior & Performance in Rank-Order Tournaments
Economic analysis of rank-order tournaments has shown that intensified competition leads to declining performance. Empirical research demonstrates that individuals in tournament-type contests perform less well on average in the presence of larger number of competitors in total and superstars. Particularly in field settings, studies often lack direct evidence about the underlying mechanisms, such as the amount of effort, that might account for these results. Here we exploit a novel dataset on algorithmic programming contests that contains data on individual effort, risk taking, and cognitive errors that may underlie tournament performance outcomes. We find that competitors on average react negatively to an increase in the total number of competitors, and react more negatively to an increase in the number of superstars than non-superstars. We also find that the most negative reactions come from a particular subgroup of competitors: those that are highly skilled, but whose abilities put them near to the top of the ability distribution. For these competitors, we find no evidence that the decline in performance outcomes stems from reduced effort or increased risk taking. Instead, errors in logic lead to a decline in performance, which suggests a cognitive explanation for the negative response to increased competition. We also find that a small group of competitors, who are at the very top of the ability distribution (non-superstars), react positively to increased competition from superstars. For them, we find some evidence of increased effort and no increase in errors of logic, consistent with both economic and psychological explanations
Negative control of CSL gene transcription by stress/DNA damage response and p53.
CSL is a key transcriptional repressor and mediator of Notch signaling. Despite wide interest in CSL, mechanisms responsible for its own regulation are little studied. CSL down-modulation in human dermal fibroblasts (HDFs) leads to conversion into cancer associated fibroblasts (CAF), promoting keratinocyte tumors. We show here that CSL transcript levels differ among HDF strains from different individuals, with negative correlation with genes involved in DNA damage/repair. CSL expression is negatively regulated by stress/DNA damage caused by UVA, Reactive Oxygen Species (ROS), smoke extract, and doxorubicin treatment. P53, a key effector of the DNA damage response, negatively controls CSL gene transcription, through suppression of CSL promoter activity and, indirectly, by increased p21 expression. CSL was previously shown to bind p53 suppressing its activity. The present findings indicate that p53, in turn, decreases CSL expression, which can serve to enhance p53 activity in acute DNA damage response of cells
The origin of Jupiter's outer radiation belt
The intense inner radiation belt at Jupiter (>50 MeV at 1.5 RJ) is generally accepted to be created by radial diffusion of electrons from further away from the planet. However, this requires a source with energies that exceed 1 MeV outside the orbit of the moon Io at 5.9 RJ, which has never been explained satisfactorily. Here we test the hypothesis that this source population could be formed from a very soft energy spectrum, by particle injection processes and resonant electron acceleration via whistler mode chorus waves. We use the British Antarctic Survey Radiation Belt Model to calculate the change in the electron flux between 6.5 and 15 RJ; these are the first simulations at Jupiter combining wave particle interactions and radial diffusion. The resulting electron flux at 100 keV and 1 MeV lies very close to the Galileo Interim Radiation Electron model spectrum after 1 and 10 days, respectively. The primary driver for the increase in the flux is cyclotron resonant acceleration by chorus waves. A peak in phase space density forms such that inside Lâ9 radial diffusion transports electrons toward Jupiter, but outside Lâ9 radial diffusion acts away from the planet. The results are insensitive to the softness of the initial energy spectrum but do depend on the value of the flux at the minimum energy boundary. We conclude by suggesting that the source population for the inner radiation belt at Jupiter could indeed be formed by wave-particle interactions
Cusp energetic ions: A bow shock source
Recent interpretations of cusp energetic ions observed by the POLAR spacecraft have suggested a new energization process in the cusp [Chen et al., 1997; 1998]. Simultaneous enhancement of H+, He+2, and O\u3e+2 fluxes indicates that they are of solar wind origin. In the present study, we examine H+ and He+2 energy spectra from 20 eV to several 100 keV measured by the Hydra, Toroidal Imaging Mass-Angle Spectrograph (TIMAS), and Charge and Mass Magnetospheric Ion Composition Experiment (CAMMICE) on POLAR. The combined spectrum for each species is shown to be continuous with a thermal distribution below 10 keV/e and an energetic component above 20 keV/e. Energetic ions with comparable fluxes and a similar spectral shape are commonly observed downstream from the Earth\u27s quasi-parallel (Qâ„) bow shock. In addition to the similarity in the ion spectra, electric and magnetic field noise and turbulence detected in the cusp by the Plasma Wave Instrument (PWI) and Magnetic Field Experiment (MFE) onboard POLAR are similar to the previously reported observations at the bow shock. The waves appear to be coincidental to the cusp energetic ions rather than causal. We suggest that these ions are not accelerated locally in the cusp. Rather, they are accelerated at the Qâ„ bow shock and enter the cusp along open magnetic field lines connecting both regions
Electron acceleration at Jupiter: input from cyclotron-resonant interaction with whistler-mode chorus waves
Jupiter has the most intense radiation belts of all the outer planets. It is not yet known how electrons can be accelerated to energies of 10 MeV or more. It has been suggested that cyclotron-resonant wave-particle interactions by chorus waves could accelerate electrons to a few MeV near the orbit of Io. Here we use the chorus wave intensities observed by the Galileo spacecraft to calculate the changes in electron flux as a result of pitch angle and energy diffusion. We show that, when the bandwidth of the waves and its variation with L are taken into account, pitch angle and energy diffusion due to chorus waves is a factor of 8 larger at L-shells greater than 10 than previously shown. We have used the latitudinal wave intensity profile from Galileo data to model the time evolution of the electron flux using the British Antarctic Survey Radiation Belt (BAS) model. This profile confines intense chorus waves near the magnetic equator with a peak intensity at âŒ5° latitude. Electron fluxes in the BAS model increase by an order of magnitude for energies around 3 MeV. Extending our results to L = 14 shows that cyclotron-resonant interactions with chorus waves are equally important for electron acceleration beyond L = 10. These results suggest that there is significant electron acceleration by cyclotron-resonant interactions at Jupiter contributing to the creation of Jupiter's radiation belts and also increasing the range of L-shells over which this mechanism should be considered
Survey of Saturn Z-mode Emission
Because of the role of Z-mode emission in the diffusive scattering and resonant acceleration of electrons, we conduct a survey of intensity in the Saturn inner magnetosphere. Z-mode is primarily observed as â5 kHzâ narrowband emission in the lower density regions where the ratio of cyclotron to plasma frequency, fc/fp > 1 to which we limit this study. This occurs at Saturn along the inner edge of the Enceladus torus near the equator and at higher latitudes. We present profiles and parametric fits of intensity as a function of frequency, radius, latitude, and local time. The magnetic field intensity levels are lower than chorus, but the electric field intensities are comparable. We conclude that Z-mode wave-particle interactions may make a significant contribution to electron acceleration in the inner magnetosphere of Saturn, supplementing acceleration produced by chorus emission
Survey of whistler mode chorus intensity at Jupiter
Whistler mode chorus emission is important in the acceleration of electrons and filling of the radiation belts at Jupiter. In this work chorus magnetic intensity levels (frequency-integrated spectral density, PB) at Jupiter are comprehensively binned and parameterized. The frequency range of chorus under study extends from the lower hybrid frequency, flh, to fceq/2 and fceq/2â<âfâ<â0.8 fceq, where fceq is the cyclotron frequency mapped to the magnetic equator. The goal is to obtain a quantized distribution of magnetic intensity for use in stochastic modeling efforts. Parametric fits of magnetic plasma wave intensity are obtained, including PB versus frequency, latitude, and L shell. The results indicate that Jupiter chorus occurrence probability and intensity are higher than those at Saturn, reaching values observed at Earth. Jovian chorus is observed over most local times, confined primarily to the range 8â<âLâ<â15, outside the high densities of the Io torus. The largest intensity levels are seen on the dayside; however, the sampling of chorus on the nightside is much less than on the dayside. Peak intensities occur near the equator with a weak dependence on magnetic latitude, λ. We conclude that Jovian chorus average intensity levels are approximately an order of magnitude lower than those at Earth. In more isolated regions the intensities are comparable to those observed at Earth. The spatial range of the chorus emissions extends beyond that assumed in previous Jovian global diffusive models of wave-particle electron acceleration
MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors.
Cusp energetic particle events: Implications for a major acceleration region of the magnetosphere
The Charge and Mass Magnetospheric Ion Composition Experiment (CAMMICE) on board the Polar spacecraft observed 75 energetic particle events in 1996 while the satellite was at apogee. All of these events were associated with a decrease in the magnitude of the local magnetic field measured by the Magnetic Field Experiment (MFE) on Polar. These new events showed several unusual features: (1) They were detected in the dayside polar cusp near the apogee of Polar with about 79% of the total events in the afternoonside and 21% in the morningside; (2) an individual event could last for hours; (3) the measured helium ion had energies up to and many times in excess of 2.4 MeV; (4) the intensity of 1â200 KeV/e helium was anticorrelated with the magnitude of the local geomagnetic field but correlated with the turbulent magnetic energy density; (5) the events were associated with an enhancement of the low-frequency magnetic noise, the spectrum of which typically extends from a few hertz to a few hundreds of hertz as measured by the Plasma Wave Instrument (PWI) on Polar; and (6) a seasonal variation was found for the occurrence rate of the events with a maximum in September. These characterized a new phenomenon which we are calling cusp energetic particle (CEP) events. The observed high charge state of helium and oxygen ions in the CEP events indicates a solar source for these particles. Furthermore, the measured 0.52â1.15 MeV helium flux was proportional to the difference between the maximum and the minimum magnetic field in the event. A possible explanation is that the energetic helium ions are energized from lower energy helium by a local acceleration mechanism associated with the high-altitude dayside cusp. These observations represent a potential discovery of a major acceleration region of the magnetosphere
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Strong whistler mode waves observed in the vicinity of Jupiterâs moons
Understanding of wave environments is critical for the understanding of how particles are accelerated and lost in space. This study shows that in the vicinity of Europa and Ganymede, that respectively have induced and internal magnetic fields, chorus wave power is significantly increased. The observed enhancements are persistent and exceed median values of wave activity by up to 6 orders of magnitude for Ganymede. Produced waves may have a pronounced effect on the acceleration and loss of particles in the Jovian magnetosphere and other astrophysical objects. The generated waves are capable of significantly modifying the energetic particle environment, accelerating particles to very high energies, or producing depletions in phase space density. Observations of Jupiterâs magnetosphere provide a unique opportunity to observe how objects with an internal magnetic field can interact with particles trapped in magnetic fields of larger scale objects