Multicolor flickering studies of X1822-371

We report on the analysis of high-speed multicolor photometry of the eclipsing X-ray binary X1822-371. We used new eclipse timings to derive a revised optical ephemeris. A quadratic fit to the eclipse timings is not statistically significant but suggests that the orbital period is increasing on a timescale of P/|Pdot|= (4.2 +/- 1.4) 10^6 yr. We find no systematic delay or advance of the optical timings with respect to the X-ray timings. Average UBVRI light curves show the deep eclipse of the disc by the secondary star superimposed on the broader and shallower occultation of the inner disc regions by the outer disc (dip), and an orbital hump centred at phase +0.25 which is mostly seen in the U and B bands. The starting phase of the dip occurs earlier for shorter wavelengths, while the egress occurs at the same phase in all bands. This suggests that the thickening of the outer, occulting disc rim is gradual with azimuth at ingress but decreases sharply at egress. We fit synthetic photometry to the extracted colors of the inner and outer disc regions to estimate their effective temperatures. We find Teff= (9+/-5) 10^7 K and Teff= (6+/-2) 10^4 K, respectively, for the inner and outer disc regions. The orbital dependency of the flickering activity is derived from the mean scatter of the individual light curves with respect to the average UBVRI light curves. The flickering curves show a broad eclipse at the dipping phases, the depth of which decreases with increasing wavelength. The blue, eclipsed flickering component is associated with the inner disc regions and can be fitted by a blackbody spectrum of Teff= (2.1+/-0.8) 10^8 K, whereas the uneclipsed flickering component probably arises from the outermost disc regions and is well described by a blackbody of Teff= (9.6+/-0.7) 10^3 K.Comment: 8 pages, 5 postscript figures, coded with MNRAS latex file. To appear in Monthly Notices of the Royal Astronomical Societ

Is time-variant information stickiness state-dependent?

This paper estimates information stickiness with regard to inflation expectations in the United States and the Eurozone for the 1981/06–2015/12 and 1998/Q4–2015/Q2 periods, respectively, and further investigates whether such information stickiness is state- dependent. Based on a bootstrap sub-sample rolling-window estimation, we find that information stickiness varies over time, which contradicts the strict time dependency implied under sticky-information theory. We provide evidence that information stickiness depends on inflation volatility, which indicates that information stickiness is state-dependent and that it has a time trend. Using a threshold model, we estimate structural changes in the state- dependence and time-trend of information stickiness. The results show that information stickiness has been more dependent on inflation volatility and has had a higher time-trend in both regions following the 2008 financial crisis.info:eu-repo/semantics/publishedVersio

Treasuries Variance Decomposition and the Impact of Monetary Policy

This paper investigates the effect of monetary policy shifts on Treasuries over the last three decades. Using Campbell and Ammer’s (1993) framework, we decompose unexpected excess returns on 2-, 5- and 10-year Treasuries in three components related to revisions in expectations (news) about future excess returns, inflation and real interest rates. We evaluate the impact of conventional and unconventional monetary policy shocks on returns and their components. Our results indicate that expansionary monetary policy shocks are associated with declining inflation expectations and higher Treasuries’ returns

Discovery and Characterization of an Endogenous CXCR4 Antagonist

CXCL12-CXCR4 signaling controls multiple physiological processes and its dysregulation is associated with cancers and inflammatory diseases. To discover as-yet-unknown endogenous ligands of CXCR4, we screened a blood-derived peptide library for inhibitors of CXCR4-tropic HIV-1 strains. This approach identified a 16 amino acid fragment of serum albumin as an effective and highly specific CXCR4 antagonist. The endogenous peptide, termed EPI-X4, is evolutionarily conserved and generated from the highly abundant albumin precursor by pH-regulated proteases. EPI-X4 forms an unusual lasso-like structure and antagonizes CXCL12-induced tumor cell migration, mobilizes stem cells, and suppresses inflammatory responses in mice. Furthermore, the peptide is abundant in the urine of patients with inflammatory kidney diseases and may serve as a biomarker. Our results identify EPIX4 as a key regulator of CXCR4 signaling and introduce proteolysis of an abundant precursor protein as an alternative concept for chemokine receptor regulation

Cyclical period changes in the dwarf novae V2051 Oph and V4140 Sgr

We report the identification of cyclical changes in the orbital period of the eclipsing dwarf novae V2051 Ophiuchi and V4140 Sagitarii. We used sets of white dwarf mid-eclipse timings to construct observed-minus-calculated diagrams covering, respectively, 25 and 16 years of observations. The V2051 Oph data present cyclical variations that can be fitted by a linear plus sinusoidal function with period 22 +/- 2 yr and amplitude 17 +/- 3 s. The statistical significance of this period by an F-test is larger than 99.9 per cent. The V4140 Sgr data present cyclical variations of similar amplitude and period 6.9 +/- 0.3 yr which are statistically significant at the 99.7 per cent level. We derive upper limits for secular period changes of |dP/dt| < 3x10^{-12} and |dP/dt| < 1.8x10^{-11}, respectively for V2051 Oph and V4140 Sgr. We combined our results with those in the literature to construct a diagram of the amplitude versus period of the modulation for a sample of 11 eclipsing cataclysmic variables (CVs). If the cyclical period changes are the consequence of a solar-type magnetic activity cycle in the secondary star, then magnetic activity is a widespread phenomenon in CVs, being equally common among long- and short-period systems. This gives independent evidence that the magnetic field (and activity) of the secondary stars of CVs do not disappear when they become fully convective. We also find that the fractional cycle period changes of the short-period CVs are systematically smaller than those of the long-period CVs.Comment: 9 pages, 4 postscript figures, coded with MNRAS latex style file. To appear in Monthly Notices of the Royal Astronomical Societ

Cyclic stretch increases splicing noise rate in cultured human fibroblasts

BACKGROUND: Mechanical forces are known to alter the expression of genes, but it has so far not been reported whether they may influence the fidelity of nucleus-based processes. One experimental approach permitting to address this question is the application of cyclic stretch to cultured human fibroblasts. As a marker for the precision of nucleus-based processes, the number of errors that occur during co-transcriptional splicing can then be measured. This so-called splicing noise is found at low frequency in pre-mRNA splicing. FINDINGS: The amount of splicing noise was measured by RT-qPCR of seven exon skips from the test genes AATF, MAP3K11, NF1, PCGF2, POLR2A and RABAC1. In cells treated by altered uniaxial cyclic stretching for 18 h, a uniform and significant increase of splicing noise was found for all detectable exon skips. CONCLUSION: Our data demonstrate that application of cyclic stretch to cultured fibroblasts correlates with a reduced transcriptional fidelity caused by increasing splicing noise

The Impact of Political Leaders' Profession and Education on Reforms

This paper analyzes whether the educational and professional background of a head of government matters for the implementation of market-liberalizing reforms. Employing panel data over the period 1970-2002, we present empirical evidence based on a novel data set covering profession and education of more than 500 political leaders from 73 countries. Our results show that entrepreneurs, professional scientists, and trained economists are significantly more reform oriented. Contrary, union executives tend to impede reforms. We also highlight interactions between profession and education with time in office and the political leaning of the ruling party

The Role of Media for Inflation Forecast Disagreement of Households and Professional Forecasters

This paper investigates the effects of media coverage and macroeconomic conditions on inflation forecast disagreement of German households and professional forecasters. We adopt a Bayesian learning model in which media coverage of inflation affects forecast disagreement by influencing information sets as well as predictor choice. Our empirical results show that disagreement of households depends on the content of news stories (tone) but is unaffected by reporting intensity (volume) and by the heterogeneity of story content (information entropy). Disagreement of professionals does not depend on media coverage. With respect to the influence of macroeconomic variables we provide evidence that disagreement of households and professionals primarily depends on the current rate of inflation