188 research outputs found

    Strong interaction of a turbulent spot with a shock-induced separation bubble

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    Direct numerical simulations have been conducted to study the passage of a turbulent spot through a shock-induced separation bubble. Localized blowing is used to trip the boundary layer well upstream of the shock impingement, leading to mature turbulent spots at impingement, with a length comparable to the length of the separation zone. Interactions are simulated at free stream Mach numbers of two and four, for isothermal (hot) wall boundary conditions. The core of the spot is seen to tunnel through the separation bubble, leading to a transient reattachment of the flow. Recovery times are long due to the influence of the calmed region behind the spot. The propagation speed of the trailing interface of the spot decreases during the interaction and a substantial increase in the lateral spreading of the spot was observed. A conceptual model based on the growth of the lateral shear layer near the wingtips of the spot is used to explain the change in lateral growth rat

    Global visualization and quantification of compressible vortex loops

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    The physics of compressible vortex loops generated due to the rolling up of the shear layer upon the diffraction of a shock wave from a shock tube is far from being understood, especially when shock-vortex interactions are involved. This is mainly due to the lack of global quantitative data available which characterizes the flow. The present study involves the usage of the PIV technique to characterize the velocity and vorticity of compressible vortex loops formed at incident shock Mach numbers ofM=1.54 and1.66. Another perk of the PIV technique over purely qualitative methods, which has been demonstrated in the current study, is that at the same time the results also provide a clear image of the various flow features. Techniques such as schlieren and shadowgraph rely on density gradients present in the flow and fail to capture regions of the flow influenced by the primary flow structure which would have relatively lower pressure and density. Various vortex loops, namely, square, elliptic and circular, were generated using different shape adaptors fitted to the end of the shock tube. The formation of a coaxial vortex loop with opposite circulation along with the generation of a third stronger vortex loop ahead of the primary with same circulation direction are of the interesting findings of the current study

    Mixing in Circular and Non-circular Jets in Crossflow

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    Coherent structures and mixing in the flow field of a jet in crossflow have been studied using computational (large eddy simulation) and experimental (particle image velocimetry and laser-induced fluorescence) techniques. The mean scalar fields and turbulence statistics as determined by both are compared for circular, elliptic, and square nozzles. For the latter configurations, effects of orientation are considered. The computations reveal that the distribution of a passive scalar in a cross-sectional plane can be single- or double-peaked, depending on the nozzle shape and orientation. A proper orthogonal decomposition of the transverse velocity indicates that coherent structures may be responsible for this phenomenon. Nozzles which have a single-peaked distribution have stronger modes in transverse direction. The global mixing performance is superior for these nozzle types. This is the case for the blunt square nozzle and for the elliptic nozzle with high aspect ratio. It is further demonstrated that the flow field contains large regions in which a passive scalar is transported up the mean gradient (counter-gradient transport) which implies failure of the gradient diffusion hypothesis

    Statistical analysis of the velocity field in a mechanical precessing jet flow

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    An experimental investigation of a precessing jet issuing from a mechanically rotating nozzle directed at an angle of α=45° relative to the axis of rotation is reported. Both conventional and conditional statistics of the velocity field of the jet were measured using a combined hot-wire and cold-wire (to identify any reverse flow) probe. Three distinct values (≈0.005, 0.01, and 0.02) of the precession Strouhal number Stp (≡ rotation frequency × nozzle diameter / jet exit bulk velocity) were used to assess the effect of varying Stp. The measurements reveal that the Strouhal number in general has significant influence on the entire mixing field generated by a precessing jet. The occurrence of precession at all the Strouhal numbers of investigation produces a central recirculation zone at x ≤ 7d, where x is a distance measured from the rotating nozzle exit. A critical Strouhal number, i.e., Stp,cr ≈0.008 for the present case, is identified: at Stp ≥ Stp,cr the core jet converges to the axis of rotation while at Stp ≥ Stp,cr it does not. The characteristics of the turbulent flow in the near and intermediate regions are quite different and depend upon the magnitude of Stp. The near-field region, x/d ≤ 10-15, is dominated by a regime of global precession of the entire jet. As a result, the large-scale entrainment of the ambient fluid is substantially enhanced while the fine-scale turbulent mixing is suppressed. Under the supercritical regime (i.e., Stp ≥ Stp,cr), the jet in the far field resembles some features of the nonprecessing counterpart. Nevertheless, significant differences still retain in the statistical properties. © 2005 American Institute of Physics.J. Mi and G. J. Natha

    Position of static cylinder effect on base flows

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    This paper presents the effect of the cylinder as a passive controller on the recirculation zone behind high-speed objects. The low-pressure recirculation zone was measured for base and wall region with a portable data acquisition system using sixteen solo sensors between reattachment and separation points at angles 0°, 30°, 60°, 90°. Pressure measurements were done by the transducer of National Instruments 9205 Screw Term and Data Acquisition cDAQ-1974. The measurement was done using DAQ connected to 16 solo sensors of 0-150 psi range. In a second it is capable of scanning 250 samples, followed by computing the overall average and store it on the disk. The NI LabVIEW Academic Software using DAQ through pressure sensors acquires data from all the sixteen channels and displays it on the computer screen. The experiments were carried out for overexpanded and perfectly expanded supersonic jets at Mach 2 through the C-D nozzle for area ratio 9. It is found that the control has marginally influenced the base and wall flow field when the control was placed at different positions along the imaginary line from separation to reattachment angled at 30° to the horizontal base and the flow field in the base area along the separation line is mostly independent of its locations except near the exit of the enlarged duct where the flow field is mostly influenced by the back pressure. The control seems to be strongly effective when flow expanded is ideal

    Phase 3, Randomized, 20-Month Study of the Efficacy and Safety of Bimatoprost Implant in Patients with Open-Angle Glaucoma and Ocular Hypertension (ARTEMIS 2)

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    Objective- To evaluate the intraocular pressure (IOP)-lowering efficacy and safety of 10 and 15 µg bimatoprost implant in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). Methods- This randomized, 20-month, multicenter, masked, parallel-group, phase 3 trial enrolled 528 patients with OAG or OHT and an open iridocorneal angle inferiorly in the study eye. Study eyes were administered 10 or 15 µg bimatoprost implant on day 1, week 16, and week 32, or twice-daily topical timolol maleate 0.5%. Primary endpoints were IOP and IOP change from baseline through week 12. Safety measures included treatment-emergent adverse events (TEAEs) and corneal endothelial cell density (CECD). Results- Both 10 and 15 µg bimatoprost implant met the primary endpoint of noninferiority to timolol in IOP lowering through 12 weeks. Mean IOP reductions from baseline ranged from 6.2–7.4, 6.5–7.8, and 6.1–6.7 mmHg through week 12 in the 10 µg implant, 15 µg implant, and timolol groups, respectively. IOP lowering was similar after the second and third implant administrations. Probabilities of requiring no IOP-lowering treatment for 1 year after the third administration were 77.5% (10 µg implant) and 79.0% (15 µg implant). The most common TEAE was conjunctival hyperemia, typically temporally associated with the administration procedure. Corneal TEAEs of interest (primarily corneal endothelial cell loss, corneal edema, and corneal touch) were more frequent with the 15 than the 10 µg implant and generally were reported after repeated administrations. Loss in mean CECD from baseline to month 20 was ~ 5% in 10 µg implant-treated eyes and ~ 1% in topical timolol-treated eyes. Visual field progression (change in the mean deviation from baseline) was reduced in the 10 µg implant group compared with the timolol group. Conclusions- The results corroborated the previous phase 3 study of the bimatoprost implant. The bimatoprost implant met the primary endpoint and effectively lowered IOP. The majority of patients required no additional treatment for 12 months after the third administration. The benefit-risk assessment favored the 10 over the 15 µg implant. Studies evaluating other administration regimens with reduced risk of corneal events are ongoing. The bimatoprost implant has the potential to improve adherence and reduce treatment burden in glaucoma
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