dráma 3 felvonásban - írta Don Pedro Calderon de la Barka - spanyol eredetiből forditotta Győry Vilmos, a Kisfaludy-társaság tagja - zenéjét irta Nikolits Sándor - rendező: Mándoki.

Debreczeni Szinház. Csütörtökön, 1874. márczius 19-kén adatik. Calderon drámája itt másodszor.Debreceni Egyetem Egyetemi és Nemzeti Könyvtá

Learn to Spot Phishing URLs with the Android NoPhish App

Part 3: Tools and Applications for TeachingInternational audiencePhishing is a münich issue in today’s Internet. It can have financial or personal consequences. Attacks continue to become more and more sophisticated and the advanced ones (including spear phishing) can only be detected if people carefully check URLs – be it in messages or in the address bar of the web browser. We developed a game-based smartphone app – NoPhish – to educate people in accessing, parsing and checking URLs; i.e. enabling them to distinguish between trustworthy and non-trustworthy messages and websites. Throughout several levels of the game information is provided and phishing detection is exercised in a playful manner. Several learning principles were applied and the interfaces and texts were developed in a user-centered design

Arabic Quranic Search Tool Based on Ontology

This paper reviews and classifies most of the common types of search techniques that have been applied on the Holy Quran. Then, it addresses the limitations of these methods. Additionally, this paper surveys most existing Quranic ontologies and what are their deficiencies. Finally, it explains a new search tool called: a semantic search tool for Al-Quran based on Qur’anic on-tologies. This tool will overcome all limitations in the existing Quranic search applications

Polymorphonuclear myeloid-derived suppressor cells limit antigen crosspresentation by dendritic cells in cancer

DCs are a critical component of immune responses in cancer primarily due to their ability to cross-present tumor-associated antigens. Cross-presentation by DCs in cancer is impaired, which may represent one of the obstacles for the success of cancer immunotherapies. Here, we report that polymorphonuclear myeloid-derived suppressor cells (PMN-MDSC) blocked crosspresentation by DCs without affecting direct presentation of antigens by these cells. This effect did not require direct cell-cell contact and was associated with transfer of lipids. Neutrophils (PMN) and PMN-MDSC transferred lipid to DCs equally well; however, PMN did not affect DC cross-presentation. PMN-MDSC generate oxidatively truncated lipids previously shown to be involved in impaired cross-presentation by DCs. Accumulation of oxidized lipids in PMN-MDSC was dependent on myeloperoxidase (MPO). MPO-deficient PMN-MDSC did not affect cross-presentation by DCs. Cross-presentation of tumor-associated antigens in vivo by DCs was improved in MDSC-depleted or tumor-bearing MPO-KO mice. Pharmacological inhibition of MPO in combination with checkpoint blockade reduced tumor progression in different tumor models. These data suggest MPO-driven lipid peroxidation in PMN-MDSC as a possible non–cell autonomous mechanism of inhibition of antigen cross-presentation by DCs and propose MPO as potential therapeutic target to enhance the efficacy of current immunotherapies for patients with cancer

A neuronal network of mitochondrial dynamics regulates metastasis.

The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize mitochondria to the cortical cytoskeleton and power the membrane machinery of cell movements. When expressed in tumours, SNPH inhibits the speed and distance travelled by individual mitochondria, suppresses organelle dynamics, and blocks chemotaxis and metastasis, in vivo. Tumour progression in humans is associated with downregulation or loss of SNPH, which correlates with shortened patient survival, increased mitochondrial trafficking to the cortical cytoskeleton, greater membrane dynamics and heightened cell invasion. Therefore, a SNPH network regulates metastatic competence and may provide a therapeutic target in cancer

Distributed agents for online spatial searches

As the availability and utilisation of online data blossoms, automated online searches—whether to answer a simple question, seek specific sensor readings, or investigate research in a particular domain—have raised a number of issues. Simple search tools do not access the deep web of services and online forms, and cannot handle knowledge domain-specific search problems, but specialist search tools can have a narrow domain and applicability. Some online tools circumvent these problems by putting more filter controls into the hands of users, but this leads to more complex interfaces which can raise usability barriers. A distributed approach, where specialised search agents act autonomously to find contextualised information, can provide a useful compromise between a simple, general search interface and specialist searches. This paper outlines work in progress on design and use of specialist search agents, with a case study to find public transportation bus stops within a spatial region. The approach is demonstrated with a proof of concept web interface, developed to interpret a text query to find and show bus stop locations within a named boundary by coordinating multiple online search agents. Search agents were designed to follow a common model to allow for future development of agent types, including specialist agents used in the case study to search standard open web services and extract spatial features

IRX-2, a Novel Immunotherapeutic, Enhances Functions of Human Dendritic Cells

Background: In a recent phase II clinical trial for HNSCC patients, IRX-2, a cell-derived biologic, promoted T-cell infiltration into the tumor and prolonged overall survival. Mechanisms responsible for these IRX-2-mediated effects are unknown. We hypothesized that IRX-2 enhanced tumor antigen-(TA)-specific immunity by up-regulating functions of dendritic cells (DC). Methodology/Principal Findings: Monocyte-derived DC obtained from 18 HNSCC patients and 12 healthy donors were matured using IRX-2 or a mix of TNF-α, IL-1β and IL-6 ("conv. mix"). Multicolor flow cytometry was used to study the DC phenotype and antigen processing machinery (APM) component expression. ELISPOT and cytotoxicity assays were used to evaluate tumor-reactive cytotoxic T lymphocytes (CTL). IL-12p70 and IL-10 production by DC was measured by Luminex® and DC migration toward CCL21 was tested in transwell migration assays. IRX-2-matured DC functions were compared with those of conv. mix-matured DC. IRX-2-matured DC expressed higher levels (p<0.05) of CD11c, CD40, CCR7 as well as LMP2, TAP1, TAP2 and tapasin than conv. mix-matured DC. IRX-2-matured DC migrated significantly better towards CCL21, produced more IL-12p70 and had a higher IL12p70/IL-10 ratio than conv. mix-matured DC (p<0.05 for all). IRX-2-matured DC carried a higher density of tumor antigen-derived peptides, and CTL primed with these DC mediated higher cytotoxicity against tumor targets (p<0.05) compared to the conv. mix-matured DC. Conclusion: Excellent ability of IRX-2 to induce ex vivo DC maturation in HNSCC patients explains, in part, its clinical benefits and emphasizes its utility in ex vivo maturation of DC generated for therapy. © 2013 Schilling et al