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Iterative ('Turbo') Multiuser Detectors For Impulse Radio Systems

In recent years, there has been a growing interest in multiple access communication systems that spread their transmitted energy over very large bandwidths. These systems, which are referred to as ultra wide-band (UWB) systems, have various advantages over narrow-band and conventional wide-band systems. The importance of multiuser detection for achieving high data or low bit error rates in these systems has already been established in several studies. This paper presents iterative ('turbo') multiuser detection for impulse radio (IR) UWB systems over multipath channels. While this approach is demonstrated for UWB signals, it can also be used in other systems that use similar types of signaling. When applied to the type of signals used by UWB systems, the complexity of the proposed detector can be quite low. Also, two very low complexity implementations of the iterative multiuser detection scheme are proposed based on Gaussian approximation and soft interference cancellation. The performance of these detectors is assessed using simulations that demonstrate their favorable properties.Comment: To appear in IEEE Transactions on Wireless Communication

Web platform vs in-person genetic counselor for return of carrier results from exome sequencing a randomized clinical trial

© 2018 American Medical Association. All rights reserved. IMPORTANCE A critical bottleneck in clinical genomics is the mismatch between large volumes of results and the availability of knowledgeable professionals to return them. OBJECTIVE To test whether a web-based platform is noninferior to a genetic counselor for educating patients about their carrier results from exome sequencing. DESIGN, SETTING, AND PARTICIPANTS A randomized noninferiority trial conducted in a longitudinal sequencing cohort at the National Institutes of Health from February 5, 2014, to December 16, 2016, was used to compare the web-based platform with a genetic counselor. Among the 571 eligible participants, 1 to 7 heterozygous variants were identified in genes that cause a phenotype that is recessively inherited. Surveys were administered after cohort enrollment, immediately following trial education, and 1 month and 6 months later to primarily healthy postreproductive participants who expressed interest in learning their carrier results. Both intention-to-treat and per-protocol analyses were applied. INTERVENTIONS A web-based platform that integrated education on carrier results with personal test results was designed to directly parallel disclosure education by a genetic counselor. The sessions took a mean (SD) time of 21 (10.6), and 27 (9.3) minutes, respectively. MAIN OUTCOMES AND MEASURES The primary outcomes and noninferiority margins (dNI) were knowledge (0 to 8, dNI = -1), test-specific distress (0 to 30, dNI = +1), and decisional conflict (15 to 75, dNI = +6). RESULTS After 462 participants (80.9%) provided consent and were randomized, all but 3 participants (n = 459) completed surveys following education and counseling; 398 (86.1%) completed 1-month surveys and 392 (84.8%) completed 6-month surveys. Participants were predominantly well-educated, non-Hispanic white, married parents; mean (SD) age was 63 (63.1) years and 246 (53.6%) were men. The web platform was noninferior to the genetic counselor on outcomes assessed at 1 and 6 months: knowledge (mean group difference, -0.18; lower limit of 97.5% CI, -0.63; dNI = -1), test-specific distress (median group difference, 0; upper limit of 97.5% CI, 0; dNI = +1), and decisional conflict about choosing to learn results (mean group difference, 1.18; upper limit of 97.5% CI, 2.66; dNI = +6). There were no significant differences between the genetic counselors and web-based platform detected between modes of education delivery in disclosure rates to spouses (151 vs 159; relative risk [RR], 1.04; 95% CI, 0.64-1.69; P > .99), children (103 vs 117; RR, 1.07; 95% CI, 0.85-1.36; P = .59), or siblings (91 vs 78; RR, 1.17; 95% CI, 0.94-1.46; P = .18). CONCLUSIONS AND RELEVANCE This trial demonstrates noninferiority of web-based return of carrier results among postreproductive, mostly healthy adults. Replication studies among younger and more diverse populations are needed to establish generalizability. Yet return of results via a web-based platform may be sufficient for subsets of test results, reserving genetic counselors for return of results with a greater health threat

Exotic leptoquarks from superstring derived models

The H1 and ZEUS collaborations have recently reported a significant excess of events at high $Q^2$ in positron-proton collisions. While there exists insufficient data to conclusively determine the origin of this excess, one possibility is that it is due to a new leptoquark at mass scale around 200 GeV. We examine the type of leptoquark states that exist in superstring derived standard-like models, and show that, while these models may contain the standard leptoquark states which exist in Grand Unified Theories, they also generically contain new and exotic leptoquark states with fractional lepton number, $\pm1/2$. In contrast to the traditional GUT-type leptoquark states, the couplings of the exotic leptoquarks to the Standard Model states are generated after the breaking of $U(1)_{B-L}$. This important feature of the exotic leptoquark states may result in local discrete symmetries which forbid some of the undesired leptoquark couplings. We examine these couplings in several models and study the phenomenological implications. The flavor symmetries of the superstring models are found to naturally suppress leptoquark flavor changing processes.Comment: 28 pages. Standard Latex. Final version to appear in Nuclear Physics B. Minor changes. References adde

Leptonic CP Violation in Supersymmetric Standard Model

We point out the possibility of spontaneous and hard CP-violation in the scalar potential of R-parity broken supersymmetric Standard Model. The existence of spontaneous CP-violation depends crucially on the R-parity breaking terms in the superpotential and, in addition, on the choice of the soft supersymmetry breaking terms. Unlike in theories with R-parity conservation, it is natural, in the context of the present model, for the sneutrinos to acquire (complex) vacuum expectation values. In the context of this model we examine here the global implications, like the strength of the CP-violating interactions and the neutrino masses.Comment: REVTEX, 15 page

Cosmological constraints on R-parity violation from neutrino decay

If the neutrino mass is non-zero, as hinted by several experiments, then R-parity-violating supersymmetric Yukawa couplings can drive a heavy neutrino decay into lighter states. The heavy neutrino may either decay radiatively into a lighter neutrino, or it may decay into three light neutrinos through a Z-mediated penguin. For a given mass of the decaying neutrino, we calculate its lifetime for the various modes, each mode requiring certain pairs of R-parity-violating couplings be non-zero. We then check whether the calculated lifetimes fall in zones allowed or excluded by cosmological requirements. For the latter case, we derive stringent new constraints on the corresponding products of R-parity-violating couplings for given values of the decaying neutrino mass.Comment: 13 pages, Latex, uses axodraw.sty; version to appear in Physical Review

Recycling universe

If the effective cosmological constant is non-zero, our observable universe may enter a stage of exponential expansion. In such case, regions of it may tunnel back to the false vacuum of an inflaton scalar field, and inflation with a high expansion rate may resume in those regions. An ``ideal'' eternal observer would then witness an infinite succession of cycles from false vacuum to true, and back. Within each cycle, the entire history of a hot universe would be replayed. If there were several minima of the inflaton potential, our ideal observer would visit each one of these minima with a frequency which depends on the shape of the potential. We generalize the formalism of stochastic inflation to analyze the global structure of the universe when this `recycling' process is taken into account.Comment: 43 pages, 10 figure

How generic is cosmic string formation in SUSY GUTs

We study cosmic string formation within supersymmetric grand unified theories. We consider gauge groups having a rank between 4 and 8. We examine all possible spontaneous symmetry breaking patterns from the GUT down to the standard model gauge group. Assuming standard hybrid inflation, we select all the models which can solve the GUT monopole problem, lead to baryogenesis after inflation and are consistent with proton lifetime measurements. We conclude that in all acceptable spontaneous symmetry breaking schemes, cosmic string formation is unavoidable. The strings which form at the end of inflation have a mass which is proportional to the inflationary scale. Sometimes, a second network of strings form at a lower scale. Models based on gauge groups which have rank greater than 6 can lead to more than one inflationary era; they all end by cosmic string formation.Comment: 31 pages, Latex, submitted to PR

Inflation in Supersymmetric Unified Theories

We construct supersymmetric unified models which automatically lead to a period of inflation. The models all involve a U(1) symmetry which does not belong to the MSSM. We consider three different types of models depending on whether this extra U(1) is the subgroup of a non abelian gauge group, is a U(1) factor belonging to the visible sector or is a U(1) factor belonging to the hidden sector. Depending on the structure of the unified theory, on the spontaneous symmetry breaking pattern and on whether we have global or local supersymmetry, inflation may be driven by the non-vanishing vacuum expectation value of a F-term or by that of a D-term. In both scenarios cosmic strings form at the end of inflation, and they have different properties in each model. Both inflation and cosmic strings contribute to the CMBR temperature anisotropies. We show that the strings contribute to the $C_l$'s up to the level of 75 %. Hence the contribution from strings to the CMBR and to the density perturbations in the early Universe which lead to structure formation cannot be neglected. We also discuss a very interesting class of models which involve a $U(1)_{B-L}$ gauge symmetry.Comment: 22 pages, uses Revte