Investigating the relationship between interoceptive accuracy, interoceptive awareness, and emotional susceptibility

Interoception, the sense of the physiological condition of the body, provides a basis for subjective feelings and emotions. Anterior insular cortex activity represents the state of the body and varies according to personality traits, such as emotional susceptibility (ES)-the tendency to experience feelings of discomfort and vulnerability when facing emotionally-laden stimuli. The accuracy of perceiving one's own bodily signals, or interoceptive accuracy (IAc), can be assessed with the heartbeat perception task (HPT), which is the experimental measure used by most of the existing research on interoception. However, IAc is only one facet of interoception. Interoceptive awareness (IAw) is the conscious perception of sensations from inside the body, such as heart beat, respiration, satiety, and the autonomic nervous system sensations related to emotions, which create the sense of the physiological condition of the body. We developed an Italian version of the recent self-report Multidimensional Assessment of Interoceptive Awareness (MAIA), tested its psychometric properties (reliability, dimensionality, and construct validity), and examined its relationship to ES, as assessed using the Emotional Susceptibility Scale, in a sample (n = 321) of healthy Italian psychology students (293 females, mean age: 20.5 years). In a subgroup of females (n = 135), we measured IAc with the HPT. We used a series of correlation/regression analyses to examine the complex interplay between the three constructs. We provide further evidence for a substantial independence of the IAc and IAw measures, confirming previous reports and current theoretical models that differentiate between IAc and IAw. Our analyses elucidate the complex relationship between distinct dimensions of IAw and ES, highlighting the need for continued efforts to shed more light on this topic

Entanglement and particle correlations of Fermi gases in harmonic traps

We investigate quantum correlations in the ground state of noninteracting Fermi gases of N particles trapped by an external space-dependent harmonic potential, in any dimension. For this purpose, we compute one-particle correlations, particle fluctuations and bipartite entanglement entropies of extended space regions, and study their large-N scaling behaviors. The half-space von Neumann entanglement entropy is computed for any dimension, obtaining S_HS = c_l N^(d-1)/d ln N, analogously to homogenous systems, with c_l=1/6, 1/(6\sqrt{2}), 1/(6\sqrt{6}) in one, two and three dimensions respectively. We show that the asymptotic large-N relation S_A\approx \pi^2 V_A/3, between the von Neumann entanglement entropy S_A and particle variance V_A of an extended space region A, holds for any subsystem A and in any dimension, analogously to homogeneous noninteracting Fermi gases.Comment: 15 pages, 22 fig

Quantum dynamics and entanglement of a 1D Fermi gas released from a trap

We investigate the entanglement properties of the nonequilibrium dynamics of one-dimensional noninteracting Fermi gases released from a trap. The gas of N particles is initially in the ground state within hard-wall or harmonic traps, then it expands after dropping the trap. We compute the time dependence of the von Neumann and Renyi entanglement entropies and the particle fluctuations of spatial intervals around the original trap, in the limit of a large number N of particles. The results for these observables apply to one-dimensional gases of impenetrable bosons as well. We identify different dynamical regimes at small and large times, depending also on the initial condition, whether it is that of a hard-wall or harmonic trap. In particular, we analytically show that the expansion from hard-wall traps is characterized by the asymptotic small-time behavior $S \approx (1/3)\ln(1/t)$ of the von Neumann entanglement entropy, and the relation $S\approx \pi^2 V/3$ where V is the particle variance, which are analogous to the equilibrium behaviors whose leading logarithms are essentially determined by the corresponding conformal field theory with central charge $c=1$. The time dependence of the entanglement entropy of extended regions during the expansion from harmonic traps shows the remarkable property that it can be expressed as a global time-dependent rescaling of the space dependence of the initial equilibrium entanglement entropy.Comment: 19 pages, 18 fig

Recursion relations for Hylleraas three-electron integral

Recursion relations for Hylleraas three-electron integral are obtained in a closed form by using integration by parts identities. Numerically fast and well stable algorithm for the calculation of the integral with high powers of inter-electronic coordinates is presented.Comment: 12 pages, requires RevTeX4, submitted to Phys. Rev.

The uniformly frustrated two-dimensional XY model in the limit of weak frustration

We consider the two-dimensional uniformly frustrated XY model in the limit of small frustration, which is equivalent to an XY system, for instance a Josephson junction array, in a weak uniform magnetic field applied along a direction orthogonal to the lattice. We show that the uniform frustration (equivalently, the magnetic field) destabilizes the line of fixed points which characterize the critical behaviour of the XY model for T <= T_{KT}, where T_{KT} is the Kosterlitz-Thouless transition temperature: the system is paramagnetic at any temperature for sufficiently small frustration. We predict the critical behaviour of the correlation length and of gauge-invariant magnetic susceptibilities as the frustration goes to zero. These predictions are fully confirmed by the numerical simulations.Comment: 12 page

Acute and long-term effects of ACE inhibition on renal haemodynamics in glomerular and interstitial nephropathies

Background Angiotensin-converting enzyme (ACE) inhibitors are the drugs of choice for the treatment of hypertension in patients with non-diabetic nephropathies. However, not every trial has reported better results with ACE inhibitors (ACE-I) than with other drugs. This study investigates whether the acute and chronic effects of ACE inhibition on renal and glomerular haemodynamics are similar in glomerular and interstitial nephropathies. Methods We studied 20 hypertensive patients, on their usual diet, with mild-to-moderate chronic renal failure secondary to non-diabetic nephropathy. After a three-week wash out period, we determined plasma clearances of para-amino-hippurate and inulin before, and after acute oral administration of either enalapril or ramipril. This same test was carried out after one and two years of treatment with the same drug. Results Acute ACE inhibition causes a decrease of renal perfusion, glomerular filtration and pressure with an increase of afferent resistances. Long-term ACE inhibition is associated only with a decrease in renal perfusion, with a non-significant tendency to higher filtration fraction and lower afferent resistances. All the renal haemodynamic modifications mentioned above are present only in patients with glomerular diseases. Conclusions Renal and glomerular haemodynamic responses are not similar after acute and chronic ACE inhibition. Only patients with glomerular diseases show acute or long-term responses to ACE inhibition

Probing for local activity-related modulation of the infrared backscattering of the brain cortex

The possibility to measure the metabolic activity of the brain cortex, with submillimeter spatial and subsecond temporal resolution, would open up enticing scenarios in addressing basic issues on the relation between different structural components of brain signal processing, and in providing an operational pathway to interaction with (dis)functional signal patterns. In the present article, we report the description of a simple system that allows the detection of the minute changes that occur in the optical backscattering of the cortex as a metabolic response to external stimuli. The simplicity of the system is compatible with scalability to an implantable probe. We validate the system on an animal model, and we propose an algorithm to extract meaningful data from the measured signal. We thus show the detection of individual haemodynamic cortical responses to individual stimulation events, and we provide operational considerations on the signal structure

Static and dynamic structure factors in three-dimensional randomly diluted Ising models

We consider the three-dimensional randomly diluted Ising model and study the critical behavior of the static and dynamic spin-spin correlation functions (static and dynamic structure factors) at the paramagnetic-ferromagnetic transition in the high-temperature phase. We consider a purely relaxational dynamics without conservation laws, the so-called model A. We present Monte Carlo simulations and perturbative field-theoretical calculations. While the critical behavior of the static structure factor is quite similar to that occurring in pure Ising systems, the dynamic structure factor shows a substantially different critical behavior. In particular, the dynamic correlation function shows a large-time decay rate which is momentum independent. This effect is not related to the presence of the Griffiths tail, which is expected to be irrelevant in the critical limit, but rather to the breaking of translational invariance, which occurs for any sample and which, at the critical point, is not recovered even after the disorder average.Comment: 43 page

Detection of activating estrogen receptor gene (ESR1) mutations in single circulating tumor cells

Purpose: Early detection is essential for treatment plans before onset of metastatic disease. Our purpose was to demonstrate feasibility to detect and monitor estrogen receptor 1 (ESR1) gene mutations at the single circulating tumor cell (CTC) level in metastatic breast cancer (MBC). Experimental Design: We used a CTC molecular characterization approach to investigate heterogeneity of 14 hotspot mutations in ESR1 and their correlation with endocrine resistance. Combining the CellSearch and DEPArray technologies allowed recovery of 71 single CTCs and 12 WBC from 3 ER-positive MBC patients. Forty CTCs and 12 WBC were subjected to whole genome amplification by MALBAC and Sanger sequencing. Results: Among 3 selected patients, 2 had an ESR1 mutation (Y537). One showed two different ESR1 variants in a single CTC and another showed loss of heterozygosity. All mutations were detected in matched cell-free DNA (cfDNA). Furthermore, one had 2 serial blood samples analyzed and showed changes in both cfDNA and CTCs with emergence of mutations in ESR1 (Y537S and T570I), which has not been reported previously. Conclusions: CTCs are easily accessible biomarkers to monitor and better personalize management of patients with previously demonstrated ER-MBC who are progressing on endocrine therapy. We showed that single CTC analysis can yield important information on clonal heterogeneity and can be a source of discovery of novel and potential driver mutations. Finally, we also validate a workflow for liquid biopsy that will facilitate early detection of ESR1 mutations, the emergence of endocrine resistance and the choice of further target therapy. ©2017 AACR