265 research outputs found
Andreev bound states in high- superconducting junctions
The formation of bound states at surfaces of materials with an energy gap in
the bulk electron spectrum is a well known physical phenomenon. At
superconductor surfaces, quasiparticles with energies inside the
superconducting gap may be trapped in bound states in quantum wells,
formed by total reflection against the vacuum and total Andreev reflection
against the superconductor. Since an electron reflects as a hole and sends a
Cooper pair into the superconductor, the surface states give rise to resonant
transport of quasiparticle and Cooper pair currents, and may be observed in
tunneling spectra. In superconducting junctions, these surface states may
hybridize and form bound Andreev states, trapped between the superconducting
electrodes. In d-wave superconductors, the order parameter changes sign under
rotation and, as a consequence, Andreev reflection may lead to the
formation of zero energy quasiparticle bound states, midgap states (MGS). The
formation of MGS is a robust feature of d-wave superconductivity and provides a
unified framework for many important effects which will be reviewed: large
Josephson current, low-temperature anomaly of the critical Josephson current,
-junction behavior, junction crossover with temperature,
zero-bias conductance peaks, paramagnetic currents, time reversal symmetry
breaking, spontaneous interface currents, and resonance features in subgap
currents. Taken together these effects, when observed in experiments, provide
proof for d-wave superconductivity in the cuprates.Comment: 52 pages, 20 figures. Review article under consideration for
publication in Superconductor Science and Technolog
Atom chip based generation of entanglement for quantum metrology
Atom chips provide a versatile `quantum laboratory on a microchip' for
experiments with ultracold atomic gases. They have been used in experiments on
diverse topics such as low-dimensional quantum gases, cavity quantum
electrodynamics, atom-surface interactions, and chip-based atomic clocks and
interferometers. A severe limitation of atom chips, however, is that techniques
to control atomic interactions and to generate entanglement have not been
experimentally available so far. Such techniques enable chip-based studies of
entangled many-body systems and are a key prerequisite for atom chip
applications in quantum simulations, quantum information processing, and
quantum metrology. Here we report experiments where we generate multi-particle
entanglement on an atom chip by controlling elastic collisional interactions
with a state-dependent potential. We employ this technique to generate
spin-squeezed states of a two-component Bose-Einstein condensate and show that
they are useful for quantum metrology. The observed 3.7 dB reduction in spin
noise combined with the spin coherence imply four-partite entanglement between
the condensate atoms and could be used to improve an interferometric
measurement by 2.5 dB over the standard quantum limit. Our data show good
agreement with a dynamical multi-mode simulation and allow us to reconstruct
the Wigner function of the spin-squeezed condensate. The techniques
demonstrated here could be directly applied in chip-based atomic clocks which
are currently being set up
Nonlinear atom interferometer surpasses classical precision limit
Interference is fundamental to wave dynamics and quantum mechanics. The
quantum wave properties of particles are exploited in metrology using atom
interferometers, allowing for high-precision inertia measurements [1, 2].
Furthermore, the state-of-the-art time standard is based on an interferometric
technique known as Ramsey spectroscopy. However, the precision of an
interferometer is limited by classical statistics owing to the finite number of
atoms used to deduce the quantity of interest [3]. Here we show experimentally
that the classical precision limit can be surpassed using nonlinear atom
interferometry with a Bose-Einstein condensate. Controlled interactions between
the atoms lead to non-classical entangled states within the interferometer;
this represents an alternative approach to the use of non-classical input
states [4-8]. Extending quantum interferometry [9] to the regime of large atom
number, we find that phase sensitivity is enhanced by 15 per cent relative to
that in an ideal classical measurement. Our nonlinear atomic beam splitter
follows the "one-axis-twisting" scheme [10] and implements interaction control
using a narrow Feshbach resonance. We perform noise tomography of the quantum
state within the interferometer and detect coherent spin squeezing with a
squeezing factor of -8.2dB [11-15]. The results provide information on the
many-particle quantum state, and imply the entanglement of 170 atoms [16]
Recommended from our members
Sources and mixing state of size-resolved elemental carbon particles in a European megacity: Paris
An Aerosol Time-Of-Flight Mass Spectrometer (ATOFMS) was deployed to investigate the size-resolved chemical composition of single particles at an urban background site in Paris, France, as part of the MEGAPOLI winter campaign in January/February 2010. ATOFMS particle counts were scaled to match coincident Twin Differential Mobility Particle Sizer (TDMPS) data in order to generate hourly size-resolved mass concentrations for the single particle classes observed. The total scaled ATOFMS particle mass concentration in the size range 150–1067 nm was found to agree very well with the sum of concurrent High-Resolution Time-of-Flight Aerosol Mass Spectrometer (HR-ToF-AMS) and Multi-Angle Absorption Photometer (MAAP) mass concentration measurements of organic carbon (OC), inorganic ions and black carbon (BC) (R2 = 0.91). Clustering analysis of the ATOFMS single particle mass spectra allowed the separation of elemental carbon (EC) particles into four classes: (i) EC attributed to biomass burning (ECbiomass), (ii) EC attributed to traffic (ECtraffic), (iii) EC internally mixed with OC and ammonium sulfate (ECOCSOx), and (iv) EC internally mixed with OC and ammonium nitrate (ECOCNOx). Average hourly mass concentrations for EC-containing particles detected by the ATOFMS were found to agree reasonably well with semi-continuous quantitative thermal/optical EC and optical BC measurements (r2 = 0.61 and 0.65–0.68 respectively, n = 552). The EC particle mass assigned to fossil fuel and biomass burning sources also agreed reasonably well with BC mass fractions assigned to the same sources using seven-wavelength aethalometer data (r2 = 0.60 and 0.48, respectively, n = 568). Agreement between the ATOFMS and other instrumentation improved noticeably when a period influenced by significantly aged, internally mixed EC particles was removed from the intercomparison. 88% and 12% of EC particle mass was apportioned to fossil fuel and biomass burning respectively using the ATOFMS data compared with 85% and 15% respectively for BC estimated from the aethalometer model. On average, the mass size distribution for EC particles is bimodal; the smaller mode is attributed to locally emitted, mostly externally mixed EC particles, while the larger mode is dominated by aged, internally mixed ECOCNOx particles associated with continental transport events. Periods of continental influence were identified using the Lagrangian Particle Dispersion Model (LPDM) "FLEXPART". A consistent minimum between the two EC mass size modes was observed at approximately 400 nm for the measurement period. EC particles below this size are attributed to local emissions using chemical mixing state information and contribute 79% of the scaled ATOFMS EC particle mass, while particles above this size are attributed to continental transport events and contribute 21% of the EC particle mass. These results clearly demonstrate the potential benefit of monitoring size-resolved mass concentrations for the separation of local and continental EC emissions. Knowledge of the relative input of these emissions is essential for assessing the effectiveness of local abatement strategies
Recommended from our members
Quantitative determination of carbonaceous particle mixing state in Paris using single-particle mass spectrometer and aerosol mass spectrometer measurements
Single-particle mixing state information can be a powerful tool for assessing the relative impact of local and regional sources of ambient particulate matter in urban environments. However, quantitative mixing state data are challenging to obtain using single-particle mass spectrometers. In this study, the quantitative chemical composition of carbonaceous single particles has been determined using an aerosol time-of-flight mass spectrometer (ATOFMS) as part of the MEGAPOLI 2010 winter campaign in Paris, France. Relative peak areas of marker ions for elemental carbon (EC), organic aerosol (OA), ammonium, nitrate, sulfate and potassium were compared with concurrent measurements from an Aerodyne high-resolution time-of-flight aerosol mass spectrometer (HR-ToF-AMS), a thermal–optical OCEC analyser and a particle into liquid sampler coupled with ion chromatography (PILS-IC). ATOFMS-derived estimated mass concentrations reproduced the variability of these species well (R2 = 0.67–0.78), and 10 discrete mixing states for carbonaceous particles were identified and quantified. The chemical mixing state of HR-ToF-AMS organic aerosol factors, resolved using positive matrix factorisation, was also investigated through comparison with the ATOFMS dataset. The results indicate that hydrocarbon-like OA (HOA) detected in Paris is associated with two EC-rich mixing states which differ in their relative sulfate content, while fresh biomass burning OA (BBOA) is associated with two mixing states which differ significantly in their OA / EC ratios. Aged biomass burning OA (OOA2-BBOA) was found to be significantly internally mixed with nitrate, while secondary, oxidised OA (OOA) was associated with five particle mixing states, each exhibiting different relative secondary inorganic ion content. Externally mixed secondary organic aerosol was not observed. These findings demonstrate the range of primary and secondary organic aerosol mixing states in Paris. Examination of the temporal behaviour and chemical composition of the ATOFMS classes also enabled estimation of the relative contribution of transported emissions of each chemical species and total particle mass in the size range investigated. Only 22% of the total ATOFMS-derived particle mass was apportioned to fresh, local emissions, with 78% apportioned to regional/continental-scale emissions
Camparison of the Hanbury Brown-Twiss effect for bosons and fermions
Fifty years ago, Hanbury Brown and Twiss (HBT) discovered photon bunching in
light emitted by a chaotic source, highlighting the importance of two-photon
correlations and stimulating the development of modern quantum optics . The
quantum interpretation of bunching relies upon the constructive interference
between amplitudes involving two indistinguishable photons, and its additive
character is intimately linked to the Bose nature of photons. Advances in atom
cooling and detection have led to the observation and full characterisation of
the atomic analogue of the HBT effect with bosonic atoms. By contrast, fermions
should reveal an antibunching effect, i.e., a tendency to avoid each other.
Antibunching of fermions is associated with destructive two-particle
interference and is related to the Pauli principle forbidding more than one
identical fermion to occupy the same quantum state. Here we report an
experimental comparison of the fermion and the boson HBT effects realised in
the same apparatus with two different isotopes of helium, 3He (a fermion) and
4He (a boson). Ordinary attractive or repulsive interactions between atoms are
negligible, and the contrasting bunching and antibunching behaviours can be
fully attributed to the different quantum statistics. Our result shows how
atom-atom correlation measurements can be used not only for revealing details
in the spatial density, or momentum correlations in an atomic ensemble, but
also to directly observe phase effects linked to the quantum statistics in a
many body system. It may thus find applications to study more exotic situations
>.Comment: Nature 445, 402 (2007). V2 includes the supplementary informatio
What if cancer survival in Britain were the same as in Europe: how many deaths are avoidable?
OBJECTIVE: To estimate the number of deaths among cancer patients diagnosed in Great Britain that would be avoidable within 5 years of diagnosis if the mean (or highest) survival in Europe for patients diagnosed during 1985-1989, 1990-1994 and 1995-1999 were achieved. DESIGN: Five-year relative survival for cancers in Great Britain compared with that from other countries in the EUROCARE-2, -3 and -4 studies. Calculation of excess deaths (those more than expected from mortality in the general population) that would be avoidable among cancer patients in Britain if relative survival were the same as in Europe. SETTING: Great Britain (England, Wales, Scotland) and 13 other European countries. SUBJECTS: 2.8 million adults diagnosed in Britain with 1 of 39 cancers during 1985-1989 (followed up to 1994), 1990-1994 (followed up to 1999) and 1995-1999 (followed up to 2003). MAIN OUTCOME MEASURE: Annual number of avoidable deaths within 5 years of diagnosis. Percentage of the excess (cancer-related) deaths among cancer patients that would be avoidable. RESULTS: Compared with the mean European 5-year relative survival, the largest numbers of avoidable deaths for patients diagnosed during 1985-1989 were for cancers of the breast (about 18% of the excess mortality from this cancer, 7541 deaths), prostate (14%, 4285), colon (9%, 4090), stomach (8%, 3483) and lung (2%, 3548). For 1990-1994, the largest numbers of avoidable deaths were for cancers of the prostate (20%, 7335), breast (15%, 6165), colon (9%, 4376), stomach (9%, 3672), lung (2%, 3735) and kidney (22%, 2644). For 1995-1999, most of the avoidable deaths were for cancers of the prostate (17%, 5758), breast (15%, 5475), lung (3%, 4923), colon (10%, 4295), stomach (9%, 3137) and kidney (21%, 2686).Overall, some 6600-7500 premature deaths would have been avoided each year among cancer patients diagnosed in Britain during 1985-1999 if the mean survival in Europe had been achieved. This represents 6-7% of cancer-related mortality. Compared with the highest European survival, avoidable premature mortality among cancer patients fell from about 12 800 deaths a year (12.2% of cancer-related mortality) to about 11 400 deaths a year (10.6%) over the same period.A large component of the avoidable mortality is due to prostate cancer: excluding this cancer from comparison with the European mean survival reduces the annual number of avoidable deaths by 1000-1500, and the percentage of excess mortality by up to 1%. Compared with the highest survival, the annual number of avoidable deaths would be 1500-2000 fewer, and 1-2% lower as a percentage of excess mortality, but the overall trend in avoidable premature mortality among cancer patients would be similar, falling from 11.4% (1985-1989) to 10.3% (1990-1994) and 9.7% for those diagnosed during 1995-1999.For several cancers, survival in Britain was slightly higher than the mean survival in Europe; this represented some 110-180 premature deaths avoided each year during the period 1985-2003. CONCLUSIONS: Avoidable premature mortality among cancer patients diagnosed in Britain during 1985-1999 has represented 6-7% of cancer-related mortality compared with the mean survival in Europe. Compared with the highest levels of survival in Europe, the reduction from 12.2% to 10.6% of cancer-related mortality reflects small but steady progress over the period 1985-2003
UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells
UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is a multi-domain protein associated with cellular proliferation and epigenetic regulation. The UHRF1 binds to methylated CpG dinucleotides and recruits transcriptional repressors DNA methyltransferase 1 (DNMT1) and histone deacetylase 1 (HDAC1) through its distinct domains. However, the molecular basis of UHRF1-mediated transcriptional regulation via chromatin modifications is yet to be fully understood. Here we show that UHRF1 binds histone lysine methyltransferase G9a, and both are co-localized in the nucleus in a cell-cycle-dependent manner. Concurrent with the cell-cycle progression, gradual deposition of UHRF1 and G9a was observed, which mirrored H3K9me2 accumulation on chromatin. Murine Uhrf1-null embryonic stem (ES) cells displayed a reduced amount of G9a and H3K9me2 on chromatin. UHRF1 recruited and cooperated with G9a to inhibit the p21 promoter activity, which correlated with the elevated p21 protein level in both human UHRF1 siRNA-transfected HeLa cells and murine Uhrf1-null ES cells. Furthermore, endogenous p21 promoter remained bound to UHRF1, G9a, DNMT1 and HDAC1, and knockdown of UHRF1 impaired the association of all three chromatin modifiers with the promoter. Thus, our results suggest that UHRF1 may serve as a focal point of transcriptional regulation mediated by G9a and other chromatin modification enzymes
- …