CSNE: Conditional Signed Network Embedding

Signed networks are mathematical structures that encode positive and negative relations between entities such as friend/foe or trust/distrust. Recently, several papers studied the construction of useful low-dimensional representations (embeddings) of these networks for the prediction of missing relations or signs. Existing embedding methods for sign prediction generally enforce different notions of status or balance theories in their optimization function. These theories, however, are often inaccurate or incomplete, which negatively impacts method performance. In this context, we introduce conditional signed network embedding (CSNE). Our probabilistic approach models structural information about the signs in the network separately from fine-grained detail. Structural information is represented in the form of a prior, while the embedding itself is used for capturing fine-grained information. These components are then integrated in a rigorous manner. CSNE's accuracy depends on the existence of sufficiently powerful structural priors for modelling signed networks, currently unavailable in the literature. Thus, as a second main contribution, which we find to be highly valuable in its own right, we also introduce a novel approach to construct priors based on the Maximum Entropy (MaxEnt) principle. These priors can model the \emph{polarity} of nodes (degree to which their links are positive) as well as signed \emph{triangle counts} (a measure of the degree structural balance holds to in a network). Experiments on a variety of real-world networks confirm that CSNE outperforms the state-of-the-art on the task of sign prediction. Moreover, the MaxEnt priors on their own, while less accurate than full CSNE, achieve accuracies competitive with the state-of-the-art at very limited computational cost, thus providing an excellent runtime-accuracy trade-off in resource-constrained situations

Psychopathology in Huntington's disease

Dit proefschrift begint met een overzichtsartikel van oorspronkelijke onderzoek naar psychopathologie bij mutatiedragers voor de ziekte van Huntington. Aansluitend worden de resultaten van een cohortstudie naar de aanwezigheid en ernst van psychopathologie bij mensen met de ziekte van Huntington in verschillende ziektestadia en bij eerstegraads niet-dragers beschreven.UBL - phd migration 201

Modeling Life as Cognitive Info-Computation

This article presents a naturalist approach to cognition understood as a network of info-computational, autopoietic processes in living systems. It provides a conceptual framework for the unified view of cognition as evolved from the simplest to the most complex organisms, based on new empirical and theoretical results. It addresses three fundamental questions: what cognition is, how cognition works and what cognition does at different levels of complexity of living organisms. By explicating the info-computational character of cognition, its evolution, agent-dependency and generative mechanisms we can better understand its life-sustaining and life-propagating role. The info-computational approach contributes to rethinking cognition as a process of natural computation in living beings that can be applied for cognitive computation in artificial systems.Comment: Manuscript submitted to Computability in Europe CiE 201

Оцінювання закону розподілу величини збитків унаслідок реалізації загрози “Відсутність або недостатність технічного обслуговування”

The problem of estimation of size distribution law of damages in the absence or insufficient sample size of the universe and the initial data suggested approach to finding the most expected value of losses due to information security threats

Crystal Structure of 3-Hydroxybenzoate 6-Hydroxylase Uncovers Lipid-assisted Flavoprotein Strategy for Regioselective Aromatic Hydroxylation.

3-Hydroxybenzoate 6-hydroxylase (3HB6H) from Rhodococcus jostii RHA1 is a dimeric flavoprotein that catalyzes the NADH- and oxygen-dependent para-hydroxylation of 3-hydroxybenzoate to 2,5-dihydroxybenzoate. In this study, we report the crystal structure of 3HB6H as expressed in Escherichia coli. The overall fold of 3HB6H is similar to that of p-hydroxybenzoate hydroxylase and other flavoprotein aromatic hydroxylases. Unexpectedly, a lipid ligand is bound to each 3HB6H monomer. Mass spectral analysis identified the ligand as a mixture of phosphatidylglycerol and phosphatidylethanolamine. The fatty acid chains occupy hydrophobic channels that deeply penetrate into the interior of the substrate-binding domain of each subunit, whereas the hydrophilic part is exposed on the protein surface, connecting the dimerization domains via a few interactions. Most remarkably, the terminal part of a phospholipid acyl chain is directly involved in the substrate-binding site. Co-crystallized chloride ion and the crystal structure of the H213S variant with bound 3-hydroxybenzoate provide hints about oxygen activation and substrate hydroxylation. Essential roles are played by His-213 in catalysis and Tyr-105 in substrate binding. This phospholipid-assisted strategy to control regioselective aromatic hydroxylation is of relevance for optimization of flavin-dependent biocatalysts

A review on equipment protection and system protection relay in power system

Power system equipment is configured and connected together with multiple voltage levels in existing electrical power system. There are varieties of electrical equipment obtainable in the power system predominantly from generation side up to the distribution side. Consequently, appropriate protections must be apt to prevent inessential disturbances that lead to voltage instability, voltage collapse and sooner a total blackout took place in the power system. The understanding of each component on the system protection is critical. This is due to any abnormal condition and failure can be analyzed and solved effectively due to the rapid changing and development on the power system network. Therefore, the enhancement of power quality can be achieved by sheltering the equipment with protection relay in power system. Moreover, the design of a systematic network is crucial for the system protection itself. Several types of protective equipment and protection techniques are taken into consideration in this paper. Hence, the existing accessible types and methods of system protection in the power system network are reviewed

THE EUROPEAN PHYSICAL JOURNAL D High-resolution spectroscopy on ground-state transitions of samarium-I

Abstract. A high resolution laser-induced fluorescence study has been performed on thirteen ground-state transitions in samarium, using a frequency-doubled Ti:sapphire laser in the wavelength range 350-440 nm. From each spectrum isotope shifts and hyperfine structure constants A and B are derived. The results are used to determine the nuclear parameter λ AA . PACS. 32.30.Jc Visible and ultraviolet spectra -32.10.Fn Fine and hyperfine structure -32.70.Jz Line shapes, widths, and shift

Structural Ordering and Symmetry Breaking in Cd_2Re_2O_7

Single crystal X-ray diffraction measurements have been carried out on Cd_2Re_2O_7 near and below the phase transition it exhibits at Tc' ~195 K. Cd_2Re_2O_7 was recently discovered as the first, and to date only, superconductor with the cubic pyrochlore structure. Superlattice Bragg peaks show an apparently continuous structural transition at Tc', however the order parameter displays anomalously slow growth to ~Tc'/10, and resolution limited critical-like scattering is seen above Tc'. High resolution measurements show the high temperature cubic Bragg peaks to split on entering the low temperature phase, indicating a (likely tetragonal) lowering of symmetry below Tc'.Comment: 4 pages, 4 figure

Deep-ultraviolet cavity ringdown spectroscopy

The sensitive optical detection technique of cavity ringdown spectroscopy is extended to the wavelength range 197-204 nm. A novel design narrowband Fourier-transform-limited laser is used, and the technique is applied to gas-phase extinction measurements in CO2, SF6, and O-2. Further demonstration of the system capabilities is given in high-resolution recordings of the Schumann-Runge (0, 0), (1, 0), and (2, 0) bands in O-2. (C) 2004 Optical Society of America