Economics of the Sapogenin-Bearing Yam as a Crop Plant in Puerto Rico

From experiments at the Federal Experiment Station, Mayagüez, data on costs in Puerto Rico, and other estimates an analysis of the costs of production and potential profits in the growing of Dioscorea were recorded and calculated. The analysis was divided into costs of producing plants, establishing a plantation, yearly maintenance, and harvest. Values and profits were calculated on the basis of species, yields, ages, and sapogenin contents. The chief suggestions to be made as a result of the study were: That initial costs would be heavy and almost prohibitive; that the greatest single expense would be the cost of staking; that profits would not be possible within less than 3 years of field growth; that profits would increase during the fourth year; that D. composila could be grown more profitably than D. floribunda; and that plantations established from tuber-pieces would be more profitable than plantations established from seed. Provided no serious pest or disease destroys the plantings, it is concluded that Dioscorea could compete favorably with certain presently existing crops in Puerto Rico

Thyroid cancer

Thyroid cancer is the fifth most common cancer in women in the USA, and an estimated over 62 000 new cases occurred in men and women in 2015. The incidence continues to rise worldwide. Differentiated thyroid cancer is the most frequent subtype of thyroid cancer and in most patients the standard treatment (surgery followed by either radioactive iodine or observation) is effective. Patients with other, more rare subtypes of thyroid cancer-medullary and anaplastic-are ideally treated by physicians with experience managing these malignancies. Targeted treatments that are approved for differentiated and medullary thyroid cancers have prolonged progression-free survival, but these drugs are not curative and therefore are reserved for patients with progressive or symptomatic diseas

Microscopic spheroidal particles obtained by laser cutting

In this work we study the characteristics of the particles ejected from the cutting zone of a SAE 1010 steel while using a CO2 gaseous laser with the purpose of determining the feasibility to use this technique in the production of microscopic particles for nuclear applications [2] as well as for other scientific and technological uses [1].Instituto de Física La Plat

Morphology and Phase Composition of Particles Produced by Electro-Discharge-Machining of Iron

Towards producing metallic particles of controlled size and spherical shape, which are of technological importance, we have collected in the filters of an electro-discharge-machine (EDM) the material ejected from the surface of EDM iron pieces. The conditions of machining were varied for kerosene and water as dielectrics, using a discharge current of 25 A and duration times of 16 and 3072 μs for kerosene and of 32, 384 and 768 μs for water, respectively. Scanning electron microscopy was used to assess the effect of the time of discharge on the size of the particles. Mossbauer spectroscopy and X-ray diffraction revealed that for kerosene EDM particles only cementite-like carbides of diverse stoichiometry were formed. While no oxide was found for kerosene spheres, the analyses showed that besides the main fraction of α-Fe, a small percentage of wustite (and traces of hematite for the 384 μs sample) formed on the water EDM ones.Facultad de Ciencias ExactasInstituto de Física La Plat

Challenges Associated with Tyrosine Kinase Inhibitor Therapy for Metastatic Thyroid Cancer

Tyrosine kinase inhibitors (TKIs) which target angiogenesis are promising treatments for patients with metastatic medullary and differentiated thyroid cancers. Sorafenib, sunitinib, and pazopanib are commercially available drugs which have been studied in these diseases. Vandetanib is the first drug approved in the United States for treatment of medullary thyroid cancer. These TKIs are used as chronic therapies, and therefore it is imperative to understand the adverse event profile in order to avoid excessive toxicity and maintain patients on therapy as long as it proves beneficial. Here we review common toxicities, management of these, and other challenging situations that arise when using TKIs in patients with thyroid cancer

Origin of the Exclusive Ternary Electroluminescent Behavior of BN‐Doped Nanographenes in Efficient Single‐Component White Light‐Emitting Electrochemical Cells

White-light-emitting electrochemical cells (WLECs) still represent a significant milestone, since only a few examples with moderate performances have been reported. Particularly, multiemissive white emitters are highly desired, as a paradigm to circumvent phase separation and voltage-dependent emission color issues that are encountered following host:guest and multilayered approaches. Herein, the origin of the exclusive white ternary electroluminescent behavior of BN-doped nanographenes with a B3N3 doping pattern (hexa-perihexabenzoborazinocoronene) is rationalized, leading to one of the most efficient (approximate to 3 cd A(-1)) and stable-over-days single-component and single-layered WLECs. To date, BN-doped nanographenes have featured blue thermally activated delayed fluorescence (TADF). This doping pattern provides, however, white electroluminescence spanning the whole visible range (x/y CIE coordinates of 0.29-31/0.31-38 and average color rendering index (CRI) of 87) through a ternary emission involving fluorescence and thermally activated dual phosphorescence. This temperature-dependent multiemissive mechanism is operative for both photo- and electroluminescence processes and holds over the device lifespan, regardless of the device architecture, active layer composition, and operating conditions. As such, this work represents a new stepping-stone toward designing a new family of multiemissive white emitters based on BN-doped nanographenes that realizes one of the best-performing single-component white-emitting devices compared to the prior-art

Past, present, and future research on self-service merchandising: A co-word and text mining approach

Purpose This study aims to discern emerging trends and provide a longitudinal perspective on merchandising research by identifying relationships between merchandising-related subdomains/themes. Design/methodology/approach This study sourced 657 merchandising-related articles published since 1960, from the Scopus database and 425 from Web of Science. After processing and normalizing the data, this study performed co-word and thematic network analyses. Taking a text mining approach, this study used topic modeling to identify a set of coherent topics characterized by the keywords of the articles. Findings This study identified the following merchandising-related themes: branding, retail, consumer, behavior, modeling, textile and clothing industry and visual merchandising. Although visual merchandising was the first type of merchandising to be used in-store, only recently has it become an emerging topic in the academic literature. There has been a further trend over the past decade to understand the adoption of simulation technology, such as computer-aided design, particularly in supply chain management in the clothing industry. These and other findings contribute to the discussion of the merchandising concept, approached from an evolutionary perspective. Research limitations/implications The conclusions of this study hold implications at the intersection of merchandising, sectors, new technologies, research methodologies and merchandising-practitioner education. Research trends suggest that, in the future, virtual reality and augmented reality using neuroscientific methods will be applied to the e-merchandising context. Practical implications The different dimensions of merchandising can be used to leverage store managers’ decision-making process toward an integrated store-management strategy. In particular, by adopting loyalty merchandising tactics, the store can generate emotional attachment among consumers, who will perceive its value and services as unique, thanks to merchandising items designed specifically with that aim in mind. The stimulation of unplanned purchases, the strategic location of products and duration of each merchandising activity in the store, the digitalization of merchandising and the application of findings from neuroscience studies are some of the most relevant practical applications. Originality/value This study provides the first-ever longitudinal review of the state of the art in merchandising research, taking a holistic perspective of this field of knowledge spanning a 60-year period. The work makes a valuable contribution to the development of the marketing discipline.info:eu-repo/semantics/acceptedVersio

LA MIOSTATINA: REGULADOR DEL CRECIMIENTO MUSCULAR Y ALTERNATIVA PARA LA SALUD

La miostatina (MSTN) también conocida como la GDF8, es un regulador negativo del crecimiento del musculo esquelético y responsable del correcto desarrollo de la masa muscular.  Su expresión está determinada por muchos mecanismo específicos, por ejemplo dominio  de proteínas específicas y genes relacionados. A su vez también, también se obtuvo información acerca de su influencia en determinadas enfermedades que aquejan a nivel de los tejidos musculares como por ejemplo sarcopenia y también relacionándose con el gen FTO (gen de la obesidad). La revisión de la literatura d acerca de la expresión de esta proteína deja en claro que el buen manejo de esta mediante el uso de la Ingeniería Genética, podría ayudar aliviar estos males que debilitan de forma progresiva el sistema esquelético, debilitando el movimiento de las personas.   DOI: https://doi.org/10.25176/RFMH.v17.n2.84

Estudio de aleaciones cobre-arsénico

Durante mucho tiempo la posición dominante en las investigaciones arqueometalúrgicas consideró como bronces sólo a las aleaciones de cobre y estaño, este último elemento en proporciones significativas. Sin embargo, las evidencias acumuladas fueron indicando que, además de esa combinación, en la antigüedad fue importante la aleación de cobre con arsénico, a la que algunos autores llamaron cobre arsenical y otros bronce arsenical. En Asia Occidental y Europa esta aleación fue regularmente producida entre aproximadamente el 3500 y el 1600 a. C., hasta ser reemplazada por el bronce estañifero (Lechtman, 1991)

Satisfaction with mobile food delivery app (MFDA) usage and the moderating role of perceived COVID 19 risk

The purpose of this study was to determine the influence of MFDAs characteristics on satisfaction in a health emergence situation, as well as the interrelationships between satisfaction, trust, and continuance intention. Unlike other existing studies, this research examines the determinants of satisfaction classified into two groups based on the Expectation-Confirmation Model: on one hand, service-related factors (external - lifestyle compatibility and various food choices), and on the other hand, technical factors (internal - personalization, performance expectancy, and task technology fit) in the context of MFDA. Additionally, the moderating role of perceived COVID-19 risk was explored. The study provides a tool that app developers can use to test their proposed systems before commercialisation through measuring the relationship between MFDA system characteristics and user satisfaction.https://www.elsevier.com/locate/ijhmthj2024Marketing ManagementSDG-03:Good heatlh and well-beingSDG-09: Industry, innovation and infrastructur