ISO-LWS grating spectroscopy: the case of R CrA star forming region

We present the far infrared spectra of the R CrA star forming region obtained with ISO-LWS. We collected a pointed observation on the Herbig Ae star R CrA and a raster scan covering the surrounding region, where HH100 (with its exciting source) and the pre-Main Sequence star T CrA are located. The OI 63μm and the CII 158μm lines have been detected in all the pointed positions, with a ratio consistent with PDR excitation. CO rotational lines (between Jup=14 and Jup=19) are detected on R CrA; from their intensities we derived, using a LVG model, the density and temperature of the emitting region. Other molecular transitions (OH and H2O) have been detected on the investigated objects; the derived cooling of all the molecular species is in agreement with C-shock as the likely excitation mechanism. The continuum emission of R CrA peaks around 100μm (as expected for a Herbig star) while the other sources (T CrA, HH100) show increasing continua up to ~200μm, indicating that they are probably less evolved sources

Strong H₂O and high-<i>J</i> CO emission towards the Class 0 protostar L1448-mm

The spectrum of the Class 0 source L1448-mm has been measured over the wavelength range extending from 6 to 190 μm with the Long Wavelength Spectrometer (LWS) and the Short Wavelength Spectrometer (SWS) on the Infrared Space Observatory (ISO). The far infrared spectrum is dominated by strong emission from gaseous H2O and from CO transitions with rotational quantum numbers J ≥ 14; in addition, the H2 pure rotational lines S(3), S(4) and S(5), the OH fundamental line at 119 μm, as well as emission from [O I]63 μm and [C II] 158 μm are also observed. The strong CO and water emission can be consistently explained as originating in a warm gas component at T ~ 700-1400 K and nH2~(3-50) 104cm-3 , which fills about 0.2-2% of the ~ 75" LWS field of view (corresponding, assuming a single emitting region, to a physical size of about (3-12)" or (0.5-2) 10-2 pc at d = 300 pc). We derive an H2O/CO abundance ratio ~ 5, which, assuming a standard CO/H2 abundance of 10-4, corresponds to H2O/H2 ~ 5 10-4. This value implies that water is enhanced by about a factor ~ 103 with respect to its expected abundance in the ambient gas. This is consistent with models of warm shocked regions which predict that most of the free atomic oxygen will be rapidly converted into water once the temperature of the post-shocked gas exceeds ~ 300 K. The relatively high density and compact size inferred for this emission may suggest an origin in the shocked region along the molecular jet traced by SiO and EHV CO millimeter line emission. Further support is given by the fact that the observed enhancement in H2O can be explained by shock conditions similar to those expected to produce the abundant SiO observed in the region. L1448-mm shows the largest water abundance so far observed by ISO amongst young sources displaying outflow activity; we argue that the occurrence of multiple shocks over a relatively short interval of time, like that evidenced in the surroundings of L1448-mm, could have contributed to enrich the molecular jet with a high H2O column density

The pathogenesis of prostate cancer : from molecular to metabolic alterations

Prostate cancer (PCa) is a heterogeneous disease with regard to molecular alterations and clinical course. The investigation of genetic alterations associated with PCa pathogenesis is highly challenging. Genome-wide analyses and epidemiological studies have identified only a handful of candidate genes possibly associated with hereditary or sporadic PCa. Cancer cells often rely for survival on common biochemical pathways such as enhanced anaerobic glycolysis and lipogenesis. The lipogenic enzyme fatty acid synthase seems to play a crucial part in PCa by conferring growth and survival advantages to cancer cells. We summarize the current understanding of the molecular events in PCa, and highlight the importance of altered lipid metabolism in the development and progression of prostate malignancy

Resolving the shocked gas in HH54 with Herschel: CO line mapping at high spatial and spectral resolution

The HH54 shock is a Herbig-Haro object, located in the nearby Chamaeleon II cloud. Observed CO line profiles are due to a complex distribution in density, temperature, velocity, and geometry. Resolving the HH54 shock wave in the far-infrared cooling lines of CO constrain the kinematics, morphology, and physical conditions of the shocked region. We used the PACS and SPIRE instruments on board the Herschel space observatory to map the full FIR spectrum in a region covering the HH54 shock wave. Complementary Herschel-HIFI, APEX, and Spitzer data are used in the analysis as well. The observed features in the line profiles are reproduced using a 3D radiative transfer model of a bow-shock, constructed with the Line Modeling Engine code (LIME). The FIR emission is confined to the HH54 region and a coherent displacement of the location of the emission maximum of CO with increasing J is observed. The peak positions of the high-J CO lines are shifted upstream from the lower J CO lines and coincide with the position of the spectral feature identified previously in CO(10-9) profiles with HIFI. This indicates a hotter molecular component in the upstream gas with distinct dynamics. The coherent displacement with increasing J for CO is consistent with a scenario where IRAS12500-7658 is the exciting source of the flow, and the 180 K bow-shock is accompanied by a hot (800 K) molecular component located upstream from the apex of the shock and blueshifted by -7 km s$^{-1}$. The spatial proximity of this knot to the peaks of the atomic fine-structure emission lines observed with Spitzer and PACS ([OI]63, 145 $\mu$m) suggests that it may be associated with the dissociative shock as the jet impacts slower moving gas in the HH54 bow-shock.Comment: 6 pages, 5 figure

Coulomb corrections to low energy antiproton annihilation cross sections on protons and nuclei

We calculate, in a systematic way, the enhancement effect on antiproton-proton and antiproton-nucleus annihilation cross sections at low energy due to the initial state electrostatic interaction between the projectile and the target nucleus. This calculation is aimed at future comparisons between antineutron and antiproton annihilation rates on different targets, for the extraction of pure isospin channels.Comment: 18 pages, 4 figures (latex format

Molecular line emissions from pre main sequence objects

We present some preliminary results obtained with the LWS G.T. programme on the study of young objects driving molecular outflows. In particular, we discuss the importance of molecular emission in these sources and address the role of the H20 cooling

Mapping water in protostellar outflows with Herschel: PACS and HIFI observations of L1448-C

We investigate on the spatial and velocity distribution of H2O along the L1448 outflow, its relationship with other tracers, and its abundance variations, using maps of the o-H2O 1_{10}-1_{01} and 2_{12}-1_{01} transitions taken with the Herschel-HIFI and PACS instruments, respectively. Water emission appears clumpy, with individual peaks corresponding to shock spots along the outflow. The bulk of the 557 GHz line is confined to radial velocities in the range \pm 10-50 km/s but extended emission associated with the L1448-C extreme high velocity (EHV) jet is also detected. The H2O 1_{10}-1_{01}/CO(3-2) ratio shows strong variations as a function of velocity that likely reflect different and changing physical conditions in the gas responsible for the emissions from the two species. In the EHV jet, a low H2O/SiO abundance ratio is inferred, that could indicate molecular formation from dust free gas directly ejected from the proto-stellar wind. We derive averaged Tkin and n(H2) values of about 300-500 K and 5 10^6 cm-3 respectively, while a water abundance with respect to H2 of the order of 0.5-1 10^{-6} along the outflow is estimated. The fairly constant conditions found all along the outflow implies that evolutionary effects on the timescales of outflow propagation do not play a major role in the H2O chemistry. The results of our analysis show that the bulk of the observed H2O lines comes from post-shocked regions where the gas, after being heated to high temperatures, has been already cooled down to a few hundred K. The relatively low derived abundances, however, call for some mechanism to diminish the H2O gas in the post-shock region. Among the possible scenarios, we favor H2O photodissociation, which requires the superposition of a low velocity non-dissociative shock with a fast dissociative shock able to produce a FUV field of sufficient strength.Comment: 16 pages, 13 figures, accepted for publication on Astronomy & Astrophysic

ISO-LWS study of pre-main sequence sources

We present the results obtained with the ISO Long Wavelength Spectrometer on a sample of Pre-MS sources, where several molecular lines of CO, H2O and OH have been detected. The analysis of the CO lines indicates that gas temperatures as low as 200 K are consistent with the data. This would be in agreement with the relatively low abundance of water in the gas phase measured in most of the objects

First Finding of Ostreopsis cf. ovata Toxins in Marine Aerosols

Since the late 1990s, a respiratory syndrome has been repetitively observed in humans concomitant with Ostreopsis spp. blooms (mainly O. cf. ovata) in the Mediterranean area. Previous studies have demonstrated that O. cf. ovata produces analogues of palytoxin (ovatoxins and a putative palytoxin), one of the most potent marine toxins. On the basis of the observed association between O. cf. ovata blooms, respiratory illness in people, and detection of palytoxin complex in algal samples, toxic aerosols, containing Ostreopsis cells and/or the toxins they produce, were postulated to be the cause of human illness. A small scale monitoring study of marine aerosol carried out along the Tuscan coasts (Italy) in 2009 and 2010 is reported. Aerosols were collected concomitantly with O. cf. ovata blooms, and they were analyzed by both PCR assays and LC-HRMS. The results, besides confirming the presence of O. cf. ovata cells, demonstrated for the first time the occurrence of ovatoxins in the aerosol at levels of 2.4 pg of ovatoxins per liter of air. Given the lack of toxicological data on palytoxins by inhalation exposure, our results are only a first step toward a more comprehensiveunderstanding of the Ostreopsis-related respiratory syndrome

ISO observations of the HH 24-26 regions

We report the results of an investigation, performed with the Long Wavelength Spectrometer (LWS) and the Short Wavelength Spectrometer (SWS) on-board the ISO satellite, on the star forming region associated with the Herbig-Haro objects HH24-25 and 26. In particular, we obtained low-resolution LWS spectra towards the two Class 0 sources HH24MMS and HH25MMS as well as towards the Class I source HH26IR and its associated flow. In addition, SWS scans of pure H2 rotational lines in HH24MMS where acquired. All the spectra present the [OI] 63 μm and the [CII] 158 μm lines, while significant molecular emission from CO and H2O is detected only from HH25MMS and along the blue lobe of the HH26IR outflow, where the shocked activity is also evidenced by the presence of strong near infrared knots. The physical conditions of the regions strongly emitting in molecular lines are derived, showing that the two Class 0 sources are characterised by lower temperatures and higher densities than the HH26IR flow. The presence of both J and C shocks are envisaged to take into account the observed emission