A Na+ conducting hydrogel for protection of organic electrochemical transistors.

Organic electrochemical transistors (OECTs) are being intensively developed for applications in electronics and biological interfacing. These devices rely on ions injected in a polymer film from an aqueous liquid electrolyte for their operation. However, the development of solid or semi-solid electrolytes are needed for future integration of OECTs into flexible, printed or conformable bioelectronic devices. Here, we present a new polyethylene glycol hydrogel with high Na+ conductivity which is particularly suitable for OECTs. This novel hydrogel was synthesized using cost-effective photopolymerization of poly(ethylene glycol)-dimethacrylate and sodium acrylate. Due to the high water content (83% w/w) and the presence of free Na+, the hydrogel showed high ionic conductivity values at room temperature (10-2 S cm-1) as characterized by electrochemical impedance spectroscopy. OECTs made using this hydrogel as a source of ions showed performance that was equivalent to that of OECTs employing a liquid electrolyte. They also showed improved stability, with only a 3% drop in current after 6 h of operation. This hydrogel paves the way for the replacement of liquid electrolytes in high performance OECTs bringing about advantages in terms of device integration and protection

Ionic Hydrogel for Accelerated Dopamine Delivery via Retrodialysis.

Local drug delivery directly to the source of a given pathology using retrodialysis is a promising approach to treating otherwise untreatable diseases. As the primary material component in retrodialysis, the semipermeable membrane represents a critical point for innovation. This work presents a new ionic hydrogel based on polyethylene glycol and acrylate with dopamine counterions. The ionic hydrogel membrane is shown to be a promising material for controlled diffusive delivery of dopamine. The ionic nature of the membrane accelerates uptake of cationic species compared to a nonionic membrane of otherwise similar composition. It is demonstrated that the increased uptake of cations can be exploited to confer an accelerated transport of cationic species between reservoirs as is desired in retrodialysis applications. This effect is shown to enable nearly 10-fold increases in drug delivery rates from low concentration solutions. The processability of the membrane is found to allow for integration with microfabricated devices which will in turn accelerate adaptation into both existing and emerging device modalities. It is anticipated that a similar materials design approach may be broadly applied to a variety of cationic and anionic compounds for drug delivery applications ranging from neurological disorders to cancer

Manual de requerimientos minimos para intervenciones en agua, saneamiento e higiene en emergencias

Los autores realizaron el trabajo para FLASH (Formacion en Logistica, Agua, Saneamiento e Higiene

Título distintivo: Guía práctica para la distribución de agua

Este manual pretende ser una guía clara y de fácil uso para poner en marcha soluciones a la escasez de agua potable en caso de desastre natural o crisis prolongadas en los primeros momentos de la respuesta de la emergencia o en situaciones prolongadas de escasez de agua

Expansion of activated cxcr5+icos+ tfh cells and plasmablasts induced by seasonal influenza vaccine is impaired in anti-il-6r treated rheumatoid arthritis patients

Objectives: To investigate the importance of IL-6 for the in vivo differentiation of human Tfh cells, taking advantage of influenza vaccination in patients under anti-IL-6R therapy.info:eu-repo/semantics/publishedVersio

Defining complementary tools to the IVI. The Infrastructure Degradation Index (IDI) and the Infrastructure Histogram (HI)

[EN] The Infrastructure Value Index (IVI) is quickly becoming a standard as a valuable tool to quickly assess the state of urban water infrastructure. However, its simple nature (as a single metric) can mask some valuable information and lead to erroneous conclusions. This paper introduces two complementary tools to IVI: The Infrastructure Degradation Index (IDI) and the Infrastructure Histogram (HI). The IDI is focused on time (compared to the IVI, focused on value), represents an intuitive concept and behaves in a linear way. The joint analysis of IVI and IDI provides results in a more complete understanding of the state of the assets, while maintaining the simplicity of the tools. The Infrastructure Histogram allows for a full evaluation of the infrastructure state and provides a detailed picture of network age compared to its expected life, as well as an order of magnitude of the required investments in the following years.Cabrera Rochera, E.; Estruch-Juan, ME.; Gomez Selles, E.; Del Teso-March, R. (2019). Defining complementary tools to the IVI. The Infrastructure Degradation Index (IDI) and the Infrastructure Histogram (HI). Urban Water Journal. 16(5):343-352. https://doi.org/10.1080/1573062X.2019.1669195S343352165Alegre, H., Vitorino, D., & Coelho, S. (2014). Infrastructure Value Index: A Powerful Modelling Tool for Combined Long-term Planning of Linear and Vertical Assets. Procedia Engineering, 89, 1428-1436. doi:10.1016/j.proeng.2014.11.469Amaral, R., Alegre, H., & Matos, J. S. (2016). A service-oriented approach to assessing the infrastructure value index. Water Science and Technology, 74(2), 542-548. doi:10.2166/wst.2016.250Aware-p.org. 2014. “AWARE-P/Software.” Accessed 25 November 2018. http://www.aware-p.org/np4/software/Baseform. 2018. “Baseform.” Accessed 24 November 2018. https://baseform.com/np4/productCanal de Isabel II Gestión. 2012. Normas Para Redes de Abastecimiento. [Standards for Water Supply Networks.]. https://www.canalgestion.es/es/galeria_ficheros/pie/normativa/normativa/Normas_redes_abastecimiento2012_CYIIG.pdfFrost, and Sullivan. 2011. “Western European Water and Wastewater Utilities Market.” https://store.frost.com/western-european-water-and-wastewater-utilities-market.html#section1Leitão, J. P., Coelho, S. T., Alegre, H., Cardoso, M. A., Silva, M. S., Ramalho, P., … Carriço, N. (2014). Moving urban water infrastructure asset management from science into practice. Urban Water Journal, 13(2), 133-141. doi:10.1080/1573062x.2014.939092Marchionni, V., Cabral, M., Amado, C., & Covas, D. (2016). Estimating Water Supply Infrastructure Cost Using Regression Techniques. Journal of Water Resources Planning and Management, 142(4), 04016003. doi:10.1061/(asce)wr.1943-5452.0000627Marchionni, V., Lopes, N., Mamouros, L., & Covas, D. (2014). Modelling Sewer Systems Costs with Multiple Linear Regression. Water Resources Management, 28(13), 4415-4431. doi:10.1007/s11269-014-0759-zPulido-Velazquez, M., Cabrera Marcet, E., & Garrido Colmenero, A. (2014). Economía del agua y gestión de recursos hídricos. Ingeniería del agua, 18(1), 95. doi:10.4995/ia.2014.3160Rokstad, M. M., Ugarelli, R. M., & Sægrov, S. (2015). Improving data collection strategies and infrastructure asset management tool utilisation through cost benefit considerations. Urban Water Journal, 13(7), 710-726. doi:10.1080/1573062x.2015.102469

Development of a Pediatric Ebola Predictive Score, Sierra Leone1.

We compared children who were positive for Ebola virus disease (EVD) with those who were negative to derive a pediatric EVD predictor (PEP) score. We collected data on all children <13 years of age admitted to 11 Ebola holding units in Sierra Leone during August 2014-March 2015 and performed multivariable logistic regression. Among 1,054 children, 309 (29%) were EVD positive and 697 (66%) EVD negative, with 48 (5%) missing. Contact history, conjunctivitis, and age were the strongest positive predictors for EVD. The PEP score had an area under receiver operating characteristics curve of 0.80. A PEP score of 7/10 was 92% specific and 44% sensitive; 3/10 was 30% specific, 94% sensitive. The PEP score could correctly classify 79%-90% of children and could be used to facilitate triage into risk categories, depending on the sensitivity or specificity required

Modelos de pronóstico a largo plazo del fenómeno El Niño y de un óptimo manejo de sistemas hidroenergéticos

Formula una propuesta de investigación científica orientada a desarrollar un modelo de pronóstico del fenómeno El Niño a largo plazo para un óptimo manejo de sistemas hidroenergéticos