New Technologies and Innovative Solutions in the Development of Multimedia Corpus of Mezen Robinsons Texts

Objective: New Technologies and Innovative Solutions in creating a multimedia corpus of texts about the "Mezen Robinsons" aims to preserve the memory of an event that occurred in the 18th century and to study the history of Spitsbergen development. This article presents a multimedia corpus of Russian-language texts about the "Mezen Robinsons" written in 1766–2022. Observations show that the history of the survival of the Mezen hunters on Edge Island in 1743–1749 has repeatedly attracted the attention of specialists from various fields of knowledge: historians, archaeologists, publicists, professional writers, translators, etc. The corpus unites texts, audio, video, and multimedia resources. Methods: continuous sampling was used to collect the material; when analyzing and describing the data, we applied a descriptive method, a biographical method of studying literature, statistical data processing, philological analysis, observation, assessment, and corpus modeling methods. Findings: the methodology and technology of building an independent multimedia corpus, its architecture, and its design are described. Novelty: the multimedia corpus is a contribution to the development of a new approach to studying the subjectology of Russian literature. Practical significance:the findings can become the basis for studying the biographies and creativity of various authors who built their works on the plot of the Mezen industrialists and for further comparison of various interpretations of one event from the history of the development of the Arctic. Doi: 10.28991/HIJ-2023-04-01-07 Full Text: PD

The use of logistics n the quality parameters control system of material flow

The relevance of the research problem is conditioned on the need to justify the use of the logistics methodologies in the quality parameters control process of material flows. The goal of the article is to develop theoretical principles and practical recommendations for logistical system control in material flows quality parameters. A leading approach to study this problem is a set of scientific knowledge and special methods, allowing identifying the main trends and features for the quality parameters control of material flows. The main results of the research with the scientific novelty are the following: - grounded conceptual framework for the qualitative parameters management of material flows and business processes; - defined the relationship of the evaluation criteria to characterize products and processes, and to highlight typical and assigned material flow characteristics; - proved the necessity of quality parameters logistical system control of material flows. The article can be useful to set up the quality parameters control system of material flow in the micro – mesa-logistics systems to optimize total costs, improve quality, material flow and processes and, as a consequence, improve the products competitiveness. © 2016 Karpova et al

IMPROVEMENT OF ANTIMONOPOLY REGULATION OF THE INSURANCE MARKET OF RUSSIA SYSTEM

Статья посвящена актуальным вопросам антимонопольного регулирования российского страхового рынка. На основе анализа ситуации, сложившейся на страховом рынке, выявлены противоречия участников страховых отношений, которые в настоящее время обостряются в результате монополизации страхового рынка. Обоснована возможность достижения локального компромисса между страховщиком и страхователем в условиях конкурентного предложения страховой защиты на страховом рынке.The article is devoted to topical issues of antimonopoly regulation of the Russian insurance market. Based on the analysis of the situation in the insurance market, revealed contradictions participants of insurance relations, which are now exacerbated as a result of the monopolization of the insurance market. The possibility of achieving local compromise between the insurer and the insured in a competitive offer insurance protection in the insurance market

Determination of zinc content in insulin products by inductively coupled plasma mass spectrometry

Scientific relevance. Zinc content is a quality attribute of insulin products. The State Pharmacopoeia of the Russian Federation requires that it should be determined by flame atomic absorption spectrometry (FAAS). However, many pharmaceutical manufacturers currently prefer inductively coupled plasma mass spectrometry (ICP-MS), which is considered the most promising method for pharmaceutical and biomedical elemental analysis.Aim. The study aimed to develop and validate an ICP-MS-based analytical procedure for zinc content determination in insulin products.Materials and methods. The study focused on human insulin, insulin lispro, insulin aspart, and insulin glargine in the form of active substances, suspensions for subcutaneous injection, and solutions for injection from different manufacturers. Zinc content was determined on an Agilent 7900 ICP-MS; the analysis included 66Zn signal intensity registration.Results. The study compared the results of zinc content determination in test samples with either hydrochloric or nitric acid used as the solvent for sample preparation. The authors selected the experimental conditions to achieve relative standard deviations (RSDs) of not more than 2.5% for the measurements. The ICP-MSbased analytical procedure was validated for its specificity, linearity, accuracy, and precision in the range of 0.4–1.6 mg/L. The authors compared the measurements of zinc content made using FAAS and ICP-MS.Conclusions. The ICP-MS-based analytical procedure for zinc content determination in insulin products meets the validation criteria. This analytical procedure, as developed and validated, may be used in the quality control of medicinal products in the Russian healthcare system and at the batch release stage of pharmaceutical manufacturing

The model of formation of patriotism at schoolchildren by means of folk pedagogics

© 2016, Econjournals. All rights reserved.The topicality of the study of the problem is due to the fact that the sharp change in the hierarchy of values, priorities, ideals, lack of spirituality, lack of morality, the unleashing of military conflicts, extremism and clash of religious trends have highlighted the need to strengthen the integrity and diversity of the modern world, the actualization of the problems associated with the formation of philosophical, civil and patriotic beliefs of the younger generation. In this regard, this article devotes on the development of structural and functional model of formation of patriotism at schoolchildren by means of folk pedagogy. The leading approaches to the study of this problem were the student-centered and axiological approaches to comprehensively cover this problem. The article presents a model of patriotic qualities of schoolchildren by means of folk pedagogy, which includes the target, procedural, substantive, organizational and methodical, efficiently-evaluative components that together provide effective formation of patriotic qualities of schoolchildren. This model can be applied in the practice of primary school teachers in the preparation of students of pedagogical high schools to perform the functions of primary school teachers, as well as in-service teacher training system

Selective Quantification of Organic and Inorganic Arsenic in Kelp Thalli and Kelp-Based Products

Kelp can accumulate large quantities of arsenic compounds even in the absence of considerable environmental pollution. A substantial difference in toxicity between organic and inorganic arsenic compounds makes the form of arsenic relevant for the risk assessment of consuming kelp thalli and kelp-based products.The aim of the study was to develop an analytical procedure for the selective quantification of organic and inorganic arsenic in kelp thalli by inductively coupled plasma mass spectrometry and solid-phase extraction without scheduled precursors.Materials and methods. The authors studied samples of Laminaria saccharina and Laminaria japonica, spiking mixtures of chemical compounds containing arsenic in different oxidation states, and bioactive dietary supplements based on kelp thalli. Solid-phase extraction was performed using Maxi-Clean SAX cartridges. The arsenic content was determined using an Agilent 7900 inductively coupled plasma mass spectrometer.Results. Microwave-assisted extraction with deionised water ensures 91% recovery of arsenic-containing compounds from kelp thalli, and the addition of hydrogen peroxide to the extractant provides complete extraction. Solid-phase extraction with an eluent based on 3% H2O2 can extract the organic fraction from a mixture of organic and inorganic arsenic compounds without washing the inorganic fraction off the cartridge.Conclusions. The authors offer an effective analytical procedure for the selective quantification of organic and inorganic arsenic in kelp thalli and kelp-based products. This procedure allows for the isolation of arsenic-containing compounds from the organic matrix of kelp with 3% hydrogen peroxide. Solid-phase extraction with this extractant can effectively separate organic and inorganic fractions without prior neutralisation of the test solution

Development and Validation of Procedures for Determination of Elemental Toxicants in Herbal Substances and Herbal Medicinal Products

When the approach to quality control of herbal substances (HSs) and herbal medicinal products (HMPs) changed from determination of the total content of heavy metals by calorimetry to selective determination by spectrometric techniques, many manufacturers of such products failed to meet the new requirements in their registration dossiers. Test procedures submitted by manufacturers often need to be clarified, and validation protocols often lack data.The aim of the study was to provide recommendations to HS and HMP manufacturers on the choice of test methods, materials, reagents, methods of organic matrix mineralisation, and main validation parameters, as well as recommendations on validation of the procedure for elemental toxicants determination, and preparation of the “Heavy metals and arsenic” part of the regulatory submission.Materials and methods: the study included analysis and systematisation of scientific literature, requirements of the Russian and foreign pharmacopoeias, guidelines, manuals on instrumental methods of analysis, and first-hand experience in elemental analysis of various types of HSs and HMPs.Results: the authors formulated recommendations on the choice of sample mineralisation conditions for quantification of elemental impurities in biological products, and substantiated requirements for the reagents, materials, and equipment. The paper compares different methods of elemental analysis. It was demonstrated that the main mistakes made by manufacturers stem from disregard to the organic matrix effect on the measurement results and lack of agreement between the impurity concentration being determined and the range of the calibration curve used. The paper gives acceptance criteria for validation parameters of test procedures for heavy metals and arsenic determination in HSs and HMPs.Conclusions: it is not correct to use reference standards containing heavy metals as inorganic salts not bound to organic compounds, for HS and HMP analysis. The criteria given in the European Pharmacopoeia and the United State Pharmacopoeia can be used for a number of validation parameters, when they are not included in the Russian Pharmacopoeia

Comparative analysis of thinning techniques in pine forests

Thinning is a necessary and complex forestry activity. The complexity increases due to theoretical disagreements, contradictory recommendations, and errors of modern practice, which require confirmation through long-time experiments. This article presents a summary of experimental results from plantations established 20-30 years ago and explains concepts of the theory, methods, and regime of thinning in permanent sample plots of pine stands in Gatchinsky forest of the Leningrad region. The research results allow for the clarification of growth patterns and age dynamics of pine stands subject to heavy, low thinning, as well as the results of applying the crown (high) thinning technique and a mixed treatment. A combined thinning and fertilization could improve wood quality and yield compared to conventional methods. Of particular scientific importance is the analysis of change in tree diameter classes during growth and after thinning. The research results allow for optimizing the treatment regime in pine plantations and reducing labor intensity by increasing the intensity of thinning and reducing the number of techniques

SEPARATION OF BORON ISOTOPES IN OPTIMAL CASCADES OF DIRECT-FLOW GAS CENTRIFUGES

The optimization problem of a two-stage scheme of direct-flow gas centrifuges for the separation of boron isotopes is considered. The results of minimizing the total number of cascade centrifuges using the numerical-analytical method are obtained. Calculations of optimization of cascades of direct-flow gas centrifuges by the hook-Jeeves numerical method are also presented.Рассмотрена задача оптимизации двухкаскадной схемы прямоточных газовых центрифуг для разделения изотопов бора. Получены результаты минимизации суммарного количества центрифуг каскадов при помощи численно-аналитического метода. Также представлены расчёты оптимизации каскадов прямоточных газовых центрифуг численным методом Хука-Дживса

Определение содержания цинка в инсулинах методом масс-спектрометрии с индуктивно-связанной плазмой

Scientific relevance. Zinc content is a quality attribute of insulin products. The State Pharmacopoeia of the Russian Federation requires that it should be determined by flame atomic absorption spectrometry (FAAS). However, many pharmaceutical manufacturers currently prefer inductively coupled plasma mass spectrometry (ICP-MS), which is considered the most promising method for pharmaceutical and biomedical elemental analysis.Aim. The study aimed to develop and validate an ICP-MS-based analytical procedure for zinc content determination in insulin products.Materials and methods. The study focused on human insulin, insulin lispro, insulin aspart, and insulin glargine in the form of active substances, suspensions for subcutaneous injection, and solutions for injection from different manufacturers. Zinc content was determined on an Agilent 7900 ICP-MS; the analysis included 66Zn signal intensity registration.Results. The study compared the results of zinc content determination in test samples with either hydrochloric or nitric acid used as the solvent for sample preparation. The authors selected the experimental conditions to achieve relative standard deviations (RSDs) of not more than 2.5% for the measurements. The ICP-MSbased analytical procedure was validated for its specificity, linearity, accuracy, and precision in the range of 0.4–1.6 mg/L. The authors compared the measurements of zinc content made using FAAS and ICP-MS.Conclusions. The ICP-MS-based analytical procedure for zinc content determination in insulin products meets the validation criteria. This analytical procedure, as developed and validated, may be used in the quality control of medicinal products in the Russian healthcare system and at the batch release stage of pharmaceutical manufacturing.Актуальность. Одним из показателей качества препаратов инсулина является содержание в них цинка. В фармакопейном анализе цинк в инсулинах определяют методом атомно-абсорбционной спектрометрии с пламенной атомизацией (ПААС). В настоящее время многие производители лекарственных средств отдают предпочтение методу масс-спектрометрии с индуктивно-связанной плазмой (ИСП-МС), который признан наиболее перспективным методом элементного анализа в фармацевтике и биомедицине.Цель. Разработка и валидация методики определения цинка в инсулинах методом ИСП-МС.Материалы и методы. В качестве объектов исследования использованы фармацевтические субстанции, суспензии для подкожного введения и растворы для инъекций инсулина человеческого, лизпро, аспарта и гларгина различных производителей. Содержание цинка определяли методом масс-спектрометрии с индуктивно-связанной плазмой с использованием прибора Agilent 7900, фиксируя интенсивность сигналов 66Zn.Результаты. Проведено сравнение результатов определения содержания цинка в исследуемых образцах при использовании в качестве растворителей при пробоподготовке хлороводородной и азотной кислот. Подобраны условия эксперимента, обеспечивающие относительное стандартное отклонение RSD результата измерения не выше 2,5%. В диапазоне 0,4–1,6 мг/л оценены специфичность, линейность, правильность и прецизионность методики определениясодержания цинка методом ИСП-МС. Проведено сравнение результатов измерения содержания цинка в испытуемых образцах с использованием методик ПААС и ИСП-МС.Выводы. Валидационные характеристики методики определения содержания цинка в инсулинах методом ИСП-МС соответствуют критериям приемлемости методики. Разработанная и валидированная методика рекомендуется к использованию при проведении экспертизы качества в системе здравоохранения России и в производстве на стадии выходного контроля готовой продукции