Efficiently Learning from Revealed Preference

In this paper, we consider the revealed preferences problem from a learning perspective. Every day, a price vector and a budget is drawn from an unknown distribution, and a rational agent buys his most preferred bundle according to some unknown utility function, subject to the given prices and budget constraint. We wish not only to find a utility function which rationalizes a finite set of observations, but to produce a hypothesis valuation function which accurately predicts the behavior of the agent in the future. We give efficient algorithms with polynomial sample-complexity for agents with linear valuation functions, as well as for agents with linearly separable, concave valuation functions with bounded second derivative.Comment: Extended abstract appears in WINE 201

New Models for X-Ray Synchrotron Radiation from the Remnant of Supernova 1006 AD

Galactic cosmic rays up to energies of around 10^15 eV are assumed to originate in supernova remnants (SNRs). The shock wave of a young SNR like SN 1006 AD can accelerate electrons to energies greater than 1 TeV, where they can produce synchrotron radiation in the X-ray band. A new model (SRESC) designed to model synchrotron X-rays from Type Ia supernovae can constrain values for the magnetic-field strength and electron scattering properties, with implications for the acceleration of the unseen ions which dominate the cosmic-ray energetics. New observations by ASCA, ROSAT, and RXTE have provided enormously improved data, which now extend to higher X-ray energies. These data allow much firmer constraints. We will describe model fits to these new data on SN 1006 AD, emphasizing the physical constraints that can be placed on SNRs and on the cosmic-ray acceleration process.Comment: 10 pages, 2 figures. to appear in "Cosmic Explosions", proceeding of the 10th Annual October Astrophysics Conference (ed. S.S. Holt and W. W. Zhang) LaTex aipproc.st

Surface activation of Concorde by Be-7

Activation analysis of two airframe components from the Concorde aircraft has identified the presence of Be-7, a nuclide found by other investigators that was deposited on the forward edge of the Long Duration Exposure Facility (LDEF) structure. The results of the Concorde analysis indicate that this phenomenon is very much a surface effect, and that the areal densities of the Be-7 are comparable to those found for LDEF. The collection of Be-7 by the aircraft must be greater than in the case of LDEF (since duration for which Concorde is accumulating the nuclide is shorter) and is of the order of 1.2 to 41 nuclei/sq cm(-)s(exp -1) depending upon assumptions made regarding the altitude at which collection becomes appreciable, and the efficiency of the process which removes the radionuclide

Ablation debris control by means of closed thick film filtered water immersion

The performance of laser ablation generated debris control by means of open immersion techniques have been shown to be limited by flow surface ripple effects on the beam and the action of ablation plume pressure loss by splashing of the immersion fluid. To eradicate these issues a closed technique has been developed which ensured a controlled geometry for both the optical interfaces of the flowing liquid film. This had the action of preventing splashing, ensuring repeatable machining conditions and allowed for control of liquid flow velocity. To investigate the performance benefits of this closed immersion technique bisphenol A polycarbonate samples have been machined using filtered water at a number of flow velocities. The results demonstrate the efficacy of the closed immersion technique: a 93% decrease in debris is produced when machining under closed filtered water immersion; the average debris particle size becomes larger, with an equal proportion of small and medium sized debris being produced when laser machining under closed flowing filtered water immersion; large debris is shown to be displaced further by a given flow velocity than smaller debris, showing that the action of flow turbulence in the duct has more impact on smaller debris. Low flow velocities were found to be less effective at controlling the positional trend of deposition of laser ablation generated debris than high flow velocities; but, use of excessive flow velocities resulted in turbulence motivated deposition. This work is of interest to the laser micromachining community and may aide in the manufacture of 2.5D laser etched patterns covering large area wafers and could be applied to a range of wavelengths and laser types

Fluorides, orthodontics and demineralization: a systematic review

Objectives: To evaluate the effectiveness of fluoride in preventing white spot lesion (WSL) demineralization during orthodontic treatment and compare all modes of fluoride delivery. Data sources: The search strategy for the review was carried out according to the standard Cochrane systematic review methodology. The following databases were searched for RCTs or CCTs: Cochrane Clinical Trials Register, Cochrane Oral Health Group Specialized Trials Register, MEDLINE and EMBASE. Inclusion and exclusion criteria were applied when considering studies to be included. Authors of trials were contacted for further data. Data selection: The primary outcome of the review was the presence or absence of WSL by patient at the end of treatment. Secondary outcomes included any quantitative assessment of enamel mineral loss or lesion depth. Data extraction: Six reviewers independently, in duplicate, extracted data, including an assessment of the methodological quality of each trial. Data synthesis: Fifteen trials provided data for this review, although none fulfilled all the methodological quality assessment criteria. One study found that a daily NaF mouthrinse reduced the severity of demineralization surrounding an orthodontic appliance (lesion depth difference –70.0 µm; 95% CI –118.2 to –21.8 µm). One study found that use of a glass ionomer cement (GIC) for bracket bonding reduced the prevalence of WSL (Peto OR 0.35; 95% CI 0.15–0.84) compared with a composite resin. None of the studies fulfilled all of the methodological quality assessment criteria. Conclusions: There is some evidence that the use of a daily NaF mouthrinse or a GIC for bonding brackets might reduce the occurrence and severity of WSL during orthodontic treatment. More high quality, clinical research is required into the different modes of delivering fluoride to the orthodontic patient

Granular cell tumour of the tongue in a 17‐year‐old orthodontic patient: a case report

To describe the clinical presentation of a granular cell tumour ( GCT ) in an orthodontic patient, as well as discuss its aetiology and treatment of choice. We present a case of GCT of the tongue in an otherwise healthy 17‐year‐old male patient along with a brief review of literature on GCT s. The lesion was surgically excised and orthodontic treatment was successfully finalised. Clinically, GCTs are indistinguishable from other benign connective tissue and neural tissue neoplasms and may be found in any site, with cases commonly involving the gastrointestinal system, breast and lung. However, over 50% of cases involve the head and neck, with the tongue being the most frequently involved site (65–85% of oral GCTs ). GCTs demonstrate a close anatomical relationship with peripheral nerve fibres and demonstrate the presence of myelin and axon‐like structures thus lending credence to their neural origin. The treatment of choice for GCTs is conservative surgical excision. Because GCTs present with a potential for recurrence, follow‐up is recommended. While the primary focus of orthodontic treatment is the position of the teeth within the orofacial complex, the health and wellness of the patient and his/her surrounding oral tissues always take precedence. This case demonstrates the importance of routine physical examination of the intraoral and extraoral tissues during routine orthodontic care.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/106806/1/ors12055.pd

Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism

Polycistronic transcripts are considered rare in the human genome. Initiation of translation of internal ORFs of eukaryotic genes has been shown to use either leaky scanning or highly structured IRES regions to access initiation codons. Studies on mammalian viruses identified a mechanism of coupled translation termination-reinitiation that allows translation of an additional ORF. Here, the ribosome terminating translation of ORF-1 translocates upstream to reinitiate translation of ORF-2. We have devised an algorithm to identify mRNAs in the human transcriptome in which the major ORF-1 overlaps a second ORF capable of encoding a product of at least 50 aa in length. This identified 4368 transcripts representing 2214 genes. We investigated 24 transcripts, 22 of which were shown to express a protein from ORF-2 highlighting that 3' UTRs contain protein-coding potential more frequently than previously suspected. Five transcripts accessed ORF-2 using a process of coupled translation termination-reinitiation. Analysis of one transcript, encoding the CASQ2 protein, showed that the mechanism by which the coupling process of the cellular mRNAs was achieved was novel. This process was not directed by the mRNA sequence but required an aspartate-rich repeat region at the carboxyl terminus of the terminating ORF-1 protein. Introduction of wobble mutations for the aspartate codon had no effect, whereas replacing aspartate for glutamate repeats eliminated translational coupling. This is the first description of a coordinated expression of two proteins from cellular mRNAs using a coupled translation termination-reinitiation process and is the first example of such a process being determined at the amino acid level