Inhibition of pancreatic cancer cell growth in vitro by the tyrphostin group of tyrosine kinase inhibitors.

Tyrphostins are a group of low molecular weight synthetic inhibitors of protein tyrosine kinases (PTK). The intracellular domains of the receptors for epidermal growth factor (EGF), transforming growth factor-alpha (TGF-alpha), insulin-like growth factor 1 (IGF-1) possess PTK activity. Since EGF, TGF-alpha and IGF-1 are considered to play an important role in the proliferation of pancreatic cancer cells, we studied the effects of tyrphostins on the growth of three human pancreatic cancer cell lines (MiaPaCa-2, Panc-1 and CAV). The tyrphostins AG17, T23 and T47 all inhibited EGF and serum-stimulated DNA synthesis. AG17 was found to be the most potent of these agents and caused a dose-dependent but reversible inhibition of cell growth. Furthermore using an immunoblotting procedure we also found AG17 to inhibit EGF-induced tyrosine phosphorylation in the MiaPaCa-2 cell line. Tyrosine kinase inhibitors may prove to be useful agents for the treatment of pancreatic cancer

Conical scan impact study. Volume 2: Small local user data processing facility

The impact of a conical scan versus a linear scan multispectral scanner (MSS) instrument on a small local-user data processing facility was studied. User data requirements were examined to determine the unique system rquirements for a low cost ground system (LCGS) compatible with the Earth Observatory Satellite (EOS) system. Candidate concepts were defined for the LCGS and preliminary designs were developed for selected concepts. The impact of a conical scan MSS versus a linear scan MSS was evaluated for the selected concepts. It was concluded that there are valid user requirements for the LCGS and, as a result of these requirements, the impact of the conical scanner is minimal, although some new hardware development for the LCGS is necessary to handle conical scan data

The OLS-lens survey: The discovery of five new galaxy-galaxy strong lenses from the SDSS

Bright galaxy-galaxy strong lenses are much more powerful than lensed quasars for measuring the mass profiles of galaxies, but until this year only a handful have been known. Here we present five new examples, identified via the optimal line-of-sight gravitational lens search strategy applied to luminous red galaxies in the Sloan Digital Sky Survey (SDSS). Our survey largely complements a similar survey by Bolton et al., who recently presented several new lenses. The lensed background galaxies are selected from the SDSS spectra via the presence of narrow emission line signatures, including the [OII] 3726,3729, Hb and [OIII] 4960,5008 lines, superposed on the spectra of the bright, intervening, deflector galaxies. Our five confirmed new systems include deflector galaxies with redshifts z=0.17-0.28 and lensed galaxies with redshifts z=0.47-1.18. Simulations of moderately deep (few orbits) HST-ACS imaging of systems such as these, where the lensed source is brighter than r~23, are presented. These demonstrate the feasibility of measuring accurately the inner slope of the dark matter halo to within an uncertainty sigma(gamma)~0.1, the dark matter fraction within the Einstein radius, and the mass-to-light ratio of the stars alone, independently of dynamical measurements. The high success rate of our search so far, >60%, and the relatively modest observational resources necessary to confirm the gravitational lens nature of the candidates, demonstrate that compilation of a sample of ~100 galaxy-galaxy lenses from the SDSS is readily achievable, opening up a rich new field in dark matter studies.Comment: To appear in MNRAS. Three figs provided as low-res jpegs. Full-resolution PS of paper at http://astro.ic.ac.uk/~sjw4/MF1373rv.ps.g

Some mixed Hodge structure on l^2-cohomology of covering of K\"ahler manifolds

We give methods to compute l^2-cohomology groups of a covering manifolds obtained by removing pullback of a (normal crossing) divisor to a covering of a compact K\"ahler manifold. We prove that in suitable quotient categories, these groups admit natural mixed Hodge structure whose graded pieces are given by expected Gysin maps.Comment: 40 pages. This revised version will be published in Mathematische Annale

Finite Projective Spaces, Geometric Spreads of Lines and Multi-Qubits

Given a (2N - 1)-dimensional projective space over GF(2), PG(2N - 1, 2), and its geometric spread of lines, there exists a remarkable mapping of this space onto PG(N - 1, 4) where the lines of the spread correspond to the points and subspaces spanned by pairs of lines to the lines of PG(N - 1, 4). Under such mapping, a non-degenerate quadric surface of the former space has for its image a non-singular Hermitian variety in the latter space, this quadric being {\it hyperbolic} or {\it elliptic} in dependence on N being {\it even} or {\it odd}, respectively. We employ this property to show that generalized Pauli groups of N-qubits also form two distinct families according to the parity of N and to put the role of symmetric operators into a new perspective. The N=4 case is taken to illustrate the issue.Comment: 3 pages, no figures/tables; V2 - short introductory paragraph added; V3 - to appear in Int. J. Mod. Phys.

Progressive metabolic impairment underlies the novel nematicidal action of fluensulfone on the potato cyst nematode Globodera pallida

Background: Fluensulfone is a new nematicide with an excellent profile of selective toxicity against plant parasitic nematodes. Here, its effects on the physiology and biochemistry of the potato cyst nematode Globodera pallida have been investigated and comparisons made with its effect on the life-span of the free-living nematode Caenorhabditis elegans to provide insight into its mode of action and its selective toxicity. Results: Fluensulfone exerts acute effects (≤ 1 h; ≥ 100 μM) on stylet thrusting and motility of hatched second stage G. pallida juveniles (J2s). Chronic exposure to lower concentrations of fluensulfone (≥ 3 days; ≤ 30 μM), reveals a slowly developing metabolic insult in which G. pallida J2s sequentially exhibit a reduction in motility, loss of a metabolic marker for cell viability, high lipid content and tissue degeneration prior to death. These effects are absent in adults and dauers of the model genetic nematode Caenorhabditis elegans. Conclusion: The nematicidal action of fluensulfone follows a time-course which progresses from an early impact on motility through to an accumulating metabolic impairment, an inability to access lipid stores and death

Lens magnification by CL0024+1654 in the U and R band

[ABRIDGED] We estimate the total mass distribution of the galaxy cluster CL0024+1654 from the measured source depletion due to lens magnification in the R band. Within a radius of 0.54Mpc/h, a total projected mass of (8.1+/-3.2)*10^14 M_sol/h (EdS) is measured, which corresponds to a mass- to-light ratio of M/L(B)=470+/-180. We compute the luminosity function of CL0024+1654 in order to estimate contamination of the background source counts from cluster galaxies. Three different magnification-based reconstruction methods are employed using both local and non-local techniques. We have modified the standard single power-law slope number count theory to incorporate a break and applied this to our observations. Fitting analytical magnification profiles of different cluster models to the observed number counts, we find that the cluster is best described either by a NFW model with scale radius r_s=334+/-191 kpc/h and normalisation kappa_s=0.23+/-0.08 or a power-law profile with slope xi=0.61+/-0.11, central surface mass density kappa_0=1.52+/-0.20 and assuming a core radius of r_core=35 kpc/h. The NFW model predicts that the cumulative projected mass contained within a radius R scales as M(<R)=2.9*10^14*(R/1')^[1.3-0.5lg (R/1')] M_sol/h. Finally, we have exploited the fact that flux magnification effectively enables us to probe deeper than the physical limiting magnitude of our observations in searching for a change of slope in the U band number counts. We rule out both a total flattening of the counts with a break up to U_AB<=26.6 and a change of slope, reported by some studies, from dlog N/dm=0.4->0.15 up to U_AB<=26.4 with 95% confidence.Comment: 19 pages, 12 figures, submitted to A&A. New version includes more robust U band break analysis and contamination estimates, plus new plot

Shift of percolation thresholds for epidemic spread between static and dynamic small-world networks

The aim of the study was to compare the epidemic spread on static and dynamic small-world networks. The network was constructed as a 2-dimensional Watts-Strogatz model (500x500 square lattice with additional shortcuts), and the dynamics involved rewiring shortcuts in every time step of the epidemic spread. The model of the epidemic is SIR with latency time of 3 time steps. The behaviour of the epidemic was checked over the range of shortcut probability per underlying bond 0-0.5. The quantity of interest was percolation threshold for the epidemic spread, for which numerical results were checked against an approximate analytical model. We find a significant lowering of percolation thresholds for the dynamic network in the parameter range given. The result shows that the behaviour of the epidemic on dynamic network is that of a static small world with the number of shortcuts increased by 20.7 +/- 1.4%, while the overall qualitative behaviour stays the same. We derive corrections to the analytical model which account for the effect. For both dynamic and static small-world we observe suppression of the average epidemic size dependence on network size in comparison with finite-size scaling known for regular lattice. We also study the effect of dynamics for several rewiring rates relative to latency time of the disease.Comment: 13 pages, 6 figure

Using coupled micropillar compression and micro-Laue diffraction to investigate deformation mechanisms in a complex metallic alloy Al13Co4

In this investigation, we have used in-situ micro-Laue diffraction combined with micropillar compression of focused ion beam milled Al13Co4 complex metallic alloy to study the evolution of deformation in Al13Co4. Streaking of the Laue spots showed that the onset of plastic flow occured at stresses as low as 0.8 GPa, although macroscopic yield only becomes apparent at 2 GPa. The measured misorientations, obtained from peak splitting, enabled the geometrically necessary dislocation density to be estimated as 1.1 x 1013 m-2

The Optimal Gravitational Lens Telescope

Given an observed gravitational lens mirage produced by a foreground deflector (cf. galaxy, quasar, cluster,...), it is possible via numerical lens inversion to retrieve the real source image, taking full advantage of the magnifying power of the cosmic lens. This has been achieved in the past for several remarkable gravitational lens systems. Instead, we propose here to invert an observed multiply imaged source directly at the telescope using an ad-hoc optical instrument which is described in the present paper. Compared to the previous method, this should allow one to detect fainter source features as well as to use such an optimal gravitational lens telescope to explore even fainter objects located behind and near the lens. Laboratory and numerical experiments illustrate this new approach