Book Reviews

The following publications have been reviewed by the authors;Sensors & Security, Flashing Lights and Making Noises - reviewed by Dr Rowland DyeMetals and Technology - reviewed by R.M. GawelWood and Technology - reviewed by R.M. GawelNutrition and Food Design - reviewed by Anne GilbertCorporate Identity & Package Design - reviewed by G. AsquithYoung Engineers Handbook - reviewed by John DurrellSpreading the Word - reviewed by David Foste

Reviews

The following publications have been reviewed by the mentioned authors;Textile Innovation - reviewed by Helen WilsonTransferring Designs to Textiles - reviewed by Helen WilsonFood Solutions - reviewed by Jonty KinsellaICT Activities for Food Technology - reviewed by Jenny JupeGCSE Food Technology for OCR - reviewed by Karen O'MahonyFocus on Wood Joints - reviewed by Alison HardyDesigning for the future - reviewed by Ian CapewellLearning to Teach Design and Technology in the Secondary School - reviewed by Jenny JupeUnlocking Potential - reviewed by Rowland DyeThe E-learning Revolution - reviewed by Les Porte

Reviews

The following publications have been reviewed by the mentioned authors;Ideas Bank Design Technology: Designing & Making Book 1 - reviewed by Robert BowenAztecs - Your Move - reviewed by Bridget A. EganChanging Technology - reviewed by John Hill & Elizabeth WrightElectronic Circuits and Components/ The Parts Gallery - reviewed by Mark HudsonGCSE Design and Technology: Resistant Materials - reviewed by John DurrellGlobal contexts: an introduction for design and technology teachers - reviewed by Anne RiggsScience Resources for Key Stage 2: SATIS 8-14 Technology - reviewed by Richard AgerScience Resources for Key Stage 2: SATIS 8-14 Health - reviewed by Richard AgerScience Resources for Key Stage 2: SATIS 8-14 Materials/Transport/Environment - reviewed by Robert BowenTechnology an Enterprising Approach - reviewed by Dr Ron RichieUnderstanding Electronic Circuits CD-ROM - reviewed by Dr Rowland Dye and Phil NormanTextiles and Technology - reviewed by Jillian MellorArt and Design 97 - reviewed by Andy Brecko

Roles for Treg expansion and HMGB1 signaling through the TLR1-2-6 axis in determining the magnitude of the antigen-specific immune response to MVA85A

© 2013 Matsumiya et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are creditedA better understanding of the relationships between vaccine, immunogenicity and protection from disease would greatly facilitate vaccine development. Modified vaccinia virus Ankara expressing antigen 85A (MVA85A) is a novel tuberculosis vaccine candidate designed to enhance responses induced by BCG. Antigen-specific interferon-γ (IFN-γ) production is greatly enhanced by MVA85A, however the variability between healthy individuals is extensive. In this study we have sought to characterize the early changes in gene expression in humans following vaccination with MVA85A and relate these to long-term immunogenicity. Two days post-vaccination, MVA85A induces a strong interferon and inflammatory response. Separating volunteers into high and low responders on the basis of T cell responses to 85A peptides measured during the trial, an expansion of circulating CD4+ CD25+ Foxp3+ cells is seen in low but not high responders. Additionally, high levels of Toll-like Receptor (TLR) 1 on day of vaccination are associated with an increased response to antigen 85A. In a classification model, combined expression levels of TLR1, TICAM2 and CD14 on day of vaccination and CTLA4 and IL2Rα two days post-vaccination can classify high and low responders with over 80% accuracy. Furthermore, administering MVA85A in mice with anti-TLR2 antibodies may abrogate high responses, and neutralising antibodies to TLRs 1, 2 or 6 or HMGB1 decrease CXCL2 production during in vitro stimulation with MVA85A. HMGB1 is released into the supernatant following atimulation with MVA85A and we propose this signal may be the trigger activating the TLR pathway. This study suggests an important role for an endogenous ligand in innate sensing of MVA and demonstrates the importance of pattern recognition receptors and regulatory T cell responses in determining the magnitude of the antigen specific immune response to vaccination with MVA85A in humans.This work was funded by the Wellcome Trust. MM has a Wellcome Trust PhD studentship and HM is a Wellcome Trust Senior Fello

A Systematic Review of Music Therapy Practice and Outcomes with Acute Adult Psychiatric In-Patients

PMCID: PMC3732280This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

SOTLl: Building Interdisciplinary Community

Mercer University faculty in Atlanta have taken an organic approach in creating cross-campus conversations about Scholarship of Teaching and Learning projects. The panel will consist of faculty for graduate colleges including education, pharmacy, physical therapy and counseling. Our goal is to share individual projects and how we are supported at the provost, dean and individual level to make connections among the ongoing faculty research from professional colleges. We are interested in creating a dialogue with conference participants to strengthen our interdisciplinary dialogue

Reviews

The following publications have been reviewed by the mentioned authors;Exploring Primary Design and Technology - reviewed by Alan CrossCreative Computing - reviewed by Alan CrossAll About Food - reviewed by Jonty KinsellaProducts and Packages for Key Stage 4 - reviewed by Chris SnellExamining Textiles Technology - reviewed by Glen Reeve-FowkesPCB Wizard V2.0 - reviewed by Rowland Dye and Phil NormanSkills in Textiles Technology - reviewed by Christine TwisletonGraphic Products to GCSE - reviewed by George AsquithCollins Real World Technology Series: Food Technology - reviewed by Roy BallamPackaging - reviewed by Melanie FasciatoThe Cutting Edge of Manufacturing - reviewed by Alan TruemanUnderstanding Ingredients - reviewed by Jonty KinsellaJapanese Art and Design - reviewed by Christine TwisletonTextiles: A Handbook for Teachers - reviewed by Christine TwisletonPICtutor - reviewed by David FosterDesign and Make It! Systems and Control Technology - reviewed by Trevor Taylo