3,938 research outputs found
Past electron-positron g-2 experiments yielded sharpest bound on CPT violation for point particles
In our past experiments on a single electron and positron we measured the
cyclotron and spin-cyclotron difference frequencies omega_c and omega_a and the
ratios a = omega_a/ omega_c at omega_c = 141 Ghz for e^- and e^+ and later,
only for e^-, also at 164 Ghz. Here, we do extract from these data, as had not
done before, a new and very different figure of merit for violation of CPT
symmetry, one similar to the widely recognized impressive limit |m_Kaon -
m_Antikaon|/m_Kaon < 10^-18 for the K-mesons composed of two quarks. That
expression may be seen as comparing experimental relativistic masses of
particle states before and after the C, P, T operations had transformed
particle into antiparticle. Such a similar figure of merit for a non-composite
and quite different lepton, found by us from our Delta a = a^- - a^+ data, was
even smaller, h_bar |omega_a^- - omega_a^+|/2m_0 c^2 = |Delta a| h_bar
omega_c/2m_0 c^2) < 3(12) 10^-22.Comment: Improved content, Editorially approved for publication in PRL, LATEX
file, 5 pages, no figures, 16
Clinical surveillance of thrombotic microangiopathies in Scotland, 2003-2005
The prevalence, incidence and outcomes of haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopaenic purpura (TTP) are not well established in adults or children from prospective studies. We sought to identify both outcomes and current management strategies using prospective, national surveillance of HUS and TTP, from 2003 to 2005 inclusive. We also investigated the links between these disorders and factors implicated in the aetiology of HUS and TTP including infections, chemotherapy, and immunosuppression. Most cases of HUS were caused by verocytotoxin-producing Escherichia coli (VTEC), of which serotype O157 predominated, although other serotypes were identified. The list of predisposing factors for TTP was more varied although use of immunosuppressive agents and severe sepsis, were the most frequent precipitants. The study demonstrates that while differentiating between HUS and TTP is sometimes difficult, in most cases the two syndromes have quite different predisposing factors and clinical parameters, enabling clinical and epidemiological profiling for these disorders
Shell-model description of monopole shift in neutron-rich Cu
Variations in the nuclear mean-field, in neutron-rich nuclei, are
investigated within the framework of the nuclear shell model. The change is
identified to originate mainly from the monopole part of the effective two-body
proton-neutron interaction. Applications for the low-lying states in odd- Cu
nuclei are presented. We compare the results using both schematic and realistic
forces. We also compare the monopole shifts with the results obtained from
large-scale shell-model calculations, using the same realistic interaction, in
order to study two-body correlations beyond the proton mean-field variations.Comment: Phys. Rev. C (in press
Quantum Logic with a Single Trapped Electron
We propose the use of a trapped electron to implement quantum logic
operations. The fundamental controlled-NOT gate is shown to be feasible. The
two quantum bits are stored in the internal and external (motional) degrees of
freedom.Comment: 7 Pages, REVTeX, No Figures, To appear in Phys. Rev.
Infrared and visual lunar occultations measurements of stellar diameters and new binary stars detections at the Calar Alto 1.5m telescope
We present a program of routine lunar occultations, at optical and near-IR
wavelengths, recently started at the 1.5m Spanish telescope at the Calar Alto
Observatory. Both a CCD and an infrared array detector are used. The program is
aimed mainly at the detection and investigation of binary systems, although
results in other areas of stellar research are also anticipated.
Occultations are reported for a total of 40 stars. Among these, SAO 164567,
SAO 78258 and AG+24 788 have been discovered to be binaries, with projected
separations as small as 0.006". Furthermore, binarity is suspected in the case
of SAO 78119 and SAO 79251. Additionally, the angular diameter of the late-type
giant 30 Psc and of the infrared star V349 Gem have been accurately measured,
this latter for the first time.
We finally evaluate the instrumentation performance in terms of limiting
magnitude and angular resolution, and discuss applications to larger
telescopes.Comment: 15 pages, 3 figures, LaTeX, uses aa.cls. Accepted for publication in
A&
development of measures of polyneuropathy impairment in hattr amyloidosis from nis to mnis 7
Abstract Hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis) is a rare, life-threatening disease, caused by point mutations in the transthyretin gene. It is a heterogeneous, multisystem disease with rapidly progressing polyneuropathy (including sensory, motor, and autonomic impairments) and cardiac dysfunction. Measures used to assess polyneuropathy in other diseases have been tested as endpoints in hATTR amyloidosis clinical trials (i.e. Neuropathy Impairment Score [NIS], NIS-lower limb, and NIS + 7), yet the unique nature of the polyneuropathy in this disease has necessitated modifications to these scales. In particular, the heterogeneous impairment and the aggressive disease course have been key drivers in developing scales that better capture the disease burden and progression of polyneuropathy in hATTR amyloidosis. The modified NIS + 7 (mNIS + 7) scale was specifically designed to assess polyneuropathy impairment in patients with hATTR amyloidosis, and has been the primary endpoint in two recent, phase III studies in this disease. The mNIS + 7 uses highly standardized, quantitative, and referenced assessments to quantify decreased muscle weakness, muscle stretch reflexes, sensory loss, and autonomic impairment. Physicians using this scale in clinical trials should be specifically trained and monitored to minimize variability. This article discusses the different scales that have been/are being used to assess polyneuropathy in patients with hATTR amyloidosis, their correlation with other disease assessments, and reflects on how and why scales have evolved to the latest iteration of mNIS + 7
Neighbourhood, Route and Workplace-Related Environmental Characteristics Predict Adults' Mode of Travel to Work
Commuting provides opportunities for regular physical activity which can reduce the risk of chronic disease. Commuters' mode of travel may be shaped by their environment, but understanding of which specific environmental characteristics are most important and might form targets for intervention is limited. This study investigated associations between mode choice and a range of objectively assessed environmental characteristics.Participants in the Commuting and Health in Cambridge study reported where they lived and worked, their usual mode of travel to work and a variety of socio-demographic characteristics. Using geographic information system (GIS) software, 30 exposure variables were produced capturing characteristics of areas around participants' homes and workplaces and their shortest modelled routes to work. Associations between usual mode of travel to work and personal and environmental characteristics were investigated using multinomial logistic regression.Of the 1124 respondents, 50% reported cycling or walking as their usual mode of travel to work. In adjusted analyses, home-work distance was strongly associated with mode choice, particularly for walking. Lower odds of walking or cycling rather than driving were associated with a less frequent bus service (highest versus lowest tertile: walking OR 0.61 [95% CI 0.20–1.85]; cycling OR 0.43 [95% CI 0.23–0.83]), low street connectivity (OR 0.22, [0.07–0.67]; OR 0.48 [0.26–0.90]) and free car parking at work (OR 0.24 [0.10–0.59]; OR 0.55 [0.32–0.95]). Participants were less likely to cycle if they had access to fewer destinations (leisure facilities, shops and schools) close to work (OR 0.36 [0.21–0.62]) and a railway station further from home (OR 0.53 [0.30–0.93]). Covariates strongly predicted travel mode (pseudo r-squared 0.74).Potentially modifiable environmental characteristics, including workplace car parking, street connectivity and access to public transport, are associated with travel mode choice, and could be addressed as part of transport policy and infrastructural interventions to promote active commuting
Possible Spontaneous Breaking of Lorentz and CPT Symmetry
One possible ramification of unified theories of nature such as string theory
that may underlie the conventional standard model is the possible spontaneous
breakdown of Lorentz and CPT symmetry. In this talk, the formalism for
inclusion of such effects into a low-energy effective field theory is
presented. An extension of the standard model that includes Lorentz- and
CPT-breaking terms is developed. The restriction of the standard model
extension to the QED sector is then discussed.Comment: Talk presented at Non-Accelerator New Physics, Dubna, Russia, July
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