193 research outputs found
Integration of ejectors into high-speed aircraft
The integration of ejectors into forebodies is considered for transonic and supersonic flight. Topics discussed include mixing flow in ducts, prediction of flow fields and external aerodynamics
The Laser Astrometric Test of Relativity Mission
This paper discusses new fundamental physics experiment to test relativistic
gravity at the accuracy better than the effects of the 2nd order in the
gravitational field strength. The Laser Astrometric Test Of Relativity (LATOR)
mission uses laser interferometry between two micro-spacecraft whose lines of
sight pass close by the Sun to accurately measure deflection of light in the
solar gravity. The key element of the experimental design is a redundant
geometry optical truss provided by a long-baseline (100 m) multi-channel
stellar optical interferometer placed on the International Space Station. The
geometric redundancy enables LATOR to measure the departure from Euclidean
geometry caused by the solar gravity field to a very high accuracy. LATOR will
not only improve the value of the parameterized post-Newtonian (PPN) parameter
gamma to unprecedented levels of accuracy of 1 part in 1e8, it will also reach
ability to measure effects of the next post-Newtonian order (1/c^4) of light
deflection resulting from gravity's intrinsic non-linearity. The solar
quadrupole moment parameter, J2, will be measured with high precision, as well
as a variety of other relativistic. LATOR will lead to very robust advances in
the tests of fundamental physics: this mission could discover a violation or
extension of general relativity, or reveal the presence of an additional long
range interaction in the physical law. There are no analogs to the LATOR
experiment; it is unique and is a natural culmination of solar system gravity
experiments.Comment: 8 pages, 2 figures, invited talk given at the Second International
Conference on Particle and Fundamental Physics in Space (SpacePart'03), 10-12
December 2003, Washington, D
Evidence for the role of EPHX2 gene variants in anorexia nervosa.
Anorexia nervosa (AN) and related eating disorders are complex, multifactorial neuropsychiatric conditions with likely rare and common genetic and environmental determinants. To identify genetic variants associated with AN, we pursued a series of sequencing and genotyping studies focusing on the coding regions and upstream sequence of 152 candidate genes in a total of 1205 AN cases and 1948 controls. We identified individual variant associations in the Estrogen Receptor-Ăź (ESR2) gene, as well as a set of rare and common variants in the Epoxide Hydrolase 2 (EPHX2) gene, in an initial sequencing study of 261 early-onset severe AN cases and 73 controls (P=0.0004). The association of EPHX2 variants was further delineated in: (1) a pooling-based replication study involving an additional 500 AN patients and 500 controls (replication set P=0.00000016); (2) single-locus studies in a cohort of 386 previously genotyped broadly defined AN cases and 295 female population controls from the Bogalusa Heart Study (BHS) and a cohort of 58 individuals with self-reported eating disturbances and 851 controls (combined smallest single locus P<0.01). As EPHX2 is known to influence cholesterol metabolism, and AN is often associated with elevated cholesterol levels, we also investigated the association of EPHX2 variants and longitudinal body mass index (BMI) and cholesterol in BHS female and male subjects (N=229) and found evidence for a modifying effect of a subset of variants on the relationship between cholesterol and BMI (P<0.01). These findings suggest a novel association of gene variants within EPHX2 to susceptibility to AN and provide a foundation for future study of this important yet poorly understood condition
Simulation-based cheminformatic analysis of organelle-targeted molecules: lysosomotropic monobasic amines
Cell-based molecular transport simulations are being developed to facilitate exploratory cheminformatic analysis of virtual libraries of small drug-like molecules. For this purpose, mathematical models of single cells are built from equations capturing the transport of small molecules across membranes. In turn, physicochemical properties of small molecules can be used as input to simulate intracellular drug distribution, through time. Here, with mathematical equations and biological parameters adjusted so as to mimic a leukocyte in the blood, simulations were performed to analyze steady state, relative accumulation of small molecules in lysosomes, mitochondria, and cytosol of this target cell, in the presence of a homogenous extracellular drug concentration. Similarly, with equations and parameters set to mimic an intestinal epithelial cell, simulations were also performed to analyze steady state, relative distribution and transcellular permeability in this non-target cell, in the presence of an apical-to-basolateral concentration gradient. With a test set of ninety-nine monobasic amines gathered from the scientific literature, simulation results helped analyze relationships between the chemical diversity of these molecules and their intracellular distributions
Anisotropic Inflation and the Origin of Four Large Dimensions
In the context of (4+d)-dimensional general relativity, we propose an
inflationary scenario wherein 3 spatial dimensions grow large, while d extra
dimensions remain small. Our model requires that a self-interacting d-form
acquire a vacuum expectation value along the extra dimensions. This causes 3
spatial dimensions to inflate, whilst keeping the size of the extra dimensions
nearly constant. We do not require an additional stabilization mechanism for
the radion, as stable solutions exist for flat, and for negatively curved
compact extra dimensions. From a four-dimensional perspective, the radion does
not couple to the inflaton; and, the small amplitude of the CMB temperature
anisotropies arises from an exponential suppression of fluctuations, due to the
higher-dimensional origin of the inflaton. The mechanism triggering the end of
inflation is responsible, both, for heating the universe, and for avoiding
violations of the equivalence principle due to coupling between the radion and
matter.Comment: 24 pages, 2 figures; uses RevTeX4. v2: Minor changes and added
references. v3: Improved discussion of slow-rol
The conformal frame freedom in theories of gravitation
It has frequently been claimed in the literature that the classical physical
predictions of scalar tensor theories of gravity depend on the conformal frame
in which the theory is formulated. We argue that this claim is false, and that
all classical physical predictions are conformal-frame invariants. We also
respond to criticisms by Vollick [gr-qc/0312041], in which this issue arises,
of our recent analysis of the Palatini form of 1/R gravity.Comment: 9 pages, no figures, revtex; final published versio
corrections to the cosmological dynamics of inflation in the Palatini formulation
We investigate the corrections to the inflationary cosmological dynamics due
to a term in the Palatini formulation which may arise as quantum
corrections to the effective Lagrangian in early universe. We found that the
standard Friedmann equation will not be changed when the scalar field is in the
potential energy dominated era. However, in the kinetic energy dominated era,
the standard Friedmann equation will be modified and in the case of closed and
flat universe, the Modified Friedmann equation will automatically require that
the initial kinetic energy density of the scalar field must be in sub-Planckian
scale.Comment: 11 pages, no figures. Accepted by Class.Quant.Grav.v2:References
adde
Modified-Source Gravity and Cosmological Structure Formation
One way to account for the acceleration of the universe is to modify general
relativity, rather than introducing dark energy. Typically, such modifications
introduce new degrees of freedom. It is interesting to consider models with no
new degrees of freedom, but with a modified dependence on the conventional
energy-momentum tensor; the Palatini formulation of theories is one
example. Such theories offer an interesting testing ground for investigations
of cosmological modified gravity. In this paper we study the evolution of
structure in these ``modified-source gravity'' theories. In the linear regime,
density perturbations exhibit scale dependent runaway growth at late times and,
in particular, a mode of a given wavenumber goes nonlinear at a higher redshift
than in the standard CDM model. We discuss the implications of this
behavior and why there are reasons to expect that the growth will be cut off in
the nonlinear regime. Assuming that this holds in a full nonlinear analysis, we
briefly describe how upcoming measurements may probe the differences between
the modified theory and the standard CDM model.Comment: 22 pages, 6 figures, uses iopart styl
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