16 research outputs found
Evolution de l'incidence des lymphomes cutanés primitifs en Seine Maritime sur une période de 10 ans
Le but de cette Ă©tude Ă©tait d'Ă©valuer les lymphomes cutanĂ©s primitifs en Seine-Maritime sur une pĂ©riode de dix ans. L'Ă©tude Ă©tait rĂ©trospective et rĂ©alisĂ©e du 01.01.1991 au 01.01.2001. L'identification des lymphomes cutanĂ©s a Ă©tĂ© faite Ă partir des registres des 11 laboratoires d'anatomopathologie du dĂ©partement (4 laboratoires hospitaliers et 7 laboratoires libĂ©raux). Les comptes rendus et les lames ont Ă©tĂ© centralisĂ©es au CHU. L'ensemble des lames a Ă©tĂ© relu en insu par le mĂȘme dermatopathologiste (Ph. C.). L'INSEE nous a fourni les recensements du dĂ©partement des annĂ©es 1990 et 1999. Le calcul de l'incidence a Ă©tĂ© fait Ă l'aide du logiciel Excel Âź. La tendance Ă©volutive sur 10 ans a Ă©tĂ© analysĂ©e par rĂ©gression linĂ©aire. Cent soixante quinze cas de lymphomes ont Ă©tĂ© identifiĂ©s pendant la pĂ©riode de l'Ă©tude. Il s'agissait de 117 cas de lymphomes T (67%), de 55 cas de lymphomes B (31%), et de 3 cas de lymphomes non B non T (2%). Il existait une augmentation de l'incidence annuelle, sur 10 ans, des lymphomes cutanĂ©s primitifs de phĂ©notype T dans les 2 sexes. L'incidence augmentait chez les hommes pour le MF et chez les femmes pour la papulose lymphomatoĂŻde. Pour les lymphomes cutanĂ©s primitifs de phĂ©nomĂšne B, l'incidence est restĂ©e stable sur dix ans. L'augmentation des lymphomes cutanĂ©s T peut ĂȘtre rĂ©elle, en dehors de biais de sĂ©lection et de recrutement. Ce qui soulĂšve, comme pour les LMNH, l'hypothĂšse de facteurs environnementaux et viraux.ROUEN-BU MĂ©decine-Pharmacie (765402102) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF
Successful use of dabrafenib after the occurrence of drug rash with eosinophilia and systemic symptoms (DRESS) induced by vemurafenib
International audienc
Simultaneous long-lasting regression of multiple nevi and melanoma metastases after ipilimumab therapy
International audienc
Lack of association between chilblains outbreak and severe acute respiratory syndrome coronavirus 2: Histologic and serologic findings from a new immunoassay
Association of occupational exposure with features of systemic sclerosis
International audienceOccupational exposure is reported as playing a substantial causative role in systemic sclerosis (SSc)
Clostridium difficile infection and immune checkpoint inhibitorâinduced colitis in melanoma: 18 cases and a review of the literature
International audienceImmunotherapy has become the standard of care for several types of cancer, such as melanoma. However, it can induce toxicity, including immune checkpoint inhibitor-induced colitis (CIC). CIC shares several clinical, histological, biological, and therapeutic features with inflammatory bowel disease (IBD). Clostridium difficile infection (CDI) can complicate the evolution of IBD. We aimed to characterize the association between CDI and CIC in patients treated with anti-CTLA-4 and anti-PD-1 for melanoma. Patients from nine centers treated with anti-CTLA-4 and anti-PD-1 for melanoma and presenting with CDI from 2010 to 2021 were included in this retrospective cohort. The primary endpoint was the occurrence of CIC. The secondary endpoints were findings allowing us to characterize CDI. Eighteen patients were included. Eleven were treated with anti-PD-1, four with anti-CTLA-4, and three with anti-PD-1 in combination with anti-CTLA-4. Among the 18 patients, six had isolated CDI and 12 had CIC and CDI. Among these 12 patients, eight had CIC complicated by CDI, three had concurrent CIC and CDI, and one had CDI followed by CIC. CDI was fulminant in three patients. Endoscopic and histological features did not specifically differentiate CDI from CIC. Nine of 11 patients required immunosuppressive therapy when CDI was associated with CIC. In nine cases, immunotherapy was discontinued due to digestive toxicity. CDI can be isolated or can complicate or reveal CIC. CDI in patients treated with immunotherapy shares many characteristics with CDI complicating IBD. Stool tests for Clostridium difficile should be carried out for all patients with diarrhea who are being treated with immunotherapy
Effectiveness and tolerance of Janus kinase inhibitors for the treatment of recalcitrant atopic dermatitis in a real-life French multicenter adult cohort
International audienc
A Single-Arm Phase II Trial of Lenalidomide in Relapsing or Refractory Primary Cutaneous Large B-Cell Lymphoma, Leg Type
International audienc