Over-the-Counter Relief from Pains and Pleasures Alike: Acetaminophen Blunts Sensitivity to Both Negative and Positive Reactions

Social and Behavioral Sciences; Social Work; Law: 2nd Place (The Ohio State University Edward F. Hayes Graduate Research Forum)Acetaminophen, an effective and popular over-the-counter pain reliever (e.g., Tylenol®), has recently been shown to blunt individuals’ reactivity to a range of negative stimuli beyond physical pain. Because past psychological and neuroimaging research has linked reduced sensitivity to negative reactions to similarly diminished sensitivity to positive reactions, we conducted two experiments testing whether acetaminophen might blunt individuals’ evaluations and emotional experiences to both negative and positive stimuli alike. In each study, participants received either acetaminophen or placebo, and evaluated emotionally evocative stimuli on valence (Study 1 and 2), emotional arousal (Study 1 and 2), and non-evaluative aspects (Study 2). Results revealed that participants taking acetaminophen (versus placebo) evaluated unpleasant stimuli less negatively and pleasant stimuli less positively, and were less emotionally aroused overall. Conversely, non-evaluative judgments were unaffected by treatment. These findings suggest that the mechanism by which acetaminophen reduces pain may more broadly blunt individuals’ evaluative and emotional processing.A one-year embargo was granted for this item

Impact of Vegetative Treatment Systems on Multiple Measures of Antibiotic Resistance in Agricultural Wastewater

Wastewater is an important vector of antibiotic resistant bacteria and antibiotic resistance genes (ARB/G). While there is broad agreement that ARB/G from agricultural (ag) wastewaters can be transported through the environment and may contribute to untreatable infectious disease in humans and animals, there remain large knowledge gaps surrounding applied details on the types and amounts of ARB/G associated with different agricultural wastewater treatment options and different ag production systems. This study evaluates a vegetative treatment system (VTS) built to treat the wastewater from a beef cattle feedlot. Samples were collected for three years, and plated on multiple media types to enumerate tetracycline and cefotaxime-resistant bacteria. Enterobacteriaceae isolates (n = 822) were characterized for carriage of tetracycline resistance genes, and E. coli isolates (n = 673) were phenotyped to determine multi-drug resistance (MDR) profiles. Tetracycline resistance in feedlot runoff wastewater was 2-to-3 orders of magnitude higher compared to rainfall runoff from the VTS fields, indicating efficacy of the VTA for reducing ARB over time following wastewater application. Clear differences in MDR profiles were observed based on the specific media on which a sample was plated. This result highlights the importance of method, especially in the context of isolate-based surveillance and monitoring of ARB in agricultural wastewaters

On the inverse spectral problem for polygonal domains

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Mathematics, 1988.Includes bibliographical references.by Catherine Durso.Ph.D

Ted Durso to Mr. Meredith (7 October 1962)

https://egrove.olemiss.edu/mercorr_pro/2037/thumbnail.jp