Setting up and Managing Chain Initiatives

Chain coordination is growing in importance to maintain access to global markets and competitive advantage. Of particular interest is how to set up and manage an initiative in a chain. Much of the research in the area of chains is based on case study examples of initiatives to improve chain performance. While this research is very rich in providing details about what was done, there can be questions of how applicable it may be in other situations. This research aimed to provide some more generalisable results that may be applied in a range of different situations

Posterior retinal contour in adult human anisomyopia

PURPOSE. It is well documented that myopia is associated with an increase in axial length or, more specifically, in vitreous chamber depth. Whether the transverse dimensions of the eye also increase in myopia is relevant to further understanding of its development. METHODS. The posterior retinal surface was localized in two-dimensional space in both eyes of young adult white and Taiwanese-Chinese iso- and anisomyopes (N = 56), from measured keratometry, A-scan ultrasonography, and central and peripheral refraction (±35°) data, with the aid of a computer modeling program designed for this purpose. Anisomyopes had 2 D or more interocular difference in their refractive errors, with mean values in their more myopic eyes of -5.57 D and in their less myopic eyes of -3.25 D, similar to the means of the two isomyopic groups. The derived retinal contours for the more and less myopic eyes were compared by way of investigating ocular shape changes that accompany myopia, in the posterior region of the vitreous chamber. The presence and size of optic disc crescents were also investigated as an index of retinal stretching in myopia. RESULTS. Relative to the less myopic eyes of anisometropic subjects, the more myopic eyes were more elongated and also distorted into a more prolate shape in both the white and Chinese groups. However, the Chinese eyes showed a greater and more uniform relative expansion of the posterior retinal surface in their more myopic eyes, and this was associated with larger optic disc crescents. The changes in the eyes of whites displayed a nasal-temporal axial asymmetry, reflecting greater enlargement of the nasal retinal sector. CONCLUSIONS. Myopia is associated with increased axial length and a prolate shape. This prolate shape is consistent with the proposed idea that axial and transverse dimensions of the eye are regulated differently. The observations that ocular shape changes are larger but more symmetrical in Chinese eyes than in eyes of whites warrant further investigation

Sustained High Rates Of Job Creation And Destruction In Substate Economies

Widely utilized net employment change statistics actually mask an extremely volatile process of job creation and destruction.  In the past decade economists have addressed this problem by exploiting newly available longitudinal data series to estimate these job flows and the subsequent amount of job churning at the national, state and MSA level.  This study is unique in that it uses an innovative technique to capture job flows within and between industries at the local area level where longitudinal BLS data series are not available.  The geographic unit of analysis in this paper is a Cohesive Commercial Statistical Area™ (CCSA), a substate aggregate of cities and towns sharing common economic interests but not a Metropolitan Statistical Area.  The paper examines job flows in two very different Massachusetts substate economies: the MetroWest CCSA, a technology sensitive research and development economy, and the South Shore CCSA, a mature economy with a competitive edge in financial services. This study establishes that a sizable portion of disaggregated job flows can be captured at a substate level using available employment data. Building upon techniques used in earlier studies, the authors confirmed very high levels of employment volatility, “job churning”, in both substate regions.  The authors found that over two decades, job reallocation rates in MetroWest averaged 9%, affecting one out of 11 jobs annually. The study traced the pattern of job creation and destruction over the course of local business cycles and found that both job creation and destruction existed during all phases of the business cycle. Although, as expected, job creation dominated the expansion phase and destruction dominated the contraction phase, the total amount of job reallocation (creation plus destruction) remained relatively stable through all stages of the business cycle.   However, the composition of the job reallocation varied dramatically by stage of business cycle.  A Job Replacement Ratio has been developed as a quick test to confirm economic expansion or contraction and to focus economic development efforts

Vine Weevil Control in Ireland with Entomopathogenic Nematodes: Optimal Time of Application

Outdoor trials with potted primroses (1997 and 1998) and field-grown strawberries (1998) artificially infected with vine weevil (Otiorhynchus sulcatus) were conducted in Ireland to assess the best time of nematode (Heterorhabditis megidis, isolate UK211) application in autumn. Approximately 75 to 85% control was obtained in primrose in both years when nematodes were applied at the end of September to mid-October. The 1997 primrose trial showed that an early September nematode application helped to avoid plant damage (important when protecting young and vulnerable plants), but that October and November nematode applications gave a higher (95%), but delayed, control level when left until spring. Control in strawberry was similar to that in primrose, with maximum 76% control. Maximum control levels obtained with nema todes were similar to those obtained with chlorpyrifos (Dursban) in strawberry and gamma HCH (Lindane) in primrose. These results clearly show that nematodes can be applied successfully outdoors, under Irish weather conditions, until mid-October

Schistosoma mansoni, nematode infections, and progression to active tuberculosis among HIV-1-infected Ugandans.

Rates of tuberculosis (TB) in Africa are highest among people infected with HIV. Searching for additional risk factors in a cohort of HIV-infected Ugandan adults, we previously found that a type 2 cytokine bias and eosinophilia were associated with progression to active TB. A possible role for helminth infection was assessed in this study. We analyzed TB incidence in 462 members of this cohort who were screened for filarial infections, gastrointestinal nematodes, and schistosomiasis. Progression to TB was not associated with gastrointestinal nematodes (rate ratio [RR], 1.18; confidence intervals [CIs], 0.66-2.10) or Mansonella perstans (RR, 0.42; CI, 0.13-1.34). A weak association between Schistosoma mansoni infection and TB was found (RR, 1.42; CI, 0.86-2.34); after adjusting for potential explanatory variables and using more stringent diagnostic criteria, the association was strengthened (RR, 2.31; 1.00-5.33). This analysis suggests an effect of S. mansoni infection on progression to active TB among HIV-1-infected Ugandans

Prehospital Tibial Intraosseous Drug Administration is Associated with Reduced Survival Following Out of Hospital Cardiac Arrest: A study for the CARES Surveillance Group

BACKGROUND: Recent reports have questioned the efficacy of intraosseous (IO) drug administration for out-of-hospital cardiac arrest (OHCA) resuscitation. Our aim was to determine whether prehospital administration of resuscitative medications via the IO route was associated with lower rates of return of spontaneous circulation (ROSC) and survival to hospital discharge than peripheral intravenous (IV) infusion in the setting of OHCA. METHODS: We obtained data on all OHCA patients receiving prehospital IV or IO drug administration from the three most populous counties in Michigan over three years. Data was from the Michigan Cardiac Arrest Registry to Enhance Survival (CARES) database. The association between route of drug administration and outcomes was tested using a matched propensity score analysis. RESULTS: From a total of 10,626 OHCA patients, 6869 received parenteral drugs during their prehospital resuscitation (37.8% by IO) and were included in analysis. Unadjusted outcomes were lower in patients with IO vs. IV access: 18.3% vs. 23.8% for ROSC (p \u3c 0.001), 3.2% vs. 7.6% for survival to hospital discharge (p \u3c 0.001), and 2.0% vs. 5.8% for favorable neurological function (p \u3c 0.001). After adjustment, IO route remained associated with lower odds of sustained ROSC (OR 0.72, 95% CI 0.63-0.81, p \u3c 0.001), hospital survival (OR 0.48, 95% CI 0.37-0.62, p \u3c 0.001), and favorable neurological outcomes (OR 0.42, 95% CI 0.30-0.57, p \u3c 0.001). CONCLUSION: In this cohort of OHCA patients, the use of prehospital IO drug administration was associated with unfavorable clinical outcomes

Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

The Soil Moisture Active Passive Marena, Oklahoma, In Situ Sensor Testbed (SMAP-MOISST): Testbed Design and Evaluation of In Situ Sensors

n situ soil moisture monitoring networks are critical to the development of soil moisture remote sensing missions as well as agricultural and environmental management, weather forecasting, and many other endeavors. These in situ networks utilize a variety of sensors and installation practices, which confounds the development of a unified reference database for satellite calibration and validation programs. As part of the Soil Moisture Active Passive Mission, the Marena, Oklahoma, In Situ Sensor Testbed (SMAP-MOISST) was initiated to perform inter-comparisons and study sensor limitations. Soil moisture sensors that are deployed in major monitoring networks were included in the study, along with new and emerging technologies, such as the Cosmic Ray Soil Moisture Observing System (COSMOS), passive/active distributed temperature sensing (DTS), and global positioning system reflectometers (GPSR). Four profile stations were installed in May of 2010, and soil moisture was monitored to a depth of 1 m on an hourly basis. The four stations were distributed within a circular domain of approximately 600 m diameter, adequate to encompass the sensing range of COSMOS. The sensors included in the base station configuration included the Stevens Water Hydra Probe, Campbell Scientific 616 and 229, Decagon EC-TM, Delta-T Theta Probe, Acclima, and Sentek EnviroSMART capacitance system. In addition, the Pico TRIME system and additional time-domain reflectometry (TDR) systems were deployed when available. It was necessary to apply site-specific calibration to most sensors to reach an RMSE below 0.04 m³ m⁻³. For most sensor types, a single near surface sensor could be scaled to represent the areal-average of a field domain by simple linear regression, resulting in RMSE values around 0.03 m³ m⁻³.This is the publisher’s final pdf. The published article is copyrighted by the Soil Science Society of America and can be found at: https://dl.sciencesocieties.org/publications/vz

A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni

Schistosomiasis is one of the most prevalent parasitic diseases, affecting millions of people in developing countries. Amongst the human-infective species, Schistosoma mansoni is also the most commonly used in the laboratory and here we present the systematic improvement of its draft genome. We used Sanger capillary and deep-coverage Illumina sequencing from clonal worms to upgrade the highly fragmented draft 380 Mb genome to one with only 885 scaffolds and more than 81% of the bases organised into chromosomes. We have also used transcriptome sequencing (RNA-seq) from four time points in the parasite's life cycle to refine gene predictions and profile their expression. More than 45% of predicted genes have been extensively modified and the total number has been reduced from 11,807 to 10,852. Using the new version of the genome, we identified trans-splicing events occurring in at least 11% of genes and identified clear cases where it is used to resolve polycistronic transcripts. We have produced a high-resolution map of temporal changes in expression for 9,535 genes, covering an unprecedented dynamic range for this organism. All of these data have been consolidated into a searchable format within the GeneDB (www.genedb.org) and SchistoDB (www.schistodb.net) databases. With further transcriptional profiling and genome sequencing increasingly accessible, the upgraded genome will form a fundamental dataset to underpin further advances in schistosome research