Long‐term Production and Profitability from Grazing Cattle in the Northern Mixed GrassPrairie

Conventional wisdom among rangeland professionals has been that for long‐term sustainability of grazing livestock operations, rangeland should be kept in high good to low excellent range condition. Our objective was to analyze production parameters, economic costs, returns, and profit using data generated over a thirty‐four year period (1969‐2002) from grazing a Clayey range site in the mixed‐grass prairie of western South Dakota with variable stocking rates required to maintain pastures in low‐fair, good, and excellent range condition classes. Cattle weights were measured at turnout and at the end of the grazing season. Gross income per acre was calculated by multiplying total gain per acre times price using historical National Agricultural Statistics Services feeder cattle prices. Annual variable costs were estimated from a historical yearling cattle budget developed by South Dakota State University (SDSU) agricultural economists. All economic values were adjusted to a constant dollar using the Bureau of Labor Statistics’ Consumer Price Index. Stocking rate, average daily gain, total gain, net profit, gross revenue, and annual costs per acre varied among range condition classes. Net income for low‐fair range condition ($11.18 per acre) and good range condition ($11.86 per acre) were not different, but both were greater (P \u3c 0.01) than excellent range condition ($ 9.31 per acre). Over the life of the study, real profit (adjusted for inflation) steadily increased (P \u3c 0.01) for the low‐fair and good treatments while it remained level for the excellent treatment. Neither drought nor wet springs impacted profit differently for the three treatments. These results support generally observed rancher behavior regarding range condition: to maintain their rangeland in a lower range condition than would be normally recommend by rangeland professionals. Ecosystem goods and services of increasing interest to society and associated with high range condition, such as floristic diversity, hydrologic function, and wildlife cover, come at an opportunity cost to the rancher

Characterization of anticoagulant heparinoids by immunoprofiling

Heparinoids are used in the clinic as anticoagulants. A specific pentasaccharide in heparinoids activates antithrombin III, resulting in inactivation of factor Xa and–when additional saccharides are present–inactivation of factor IIa. Structural and functional analysis of the heterogeneous heparinoids generally requires advanced equipment, is time consuming, and needs (extensive) sample preparation. In this study, a novel and fast method for the characterization of heparinoids is introduced based on reactivity with nine unique anti-heparin antibodies. Eight heparinoids were biochemically analyzed by electrophoresis and their reactivity with domain-specific anti-heparin antibodies was established by ELISA. Each heparinoid displayed a distinct immunoprofile matching its structural characteristics. The immunoprofile could also be linked to biological characteristics, such as the anti-Xa/anti-IIa ratio, which was reflected by reactivity of the heparinoids with antibodies HS4C3 (indicative for 3-O-sulfates) and HS4E4 (indicative for domains allowing anti-factor IIa activity). In addition, the immunoprofile could be indicative for heparinoid-induced side-effects, such as heparin-induced thrombocytopenia, as illustrated by reactivity with antibody NS4F5, which defines a very high sulfated domain. In conclusion, immunoprofiling provides a novel, fast, and simple methodology for the characterization of heparinoids, and allows high-throughput screening of (new) heparinoids for defined structural and biological characteristics

On the Relation Between Jovian Aurorae and the Loading/Unloading of the Magnetic Flux:Simultaneous Measurements From Juno, Hubble Space Telescope, and Hisaki

We present simultaneous observations of aurorae at Jupiter from the Hubble Space Telescope and Hisaki, in combination with the in situ measurements of magnetic field, particles, and radio waves from the Juno Spacecraft in the outer magnetosphere, from ~ 80RJ to 60RJ during 17 to 22 March 2017. Two cycles of accumulation and release of magnetic flux, named magnetic loading/unloading, were identified during this period, which correlate well with electron energization and auroral intensifications. Magnetic reconnection events are identified during both the loading and unloading periods, indicating that reconnection and unloading are independent processes. These results show that the dynamics in the middle magnetosphere are coupled with auroral variability

'It is fun, fitness and football really': a process evaluation of a football-based health intervention for men

Concerns about gender inequalities in longevity, particularly premature male mortality, have prompted a range of innovative approaches to health promotion work dating back to the 1980s. In developing such work, sport, and football in particular, has emerged as a gendered cultural field that has utility for engaging men in community health initiatives. Evaluations of such work have shown that health initiatives using football settings, football interventions or even club branding can have positive impact on various health measures in the short and longer term. However, little work to date has looked at the underlying mechanisms that generate success in such projects. This paper presents secondary analysis of data collected during the evaluation of the Premier League Health (PLH) programme specifically focusing on these underlying mechanisms and how/where gender (masculinities) appears in these processes. We draw on interview data with 16 staff who had been involved in the delivery of the PLH initiative and 58 men who took part. Thematic analysis highlighted two overarching (and underpinning) themes: 'Trust', what processes it was key to and how it was developed and sustained; and 'Change', including what it was facilitated by and what impact it had. The paper adds to our understanding of how active listening, flexibility and sustained engagement are key to community-based sports projects' success. Furthermore, it demonstrates how the physicality and sociability of involvement, rather than any direct focus on 'health', are important in acting as a springboard for facilitating reflection and aiding lifestyle changes for men. © 2013 Taylor & Francis

Long COVID and cardiovascular disease: a prospective cohort study

Background Pre-existing cardiovascular disease (CVD) or cardiovascular risk factors have been associated with an increased risk of complications following hospitalisation with COVID-19, but their impact on the rate of recovery following discharge is not known. Objectives To determine whether the rate of patient-perceived recovery following hospitalisation with COVID-19 was affected by the presence of CVD or cardiovascular risk factors. Methods In a multicentre prospective cohort study, patients were recruited following discharge from the hospital with COVID-19 undertaking two comprehensive assessments at 5 months and 12 months. Patients were stratified by the presence of either CVD or cardiovascular risk factors prior to hospitalisation with COVID-19 and compared with controls with neither. Full recovery was determined by the response to a patient-perceived evaluation of full recovery from COVID-19 in the context of physical, physiological and cognitive determinants of health. Results From a total population of 2545 patients (38.8% women), 472 (18.5%) and 1355 (53.2%) had CVD or cardiovascular risk factors, respectively. Compared with controls (n=718), patients with CVD and cardiovascular risk factors were older and more likely to have had severe COVID-19. Full recovery was significantly lower at 12 months in patients with CVD (adjusted OR (aOR) 0.62, 95% CI 0.43 to 0.89) and cardiovascular risk factors (aOR 0.66, 95% CI 0.50 to 0.86). Conclusion Patients with CVD or cardiovascular risk factors had a delayed recovery at 12 months following hospitalisation with COVID-19. Targeted interventions to reduce the impact of COVID-19 in patients with cardiovascular disease remain an unmet need

Untargeted metabolomic analysis and pathway discovery in perinatal asphyxia and hypoxic-ischaemic encephalopathy

Elucidating metabolic effects of hypoxic-ischaemic encephalopathy (HIE) may reveal early biomarkers of injury and new treatment targets. This study uses untargeted metabolomics to examine early metabolic alterations in a carefully defined neonatal population. Infants with perinatal asphyxia who were resuscitated at birth and recovered (PA group), those who developed HIE (HIE group) and healthy controls were all recruited at birth. Metabolomic analysis of cord blood was performed using direct infusion FT-ICR mass spectrometry. For each reproducibly detected metabolic feature, mean fold differences were calculated HIE vs. controls (ΔHIE) and PA vs. controls (ΔPA). Putative metabolite annotations were assigned and pathway analysis was performed. Twenty-nine putatively annotated metabolic features were significantly different in ΔPA after false discovery correction ( q < 0.05), with eight of these also significantly altered in ΔHIE. Altered putative metabolites included; melatonin, leucine, kynurenine and 3-hydroxydodecanoic acid which differentiated between infant groups (ΔPA and ΔHIE); and D-erythrose-phosphate, acetone, 3-oxotetradecanoic acid and methylglutarylcarnitine which differentiated across severity grades of HIE. Pathway analysis revealed ΔHIE was associated with a 50% and 75% perturbation of tryptophan and pyrimidine metabolism, respectively. We have identified perturbed metabolic pathways and potential biomarkers specific to PA and HIE, which measured at birth, may help direct treatment