The Urban Political Ecology of Post-industrial Scottish Towns: Examining Greengairs and Ravenscraig

Urban ecological politics is shaped by both moments of concerted action and more silent perceptions and responses. Instead of only being evident in situations of organised protest, the politics of urban ecology is also manifested, in material and symbolic terms, in the daily life of the residents. The fragmentation of urban political ecology turns out to be an important element in the affirmation of post-political forms of urban governance. Those issues were the object of fieldwork research carried out in Greengairs and Ravenscraig, two towns in North Lanarkshire, near Glasgow, with the goal of unravelling the understanding and the coping mechanisms of environmentally deprived residents. The towns are permeated by a widespread, often dissimulated, political ecology that is nonetheless always present. Empirical results demonstrate that a more comprehensive handling of the political ecology of the urban is crucial in order to halt the sources of marginalisation and ecological degradation

The Saharan Air Layer and the Fate of African Easterly Waves—NASA's AMMA Field Study of Tropical Cyclogenesis

In 2006, NASA led a field campaign to investigate the factors that control the fate of African easterly waves (AEWs) moving westward into the tropical Atlantic Ocean. Aircraft and surface-based equipment were based on Cape Verde's islands, helping to fill some of the data void between Africa and the Caribbean. Taking advantage of the international African Monsoon Multidisciplinary Analysis (AMMA) program over the continent, the NASA–AMMA (NAMMA) program used enhanced upstream data, whereas NOAA aircraft farther west in the Atlantic studied several of the storms downstream. Seven AEWs were studied during AMMA, with at least two becoming tropical cyclones. Some of the waves that did not develop while being sampled near Cape Verde likely intensified in the central Atlantic instead. NAMMA observations were able to distinguish between the large-scale wave structure and the smaller-scale vorticity maxima that often form within the waves. A special complication of the east Atlantic environment is the Saharan air layer (SAL), which frequently accompanies the AEWs and may introduce dry air and heavy aerosol loading into the convective storm systems in the AEWs. One of the main achievements of NAMMA was the acquisition of a database of remote sensing and in situ observations of the properties of the SAL, enabling dynamic models and satellite retrieval algorithms to be evaluated against high-quality real data. Ongoing research with this database will help determine how the SAL influences cloud micro-physics and perhaps also tropical cyclogenesis, as well as the more general question of recognizing the properties of small-scale vorticity maxima within tropical waves that are more likely to become tropical cyclones

A Scottish parliament and overseas aid - scope for a distinctive approach?

3.50Available from British Library Document Supply Centre- DSC:6217.2385(EU-CAS-OP--32) / BLDSC - British Library Document Supply CentreSIGLEGBUnited Kingdo

Inhibitors of Leishmania mexicana CRK3 cyclin-dependent kinase: chemical library screen and antileishmanial activity

The CRK3 cyclin-dependent kinase of Leishmania has been shown by genetic manipulation of the parasite to be essential for proliferation. We present data which demonstrate that chemical inhibition of CRK3 impairs the parasite's viability within macrophages, thus further validating CRK3 as a potential drug target. A microtiter plate-based histone H1 kinase assay was developed to screen CRK3 against a chemical library enriched for protein kinase inhibitors. Twenty-seven potent CRK3 inhibitors were discovered and screened against Leishmania donovani amastigotes in vitro. Sixteen of the CRK3 inhibitors displayed antileishmanial activity, with a 50% effective dose (ED50) of less than 10 microM. These compounds fell into four chemical classes: the 2,6,9-trisubstituted purines, including the C-2-alkynylated purines; the indirubins; the paullones; and derivatives of the nonspecific kinase inhibitor staurosporine. The paullones and staurosporine derivatives were toxic to macrophages. The 2,6,9-trisubstituted purines inhibited CRK3 in vitro, with 50% inhibitory concentrations ranging from high nanomolar to low micromolar concentrations. The most potent inhibitors of CRK3 (compounds 98/516 and 97/344) belonged to the indirubin class; the 50% inhibitory concentrations for these inhibitors were 16 and 47 nM, respectively, and the ED50s for these inhibitors were 5.8 and 7.6 microM, respectively. In culture, the indirubins caused growth arrest, a change in DNA content, and aberrant cell types, all consistent with the intracellular inhibition of a cyclin-dependent kinase and disruption of cell cycle control. Thus, use of chemical inhibitors supports genetic studies to confirm CRK3 as a validated drug target in Leishmania and provides pharmacophores for further drug development

“Some are More Open than Others”: Comparing the impact of the Freedom of Information Act 2000 on local and central government in the UK

This article examines the impact of freedom of information (FOI) on English local government and compares it with UK central government. It asks whether FOI has increased transparency and accountability and improved decision-making, public understanding, participation or trust. It also looks at whether FOI has affected local leadership, service delivery and partnership work. FOI has not had a “transformative” impact on local government. Local authorities are more transparent, supported by new online disclosure reforms. FOI has also increased accountability but only increased public understanding in a small way. It has had no effect on decision-making except in particularly sensitive issues. It has not increased participation and has had no general impact upon trust. Core activities remain unaffected though private contractors’ information and media use cause concern. The variable openness of institutions depends on context, culture and political leadership. The diversity is also driven by requesters’ varying motivations

Saharan dust and heterogeneous ice formation : Eleven years of cloud observations at a central European EARLINET site

More than 2300 observed cloud layers were analyzed to investigate the impact of aged Saharan dust on heterogeneous ice formation. The observations were performed with a polarization/Raman lidar at the European Aerosol Research Lidar Network site of Leipzig, Germany (51.3 degrees N, 12.4 degrees E) from February 1997 to June 2008. The statistical analysis is based on lidar-derived information on cloud phase (liquid water, mixed phase, ice cloud) and cloud top height, cloud top temperature, and vertical profiles of dust mass concentration calculated with the Dust Regional Atmospheric Modeling system. Compared to dust-free air masses, a significantly higher amount of ice-containing clouds (25%-30% more) was observed for cloud top temperatures from -10 degrees C to -20 degrees C in air masses that contained mineral dust. The midlatitude lidar study is compared with our SAMUM lidar study of tropical stratiform clouds at Cape Verde in the winter of 2008. The comparison reveals that heterogeneous ice formation is much stronger over central Europe and starts at higher temperatures than over the tropical station. Possible reasons for the large difference are discussed.Peer reviewe