Searching for Earth-mass planets around α\alpha Centauri: precise radial velocities from contaminated spectra

This work is part of an ongoing project which aims to detect terrestrial planets in our neighbouring star system $\alpha$ Centauri using the Doppler method. Owing to the small angular separation between the two components of the $\alpha$ Cen AB binary system, the observations will to some extent be contaminated with light coming from the other star. We are accurately determining the amount of contamination for every observation by measuring the relative strengths of the H-$\alpha$ and NaD lines. Furthermore, we have developed a modified version of a well established Doppler code that is modelling the observations using two stellar templates simultaneously. With this method we can significantly reduce the scatter of the radial velocity measurements due to spectral cross-contamination and hence increase our chances of detecting the tiny signature caused by potential Earth-mass planets. After correcting for the contamination we achieve radial velocity precision of $\sim 2.5\,\mathrm{m\,s^{-1}}$ for a given night of observations. We have also applied this new Doppler code to four southern double-lined spectroscopic binary systems (HR159, HR913, HR7578, HD181958) and have successfully recovered radial velocities for both components simultaneously.Comment: accepted for publication in the International Journal of Astrobiology (published by Cambridge University Press); will appear in a revised form, subsequent to editorial input by Cambridge University Pres

Modeling and performance of a 100-element pHEMT grid amplifier

A 100-element hybrid grid amplifier has been fabricated, The active devices in the grid are custom-made pseudomorphic high electron mobility transistor (pHEMT) differential-pair chips. We present a model for gain analysis and compare measurements with theory. The grid includes stabilizing resistors in the gate. Measurements show the grid has a peak gain of 10 db when tuned for 10 GHz and a gain of 12 dB when tuned for 9 GHz. The maximum 3-dB bandwidth is 15% at 9 GHz. The minimum noise figure is 3 dB. The maximum saturated output power is 3.7 W, with a peak power-added efficiency of 12%. These results area significant improvement over previous grid amplifiers based on heterojunction bipolar transistors (HBT's)

High-accuracy comparison of numerical relativity simulations with post-Newtonian expansions

Numerical simulations of 15 orbits of an equal-mass binary black hole system are presented. Gravitational waveforms from these simulations, covering more than 30 cycles and ending about 1.5 cycles before merger, are compared with those from quasi-circular zero-spin post-Newtonian (PN) formulae. The cumulative phase uncertainty of these comparisons is about 0.05 radians, dominated by effects arising from the small residual spins of the black holes and the small residual orbital eccentricity in the simulations. Matching numerical results to PN waveforms early in the run yields excellent agreement (within 0.05 radians) over the first $\sim 15$ cycles, thus validating the numerical simulation and establishing a regime where PN theory is accurate. In the last 15 cycles to merger, however, {\em generic} time-domain Taylor approximants build up phase differences of several radians. But, apparently by coincidence, one specific post-Newtonian approximant, TaylorT4 at 3.5PN order, agrees much better with the numerical simulations, with accumulated phase differences of less than 0.05 radians over the 30-cycle waveform. Gravitational-wave amplitude comparisons are also done between numerical simulations and post-Newtonian, and the agreement depends on the post-Newtonian order of the amplitude expansion: the amplitude difference is about 6--7% for zeroth order and becomes smaller for increasing order. A newly derived 3.0PN amplitude correction improves agreement significantly ($<1$ amplitude difference throughout most of the run, increasing to 4% near merger) over the previously known 2.5PN amplitude terms.Comment: Updated to agree with published version (various minor clarifications; added description of AH finder in Sec IIB; added discussion of tidal heating in Sec VC

INFLAMAÇÃO SUBCLÍNICA, OBESIDADE, DIABETES E DOENÇAS RELACIONADAS

Um estado de inflamação crônica subclínica, originado de uma dieta pró-inflamatória, do sedentarismo e de insultos intra-uterinos, entre outros fatores, está associado ao desenvolvimento do diabetes e de doenças cardiovasculares. Esse processo é mediado, em parte, pelo estresse oxidativo e por citocinas pró-inflamatórias, que interferem nos mecanismos de sinalização da insulina. A obesidade contribui para esse processo, uma vez que o tecido adiposo é hoje compreendido como um órgão secretor de produtos e mediadores pró-inflamatórios, como a interleucina-6 (IL-6) e o componente 3 do complemento (C3), e anti-inflamatórios, como a adiponectina. Outros fatores envolvidos são a alteração funcional do sistema nervoso autônomo e do sistema neuroendócrino, em resposta ao estresse. A insulina, em condições normais, apresenta efeitos antiinflamatórios. A resistência à insulina, uma vez presente, interromperia as ações inibitórias da insulina contra a inflamação, favorecendo também a manutenção do estado inflamatório crônico. Uma melhor compreensãodo papel do sistema imune inato na fisiopatologia da síndrome metabólica, do diabetes, da hipertensão e da doença cardiovascular, assim como das causas da ativação crônica desse sistema, deve levar a importantes avanços na predição, na prevenção e no manejo clínico dessas doenças.Unitermos: Diabetes melito, inflamação, obesidade, síndrome metabólica

Dysflective cones: Visual function and cone reflectivity in long-term follow-up of acute bilateral foveolitis.

PURPOSE:Confocal adaptive optics scanning laser ophthalmoscope (AOSLO) images provide a sensitive measure of cone structure. However, the relationship between structural findings of diminished cone reflectivity and visual function is unclear. We used fundus-referenced testing to evaluate visual function in regions of apparent cone loss identified using confocal AOSLO images. METHODS:A patient diagnosed with acute bilateral foveolitis had spectral-domain optical coherence tomography (SD-OCT) (Spectralis HRA + OCT system [Heidelberg Engineering, Vista, CA, USA]) images indicating focal loss of the inner segment-outer segment junction band with an intact, but hyper-reflective, external limiting membrane. Five years after symptom onset, visual acuity had improved from 20/80 to 20/25, but the retinal appearance remained unchanged compared to 3 months after symptoms began. We performed structural assessments using SD-OCT, directional OCT (non-standard use of a prototype on loan from Carl Zeiss Meditec) and AOSLO (custom-built system). We also administered fundus-referenced functional tests in the region of apparent cone loss, including analysis of preferred retinal locus (PRL), AOSLO acuity, and microperimetry with tracking SLO (TSLO) (prototype system). To determine AOSLO-corrected visual acuity, the scanning laser was modulated with a tumbling E consistent with 20/30 visual acuity. Visual sensitivity was assessed in and around the lesion using TSLO microperimetry. Complete eye examination, including standard measures of best-corrected visual acuity, visual field tests, color fundus photos, and fundus auto-fluorescence were also performed. RESULTS:Despite a lack of visible cone profiles in the foveal lesion, fundus-referenced vision testing demonstrated visual function within the lesion consistent with cone function. The PRL was within the lesion of apparent cone loss at the fovea. AOSLO visual acuity tests were abnormal, but measurable: for trials in which the stimulus remained completely within the lesion, the subject got 48% correct, compared to 78% correct when the stimulus was outside the lesion. TSLO microperimetry revealed reduced, but detectible, sensitivity thresholds within the lesion. CONCLUSIONS AND IMPORTANCE:Fundus-referenced visual testing proved useful to identify functional cones despite apparent photoreceptor loss identified using AOSLO and SD-OCT. While AOSLO and SD-OCT appear to be sensitive for the detection of abnormal or absent photoreceptors, changes in photoreceptors that are identified with these imaging tools do not correlate completely with visual function in every patient. Fundus-referenced vision testing is a useful tool to indicate the presence of cones that may be amenable to recovery or response to experimental therapies despite not being visible on confocal AOSLO or SD-OCT images

Columbia River Basin Water Law Institutions and Policies Survey: Report to the Western Water Policy Review Advisory Commission

Report to the Western Water Policy Review Advisory Commissio

High-Quality Draft Genome Sequence of Vagococcus lutrae Strain LBD1, Isolated from the Largemouth Bass Micropterus salmoides

Vagococci are usually isolated from marine hosts and occasionally from endodontic infections. Using 16S rRNA gene comparison, the closest relatives are members of the genera Enterococcus and Carnobacterium. A draft sequence of Vagococcus lutrae was generated to clarify the relationship of Vagococcus to these and other related low-G+C Gram-positive bacteria

Maximal variance reduction for stochastic propagators with applications to the static quark spectrum

We study a new method -- maximal variance reduction -- for reducing the variance of stochastic estimators for quark propagators. We find that while this method is comparable to usual iterative inversion for light-light mesons, a considerable improvement is achieved for systems containing at least one infinitely heavy quark. Such systems are needed for heavy quark effective theory. As an illustration of the effectiveness of the method we present results for the masses of the ground state and excited states of $\bar{Q}q$ mesons and $\bar{Q}qq$ baryons. We compare these results with the experimental spectra involving $b$ quarks.Comment: 31 pages with 7 postscript file