Human behaviors: a threat for mosquito control?

Community involvement and the preventive behavior of households are considered to be at the heart of vector-control strategies. In this work, we consider a simple theoretical model that enables us to take into account human behaviors that may interfere with vector control. The model reflects the trade-off between perceived costs and observed efficacy. Our theoretical results emphasize that households may reduce their protective behavior in response to mechanical elimination techniques piloted by a public agent, leading to an increase of the total number of mosquitoes in the surrounding environment and generating a barrier for vector-borne diseases control. Our study is sufficiently generic to be applied to different arboviral diseases. It also shows that vector-control models and strategies have to take into account human behaviors.Comment: 27 pages, 7 figure

Tumor angiogenesis and anti-angiogenic therapy in malignant gliomas revisited

The cellular and molecular mechanisms of tumor angiogenesis and its prospects for anti-angiogenic cancer therapy are major issues in almost all current concepts of both cancer biology and targeted cancer therapy. Currently, (1) sprouting angiogenesis, (2) vascular co-option, (3) vascular intussusception, (4) vasculogenic mimicry, (5) bone marrow-derived vasculogenesis, (6) cancer stem-like cell-derived vasculogenesis and (7) myeloid cell-driven angiogenesis are all considered to contribute to tumor angiogenesis. Many of these processes have been described in developmental angiogenesis; however, the relative contribution and relevance of these in human brain cancer remain unclear. Preclinical tumor models support a role for sprouting angiogenesis, vascular co-option and myeloid cell-derived angiogenesis in glioma vascularization, whereas a role for the other four mechanisms remains controversial and rather enigmatic. The anti-angiogenesis drug Avastin (Bevacizumab), which targets VEGF, has become one of the most popular cancer drugs in the world. Anti-angiogenic therapy may lead to vascular normalization and as such facilitate conventional cytotoxic chemotherapy. However, preclinical and clinical studies suggest that anti-VEGF therapy using bevacizumab may also lead to a pro-migratory phenotype in therapy resistant glioblastomas and thus actively promote tumor invasion and recurrent tumor growth. This review focusses on (1) mechanisms of tumor angiogenesis in human malignant glioma that are of particular relevance for targeted therapy and (2) controversial issues in tumor angiogenesis such as cancer stem-like cell-derived vasculogenesis and bone-marrow-derived vasculogenesis

Tree-Grass interactions dynamics and Pulse Fires: mathematical and numerical studies

Savannas are dynamical systems where grasses and trees can either dominate or coexist. Fires are known to be central in the functioning of the savanna biome though their characteristics are expected to vary along the rainfall gradients as observed in Sub-Saharan Africa. In this paper, we model the tree-grass dynamics using impulsive differential equations that consider fires as discrete events. This framework allows us to carry out a comprehensive qualitative mathematical analysis that revealed more diverse possible outcomes than the analogous continuous model. We investigated local and global properties of the equilibria and show that various states exist for the physiognomy of vegetation. Though several abrupt shifts between vegetation states appeared determined by fire periodicity, we showed that direct shading of grasses by trees is also an influential process embodied in the model by a competition parameter leading to bifurcations. Relying on a suitable nonstandard finite difference scheme, we carried out numerical simulations in reference to three main climatic zones as observable in Central Africa.Comment: 51 pages, 7 figure

Adding SALT to Coupled Microcavities: the making of active photonic molecule lasers

A large body of work has accumulated over the years in the study of the optical properties of single and coupled microcavities for a variety of applications, ranging from filters to sensors and lasers. The focus has been mostly on the geometry of individual resonators and/or on their combination in arrangements often referred to as photonic molecules (PMs). Our primary concern will be the lasing properties of PMs as ideal candidates for the fabrication of integrated microlasers, photonic molecule lasers. Whereas most calculations on PM lasers have been based on cold-cavity (passive) modes, i.e. quasi-bound states, a recently formulated steady-state ab initio laser theory (SALT) offers the possibility to take into account the spectral properties of the underlying gain transition, its position and linewidth, as well as incorporating an arbitrary pump profile. We will combine two theoretical approaches to characterize the lasing properties of PM lasers: for two-dimensional systems, the generalized Lorenz-Mie theory will obtain the resonant modes of the coupled molecules in an active medium described by SALT. Not only is then the theoretical description more complete, the use of an active medium provides additional parameters to control, engineer and harness the lasing properties of PM lasers for ultra-low threshold and directional single-mode emission.Comment: 16th International Conference on Transparent Optical Networks (2014

Optimization of integrated polarization filters

This study reports on the design of small footprint, integrated polarization filters based on engineered photonic lattices. Using a rods-in-air lattice as a basis for a TE filter and a holes-in-slab lattice for the analogous TM filter, we are able to maximize the degree of polarization of the output beams up to 98 % with a transmission efficiency greater than 75 %. The proposed designs allow not only for logical polarization filtering, but can also be tailored to output an arbitrary transverse beam profile. The lattice configurations are found using a recently proposed parallel tabu search algorithm for combinatorial optimization problems in integrated photonics

S and Q Matrices Reloaded: applications to open, inhomogeneous, and complex cavities

We present a versatile numerical algorithm for computing resonances of open dielectric cavities. The emphasis is on the generality of the system's configuration, i.e. the geometry of the (main) cavity (and possible inclusions) and the internal and external dielectric media (homogeneous and inhomogeneous). The method is based on a scattering formalism to obtain the position and width of the (quasi)-eigenmodes. The core of the method lies in the scattering S-matrix and its associated delay Q-matrix which contain all the relevant information of the corresponding scattering experiment. For instance, the electromagnetic near- and far-fields are readily extracted. The flexibility of the propagation method is displayed for a selected system.Comment: 15th International Conference on Transparent Optical Networks (2013

Ab initio investigation of lasing thresholds in photonic molecules

We investigate lasing thresholds in a representative photonic molecule composed of two coupled active cylinders of slightly different radii. Specifically, we use the recently formulated steady-state ab initio laser theory (SALT) to assess the effect of the underlying gain transition on lasing frequencies and thresholds. We find that the order in which modes lase can be modified by choosing suitable combinations of the gain center frequency and linewidth, a result that cannot be obtained using the conventional approach of quasi-bound modes. The impact of the gain transition center on the lasing frequencies, the frequency pulling effect, is also quantified

Global fit to Higgs signal strengths and couplings and implications for extended Higgs sectors

The most recent LHC data have provided a considerable improvement in the precision with which various Higgs production and decay channels have been measured. Using all available public results from ATLAS, CMS and the Tevatron, we derive for each final state the combined confidence level contours for the signal strengths in the (gluon fusion + ttH associated production) versus (vector boson fusion + VH associated production) space. These "combined signal strength ellipses" can be used in a simple, generic way to constrain a very wide class of New Physics models in which the couplings of the Higgs boson deviate from the Standard Model prediction. Here, we use them to constrain the reduced couplings of the Higgs boson to up-quarks, down-quarks/leptons and vector boson pairs. We also consider New Physics contributions to the loop-induced gluon-gluon and photon-photon couplings of the Higgs, as well as invisible/unseen decays. Finally, we apply our fits to some simple models with an extended Higgs sector, in particular to Two-Higgs-Doublet models of Type I and Type II, the Inert Doublet model, and the Georgi-Machacek triplet Higgs model.Comment: 31 pages, 15 figures; v2: fixed important factor of 2 missing in Eq. (1) (results unchanged), extended discussion in the next-to-last paragraph of Section 3, some references added; v3: appendices and references added, matches version accepted by PR

The primordial deuterium abundance at z = 2.504 from a high signal-to-noise spectrum of Q1009+2956

The spectrum of the $z_{\rm em} = 2.63$ quasar Q1009+2956 has been observed extensively on the Keck telescope. The Lyman limit absorption system $z_{\rm abs} = 2.504$ was previously used to measure D/H by Burles & Tytler using a spectrum with signal to noise approximately 60 per pixel in the continuum near Ly {\alpha} at $z_{\rm abs} = 2.504$. The larger dataset now available combines to form an exceptionally high signal to noise spectrum, around 147 per pixel. Several heavy element absorption lines are detected in this LLS, providing strong constraints on the kinematic structure. We explore a suite of absorption system models and find that the deuterium feature is likely to be contaminated by weak interloping Ly {\alpha} absorption from a low column density H I cloud, reducing the expected D/H precision. We find D/H = $2.48^{+0.41}_{-0.35}\times10^{-5}$ for this system. Combining this new measurement with others from the literature and applying the method of Least Trimmed Squares to a statistical sample of 15 D/H measurements results in a "reliable" sample of 13 values. This sample yields a primordial deuterium abundance of (D/H)$_{\rm p} = (2.545 \pm 0.025)\times10^{-5}$. The corresponding mean baryonic density of the Universe is $\Omega_{\rm b}h^2 = 0.02174\pm0.00025$. The quasar absorption data is of the same precision as, and marginally inconsistent with, the 2015 CMB Planck (TT+lowP+lensing) measurement, $\Omega_{\rm b}h^2 = 0.02226\pm0.00023$. Further quasar and more precise nuclear data are required to establish whether this is a random fluctuation.Comment: accepted by MNRAS, 18 pages, 12 figures, 6 table

Power Allocation Games in Wireless Networks of Multi-antenna Terminals

We consider wireless networks that can be modeled by multiple access channels in which all the terminals are equipped with multiple antennas. The propagation model used to account for the effects of transmit and receive antenna correlations is the unitary-invariant-unitary model, which is one of the most general models available in the literature. In this context, we introduce and analyze two resource allocation games. In both games, the mobile stations selfishly choose their power allocation policies in order to maximize their individual uplink transmission rates; in particular they can ignore some specified centralized policies. In the first game considered, the base station implements successive interference cancellation (SIC) and each mobile station chooses his best space-time power allocation scheme; here, a coordination mechanism is used to indicate to the users the order in which the receiver applies SIC. In the second framework, the base station is assumed to implement single-user decoding. For these two games a thorough analysis of the Nash equilibrium is provided: the existence and uniqueness issues are addressed; the corresponding power allocation policies are determined by exploiting random matrix theory; the sum-rate efficiency of the equilibrium is studied analytically in the low and high signal-to-noise ratio regimes and by simulations in more typical scenarios. Simulations show that, in particular, the sum-rate efficiency is high for the type of systems investigated and the performance loss due to the use of the proposed suboptimum coordination mechanism is very small