Management of severe allergic conjunctivitis with topical cyclosporin A 0.05% eyedrops

PubMedID: 17893529PURPOSE: To evaluate the efficacy of topical cyclosporin A 0.05% in the management of severe allergic conjunctivitis. METHODS: Seven patients with severe allergic conjunctivitis who were not responding to topical steroids, antihistamines, and mast cell stabilizers were given topical cyclosporin A 0.05%. All patients had an active disease when they were included in the study. Signs and symptoms were recorded before and after treatment. RESULTS: Seven patients, 6 boys and 1 girl, 6-14 years old, 6 with vernal keratoconjunctivitis and 1 with atopic keratoconjunctivitis, were enrolled in the study. Treatment with topical cyclosporin A 0.05% decreased the severity of symptoms and clinical signs significantly after 6 months (P < 0.05, Wilcoxon signed rank test). In addition, the need for steroids was reduced or even stopped. The patients experienced no side effects during the follow-up periods (mean, 14.0 ± 2.1 months; range, 8-18 months). CONCLUSIONS: Topical cyclosporin A is an effective treatment in the management of severe allergic conjunctivitis with a benefit as a steroid-sparing agent. © 2007 Lippincott Williams & Wilkins, Inc

Spectroscopic studies, antimicrobial activities and crystal structures of N-(2-hydroxy-3-methoxybenzalidene) 1-aminonaphthalene

Dulger, Basaran/0000-0002-3184-2652; Dulger, Basaran/0000-0002-3184-2652; Unver, Huseyin/0000-0003-3968-4385WOS: 000227082800012Schiff base N-(2-hydroxy-3-methoxybenzalidene)1-aminonaphthalene has been synthesized from the reaction of 2-hydroxy-3-methoxybenzaldehyde with 1-aminonaphthalene. The compound were characterized by elemental analysis, FT-IR, H-1 NMR, C-13 NMR and UV-visible techniques. The UV-visible spectra of the Schiff base were studied in polar and nonpolar solvents in acidic and basic media. The structure of the compound has been examined cyrstallographically. There are two independent molecules in the asymmetric unit. It crystallizes in the monoclinic space group P2(l)/c, with unit cell parameters: a=14,602(2), b=5,800(1), c= 16,899(1) Angstrom, V= 1394.4(2) Angstrom(3) D-x=1.321 g cm(-3) and Z = 4. The crystal structure was solved by direct methods and refined by full-matrix least squares to a find R = 0.041 of for 1179 observed reflections. The title compound's antimicrobial activities also have been studied. The antimicrobial activities of the ligand has been screened in vitro against the organisms Escherichia coli ATCC 11230, Staphylococcus aureus ATCC 6538, Klebsiella pneumoniae UC57, Micrococcus luteus La 2971, Proteus vulgaris ATCC 8427, Pseudomonas aeruginosa ATCC 27853, Mycobacterium smegmatis CCM 2067, Bacillus cereus ATCC 7064 and Listeria monocytogenes ATCC 15313, the yeast cultures Candida albicans ATCC 1023 1, Kluyveromyces fragilis NRRL 2415, Rhodotorula rubra DSM 70403, Debaryomyces hansenii DSM 70238 and Hanseniaspora guilliemodii DSM 3432. (C) 2004 Elsevier B.V. All rights reserved

formation

Objective: To investigate the potential role of mast cell stabilisation in the prevention of post-operative adhesions.Design: Laboratory animal experiment.Setting: University hospital, Turkey,Subjects: Ninety Wistar albino rats.Intervention: Under anaesthesia, a lower midline laparotomy was performed, the caecum exposed and grasped until haemorrhage occurred. The rats were divided into three groups. Group 1, 2 and 3 were intra-peritoneally administered 1 mi of saline, disodium cromoglycate 5mg/kg in 1 ml of saline and 10mg/kg in 1 ml of saline, respectively thirty minutes prior to laparotomy and immediately subsequent to abdominal closure. They were later sacrificed, laparotomy repeated and the presence and extent of intra-abdominal adhesions evaluated.Results: Adhesion scores were best in the high disodium cromoglycate dose group of rats (p<0.05) and the number of degranulated mast cells was significantly low in this group (p<0.05),Conclusion: Disodium cromoglycate may be an effective agent for attenuating adhesion formation when administered in suitable doses

INVESTIGATION OF THE RELATIONSHIP BETWEEN PLANTAR PRESSURE DISTRIBUTION AND LUMBAR MULTIFIDUS MUSCLE THICKNESS

Congress of the European-League-Against-Rheumatism (EULAR) -- JUN 13-16, 2018 -- Amsterdam, NETHERLANDSWOS: 000444351002345…European League Against Rheumatis

formation

Objective: To investigate the potential role of mast cell stabilisation in the prevention of post-operative adhesions.Design: Laboratory animal experiment.Setting: University hospital, Turkey,Subjects: Ninety Wistar albino rats.Intervention: Under anaesthesia, a lower midline laparotomy was performed, the caecum exposed and grasped until haemorrhage occurred. The rats were divided into three groups. Group 1, 2 and 3 were intra-peritoneally administered 1 mi of saline, disodium cromoglycate 5mg/kg in 1 ml of saline and 10mg/kg in 1 ml of saline, respectively thirty minutes prior to laparotomy and immediately subsequent to abdominal closure. They were later sacrificed, laparotomy repeated and the presence and extent of intra-abdominal adhesions evaluated.Results: Adhesion scores were best in the high disodium cromoglycate dose group of rats (p<0.05) and the number of degranulated mast cells was significantly low in this group (p<0.05),Conclusion: Disodium cromoglycate may be an effective agent for attenuating adhesion formation when administered in suitable doses